Effect of ethanol extract of seed of mucuna pruriens on gastric ulcers
Journal name: World Journal of Pharmaceutical Research
Original article title: Effect of ethanol extract of seed of mucuna pruriens on gastric ulcers
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Summary of article contents:
Introduction
The study investigates the effects of ethanol extract from the seeds of Mucuna pruriens on gastric ulcers. Mucuna pruriens has traditional applications in various medicinal practices, particularly in treating conditions associated with digestion and ulcers. The research aims to evaluate its efficacy in different gastric ulcer models, including pylorus ligation, indomethacin-induced ulcers, and stress-induced ulcers. The standard treatments used for comparison include ranitidine and misoprostol, which are recognized for their anti-ulcer properties. The primary focus of the study is to establish the antisecretory and cytoprotective effects of Mucuna pruriens in mitigating gastric ulcers.
Cytoprotective and Antisecretory Effects
One significant finding of the study is the cytoprotective and antisecretory effects of the ethanol extract of Mucuna pruriens. The research demonstrates that both lower (0.5 g/kg) and higher (1 g/kg) doses of the extract significantly reduce the ulcer index and total acidity in pylorus-ligated rats. Specifically, the higher dose exhibited greater efficacy compared to the lower dose. The extract also demonstrated a notable increase in mucin content, though this increase was not statistically significant when compared to control groups. These results suggest that Mucuna pruriens may enhance gastric protection and reduce acid secretion, contributing to its potential therapeutic role in treating gastric ulcers.
Anti-Ulcer Activity Against Indomethacin-Induced Ulcers
Another important aspect of the study is the impact of Mucuna pruriens on indomethacin-induced gastric ulcers. Indomethacin is known to cause gastric mucosal damage primarily by inhibiting prostaglandin synthesis, which is essential for maintaining the gastric barrier. The results reveal that the ethanol extract of Mucuna pruriens significantly decreased the ulcer index and promoted an increase in mucus content, implying a cytoprotective effect. The extract also influenced antioxidant factors, indicating the possibility of oxidative stress playing a role in ulcer formation. This highlights the effectiveness of Mucuna pruriens in combating ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs).
Stress-Induced Gastric Ulcers and Its Mechanism
The study also delves into the effects of Mucuna pruriens on stress-induced gastric ulcers. Stress is a known contributing factor in the development of gastric ulcers. The administration of Mucuna pruriens was shown to significantly reduce the ulcer index in rats subjected to cold restraint stress. This suggests that the extract may help alleviate the physiological effects of stress on gastric health. Moreover, the ethanol extract appears to possess the ability to modulate gastric motility and secretion, possibly through central mechanisms, which could help in preventing ulcer formation during stress conditions.
Conclusion
In conclusion, the ethanol extract of Mucuna pruriens exhibits substantial anti-ulcer effects across various experimental models. The extract demonstrates both antisecretory and cytoprotective properties, suggesting it could be a beneficial treatment option for managing gastric ulcers. This study emphasizes the need for further research to fully elucidate the mechanisms through which Mucuna pruriens exerts its protective effects on the gastric mucosa and its potential application in clinical settings. The findings support the traditional use of Mucuna pruriens in herbal medicine and point towards its relevance in developing new therapeutic approaches for ulcer management.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Har Govind Garg, Ashish Chourasiya and Dr. H. S. Chandel
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Effect of ethanol extract of seed of mucuna pruriens on gastric ulcers
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201710-9341
Download the PDF file of the original publication
FAQ section (important questions/answers):
What is the focus of the study on Mucuna pruriens?
The study evaluates the effect of ethanol extract of Mucuna pruriens seeds on gastric ulcers using various experimental models, including pylorus ligation, indomethacin-induced ulcers, and stress-induced ulcers.
How does Mucuna pruriens affect gastric ulcers?
The ethanol extract demonstrates gastric ulcer healing effects, gastric antisecretory effects, and gastric cytoprotection, significantly reducing ulcer indices and acidity levels in treated rats.
What standard drugs were used in the research?
Standard drugs such as ranitidine and misoprostol were used at specific doses for comparison with the effects of Mucuna pruriens extract on gastric ulcers.
What were the key findings of the study?
Both doses of Mucuna pruriens extract showed significant gastric healing effects, with the higher dose (1 g/kg) being more effective than the lower dose (0.5 g/kg).
What compounds were identified in Mucuna pruriens extract?
Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins, steroids, and glycosides, which may contribute to its anti-ulcer properties.
