Treatment of acute hepatitis a with unani medicine

a case report

| Posted in: Scientific

Journal name: World Journal of Pharmaceutical Research
Original article title: Treatment of acute hepatitis a with unani medicine
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a case report

Original source:

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Author:

Mohd. Khalid, Arzeena Jabeen, M. Abdul Mutalib and Munawwar Husain Kazmi


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Treatment of acute hepatitis a with unani medicine

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20198-15287


Download the PDF file of the original publication


Summary of article contents:

Introduction

Hepatitis A virus (HAV) is a significant public health concern globally, particularly in developing countries such as India. This case report discusses the treatment of a 34-year-old woman suffering from acute Hepatitis A using Unani medicine, specifically a compound known as Sharbat-e-Deenar. The report highlights not only the patient's symptoms and laboratory findings but also the potential therapeutic effects of traditional herbal formulations.

Treatment with Sharbat-e-Deenar

The patient presented with symptoms of fever, malaise, nausea, abdominal discomfort, and jaundice lasting four weeks. Subsequent laboratory tests confirmed hyperbilirubinemia and elevated liver transaminases. The treatment prescribed was Sharbat-e-Deenar, a traditional Unani medicine specifically formulated for liver ailments. Following this treatment, the patient showed significant improvement, with her symptoms subsiding and liver function indicators returning to normal levels within two months.

Hepatoprotective Ingredients in Unani Medicine

Sharbat-e-Deenar comprises several botanicals known for their hepatoprotective properties. Key ingredients include Cichorium intybus, Rheum emodi, and Rosa damascena, each recognized for their antioxidant effects and ability to restore liver function. Research supports the efficacy of these compounds in preventing liver damage, partly due to their action in reducing oxidative stress, which is crucial for Hepatitis A recovery.

Clinical Implications of Unani Treatments

The case presented demonstrates the relevance of traditional medicine, especially Unani formulations, in contemporary healthcare settings. With increasing prevalence and recognition of viral hepatitis as a public health challenge in India, the results of this case suggest that herbal treatments may serve as a complementary option alongside conventional therapies. The patient's complete recovery underscores the importance of integrating traditional medicine into patient care paradigms, particularly in socio-economically diverse settings.

Conclusion

In summary, this case report illustrates the potential of Unani medicine, specifically Sharbat-e-Deenar, as an effective treatment for Hepatitis A. The encouraging results observed in alleviating the patient's symptoms and restoring liver function markers indicate that traditional herbal remedies may hold significant promise in managing viral hepatitis. Future research could strengthen these findings, potentially leading to broader acceptance and integration of such treatments within mainstream medical practice.

FAQ section (important questions/answers):

What are the primary symptoms of Hepatitis A in adults?

Symptoms of Hepatitis A include fever, malaise, anorexia, nausea, abdominal discomfort, jaundice, and dark-colored urine. In adults, the disease can be more symptomatic compared to children, which may present with milder forms.

What is the case report about in this document?

The case report details a 34-year-old woman treated for acute Hepatitis A using Unani medicine, specifically Sharbat-e-Deenar. The report highlights her symptoms, diagnostic results, treatment regimen, and successful recovery.

What is Sharbat-e-Deenar and its key ingredients?

Sharbat-e-Deenar is a Unani herbal formulation intended for hepatoprotection. Its key ingredients include Cichorium intybus, Cuscuta reflexa, Rosa damascena, Rheum emodi, and Nymphaea alba, known for their beneficial properties against liver ailments.

How was the effectiveness of Sharbat-e-Deenar measured?

The effectiveness of Sharbat-e-Deenar was measured through lab investigations, assessing liver enzyme levels (ALT, AST), bilirubin levels, and viral load over multiple follow-ups. The patient showed significant improvement and normalization of these parameters after treatment.

What are the possible causes of Hepatitis A infection?

