Fighting diabetes with herbal technological developments
Journal name: World Journal of Pharmaceutical Research
Original article title: Fighting diabetes with herbal technological developments
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Seema Talreja, Chanchal Deep Kaur
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Fighting diabetes with herbal technological developments
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Diabetes mellitus is a prevalent metabolic disorder marked by hyperglycemia, which leads to serious long-term complications affecting various body organs, including the eyes, nerves, and kidneys. Traditional treatments for diabetes include insulin management and oral hypoglycemic agents. However, these synthetic remedies often come with a high cost and the potential for adverse side effects. This has led to increased interest in the use of herbal medicines, which have a long history of usage in Ayurveda and other traditional systems due to their perceived effectiveness, lower cost, and reduced side effects.
Herbal Medicines as Antidiabetics
A wide range of medicinal plants has been documented for their anti-diabetic properties, with active constituents that can regulate glucose levels through several mechanisms. Compounds from these plants can promote pancreatic beta-cell regeneration, stimulate insulin release, and fight insulin resistance. Examples of well-studied herbs include Momordica charantia (bitter gourd), Gymnema sylvestre, and Trigonella foenum-graecum (fenugreek), each showcasing their ability to enhance insulin output or inhibit glucose absorption in the intestines. The combination of these active constituents in various herbal formulations represents a burgeoning area of research and development in antidiabetic therapies.
Advances in Herbal Technological Developments
Recent advancements in herbal technology have focused on improving delivery systems for herbal extracts to maximize their therapeutic effects. This includes the development of novel drug delivery systems like liposomes and microemulsions, designed to protect sensitive compounds from degradation, enhance absorption, and ensure sustained release. Innovations such as transdermal patches also seek to bypass first-pass metabolism and maintain stable drug levels, thereby improving patient compliance. Such technological innovations can significantly augment the efficacy of herbal extracts in managing diabetes.
Herbal Formulations and Their Composition
Numerous herbal formulations have been developed that combine various medicinal plants to enhance their antidiabetic effects. These formulations often incorporate multiple herbs, each contributing unique active ingredients and mechanisms of action. For instance, formulations may include combinations of Gymnema sylvestre, Eugenia jambolana, and Momordica charantia, which can coalesce their distinct properties for a synergistic effect against diabetes. The strategic blending of these herbal components highlights a comprehensive approach to diabetes management based on traditional practices.
Conclusion
To combat diabetes mellitus effectively, a multidimensional approach is crucial. While traditional synthetic drugs have their place in treatment, the potential of herbal medicines provides an alternative that can lead to significant therapeutic opportunities with fewer side effects. The active principles found in various medicinal plants offer promising mechanisms that address the root causes of diabetes. Future research should focus on rigorous scientific evaluations and the potential development of new therapeutics derived from these traditional medicines to enhance diabetes management.
FAQ section (important questions/answers):
What is diabetes mellitus and its major complications?
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, resulting from insulin deficiency or resistance. Major complications include damage to organs such as the eyes, kidneys, nerves, and blood vessels, increasing risk for conditions like retinopathy, nephropathy, and atherosclerotic vascular disease.
What are common treatments for diabetes mentioned in the document?
Common treatments include insulin management for type 1 diabetes and various oral hypoglycemic agents like Sulphonylureas and Biguanides. However, these synthetic drugs can be costly and have side effects, prompting exploration of herbal alternatives.
How do herbal medicines compare to synthetic drugs for diabetes?
Herbal medicines are perceived as safer, with fewer side effects and lower costs. They often contain multiple active constituents that can help regenerate pancreatic beta cells, stimulate insulin release, and enhance glucose metabolism, making them attractive alternatives.
Which plants are noted for their anti-diabetic properties?
Notable plants include Trigonella foenum-graecum, Momordica charantia, Gymnema sylvestre, and Syzygium cumini, known for their effective antidiabetic actions such as enhancing insulin release and improving glucose uptake, supported by various active phytoconstituents.