What methods were used for statistical analysis in the study?
One-way ANOVA followed by Bonferroni's comparison test was employed to assess the significance of results, considering p-values less than 0.05 as significant.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effect of ethanol extract of seed of mucuna pruriens on gastric ulcers”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ulcer:
Ulcers represent localized damage or sores that form on the digestive tract lining. They can emerge due to factors like excessive acid secretion, stress, or the use of certain medications such as non-steroidal anti-inflammatory drugs. Understanding ulcers is crucial for developing effective treatments and preventive measures against gastric diseases.
2) Activity:
Activity refers to the actions or mechanisms by which substances like herbal extracts exert their effects. In the context of pharmaceuticals, studying the activity of compounds helps in determining their potential therapeutic benefits, such as healing gastric ulcers or reducing inflammation, thus guiding further drug development and usage.
3) Indian:
The term 'Indian' denotes cultural, geographical, or historical ties to India, a country known for its rich tradition of using medicinal plants in healthcare. Understanding the relevance of Indian herbal remedies provides insight into their cultural significance and therapeutic applications, particularly in traditional healthcare systems like Ayurveda.
4) Drug:
Drugs are substances that lead to physiological changes in the body and are typically used for treatment, prevention, or diagnosis of diseases. In the context of research, studying new drugs allows the exploration of their effectiveness and safety for treating conditions like gastric ulcers or other health issues.
5) Animal:
In research contexts, animals play a vital role as models for understanding disease mechanisms and evaluating potential treatments. Experiments involving animals can help scientists assess the efficacy and safety of drugs, such as those derived from medicinal plants, before proceeding to clinical trials in human subjects.
6) Study (Studying):
A study involves systematic investigation aimed at discovering new insights, validating hypotheses, or testing the effectiveness of treatments. Research studies on plant extracts like Mucuna pruriens provide valuable data regarding their potential benefits, safety, and mechanisms of action, which is essential for developing new therapeutic approaches.
7) New Delhi:
New Delhi is the capital of India, a hub for research and development in various fields, including pharmaceuticals and healthcare. The city's institutions contribute significantly to scientific advancements, including studies on traditional medicine and the efficacy of herbal treatments like those derived from Mucuna pruriens.
8) Disease:
Diseases are pathological conditions characterized by specific symptoms and clinical signs. A deep understanding of diseases, particularly those affecting the gastrointestinal tract, is essential for developing effective treatments and preventive measures, enhancing overall public health, and improving patients' quality of life.
9) Delhi:
Delhi, as a major metropolitan area, significantly influences healthcare research in India. The concentration of educational and research institutions facilitates advancements in medical science, including studies related to traditional medicine, thereby helping to bridge ancient practices with modern therapeutic applications.
10) Table:
In research, tables represent organized data that summarize findings or results, making it easier for readers to comprehend the information. Tables are valuable for presenting experimental outcomes, comparative analyses, and statistically significant results that help in validating hypotheses and shaping scientific conclusions.
11) Flavonoid:
Flavonoids are bioactive compounds found in many plants known for their antioxidant and anti-inflammatory properties. Research into flavonoids, particularly in relation to gastric ulcers, highlights their potential therapeutic effects and how they can contribute to healing processes or protect against oxidative damage in the digestive tract.
12) Gupta:
The name 'Gupta' likely refers to a contributor or researcher in the field of pharmacology or herbal medicine. Individuals with this surname may be involved in studies that investigate the therapeutic potentials of various plants, including their mechanisms of action against diseases like gastric ulcers.
13) Phytochemical:
Phytochemicals are naturally occurring compounds in plants that may have health benefits. Understanding phytochemicals' roles allows researchers to explore their potential as therapeutic agents in managing diseases, particularly through the study of herbal extracts that can provide insights into their health-promoting properties.
14) Pharmacology:
Pharmacology is the study of how drugs interact with biological systems. Research in this field helps elucidate the mechanisms of action, therapeutic effects, and potential side effects of drugs, enabling the development of innovative treatments based on natural products like those derived from medicinal plants.
15) India:
India is known for its rich tradition of herbal medicine and diverse flora, making it a key area for studying the therapeutic potential of various plants. Research conducted here is crucial for understanding how indigenous resources can be leveraged in modern medicine to treat diseases.
16) Beta:
Beta may refer to beta-carotene, a plant pigment and antioxidant found in many fruits and vegetables. In gastroenterological studies, the significance of beta-carotene relates to its protective properties against oxidative stress and potential role in promoting mucosal health and healing in gastric ulcers.
