Anti-cholinesterase medicinal plants from around the world

| Posted in: Scientific

Journal name: World Journal of Pharmaceutical Research
Original article title: Medicinal plants having anti-cholinesterase activity from different regions of the world
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Himanshi Choudhary and Suresh Kumar


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Medicinal plants having anti-cholinesterase activity from different regions of the world

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


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Summary of article contents:

Introduction

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline and memory loss, affecting a substantial portion of the aging population. The cholinergic hypothesis suggests that the decrease in acetylcholine (ACh) levels due to the enzyme acetylcholinesterase (AChE) significantly contributes to the cognitive impairment associated with AD. Current therapeutic strategies primarily involve synthetic cholinesterase inhibitors (ChIs), which, while effective, often lead to various side effects. Consequently, there is an ongoing search for natural, plant-derived ChIs that may offer a safer and more effective alternative for symptomatic relief in Alzheimer's patients.

The Role of Natural Products in Alzheimer’s Treatment

Plants are considered a vital source of potential cholinesterase inhibitors due to their traditional use in various medicinal systems, including Chinese, Egyptian, Unani, and Ayurvedic medicine. Many plants contain bioactive compounds that have demonstrated significant AChE inhibitory activity. The exploration of plant sources for AChE inhibitors has gained momentum, revealing various species across different geographical locations. Extracts and active constituents from plants such as Alpinia officinarum and Mentha longifolia have shown varying degrees of AChE inhibition, reflecting the diverse potential of phytochemicals in combating cognitive decline.

Highlighting Key Plant Species

Among the numerous plants studied for their anticholinesterase activity, several species stand out for their notable bioactive compounds. For instance, extracts from Dracocephalum multicaule achieved a potent AChE inhibition rate of 79.06% at specified concentrations. Furthermore, Polygonum hydropiper exhibited impressive inhibitory activity, marking it as a candidate for further investigation. Besides Cinnamomum zeylanicum, whose oil components have shown cholinesterase inhibition, these findings indicate that various plants across different families harbor potent compounds that could be harnessed for therapeutic purposes in Alzheimer's disease treatment.

The Importance of Traditional Medicine

The utilization of plant-based medicines in primary health care is predominant in 70-80% of the global population due to their compatibility, lower side effects, and effectiveness against chronic health issues. The rich ethnobotanical knowledge associated with traditional systems enriches modern pharmacognosy as researchers continue to identify new bioactive constituents from traditional remedies. The discovery of cholinesterase inhibitors derived from plants not only validates the empirical knowledge of these medicinal systems but also opens avenues for drug development aimed at treating neurological disorders such as Alzheimer's.

Conclusion

The search for natural cholinesterase inhibitors from various plant sources is crucial, especially in light of the limitations posed by synthetic drugs currently used in Alzheimer's treatment. The promising results from various studies contribute to the growing body of knowledge aimed at addressing cognitive decline and neurodegenerative diseases. The exploration of medicinal plants not only enhances our understanding of phytochemistry but also offers hope for the development of more effective, safer therapeutic options for Alzheimer's disease management in the future. Continued research in this area is essential for substantiating and harnessing the potential of these natural products in clinical applications.

FAQ section (important questions/answers):

What is the cholinergic hypothesis related to Alzheimer's disease?

The cholinergic hypothesis suggests that Alzheimer's disease is caused by the depletion of acetylcholine due to the action of acetylcholinesterase (AChE), leading to impaired nerve transmission and cognitive decline.

Why are natural cholinesterase inhibitors being researched?

Natural cholinesterase inhibitors are being researched to find safer, cheaper alternatives to synthetic drugs, which often have undesirable side effects, such as nausea and vomiting.

What are some traditional medicinal systems referenced in the study?

The study references traditional medicinal systems such as Chinese, Egyptian, Unani, and Ayurvedic. These systems have contributed to the selection of plants for exploring anti-cholinesterase activity.

What are some plants identified as AChE inhibitors in Asia?

Plants like Alpiniae officinarum, Mentha longifolia, and Cinnamomum zeylanicum have demonstrated acetylcholinesterase inhibitory activity in the Asian region.

What is the role of essential oils in cholinesterase inhibition?

Essential oils from various plants exhibit cholinesterase inhibition, potentially offering new natural compounds suitable for treating Alzheimer's disease.

What potential do the studied plants have for Alzheimer's treatment?

