Hydrogen peroxide scavenging in tudri surkh seed extracts.
Journal name: World Journal of Pharmaceutical Research
Original article title: Evaluation of hydrogen peroxide scavenging activity of seed extracts of tudri surkh (cheiranthus cheiri)
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Summary of article contents:
Introduction
The study explores the hydrogen peroxide (H₂O₂) scavenging activity of seed extracts from Tudri Surkh (Cheiranthus cheiri), a plant used in the Unani system of medicine. Hydrogen peroxide is converted into harmful free radicals, which can cause severe cellular damage and contribute to diseases like cancer and other oxidative stress-related conditions. Thus, evaluating the antioxidant potential of natural sources like Tudri Surkh offers an important avenue for developing safer and effective treatments against oxidative stress.
Antioxidants and Oxidative Stress
Antioxidants play an essential role in safeguarding biological systems by neutralizing free radicals, thereby preventing cell damage and related diseases. Free radicals, particularly reactive oxygen species (ROS) and reactive nitrogen species (RNS), are generated during normal cellular metabolism and can lead to oxidative stress when their production exceeds the body's ability to eliminate them. The article highlights that conventional synthetic antioxidants can be toxic, prompting a search for natural alternatives like plant extracts that can effectively scavenge these free radicals without the associated risks.
Hydrogen Peroxide Scavenging Activity
The investigation focused on the hydrogen peroxide scavenging ability of both ethanolic and hydroalcoholic extracts of Tudri Surkh seeds. Using a UV-Vis spectrophotometric method, the study revealed that the ethanolic extract demonstrated superior scavenging activity compared to the hydroalcoholic extract at lower concentrations. This higher activity was attributed to the greater solubility of phenolic compounds in the purely organic solvent. Notably, when the concentrations increased above 750 µg/ml, both extracts showed comparable scavenging activity to that of the standard antioxidant, Gallic acid, underscoring their potential as effective natural antioxidants.
Role of Flavonoids in Antioxidant Activity
Flavonoids are highlighted as key compounds responsible for the antioxidant capabilities of Tudri Surkh. The study identified the presence of flavonoids such as quercetin and erysmoside in the extracts, suggesting that the high concentrations of these compounds contribute to the effective scavenging of hydrogen peroxide. The correlation between the phenolic content of plant extracts and their antioxidant activity is well-documented, reinforcing the potential health benefits of such natural sources.
Conclusion
In conclusion, the study illustrates that both ethanolic and hydroalcoholic extracts from Tudri Surkh (Cheiranthus cheiri) exhibit significant hydrogen peroxide scavenging activity, suggesting strong antioxidant properties. These findings support the traditional use of Tudri Surkh in herbal medicine and encourage further exploration of its antioxidant potential. Investigating such natural sources can lead to the development of safer, more effective alternatives to synthetic antioxidants, possibly enhancing treatment options for various oxidative stress-related conditions.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Aasiy U. L. Erum, Mohd. Aslam, M. A. Jafri and Kalim Javed
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Evaluation of hydrogen peroxide scavenging activity of seed extracts of tudri surkh (cheiranthus cheiri)
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201710-9361
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FAQ section (important questions/answers):
What is the significance of hydrogen peroxide scavenging activity in plants?
Hydrogen peroxide scavenging activity serves as an important indicator of antioxidant potential in plants. It helps in preventing oxidative stress, which is linked to various health issues including carcinogenesis and cytotoxicity.
What were the objectives of the study on Tudri surkh?
The study aimed to evaluate the hydrogen peroxide scavenging activity of ethanolic and hydroalcoholic extracts of Tudri surkh seeds, scientifically validating its use in traditional medicine as an antioxidant.
How were the seed extracts of Tudri surkh prepared?
The seed extracts were obtained using the Soxhlet extraction method with ethanol and hydroalcohol, resulting in yields of 16.65% and 12.64% respectively after removal of solvents.
What were the findings regarding H2O2 scavenging activity?
The extracts demonstrated concentration-dependent scavenging of hydrogen peroxide. Ethanol extract showed better activity at lower concentrations compared to hydroalcoholic extract, owing to the higher solubility of phenolic compounds.
What compounds contribute to the antioxidant properties of Tudri surkh?
Tudri surkh contains flavonoids like quercetin, erysmoside, and alliside, which are known for their antioxidant capabilities and play a significant role in the effective scavenging of hydrogen peroxide.
What conclusion can be drawn from the study's results?
Both ethanolic and hydroalcoholic extracts of Tudri surkh exhibit significant H2O2 scavenging activity, suggesting they could serve as natural antioxidants in traditional medicine for treating oxidative stress-related diseases.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Hydrogen peroxide scavenging in tudri surkh seed extracts.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of the research, 'activity' refers to the hydrogen peroxide (H2O2) scavenging activity of the seed extracts. This is a measure of the extracts' ability to neutralize reactive oxygen species, reflecting their potential antioxidant properties. Such activity is crucial for evaluating the extracts' therapeutic benefits.