What novel approaches are being developed for diabetic treatment?
Research is focusing on novel drug delivery systems like liposomes and transdermal patches, which aim to enhance the stability and bioavailability of herbal extracts, targeting specific areas for improved therapeutic effects in diabetes management.
Why are herbal formulations becoming more popular for diabetes treatment?
Herbal formulations are becoming more popular due to their effectiveness, perceived lower side effects compared to synthetic medications, controlled drug release, and ability to target diabetes-specific actions, making them an appealing choice among patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Fighting diabetes with herbal technological developments”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Beta (Bēṭa, Beṭa):
Beta refers to beta cells of the pancreas, which are crucial for insulin production and regulation of blood glucose levels. Their dysfunction plays a key role in diabetes, making their preservation or regeneration significant in anti-diabetic treatment strategies.
2) Activity:
Activity in this context pertains to the biological effects of medicinal plants and their constituents in combating diabetes. This can include insulin secretion stimulation, glucose absorption inhibition, or enhancing peripheral glucose utilization, highlighting the potential therapeutic benefits.
3) Blood:
Blood is the medium for transporting glucose and insulin, essential for maintaining metabolic homeostasis. In diabetes, hyperglycemia indicates improper regulation, emphasizing the need for interventions that normalize blood glucose levels through various therapeutic strategies.
4) Drug:
Drugs refer to pharmacological interventions in diabetes management, such as synthetic medications and herbal formulations. This highlights the diversity in treatment approaches, from traditional herbal remedies to modern pharmaceutical therapies, aimed at controlling blood sugar levels.
5) Momordica charantia:
Momordica charantia, or bitter gourd, is a well-studied medicinal plant known for its blood sugar-lowering properties. Its active constituents have demonstrated effects such as insulin secretion stimulation and glucose absorption inhibition, making it valuable in diabetes management.
6) Powder:
Powder often refers to the powdered form of herbal medicines, enabling easier consumption and dosage management. Powders derived from medicinal plants are commonly used in formulations to exploit their therapeutic actions against diabetes.
7) Table:
Table indicates a formal presentation of data, particularly listing various medicinal plants, their active constituents, and mechanisms of action against diabetes. Such tables facilitate quick reference and comparison among different herbal treatments.
8) Tinospora cordifolia:
Tinospora cordifolia, known as Guduchi, is a revered herb in traditional medicine for its immunomodulatory and anti-diabetic effects. It supports glycemic control by enhancing insulin sensitivity and promoting glucose uptake.
9) Azadirachta indica:
Azadirachta indica, or neem, is a plant with notable anti-diabetic properties, attributed to its ability to regenerate pancreatic beta cells and improve insulin action, making it significant for diabetes management strategies.
10) Disease:
Disease refers to the pathological condition that diabetes represents, characterized by chronic hyperglycemia. Understanding the nature of this disease is crucial for developing effective treatment regimens that incorporate both herbal and conventional therapeutic approaches.
11) Curcuma longa:
Curcuma longa, or turmeric, contains curcumin, which has demonstrated anti-inflammatory and anti-diabetic effects. Its incorporation in treatment regimens can aid in improving insulin sensitivity and reducing oxidative stress associated with diabetes.
12) Varanasi (Vārāṇasī, Varanashi, Vārāṇasi, Varaṇasī, Varāṇasī, Vāraṇasī, Vāraṇāsī):
Varanasi, a historic city in India, signifies the rich cultural heritage of traditional medicine practices like Ayurveda. The region's ancient medicinal knowledge contributes to the ongoing research and utilization of herbal treatments for diabetes.
13) Medicine:
Medicine encompasses various practices aimed at preventing and treating diseases, including diabetes management. Traditional and modern approaches, such as herbal remedies and pharmaceutical drugs, are integrated for comprehensive patient care.