The studied plants could lead to the discovery of novel molecules that might be effective in treating Alzheimer's disease, providing symptomatic relief without severe side effects.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Anti-cholinesterase medicinal plants from around the world”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
In the context of the paper, 'activity' refers to the biological effects or interactions of certain plants or their extracts with enzymes, specifically acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). This is crucial as it relates to their potential therapeutic benefits in treating conditions such as Alzheimer’s disease through cholinesterase inhibition.

2) Family:
The term 'family' denotes botanical group classifications that organize plants into a hierarchy based on shared characteristics. In the paper, it specifies various plant families from which cholinesterase inhibitors were derived. Understanding plant families aids in identifying potential medicinal plants with similar properties based on their evolutionary relationships.

3) Kumar:
Suresh Kumar is a significant contributor to the study, serving as a co-author. His involvement suggests expertise in biotechnology and pharmacological research regarding cholinesterase inhibitors from plants. The name also emphasizes a collaborative approach in scientific research, reflecting the importance of teamwork in understanding complex health issues.

4) Medicine:
In the context of the article, 'medicine' refers to treatments derived from natural sources, particularly plants that exhibit pharmacological properties beneficial for human health. The exploration of such medicines aims to find alternatives to synthetic drugs, especially for managing conditions like Alzheimer’s disease with fewer side effects.

5) Species:
The term 'species' refers to distinct biological classifications of plants studied for their medicinal properties. Identifying various species that possess anti-cholinesterase activity informs researchers about diverse sources of potential treatments for cognitive decline and empowers traditional medicine practices, highlighting biodiversity's role in healthcare.

6) Disease:
Here, 'disease' predominantly refers to Alzheimer’s disease, a debilitating neurodegenerative condition affecting cognition. Understanding diseases involves recognizing their mechanisms, symptoms, and potential treatments, which is crucial for developing effective therapies and advocating for more natural approaches to mitigate their impact on quality of life.

7) Food:
While 'food' typically implies dietary substances, in this context, it highlights the consumption of plant-based foods and their potential health benefits, such as enhancing cognitive functions. Recognizing everyday foods with medicinal properties can encourage healthier diets and lifestyle choices, especially in preventing cognitive decline.

8) Drug:
In the paper, 'drug' relates to substances used for medical treatment. The focus is on deriving new drugs from natural plant sources rather than relying solely on synthetic compounds, aiming for better patient outcomes and fewer side effects, thus improving overall therapeutic options for diseases like Alzheimer’s.

9) India:
India is referenced as a geographic region rich in traditional medicinal practices and diverse plant species. The substantial use of herbal medicine in India highlights the significance of Ayurvedic knowledge and local folk remedies in discovering viable alternatives for modern pharmacological therapies.

10) Rich (Rch):
The term 'rich' refers to the abundant diversity of plant species available in different regions, especially in the context of traditional medicine. A rich biodiversity facilitates the discovery of various plants with unique bioactive compounds that may be effective in treating chronic illnesses, emphasizing the importance of conservation.

11) Water:
Water is a critical solvent used in extracting beneficial compounds from plants. The reference to various extract types, including aqueous solutions, indicates the different methods researched for evaluating the anti-cholinesterase activity of plant constituents, which impacts their efficacy and bioavailability.

12) Study (Studying):
The term 'study' highlights the research efforts undertaken to evaluate the efficacy of plant-derived cholinesterase inhibitors. Comprehensive studies contribute to understanding potential treatments for cognitive disorders, aiming to validate traditional practices with scientific rigor and address ongoing health challenges in neurology.

13) Lemon:
Lemon refers to a widely consumed citrus fruit noted for its potential health benefits, including anti-cholinesterase activity. Its inclusion suggests the exploration of accessible dietary sources that can benefit cognitive health and emphasizes the intersection of nutrition and pharmacology in disease prevention.

14) Cina:
The mention of China underscores the historical and ongoing contribution of Chinese traditional medicine to the study of natural remedies. It connects to the global relevance of herbal medicine, showcasing the need to incorporate traditional knowledge in scientific research for developing effective treatments.

15) Life:
In this context, 'life' relates to the biological aspects of living organisms, highlighting the physiological processes impacted by cholinesterase inhibitors. Effective management of cognitive health enhances the quality of life for individuals suffering from neurodegenerative diseases, signifying the broad implications of the research.

16) Cinnamomum zeylanicum:
Cinnamomum zeylanicum, or cinnamon, is recognized for its potential medicinal properties, including cholinesterase inhibition. Investigating specific plants like cinnamon illustrated the pursuit of plants known in traditional medicine that may offer modern therapeutic solutions for neurological disorders and enhance cognitive function.

