Effect of bulk density on tensile strength of Hicelt™ tablets.
Journal name: World Journal of Pharmaceutical Research
Original article title: Effect of bulk density on tensile strength of tablets prepared by using hiceltmmcc (microcrystalline cellulose) and hiceltmsmcc (silicified microcrystalline cellulose)
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Summary of article contents:
Introduction
The study conducted by Shah et al. (2017) evaluates the impact of bulk density on the tensile strength of tablets made from two types of microcrystalline cellulose: HiCel™ MCC (Microcrystalline Cellulose) and HiCel™ SMCC (Silicified Microcrystalline Cellulose). Direct compression is a widely accepted method for tablet manufacturing, dependent on various physical parameters, including bulk density, moisture content, particle size, Carr’s index, and angle of repose. The primary goal of the research was to find correlations between the bulk density of the excipients and the tensile strength and friability of the tablets produced, ultimately leading to a better understanding of how these parameters affect tablet quality.
Importance of Bulk Density
Bulk density is a critical parameter affecting the physical properties of excipients used in tablet formulation. In this study, two grades of microcrystalline cellulose, HiCel™ MCC and HiCel™ SMCC, were examined at different bulk densities. The findings indicate an inverse correlation between bulk density and the tensile strength of the tablets; as the bulk density increases, the tensile strength tends to decrease. This relationship highlights the need for precise control of bulk density during the formulation process, as it may significantly influence the tablet's mechanical strength and functionality.
Correlation Between Tensile Strength and Friability
The research also emphasizes the relationship between tensile strength and friability – the tendency of tablets to break or crumble. Results showed that with decreasing tensile strength, the friability of the tablets increased, indicating that tablets with lower strength are more prone to mechanical failure. This relationship suggests that formulating tablets with a higher tensile strength is essential for maintaining their integrity during handling and transportation, thereby enhancing their stability as pharmaceutical products.
Manufacturing Process and Evaluation
The study elaborates on the manufacturing methods of HiCel™ MCC and HiCel™ SMCC, detailing the processes of hydrolysis and co-processing, respectively. HiCel™ MCC is prepared by hydrolyzing wood pulp with mineral acids, while HiCel™ SMCC is produced by forming a slurry of microcrystalline cellulose with colloidal silicon dioxide. Evaluation methods included measuring physical parameters such as moisture content, bulk density, and tablet characteristics like hardness, friability, and disintegration time. The consistent quality of tablets produced with both excipients underlines the versatility and importance of microcrystalline cellulose in pharmaceutical applications.
Conclusion
In conclusion, the study establishes vital correlations between bulk density, tensile strength, and friability in the context of tablet formulation using HiCel™ MCC and HiCel™ SMCC. The findings underscore the critical role of bulk density in determining tablet strength and integrity, advocating for careful monitoring of this parameter during the manufacturing process. Enhanced understanding of these relationships allows for better optimization of tablet formulations, ensuring higher quality and improved performance of pharmaceutical products. This research contributes to the broader field of pharmaceutical excipients and the continuous improvement of tablet manufacturing techniques.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Jilika Shah, Monika Tomar, Ajay Kumar Singh and Amit Raj Sinha
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Effect of bulk density on tensile strength of tablets prepared by using hiceltmmcc (microcrystalline cellulose) and hiceltmsmcc (silicified microcrystalline cellulose)
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201710-9377
Download the PDF file of the original publication
FAQ section (important questions/answers):
What is the primary objective of the study on HiCel™ excipients?
The study aims to explore the correlation between bulk density and tensile strength of HiCel™MCC and HiCel™SMCC, along with the relationship between tensile strength and friability of tablets made from these excipients.
How does bulk density affect the tensile strength of tablets?
Bulk density has an inverse relationship with tensile strength; as bulk density increases, the tensile strength of the tablets decreases, impacting their ability to withstand mechanical shocks during handling.
What makes HiCel™SMCC superior to HiCel™MCC in tablet manufacturing?
HiCel™SMCC exhibits superior flowability and 25-30% better compaction compared to HiCel™MCC, leading to better tablet qualities such as tensile strength, friability, and disintegration time.
What are the key physical parameters evaluated in the study?