Hepatitis A infection typically occurs when an individual ingests contaminated food or water from an infected person. Unsafe sanitation, poor personal hygiene, and consuming contaminated food are significant contributors to the disease's transmission.

What is the role of flavonoids in Sharbat-e-Deenar?

Flavonoids present in the ingredients of Sharbat-e-Deenar are thought to contribute to its hepatoprotective effects by enhancing antioxidant activity, reducing oxidative stress, and promoting the liver's recovery from damage, thus aiding in Hepatitis A treatment.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Treatment of acute hepatitis a with unani medicine”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
In the context of medical studies, particularly pharmacology, 'activity' often refers to the biological effects or therapeutic impacts of a substance, such as medications or herbal formulations like Sharbat-e-Deenar. Understanding the activity helps assess its efficacy against conditions like Hepatitis A, which is crucial for treatment advancements.

2) Medicine:
The term 'medicine' encompasses various practices and substances used to prevent, diagnose, and treat illness. In this case, Unani medicine represents traditional herbal and alternative therapies aimed at treating conditions such as Hepatitis A, highlighting the integration of ancient practices in modern healthcare.

3) India:
India is significant due to its high prevalence of Hepatitis A, driven by socio-economic factors affecting public health. The country serves as a focal point for studying viral hepatitis epidemiology, treatment options, and the effectiveness of traditional remedies, showcasing the intersection of culture and healthcare.

4) Study (Studying):
A 'study' in medical contexts typically involves systematic research to gather evidence regarding a particular health issue. Here, the focus is on a case report analyzing the effectiveness of Unani medicine, Sharbat-e-Deenar, in treating Hepatitis A, contributing to the body of knowledge in herbal pharmacology.

5) Flavonoid:
Flavonoids are plant metabolites known for their potential health benefits, particularly antioxidant and hepatoprotective properties. In this article, the efficacy of flavonoids in ingredients of Sharbat-e-Deenar is highlighted, suggesting their role in combatting liver diseases like Hepatitis A through cellular protection mechanisms.

6) Water:
The role of 'water' is pertinent in the discussion of Hepatitis A transmission, as the virus is primarily spread through contaminated water. Addressing safe water practices is crucial in preventing outbreaks, particularly in developing countries where sanitation and hygiene can be compromised.

7) Nymphaea alba:
Nymphaea alba, commonly known as white water lily, is noted for its hepatoprotective effects in Unani medicine. The plant's inclusion in formulations like Sharbat-e-Deenar underscores its traditional use in managing liver ailments, highlighting the synergy of botanical components in holistic health approaches.

8) Nymphaea:
The genus 'Nymphaea' includes aquatic plants recognized for their medicinal properties. In the context of Hepatitis treatment, Nymphaea alba contributes significant hepatoprotective effects, showcasing the importance of diverse flora in developing herbal remedies and the ongoing interest in bioprospecting for health applications.

9) Disease:
'Disease' refers to any impairment of normal physiological function, with Hepatitis A being a primary example. Understanding disease mechanisms is essential for developing effective treatments and public health strategies, especially in regions with high prevalence, emphasizing the need for holistic medical approaches.

10) Shakya (Sakya):
Shakya is one of the researchers involved in studies assessing the effectiveness of Unani formulations like Sharbat-e-Deenar against liver diseases. The contributions of researchers play a critical role in validating traditional medicine's relevance through scientific investigations, enhancing its credibility in modern healthcare.

11) Family:
'Family' in a biological context classifies groups of related organisms. In botanical terms, understanding plant families, such as Asteraceae or Boraginaceae, involved in formulations helps in recognizing their shared characteristics and medicinal potentials, thereby guiding herbal practice and research in medicine.

12) Nausea:
Nausea is a common symptom associated with Hepatitis A infection, impacting overall quality of life. The treatment aimed at alleviating nausea through herbal formulations can significantly contribute to the patient's comfort and recovery, showcasing the holistic approach of Unani medicine in symptom management.