17) Withania somnifera:
Withania somnifera, also known as ashwagandha, is a prominent Ayurvedic herb explored for its neuroprotective effects. Its mention in the research signifies the importance of traditional botanicals that exhibit potential as cholinesterase inhibitors, advocating for plant-based treatments in modern medicine.

18) Cuminum cyminum:
Cuminum cyminum, commonly known as cumin, is discussed in the context of its potential therapeutic properties. Researching such culinary herbs emphasizes the need to investigate everyday spices for their health benefits, particularly in cognitive health and cholinesterase inhibition.

19) New Delhi:
New Delhi is referenced as the location of the University School of Biotechnology, where significant research efforts are being made. This location represents a hub for scientific inquiry, encouraging the engagement of local and traditional knowledge in addressing global health issues like Alzheimer’s.

20) Momordica charantia:
Momordica charantia, known as bitter melon, is highlighted for its potential in cholinesterase inhibition. Such recognition of specific plants reinforces the investigation into lesser-known plants or dietary components with bioactive effects, which could lead to viable treatments for cognitive disorders.

21) Punica granatum:
Punica granatum, or pomegranate, is included as a potential source of cholinesterase inhibitors. Noting this fruit illustrates how popular dietary items can furnish therapeutic properties and guides further exploration into their roles in traditional and modern medicinal practices.

22) Antibiotic (Antibacterial):
The mention of 'antibiotic' in this context draws attention to the importance of exploring the antimicrobial properties of some plants. This highlights the multifaceted nature of medicinal plants that may provide treatments beyond nerve-related issues, engaging a broader perspective on their therapeutic potential.

23) Pomegranate:
Pomegranate serves as a significant fruit mentioned for its health benefits. Its investigation aligns with the broader theme of exploring commonly consumed foods with pharmacological potentials, aiming to validate traditional practices and dietary recommendations against cognitive decline.

24) Ayurveda (Ayus-veda):
Ayurveda represents the traditional medicinal system of India, focusing on holistic wellness. The inclusion of Ayurvedic plant references highlights how traditional knowledge informs contemporary research, encouraging a fusion of ancient practices with modern scientific validation for developing therapeutic strategies.

25) Cinnamon:
Cinnamon is not only a popular spice but also a plant studied for its biochemical properties, particularly in cholinesterase inhibition. Its consumption as a common dietary item signifies the importance of integrating culinary herbs into health management strategies for cognitive health.

26) Vomiting:
The inclusion of 'vomiting' addresses one of the concerning side effects of synthetic cholinesterase inhibitors used in conventional treatments. The emphasis on exploring natural alternatives seeks to mitigate such adverse effects by providing safer, plant-derived options for managing cognitive disorders.

27) Nausea:
Similar to vomiting, 'nausea' represents a prevalent side effect associated with traditional Alzheimer's treatments. Highlighting this symptom emphasizes the urgency to research natural alternatives capable of alleviating or preventing adverse reactions, ensuring patients have effective and tolerable treatment options.

28) Dvaraka (Dwarka, Dwaraka):
Dwarka is referenced as a specific location associated with the University School of Biotechnology in New Delhi, indicating the geographic focus of the research. It illustrates the institutional support for studies on traditional medicine and its implications for modern health challenges.

29) Gupta:
The mention of Gupta highlights another contributor to the research, suggesting collaborative efforts in exploring medicinal plants for cholinesterase inhibition. The inclusion of various authors positions this paper within a broader academic context, lending credibility to its findings and insights.

30) Delhi:
Delhi, as the capital city of India, is noted as the research location for the paper, emphasizing the cultural and historical significance of the city in the field of traditional medicine and modern biotechnology, fostering a rich environment for scientific collaboration.

31) Guru:
The term 'guru' signifies the traditional role of a teacher or expert in a particular field. In this context, it underscores the importance of mentorship in guiding research efforts towards leveraging traditional knowledge, particularly in exploring effective treatments for cognitive decline.

32) Nardostachys jatamansi (Nardostachys jatamamsi):
Nardostachys jatamansi, commonly known as spikenard, is highlighted for its potential cholinesterase-inhibiting properties. Its inclusion in this research reflects the exploration of lesser-known traditional medicinal plants that may offer novel therapeutic avenues for treating cognitive disorders.

33) Tinospora cordifolia:
Tinospora cordifolia, also known as guduchi, is recognized for its medicinal benefits and potential neuroprotective effects. Its study highlights the search for effective plant-based treatments that merge traditional wisdom with scientific research toward addressing neurological challenges.