2) Medicine:
The term 'medicine' in this article pertains to traditional and contemporary healing practices. The study explores the Unani system of medicine, which uses herbal remedies, specifically Tudri surkh (Cheiranthus cheiri), underscoring the significance of natural products in healthcare and their potential as antioxidants.
3) New Delhi:
New Delhi, the capital city of India, is significant because the conducting institution, Jamia Hamdard, is located there. This geographical connection highlights the regional focus of the research and suggests that the findings may contribute to local herbal medicine practices and the scientific community in India.
4) Disease:
The term 'disease' relates to conditions characterized by oxidative stress, highlighting the importance of understanding antioxidant sources. The study aims to validate Tudri surkh's potential in managing diseases linked to oxidative damage, thus positioning the plant as a candidate for alternative treatments in medicine.
5) Delhi:
Similar to 'New Delhi,' the reference to 'Delhi' connects the research to the location of the academic institution involved. It emphasizes the cultural and scientific framework within which the study was conducted, supporting the exploration of traditional herbal remedies prevalent in the region.
6) Flavonoid:
Flavonoids are compounds noted for their antioxidant properties, and they play a key role in the study. High concentrations of flavonoids in Tudri surkh contribute to its H2O2 scavenging activity, suggesting that these phytochemicals are crucial for the plant's health benefits and therapeutic applications.
7) India:
India is relevant as the geographical context of the research. The study focuses on local medicinal plants and their uses in traditional medicine systems, thus integrating cultural practices with scientific inquiry, and highlighting the importance of biodiversity and indigenous knowledge in healthcare.
8) Water:
Water is significant as it is used in the hydroalcoholic extraction process of the plant seeds. This solvent's role is essential in extracting a variety of compounds, affecting the yield and composition of the extracts, thereby influencing the observed antioxidant activity in the study.
9) Species:
The use of the term 'species' highlights the specific focus on Cheiranthus cheiri, underlining the study's exploration of particular plant characteristics and their biological activities. Understanding the species is vital for recognizing its distinct properties and potential applications in treating health conditions.
10) Science (Scientific):
Science plays a critical role in this research as it transforms traditional knowledge into empirical evidence through rigorous experimentation. The study integrates scientific methodologies to assess the medicinal properties of Tudri surkh, reinforcing the importance of scientific validation in herbal medicine.
11) Study (Studying):
The word 'study' refers to the systematic investigation of the hydrogen peroxide scavenging activity of Tudri surkh. It emphasizes the research's aim of discovering and validating the antioxidant potential of this plant, contributing to the broader field of phytochemistry and medicine.
12) Drug:
In this context, 'drug' refers to the medicinal use of Tudri surkh and its extracts. The research seeks to explore the potential of these natural products as therapeutic agents, illustrating the intersection of pharmacology and traditional medicine, and their role in disease management.
13) Discussion:
The term 'discussion' is pivotal in research as it contextualizes findings within existing literature. It allows for interpretation of results and implications for future studies, expanding the understanding of Tudri surkh's role in oxidative stress and potential health benefits.
14) Accumulation (Accumulating, Accumulate):
The word 'accumulate' relates to the buildup of hydrogen peroxide within cells, emphasizing the need for effective antioxidant systems to prevent oxidative stress. The study aims to show how Tudri surkh's extracts can play a role in managing such accumulations, offering a potential health benefit.
15) Substance:
In the context of this research, 'substance' refers to the chemical compounds, such as flavonoids and phenolics, present in the seed extracts. These substances are evaluated for their antioxidant properties, highlighting their importance in understanding the plant's therapeutic potential.
16) Toxicity:
The mention of 'toxicity' connects to the concerns regarding synthetic antioxidants and their adverse effects. This study positions Tudri surkh as a safer alternative by focusing on its natural antioxidant properties, potentially reducing health risks associated with conventional synthetic agents.
17) Rich (Rch):
The term 'rich' refers to the abundance of bioactive compounds, particularly antioxidants, in Tudri surkh. This richness underscores the plant’s potential value in traditional medicine, emphasizing the importance of preserving biodiversity and exploring local plants for health benefits.
18) Hand:
The inclusion of 'hand' implies a connection to manual, traditional methods of using herbs in Unani medicine. It highlights the role of practical applications of herbal knowledge, conveying the importance of traditional practices in conjunction with modern scientific validation.
19) Life:
The word 'life' encapsulates the core theme of the research, which is to improve health and address oxidative stress-related diseases. It reflects the overarching goal of using natural sources to enhance quality of life and reduce dependence on synthetic drugs.