13) Animal:
The use of 'animals' in pharmacological research provides insights into the safety and efficacy of treatments before they are applied in human medicine. Animal studies are essential for understanding biological responses and validating the therapeutic potential of herbal compounds like those in Sharbat-e-Deenar.

14) Table:
'Table' organizes data systematically, facilitating easier understanding and comparison. The tables included in the study present laboratory test results, which are critical for assessing treatment efficacy and monitoring patient progress, making them a key component of scientific documentation.

15) Food:
Nutritional aspects, particularly 'food', are crucial in managing hepatitis. Dietary restrictions, like avoiding fatty foods, emphasize the role of proper nutrition alongside herbal treatments in recovery, illustrating the intertwined nature of diet, lifestyle, and health in infectious disease management.

16) Srivastava (Shri-vastava, Shrivastava, Sri-vastava):
Shrivastava is noted in the research community for contributions related to herbal medicine and pharmacology. The acknowledgment of various authors increases the reliability of the study, demonstrating how collaborative research can enhance understanding of complex health issues like Hepatitis A treatment.

17) Developing:
The term 'developing' highlights regions, primarily in the context of public health challenges, where diseases like Hepatitis A are more prevalent due to socio-economic issues. Understanding the unique challenges faced by developing countries is important for targeted healthcare interventions and preventive strategies.

18) Vomiting:
Vomiting is often a debilitating symptom of Hepatitis A, affecting patient quality of life. Effective treatment must address this symptom directly, illustrating how comprehensive care in herbal medicine aims not only for disease resolution but also for symptomatic relief and patient comfort.

19) Epidemic:
'Epidemic' is a critical public health concern indicating the spread of infectious diseases like Hepatitis A. Understanding the patterns of epidemic outbreaks directs resources to prevention, treatment, and education efforts, raising awareness about hygiene and sanitation to reduce transmission risks.

20) Shukla (Sukla):
Shukla is another researcher referenced in the study, emphasizing the collaborative nature of pharmacological research. The diverse expertise among authors contributes to a comprehensive understanding of Unani medicine's efficacy, promoting an integrative approach to exploring traditional therapeutic options.

21) Sharman (Sarma, Sharma, Sarman):
Sharma's involvement in the study reinforces the breadth of academic inquiry into Unani medicine, highlighting how collaborative authorship enriches the research landscape. This collaborative approach fosters innovation in traditional medicine by combining diverse insights from various research fields.

22) Saxena (Sakshena, Saksena):
Saxena is mentioned as part of the research team examining the pharmacological properties of Unani medicines. The inclusion of multiple authors reflects a commitment to scientific rigor, ensuring diverse perspectives that can enhance the findings and applicability of herbal therapies in healthcare.

23) Fever:
Fever represents one of the common systemic symptoms associated with Hepatitis A. Managing fever alongside other symptoms is essential in treatment regimens, demonstrating the holistic focus of Unani medicine, which aims to improve overall health outcomes for patients suffering from infectious diseases.

24) Viru:
The study discusses viral infections, highlighting the role of 'viru', as referenced in viral hepatitis. Understanding viral pathology is crucial for developing effective treatments and preventive measures, especially as the public health landscape continues to face challenges from various viral outbreaks.

25) Pharmacological:
Pharmacological studies evaluate how herbal formulations, like Sharbat-e-Deenar, interact with biological systems. The pharmacological attributes of plant components are crucial for understanding their therapeutic effects, guiding safe and effective integration into health care practices, particularly in traditional medicine contexts.

26) Inflammation:
Inflammation is often a key pathological process in liver diseases such as Hepatitis A. Herbal treatments that possess anti-inflammatory properties can contribute to recovery by mitigating tissue damage, showcasing how traditional remedies align with modern biochemical understanding of disease mechanisms.

27) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is significant in the context of the study due to its regional healthcare challenges, including the prevalence of Hepatitis A. Exploring local medicinal practices within this geographical context enriches the discourse on traditional medicines and their relevance in contemporary public health strategies.