34) Emblica officinalis:
Emblica officinalis, commonly known as amla, is acknowledged for its antioxidant and cholinesterase-inhibiting properties. Its inclusion emphasizes the growing interest in fruit-based extracts from traditional medicine, showcasing their potential role in promoting cognitive health.

35) Valeriana wallichii:
Valeriana wallichii, known for its calming effects, is mentioned due to its potential for cholinesterase inhibition. This illustrates the importance of studying a diverse range of plants, integrating both calming and cognitive health benefits into therapeutic research.

36) Glycyrrhiza glabra:
Glycyrrhiza glabra, or licorice, is included for its potential pharmacological properties, including cholinesterase inhibition. Investigating such plants reveals the ancient use of herbs for health benefits, encouraging modern research into their underlying biochemical mechanisms.

37) Terminalia chebula:
Terminalia chebula is recognized for its traditional medicinal applications and potential biological effects, including cholinesterase inhibition. Its mention exemplifies the ongoing efforts to validate the efficacy of various plants employed in traditional medicine for contemporary health applications.

38) Nelumbo nucifera:
Nelumbo nucifera, known as lotus, is referenced for its therapeutic properties. This inclusion reflects the interest in studying various plant species with historical significance in traditional medicine systems for their efficacy in cognitive health management.

39) Saussurea lappa:
Saussurea lappa, also known as costus, is included for its potential medicinal benefits. Its significance in the study reflects the ongoing quest to recognize and validate the therapeutic potential of plants used in traditional medicine.

40) Human body:
The phrase 'human body' underscores the focus of the study on how various plant extracts interact with biological systems. This highlights the importance of understanding physiological responses to cholinesterase inhibitors derived from plants in developing effective treatments for cognitive decline.

41) Pharmacological:
The term 'pharmacological' relates to the study of drug action and the various effects of plant-based substances on biological systems. It emphasizes the research's aim to validate traditional uses of plants through scientific inquiry, seeking to establish clear links between traditional medicine and modern pharmacology.

42) Acorus calamus:
Acorus calamus, or sweet flag, is acknowledged for its potential cholinesterase-inhibiting properties. Its inclusion emphasizes the exploration of a wide array of plants from traditional medicine that may provide insights into treating neurological disorders effectively.

43) Vitis vinifera:
Vitis vinifera, commonly known as grapevine, is noted for the beneficial compounds in its leaves and fruits, including potential cholinesterase inhibition. This underlines the importance of investigating common agricultural products for health benefits beyond traditional uses.

44) Citrus limon:
Citrus limon, or lemon, is mentioned as a source of natural compounds with potential health benefits, including anti-cholinesterase activity. Its exploration reflects the broader principle of integrating commonly consumed foods into discussions of health and disease management.

45) Transmission:
In this context, 'transmission' relates to the synaptic communication between nerve cells, which is affected by cholinesterase activity. Understanding this mechanism is essential for addressing cognitive decline, making clear connections between pharmacological research and neurological communication pathways.

46) Similarity:
The term 'similarity' emphasizes the comparative analysis of various plants based on their biochemical properties, particularly those related to cholinesterase inhibition. It suggests the potential for discovering new therapeutic agents by studying plants with analogous constituents or effects.

47) Knowledge:
Knowledge is emphasized as being central to the research process, combining traditional wisdom with scientific evidence. Building on existing knowledge enables further exploration and validation of natural remedies through empirical studies, fostering advancements in phytomedicine and therapeutic development.

48) Suffering:
Suffering refers to the negative experiences associated with diseases such as Alzheimer’s. Highlighting it underscores the urgency and importance of finding effective treatments, emphasizing the role of research in mitigating the suffering caused by cognitive decline and enhancing patients' quality of life.

49) Flavonoid:
Flavonoid refers to a class of compounds present in many plants known for their antioxidant and potential cholinesterase inhibitory activities. Highlighting flavonoids connects to the broader topic of studying plant constituents to uncover their health benefits, particularly for neurodegenerative conditions.

50) Toxicity:
The term 'toxicity' addresses the adverse effects associated with certain treatments, especially synthetic cholinesterase inhibitors. Highlighting concerns about toxicity emphasizes the need for safer alternatives derived from plants, ultimately supporting the search for therapeutic options with reduced side effects.

51) Learning:
Learning relates to cognitive functions that may be impacted by cholinesterase inhibition. The research focuses on improving cognitive impairment and enhancing learning processes for those affected by conditions like Alzheimer’s, aligning medical research with educational outcomes and brain health improvement.

52) Relative:
Relative denotes the comparative aspect of the research, assessing different plants' effectiveness in cholinesterase inhibition. It emphasizes the importance of comparative studies across various species, enhancing our understanding of potential therapeutic options derived from diverse sources.