Key physical parameters include bulk density, moisture content, particle size, Carr’s index, and angle of repose, all of which significantly affect tablet compaction and quality.
What was the method used to evaluate the friability of tablets?
Tablet friability was assessed by using a friability tester, where tablets are tumbled for 100 revolutions, measuring the weight loss to ensure it remains below the USP limit of 1%.
What is the significance of co-processed excipients like HiCel™SMCC?
Co-processed excipients like HiCel™SMCC are important for enhancing the physical properties of excipients, improving flow and compaction, which simplifies the tablet manufacturing process and enhances final product quality.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effect of bulk density on tensile strength of Hicelt™ tablets.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Sah:
Shah is the name of the primary author of the research article focused on the effect of bulk density on the tensile strength of tablets. His contribution highlights the exploration of pharmaceutical excipients, particularly Microcrystalline Cellulose, in direct tablet compression, underscoring his expertise in pharmaceutical formulations.
2) Powder:
In the context of pharmaceutical research, 'powder' refers to the bulk form of excipients like microcrystalline cellulose, which is essential for tablet formulation. The properties of powders, including flowability and density, are critical as they influence the manufacturing process and the quality of the final pharmaceutical product.
3) Study (Studying):
The term 'study' encapsulates the research conducted by the authors to examine the correlations between various parameters such as bulk density, tensile strength, and friability of tablets. This investigation is crucial for improving the understanding of tablet formulation and enhancing the quality of pharmaceutical products.
4) Table:
In this article, 'table' refers to the organized presentation of data, specifically summarizing the physical properties, tensile strength, and friability measurements for different grades of excipients. Tables are instrumental in conveying complex information clearly, allowing for easy comparison and analysis of results.
5) Simha:
Sinha is one of the co-authors of the paper, contributing to the research's findings and insights into pharmaceutical excipients. Collaborations among researchers like Sinha foster innovation in drug formulation, particularly in optimizing tablet performance, thereby improving pharmaceutical manufacturing processes.
6) Water:
Water plays a key role in the manufacturing and testing of microcrystalline cellulose and its derivatives. It is used during the hydrolysis process of wood pulp to produce microcrystalline cellulose and also in tablet disintegration tests, making it vital for both excipient functionality and quality assessment.
7) Gujarat:
Gujarat is the state in India where Sigachi Industries, the company associated with the research, is located. The region’s pharmaceutical industry contributes significantly to the research and development of excipients like microcrystalline cellulose, highlighting the importance of geographical context in industry-wide advancements in drug formulation.
8) Surface:
Surface properties of excipients, such as free flow or adhesion characteristics, are crucial in tablet formulation. In this research, the surface area and interactions between excipients and active pharmaceutical ingredients can affect the manufacturing process, tablet strength, and performance, illustrating their significance in pharmaceutical formulations.
9) Miṇi (Mini):
The term 'mini' in this context refers to the Proton Mini Press, a compact tablet compression machine used in the research study. This equipment is essential for producing and analyzing tablets under controlled conditions, allowing researchers to investigate the effects of excipient properties on tablet performance.
10) Mineral:
Mineral acids are essential in the hydrolysis reaction to produce microcrystalline cellulose. The controlled use of these acids during the manufacturing process is vital for maintaining the chemical integrity and functional properties of the cellulose, which are crucial for its role as an excipient in tablet formulations.
11) Ramya:
Ramya is mentioned as one of the authors in related literature cited within the paper. This signifies collaborative efforts in exploring the formulation and performance metrics in pharmaceutical sciences, indicating a broader research community focused on improving pharmaceutical excipients and their applications.
12) India:
India is the nation where the research was conducted, emphasizing its emerging role in the global pharmaceutical industry. The country is known for its robust manufacturing capabilities and research initiatives in drug delivery systems, directly impacting the development of excipients and their applications in healthcare.
13) Kumar:
Kumar is another co-author involved in the study. His participation underscores the collaborative effort in executing the research, reflecting the importance of teamwork in conducting comprehensive studies on excipients and enhancing the quality of tablet formulations through shared knowledge and expertise.
