Preparation and evaluation of cordia myxa fruit topical cream
Journal name: World Journal of Pharmaceutical Research
Original article title: Preparation and evaluation of cordia myxa fruit topical cream
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Masoud A. Karami, Eskandar Moghimipour, Sayyed Farivar Saafi
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Preparation and evaluation of cordia myxa fruit topical cream
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The use of medicinal plants in traditional medicine has persisted over centuries, particularly in countries like Iran, where specific plants are valued for their therapeutic properties. One such plant is Cordia myxa, known for its mucilage content and applications as an expectorant and emollient for cough and respiratory issues. Recent studies have indicated potential anti-inflammatory effects, prompting the exploration of Cordia myxa fruit extract in topical formulations. This study aimed to develop a topical cream incorporating this extract, assessing its physicochemical properties for further therapeutic use.
Preparation and Evaluation of Topical Cream
The formulation of the topical cream involved various bases and emulsifiers. Eight different formulations containing a consistent 5% aqueous extract of Cordia myxa were created using a fusion method. The physicochemical properties, including pH, consistency, viscosity, and stability, were rigorously evaluated. The formulations were characterized as homogeneous, with a pH averaging 7.175 and a viscosity of approximately 9010 cps, indicating appropriate physicochemical conditions for use. Stability tests conducted at various intervals revealed no significant changes in appearance or composition over the storage period, confirming the suitability of the cream for topical applications.
Antimicrobial Effectiveness
To ensure the safety and efficacy of the formulations, an antimicrobial challenge test against Pseudomonas aeruginosa was conducted. The lack of microbial growth throughout the storage indicates that the preservatives within the formulations were effective in preventing contamination. This is critical for topical formulations where microbial activity could lead to infections or compromised product integrity. The results emphasize the importance of incorporating suitable preservatives to maintain the safety of herbal creams for dermatological use.
Importance of Physicochemical Properties
The physicochemical properties of the cream were essential for determining its potential effectiveness as a therapeutic product. Parameters such as viscosity and pH play a crucial role in the applicability and comfort of topical formulations. The study highlighted a correlation between the oil content and viscosity, which affects the spreadability and absorption of the cream on the skin. The pH of the formulations remained relatively stable, close to that of human skin, suggesting compatibility with physiological conditions which is vital for patient comfort and efficacy of treatment.
Conclusion
The study successfully demonstrated that Cordia myxa, a traditional medicinal plant, could be effectively formulated into a topical cream with favorable physicochemical properties. The results indicate strong potential for this cream in treating dermatological conditions, particularly for inflammatory skin issues. However, to fully realize its therapeutic benefits, further investigations on its efficacy in both animal models and human clinical trials are necessary. Given its widespread availability and economic potential, Cordia myxa presents a promising avenue for developing natural, therapeutic topical treatments.
FAQ section (important questions/answers):
What is the purpose of this study on Cordia myxa?
The study aimed to prepare and evaluate a topical cream containing Cordia myxa fruit extract, exploring its physicochemical properties and potential therapeutic applications.
What are the benefits of Cordia myxa as a medicinal plant?
Cordia myxa has anti-inflammatory and expectorant properties. It is traditionally used for respiratory issues and has a wide range of pharmacological effects, including wound healing.
What methods were used to extract Cordia myxa fruit?
The fruits were macerated in boiling distilled water, filtered, and centrifuged to obtain a dry powder extract for formulation into creams.
How were the physicochemical properties of the cream evaluated?
Formulations were assessed for appearance, pH, viscosity, consistency, physical stability, and antimicrobial effectiveness over different time intervals.
What were the results of the antimicrobial test?
The formulations showed no microbial growth during storage, indicating that the preservatives used were effective in protecting against bacterial contamination.
What is the significance of using a topical formulation?
Topical formulations avoid systemic effects of oral administration, provide localized treatment, and can enhance patient compliance when managing skin conditions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Preparation and evaluation of cordia myxa fruit topical cream”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing diseases. The study highlights the importance of herbal remedies, such as those derived from medicinal plants, emphasizing their significance in traditional and modern therapeutic practices. This integration seeks to provide safe and effective healthcare alternatives.
2) Study (Studying):
The study is focused on the preparation and evaluation of a topical cream using extract from the Cordia myxa fruit. It investigates the physicochemical properties of the cream, its physical stability over time, and its potential use in therapeutic applications. The methodology and findings contribute to knowledge regarding herbal formulations.
3) Table:
Tables in the study present organized data regarding formulation compositions, viscosity measurements, pH levels, and other experimental results. They allow for easy comparison and interpretation of the different experimental conditions and outcomes, facilitating better understanding and decision-making regarding the formulations being evaluated.
4) Water:
Water serves as a crucial solvent in the extraction process of Cordia myxa fruit. The study utilizes boiling distilled water to macerate the fruit to extract beneficial compounds. The quality of the water affects the efficiency of extraction, thereby influencing the effectiveness of the herbal product.
5) Species:
Species refers to the specific group of organisms being studied, in this case, Cordia myxa, which belongs to the Boraginaceae family. Understanding the characteristics and benefits of this species is essential for evaluating its pharmacological properties and potential applications in herbal medicine.