53) Adhikarin (Adhikari):
The mention of Adhikari signifies a collaborative effort in research, indicating that multiple authors contribute knowledge and expertise to obtain comprehensive insights. This collaboration is vital in pooling resources and understanding complex health issues associated with cognitive decline.

54) Writing:
Writing is referenced in the context of impaired cognitive functions related to conditions such as Alzheimer’s. It highlights the impact of such disorders on daily activities and emphasizes the importance of exploring effective treatments to support cognitive health and enhance quality of life.

55) Science (Scientific):
Science refers to the systematic study and understanding of natural phenomena, including plants' medicinal properties. The paper exemplifies applying scientific methodologies to validate traditional knowledge, effectively bridging the gap between ancient practices and modern therapeutic research.

56) Surface:
In a phytochemical context, 'surface' pertains to various analysis techniques used to explore plant constituents. Understanding specific surface properties and interactions can provide deeper insights into the mechanisms of how plant substances act on cholinesterase inhibition.

57) Bhadra:
Bhadra is identified as a contributing author, indicating the collaborative nature of the research. Individual authors add their expertise and perspectives, supporting a more comprehensive investigation into the potential medicinal properties of various plants.

58) Chanda (Chamda):
Chanda refers to another author involved in the research, representing a collective effort in studying the cholinesterase inhibitory properties of plants. This collaboration signifies the importance of pooling knowledge and resources to address complex health challenges.

59) Aureus:
Aureus, often associated with Staphylococcus aureus, emphasizes the relevance of antimicrobial research alongside cholinesterase inhibitory activities. This broadens the focus on medicinal plants, highlighting their potential roles in combating infections while providing cognitive health benefits.

60) Animal:
The term 'animal' indicates the relevance of animal models in studying pharmacological effects and testing plant extracts for cholinesterase inhibition. Understanding these interactions in vivo is crucial for assessing the efficacy and safety of potential treatments before human applications.

61) Syria (Syrian):
Syria is mentioned as part of the Middle East region, representing a geographic area rich in traditional medicinal knowledge. The inclusion of such regions broadens the exploration of diverse plants used for cholinesterase inhibition, enriching global perspectives on herbal medicine.

62) Pearl:
The reference to 'pearl' could symbolize the preciousness of knowledge and discoveries in medicinal plant research. It signifies the valuable insights and potential therapies waiting to be unearthed from the vast biodiversity found in various geographic regions.

63) Earth:
In a broader context, 'earth' emphasizes the global importance of plant biodiversity in discovering effective treatments. It highlights the collective responsibility to explore and preserve the Earth’s natural resources, particularly plant species that may hold the key to modern medicine.

64) Viti:
As part of the botanical classification, 'Viti' refers to the genus of grapevines, indicating the significance of studying diverse plant families. Understanding the genetic and biochemical diversity among plants contributes to identifying effective natural remedies for diseases.

65) Dang:
Dang is included as an author, reflecting the collaborative nature of the research effort. The contributions from various scholars enrich the discourse and findings about plant-based solutions for addressing cognitive health issues.

66) Genu:
Genu might refer to a specific concept or genus in the context of the research under discussion. Clarifying the significance of genetic diversity helps in understanding the pharmacological properties attributed to different plants.

67) Khaw:
Khaw is identified as part of the research team, illustrating the collaborative efforts in investigating the possible benefits of various plants. Collaborative research enhances the study's depth, allowing for diverse perspectives and insights.

68) Peng:
Peng, another author mentioned, signifies individual contributions to the overall study. This reflects multidisciplinary collaboration, fostering an environment conducive to rich discoveries regarding the anti-cholinesterase activities of various plants.

69) Diet:
The mention of 'diet' reflects the importance of nutritional aspects in managing health conditions like Alzheimer’s. This stresses the relevance of incorporating foods with potential neuroprotective properties into daily routines as a preventive measure against cognitive decline.

70) Crop:
The term 'crop' refers to cultivated plants that may serve as sources of medicinal compounds. Focusing on recognized crops encourages agricultural practices that align with health improvement efforts, especially in exploring their potential pharmacological benefits.

71) Line:
In a research context, 'line' may relate to the continuity of studies or a line of inquiry. Progressing along established lines of research aids in deepening knowledge about plants' effects and guiding subsequent investigation directions.

72) Gold (Golden):
Gold symbolizes value and importance, often used to convey the worth of findings in scientific research. This can reflect the aspiration to uncover 'golden' solutions through the exploration of medicinal plants to address health challenges effectively.

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