28) Discussion:
The 'discussion' section in research articles critically assesses findings in relation to existing literature. This component is crucial for contextualizing results and drawing conclusions about the efficacy of treatments like Sharbat-e-Deenar, guiding further research and clinical applications.

29) Gaozaban:
Gaozaban, or Borago officinalis, is an ingredient in Sharbat-e-Deenar. Known for its potential health benefits, the plant contributes to the overall hepatoprotective effects of the formulation, illustrating the importance of herbal diversity in developing effective traditional medicine treatments.

30) Accutan:
Achuthan's research contributions emphasize the intersection of traditional knowledge and scientific validation in exploring Unani medicinal formulations. The acknowledgment of individual researchers underscores the collaborative efforts in advancing herbal pharmacology and the importance of rigorous scientific inquiry in this field.

31) Hygiene (Hygienic):
Hygiene practices are critical in reducing the spread of Hepatitis A, with the virus primarily transmitted via fecal-oral routes. Educating communities on maintaining proper hygiene is essential for public health, particularly in areas with high endemicity, illustrating the broader impact of preventive measures.

32) Panda (Pamda):
Panda is recognized for contributions to the study of herbal medicine, particularly in relation to hepatoprotective effects. The involvement of diverse researchers emphasizes the collaborative nature of scientific exploration, driving advancements in understanding the efficacy of traditional remedies for liver health.

33) Delhi:
Delhi is relevant due to its urban public health dynamics, including the prevalence of Hepatitis A. Studying regional conditions helps identify effective interventions and healthcare strategies, fostering a better understanding of how geographical variation impacts viral transmission and disease management.

34) Sugar:
Sugar is a dietary component mentioned in the formulation of Sharbat-e-Deenar. Understanding the role of nutritional elements, including sweeteners, is essential in assessing both the therapeutic value and the palatability of herbal medicines, making it relevant for the use of traditional remedies.

35) Devi:
Devi is one of the researchers contributing to the findings related to hepatoprotective activities of Unani medicines. Collaborations among diverse researchers enhance the depth of insights provided in studies, fostering an enriched understanding of how traditional therapies can be integrated into modern health frameworks.

36) Babu:
Babu is noted as an author involved in the assessment of traditional medicine's efficacy. The collaborative efforts of researchers like Babu reflect the importance of various disciplines in advancing the understanding of herbal therapies, promoting research that bridges traditional and contemporary medical practices.

37) Pune:
Pune is significant as a base for important Unani medical research and practice. The city's role in healthcare education and traditional medicine contributes to broader discussions on the integration of ancient healing practices with modern medical approaches to address public health challenges.

38) Sign:
'Sign' refers to physical or clinical indicators of disease presence, such as jaundice in Hepatitis A. Recognizing signs is critical in diagnosis and treatment strategies, influencing clinical decisions and enhancing the understanding of disease manifestations within traditional frameworks of medicine.

39) Pain:
Pain is a symptom that affects patients with Hepatitis A, particularly due to liver inflammation. Addressing pain management within treatment regimens highlights the comprehensive approach of Unani medicine that aims to relieve discomfort while also targeting the underlying disease process.

40) Post:
In research contexts, 'post' often refers to follow-up evaluations assessing treatment outcomes after intervention. Monitoring patients post-treatment is essential for determining the efficacy and safety of herbal medicines like Sharbat-e-Deenar, which directly impacts clinical practice and patient care.

41) Ara:
Aara is likely involved in discussions related to Unani medicine and its applications in therapeutic contexts. The collaboration among various authors, including Aara, emphasizes the collective effort in driving research that validates the effectiveness of traditional remedies in modern healthcare systems.

42) Pur:
'Poor' often describes socio-economic conditions that can exacerbate public health issues, like Hepatitis A. Recognizing the impact of poverty on health disparities is essential for public health strategies focused on improving sanitation, hygiene, and access to healthcare among vulnerable populations.

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