6) Science (Scientific):
Science underpins the systematic study of the effects, mechanisms, and applications of medicinal plants in human health. The research exemplifies the integration of traditional medicine with scientific inquiry, leading to advancements in understanding herbal products' pharmacological activities and therapeutic potentials.
7) Powder:
Powder refers to the form in which the dried extract of Cordia myxa fruit is prepared for incorporation into the cream formulations. The quality and characteristics of the powder, including its particle size and solubility, are vital for ensuring even distribution and consistency in the final product.
8) Container:
Container denotes the packaging used to hold the cream formulations during testing and evaluation. The integrity of the container is crucial for preventing contamination and maintaining the physical stability of the creams throughout their storage periods, ultimately affecting their usability and effectiveness.
9) Bleeding:
Bleeding in the context of cream formulation refers to any undesired separation of liquid from the emulsion, indicating instability. It serves as a sign of potential quality issues, such as poor emulsifying capacity, which is crucial for ensuring the product's reliability and effectiveness upon application.
10) Drug:
Drug, in the context of this study, refers to a substance intended for use in the diagnosis, treatment, or prevention of disease. The herbal preparation based on Cordia myxa is being evaluated for its potential medicinal properties as a topical cream offering therapeutic benefits.
11) Pharmacological:
Pharmacological pertains to the study of drug action and the effects of chemical compounds on biological systems. The research emphasizes the pharmacological properties of Cordia myxa, exploring its biological activity and potential applications in treating various health conditions, particularly skin-related issues.
12) Activity:
Activity refers to the biological effects or actions of the Cordia myxa extract, such as its anti-inflammatory and antibacterial properties. Assessing the activity of the herbal cream is key to understanding its therapeutic potential and efficacy for medicinal use in treating skin conditions.
13) Disease:
Disease denotes any condition that negatively affects the structure or function of an organism. The study aims to explore the efficacy of Cordia myxa in managing conditions like skin inflammation, highlighting the importance of herbal remedies in treating various diseases and promoting health.
14) Borax:
Borax is included as an ingredient in the formulations prepared during the study. It serves as an emulsifying agent, contributing to the stability of the cream. The choice of ingredients, including borax, impacts the overall effectiveness and quality of the final product.
15) Genu:
Genu refers to the authentic or genuine nature of the product, emphasizing the importance of using recognized, standardized methods for extraction and formulation. Ensuring the genuineness of the Cordia myxa extract is crucial for maintaining the quality and efficacy of the medicinal cream.
16) Sign:
Sign refers to indicators or changes observed during the formulation tests, such as changes in physical stability or microbial growth. Recognizing these signs during experiments is essential for evaluating the formulation's quality and safety for potential therapeutic applications.
17) Antibiotic (Antibacterial):
Antibacterial relates to the capability of a substance to prevent bacterial growth or destroy bacteria. This study specifically evaluates the antibacterial properties of the Cordia myxa extract, aiming to establish its effectiveness as a topical cream for treating infections and promoting skin health.
18) Inflammation:
Inflammation is a biological response to harmful stimuli, often characterized by redness, swelling, and pain. The study focuses on the anti-inflammatory properties of Cordia myxa, indicating its potential role in alleviating inflammatory conditions when applied as a topical cream.
19) Measurement:
Measurement encompasses the systematic quantification of various parameters, such as viscosity and pH, during the formulation evaluation. Accurate measurements are crucial for validating the formulations' physicochemical properties and determining their suitability for therapeutic use.
20) Substance:
Substance refers to any material with a definite composition, presented in this study in the form of Cordia myxa extract. The classification of substances is important for studying their interactions and effects when formulated into creams or other pharmaceutical products.
21) Mineral:
Mineral indicates the presence of inorganic elements within the Cordia myxa fruit, which contribute to its nutritional value and therapeutic effects. The study highlights the significance of these minerals in enhancing the cream's overall activity and supporting skin health.
22) Company:
Company refers to the entities that supply raw materials such as lanolin and glycerin used in the cream formulations. Collaborating with reputable companies ensures that quality ingredients are used, which affects the efficacy and safety of the final pharmaceutical product.
23) Family:
Family in this context refers to the classification of the Cordia genus within the Boraginaceae family. Understanding family classifications helps in recognizing common characteristics and pharmacological properties shared among related plants, guiding further research and applications in herbal medicine.
24) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cellular growth. The study mentions the potential role of Cordia species in managing conditions like cancer, directing attention toward the exploration of natural compounds for therapeutic interventions against such serious health issues.
25) Nature:
Nature signifies the inherent characteristics of the Cordia myxa plant, including its pharmacological properties. The study emphasizes the importance of natural plant extracts in creating effective topical treatments, aligning with trends favoring holistic and nature-based therapeutic approaches.
26) Animal:
Animal pertains to the model systems used in pharmacological studies to assess efficacy and safety. The research highlights the need for in-vivo studies involving animal models to validate the therapeutic effects of the Cordia myxa topical cream before clinical applications.
27) Life:
Life signifies the biological aspects related to human health and wellness, underscoring the importance of natural therapies in promoting quality of life. The study aims to improve health outcomes through herbal products, bridging traditional practices with scientific understanding for better therapeutic interventions.