17) Vaidya:
'Vaidya' is a term used in India for practitioners of Ayurveda, the traditional system of medicine. The knowledge imparted by vaidya about herbal treatments, including the usage of plants like Mucuna pruriens, is pivotal for integrating traditional healing practices with modern medicinal research.
18) Male:
The term 'male' denotes the sex of certain experimental animals, like rats, used in studies. The inclusion of male subjects in research helps in understanding how various treatments, such as herbal extracts, affect biological processes differently based on sex, which is crucial for generalizing findings to broader populations.
19) Life:
Life in a biological context pertains to living organisms and their processes. Research into life processes underscores the complexities of health and disease, particularly regarding how natural extracts can modulate biological functions and improve conditions such as ulcers, emphasizing the importance of holistic health.
20) Shivananda (Sivananda, Shiva-ananda):
The name 'Shivananda' might refer to a researcher or contributor in the study of herbal medicine. Such individuals are often instrumental in advancing the scientific understanding of traditional plant-based treatments and their applications in modern therapeutic contexts, including gastroenterological health.
21) Toxicity:
Toxicity refers to the degree to which substances can cause harm to biological systems. Studies assessing the toxicity of herbal extracts are vital to ensuring their safety and efficacy for human use, particularly when considering their potential application in treating gastric ulcers and related conditions.
22) Teaching:
Teaching is the process of imparting knowledge and skills, often crucial in educational settings focused on pharmacology and herbal medicine. Effective teaching equips future researchers and healthcare practitioners with the understanding of medicinal plants' properties and the significance of scientific research in traditional therapies.
23) Govinda (Go-vinda, Govimda):
The name 'Govinda' likely represents a notable figure in the research community, particularly in fields related to medicine or pharmacology. Contributions from individuals named Govinda can enrich the collective understanding of herbal remedies and their effects on various health conditions, including ulcers.
24) Lucknow:
Lucknow is a city in India known for its academic institutions and research facilities. It serves as a significant center for medical research, particularly concerning traditional medicine, facilitating studies that examine the efficacy and safety of indigenous plants used for treating common ailments.
25) Nature:
Nature encompasses the physical world, including plants, animals, and biological systems. Recognizing the importance of nature in pharmacological research emphasizes the need to study natural products like herbal extracts, which have been historically used for therapeutic purposes and can lead to new medicinal discoveries.
26) Mishra (Misra):
The name 'Mishra' may be associated with a researcher or contributor in fields related to pharmacology or Ayurveda. Individuals with this surname might contribute valuable insights regarding herbal treatments and support the integration of traditional knowledge with scientific research.
27) Water:
Water plays a critical role in biological systems, serving as a solvent, medium for chemical reactions, and essential for maintaining homeostasis. In the context of studies involving herbal extracts, understanding water's role is vital for effective extraction, formulation, and overall efficacy of therapeutic agents derived from plants.
28) Food:
Food provides essential nutrients necessary for life and health. The study of dietary components, particularly those derived from plants known for herbal properties, can lead to insights on how certain foods influence bodily functions and potentially mitigate health issues like gastric ulcers.
29) Cage:
Cages are often employed in laboratory settings to house experimental animals during research studies. The design of the cages can affect the animals' behavior and wellbeing, which is critical to ensuring valid and humane research outcomes in pharmacological and toxicological studies.
30) Road:
The term 'road' in this context can imply paths of research or avenues to exploring medicinal plants. It underscores the importance of following systematic methodologies in research, contributing to our understanding of natural products and their applications in treating illnesses.
31) Post:
Post refers to actions taken after the completion of a study or an experiment, particularly in analyzing and publishing results. This phase is crucial for disseminating knowledge gained from research, thereby contributing to the broader scientific community and informing clinical practices.
32) Human body:
The human body is the primary subject of medical research. Understanding its complexities is fundamental for evaluating how various treatments, including herbal extracts, affect physiological processes, thus enabling researchers to develop effective therapies for conditions like gastric ulcers.
33) Accumulation (Accumulating, Accumulate):
Accumulation refers to the build-up of substances over time, which can influence biological processes such as the formation of gastric ulcers. Understanding how substances accumulate in the body helps researchers develop strategies to prevent or mitigate adverse effects associated with various treatments.
34) Measurement:
Measurement involves quantifying parameters relevant to research, such as the effectiveness of treatments or the severity of diseases. Accurate measurements are vital in validating results, ensuring that findings can be reliably interpreted and applied in clinical settings for better patient outcomes.