14) Glass:
In pharmaceutical research, a 'glass' cylinder is used as a measuring tool to determine the bulk density of powders. The accuracy of measurements obtained from glass equipment is crucial for ensuring that formulations meet required standards, essential for subsequent tablet manufacturing and quality control.
15) Drug:
This term represents the active pharmaceutical ingredients (APIs) intended to be incorporated into tablets. The relationship between the excipients used, such as Microcrystalline Cellulose, and the drug affects factors like stability, release profile, and overall efficacy of the final pharmaceutical product.
16) Biodegradable:
In pharmaceutical contexts, biodegradable materials refer to substances that can break down naturally in the environment. The use of biodegradable excipients can contribute to environmentally friendly practices in drug formulation and packaging, aligning with global trends toward sustainable pharmaceuticals.
17) Discussion:
The 'Discussion' section of the research article analyzes the results obtained from the study, interpreting them to provide insights into the correlations between bulk density, tensile strength, and friability. This analytical narrative is essential for understanding how the study's findings contribute to existing knowledge in pharmaceutical sciences.
18) Madhavi:
Madhavi is referenced in the context of related research, representing collaborative works in pharmaceutical excipients and formulation development. The inclusion of multiple authors highlights the collective efforts in advancing research methodologies and findings that enhance pharmaceutical product performance.
19) Quality:
Quality assurance is integral in pharmaceutical manufacturing, affecting product safety, efficacy, and compliance with regulatory standards. This study emphasizes the relationship between physical properties of excipients and the overall quality of tablets, critical for successful drug delivery systems in the market.
20) Bombay:
Bombay, now Mumbai, is a major city in India known for its significant contribution to the pharmaceutical industry. As a hub of commercial activity and research, the city influences the advancement of pharmaceutical technologies and the development of excipients within the industry.
21) Nature:
The term ‘nature’ in this context refers to the inherent physical and chemical properties of excipients like Microcrystalline Cellulose. Understanding these properties is essential for optimizing their function in tablet formulations, ultimately determining how they contribute to the performance and stability of the final product.
22) Desire:
The word 'desire' represents the aims or goals of researchers in improving the properties of pharmaceutical excipients. The study seeks to achieve desired outcomes such as enhanced binding capacity and optimal tablet strength, reflecting the need for effective formulations in the pharmaceutical sector.
23) Patel:
Patel is an author referenced in the research context, indicating participation in the exploration of pharmaceutical excipients. The collaboration among authors like Patel fosters a sharing of knowledge that aids in advancing the field of pharmaceutical formulations and discovering innovative solutions.
24) House:
In the pharmaceutical literature context, ‘house’ can refer to the publishing house that produces scientific journals. The credibility of published work is often associated with the publishing house, which can influence the dissemination and acceptance of research findings within the scientific community.
25) Shami (Sami):
Sami references a key figure in the literature cited, associated with research on microcrystalline cellulose and its properties. This contribution emphasizes the importance of foundational research in developing a deeper understanding of excipients and their applications in pharmaceutical formulations.
26) Babu:
Babu is another author cited in the related literature, indicating ongoing collaboration in exploring pharmaceutical formulations. The collective expertise of authors such as Babu enhances the research quality, ensuring comprehensive studies that address various dimensions of excipient functionality and formulation performance.
27) Beta:
In the biological sciences, 'beta' often refers to a form of a substance or a variant within a category, such as beta-glucan in cellulose chains. Understanding these variants helps researchers develop precise formulations with desired pharmacological effects in drug delivery systems.
28) Karin (Kari):
Kari likely refers to a researcher cited in the study, contributing to the collective understanding of microcrystalline cellulose. The collaboration amongst researchers like Kari fosters advancements in the knowledge base surrounding pharmaceutical excipients and their critical roles in effective tablet formulations.
29) Food:
The term 'food' signifies the cross-disciplinary research areas that connect pharmaceutical excipients to food science. Similarities in the formulation principles underline the versatility of compounds like microcrystalline cellulose, which can function as additives in both pharmaceuticals and food products, showcasing their multifaceted utility.
30) Wall:
The term 'wall' in the context of measuring bulk density refers to the sidewalls of the graduated measuring cylinder. Proper technique in pouring the powder down the walls is necessary to obtain accurate volume measurements, hence influencing the assessment of the excipient properties accurately.