35) Agriculture:
Agriculture pertains to practices involving crop cultivation and livestock. Understanding agricultural practices is essential for sourcing medicinal plants sustainably, ensuring that traditional remedies can be preserved and utilized effectively in contemporary medicine.
36) Discussion:
Discussion in research refers to the interpretation of findings and their implications. It is a critical component of publications, where researchers analyze their results, compare with existing literature, and propose future directions for studies, enriching scientific dialogue in academia.
37) Ramaswamy (Ramaswami):
The name 'Ramaswamy' may be associated with a researcher in traditional medicine or pharmacology. Contributions from individuals like Ramaswamy help advance the scientific understanding of herbal treatments and their potential applications in modern healthcare systems.
38) Substance:
Substance refers to any material with definite composition, including plants used for medicinal purposes. The study of various substances and their interactions with biological systems is fundamental to pharmacology, particularly in identifying potential therapeutic effects against diseases like gastric ulcers.
39) Suffering:
Suffering pertains to the distress caused by illness or disease. Understanding the burden of suffering allows researchers to address health problems effectively, guiding the development of therapeutic approaches that aim to alleviate physical and emotional discomfort experienced by patients.
40) Pesticide:
Pesticides are chemical substances used to control pests in agriculture. Understanding their effects on health, particularly in relation to herbal pharmacology, is crucial, as natural plant-based treatments must be differentiated from synthetic chemicals to ensure safety and efficacy for human use.
41) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating in India that emphasizes natural healing through herbal remedies and dietary practices. Understanding Ayurvedic principles is essential for integrating traditional knowledge with modern scientific research on medicinal plants and their health benefits.
42) Learning:
Learning refers to acquiring knowledge or skills through study and experience. In the context of pharmacology, continuous learning helps researchers stay current with advancements in medical science, ensuring the effective application of herbal treatments in healthcare.
43) Vitiation (Vitiated):
Vitiated refers to something that has been impaired or corrupted, often used in historical contexts regarding health. In Ayurvedic medicine, vitiated doshas (body energies) are thought to lead to disease, highlighting the importance of restoring balance for overall health and healing.
44) Euphoria:
Euphoria refers to a feeling of intense happiness and well-being. In the context of health, achieving a state of euphoria could be tied to effective treatment outcomes, emphasizing how successful therapies can significantly enhance patients' quality of life and emotional health.
45) Gujarat:
Gujarat is a state in India known for its diverse flora and agricultural practices. The study of herbal medicine in regions like Gujarat is important for understanding the local medicinal plants' properties and their potential applications in treating various health disorders.
46) Quality:
Quality refers to the standard or grade of something, including the efficacy and safety of medical treatments. Ensuring the quality of herbal products is essential for guaranteeing their therapeutic effects and safeguarding public health, particularly in pharmacological research.
47) Science (Scientific):
Science represents a systematic pursuit of knowledge through observation and experimentation. In pharmacology, scientific principles guide the investigation of drugs and therapies, allowing for the development of evidence-based treatments that benefit patients and improve healthcare.
48) Bengal (Bemgal):
Bengal is a region in India known for its biodiversity, including a rich array of medicinal plants used in traditional medicine. Research in Bengal contributes to the understanding of local herbal practices and their applications in modern therapeutic contexts.
49) Sharman (Sarma, Sarman, Sharma):
The name 'Sharma' likely refers to a contributor in the field of pharmacology or herbal medicine research. Contributions from individuals named Sharma can enhance the collective understanding of medicinal plants and their effects on health, particularly in addressing clinical conditions like ulcers.
50) Prayer:
Prayer often symbolizes hope and healing in cultural contexts. In terms of health, prayer may represent the emotional and psychological aspects of recovery, underscoring the importance of mental well-being alongside physical treatments in holistic approaches to healthcare.
51) Powder:
In pharmacological terms, powder refers to a dry, fine substance derived from crushed plant materials used in herbal formulations. Understanding the properties and applications of powders derived from medicinal plants is key in developing effective herbal remedies, ensuring their safety and efficacy.
52) Gold (Golden):
Golden can metaphorically represent something of great value. In research contexts, achieving 'golden' standards in drug development signifies the importance of attaining effective, safe, and quality therapeutic options derived from traditional practices, enhancing healthcare access and outcomes.
53) Pillai:
The name 'Pillai' could refer to a notable researcher or practitioner within the fields of medicine or pharmacology. Individuals with this name may contribute to the exploration of traditional medicine and the applications of herbal treatments for contemporary health issues.
54) Pitta:
Pitta is one of the three doshas in Ayurveda, associated with fire and transformation in the body. Understanding pitta's role is essential for Ayurvedic practitioners and researchers in determining how to balance this energy for promoting health and preventing diseases.
55) Lanka (Lamka, Lànkà):
Lanka, referring to Sri Lanka, is known for its rich biodiversity, including various plants with medicinal properties. Research on plants from Lanka contributes to the global understanding of herbal medicine and its potential applications in treating health conditions.
56) Simha:
The name 'Sinha' might represent a researcher or contributor in scientific studies related to pharmacology or traditional medicine. Contributions from individuals named Sinha can significantly enhance the research output in herbal treatments and their implications for health and disease management.
57) Sagar (Sagár):
Sagar may represent a researcher or an institution involved in pharmacological research or Ayurvedic studies. Individuals with this name can play an important role in advancing knowledge around herbal remedies and their therapeutic potentials in contemporary medicine.
58) Kumar:
The name 'Kumar' is often associated with researchers and contributors in various scientific fields. Individuals with this name may enhance the body of knowledge pertaining to pharmacological studies, particularly regarding the evaluation of medicinal plants and their applications in health.
59) Fever:
Fever is a common clinical symptom indicating inflammation or infection. Understanding the relationship between fever and various diseases is crucial for developing effective treatments, including the use of herbal remedies that may help alleviate symptoms and promote overall health.
60) House:
House refers to the physical setting where experimental activities take place. In research, maintaining appropriate housing conditions for laboratory animals is essential to ensure their well-being and the validity of the experimental outcomes, allowing accurate study of interventions on health.
61) Blood:
Blood is a vital fluid in the human body responsible for transporting nutrients, oxygen, and waste products. Understanding its composition and function is essential in medical research, particularly when examining diseases and the effects of potential treatments, including herbal preparations.
62) Vasu:
The name 'Vasu' could indicate a researcher or practitioner within the fields of pharmacology or Ayurvedic medicine. Contributions from individuals named Vasu may facilitate advances in the understanding and application of herbal remedies for treating health conditions.
63) Daya:
Daya potentially represents a figure in the research community, particularly in medicinal studies. Such contributors may significantly influence the understanding of herbal treatments and their applications in addressing clinical issues, thus advancing knowledge in pharmacology and traditional medicine.
64) Shri (Sri, Sr):
The term 'Shri' is a respectful title used in Indian culture. It may signify acknowledgment of individuals' contributions in scientific research or healthcare, highlighting the respect accorded to experts who advance knowledge in traditional medicine and herbal remedies.
65) Vata:
Vata is one of the three doshas in Ayurveda, characterized by qualities of movement and change. Understanding vata's role is crucial for practitioners and researchers focused on maintaining health balance and treating conditions that arise from vata imbalances in individuals.
66) Amol:
The name 'Amol' might refer to a researcher or academic in the field of pharmacology. Contributions from individuals like Amol can play an essential role in advancing the understanding of herbal treatments and their significance in addressing various health conditions.
67) Casha (Casa):
Casa may denote a contributor in the area of pharmacology or medicinal plant research. Individuals with this name might significantly engage in exploring herbal treatments' therapeutic potentials and implications in managing health-related issues.
68) Sahu:
The name 'Sahu' may be associated with researchers or professionals contributing to medical sciences. Such individuals can provide insights into pharmacological effects of herbal remedies, enhancing the overall understanding of plant-based medicines in healthcare.
69) Bell:
The name 'Bell' could refer to a researcher or contributor important in medicinal studies. Individuals with this name might advance the knowledge regarding natural products and their applicability in treating health conditions, thereby playing a vital role in the research community.
70) Crop:
Crop refers to cultivated plants harvested for various purposes, including medicinal use. Understanding the cultivation and properties of medicinal crops is essential for sustainable practices, ensuring the availability of herbal remedies and their effective application in healthcare.
71) Fish:
Fish plays a significant role in both human diet and ecological studies. Investigating the health benefits of fish and their role in disease management highlights the interconnectedness of dietary practices and health, contributing to broader research on nutrition and wellness.
72) Hand:
The hand symbolizes human effort and intervention in activities such as research and healthcare. Recognizing the role of hands in conducting experiments and administering treatments underscores the importance of manual skills and oversight in scientific investigations.