14) Andhra (Āndhra, Amdhra):
Andhra is a region in India that reflects the local practices of herbal medicine, including the use of indigenous plants for diabetes treatment. Understanding regional resources broadens the spectrum of available therapeutic options.
15) Sugar:
Sugar refers to glucose, a critical energy source in the body. In diabetes, the mismanagement of sugar levels leads to hyperglycemia, underscoring the importance of monitoring and intervention through dietary and medicinal means.
16) Trigonella foenum-graecum:
Trigonella foenum-graecum, or fenugreek, contains compounds that promote insulin release and improve glucose tolerance. Its therapeutic uses highlight the potential of herbal remedies in regulating blood sugar levels in diabetic patients.
17) Emblica officinalis:
Emblica officinalis, commonly known as amla, possesses potent antioxidant properties and can help regulate blood sugar levels. Its inclusion in dietary supplements underscores the significance of herbal medicine in diabetes management.
18) Ocimum sanctum:
Ocimum sanctum, or holy basil, is noted for its adaptogenic and blood glucose-lowering effects. Its traditional use for maintaining health supports its role as a complementary treatment in diabetes.
19) Terminalia bellirica:
Terminalia bellirica is recognized for its anti-diabetic properties, aiding in blood sugar regulation. The plant's active compounds have been researched for their potential effects on managing diabetes through herbal formulations.
20) Tribulus terrestris:
Tribulus terrestris is noted for its ability to enhance insulin secretion and improve glucose metabolism. Its applications in traditional medicine underline the importance of herbal interventions in diabetes treatment.
21) Fenugreek:
Fenugreek is a well-regarded herb in diabetes management due to its insulin-enhancing properties. Its seeds are often used in culinary practices, showcasing the intersection of food and medicine in addressing health concerns.
22) Chennai:
Chennai is a major city in India where a blend of modern and traditional medicine coexists. The city is a hub for research and development of herbal remedies aimed at managing chronic conditions like diabetes.
23) Indian:
Indian refers to the cultural and medicinal heritage of the region, particularly its extensive use of plants in traditional medicine systems like Ayurveda, which inform current methodologies for treating diabetes.
24) India:
India is the geographical context for many traditional medicinal practices, including the use of herbal plants for diabetes treatment. The country's biodiversity offers numerous plants with potential therapeutic effects.
25) Kumar (Kumār):
Kumar reflects an individual contributor or researcher in studies involving herbal remedies for diabetes. Scholars and practitioners named Kumar symbolize the rich academic and practical heritage associated with traditional medicine.
26) Patel (Paṭel, Pāṭel):
Patel signifies the presence of researchers or practitioners involved in researching herbal treatments for diabetes. This name represents individuals contributing to the validation of traditional practices through scientific inquiry.
27) Terminalia chebula:
Terminalia chebula, known as haritaki, contains bioactive compounds that possess anti-diabetic effects. Its traditional use in Ayurvedic medicine showcases its relevance in modern therapeutic approaches for managing diabetes.
28) Mangifera indica:
Mangifera indica, or mango, is known for its potential benefits in blood glucose regulation. Its leaves and extracts are often studied for their therapeutic effects against diabetes, contributing to holistic treatment approaches.
29) Ricinus communis:
Ricinus communis, or castor oil plant, is recognized for its medicinal properties, including antidiabetic effects. Its components are explored for their potential to enhance insulin action and improve glucose tolerance.
30) Syzygium cumini:
Syzygium cumini, or jamun, exhibits hypoglycemic effects that can help manage diabetes. Its use in traditional medicine emphasizes the importance of plant-derived compounds in modern therapeutic applications.
31) Developing:
Developing refers to the ongoing research and innovation in creating herbal formulations and delivery systems for diabetes management. This highlights the dynamic nature of the field, where traditional knowledge is continuously evaluated.
32) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes natural healing and the use of herbal remedies for various ailments, including diabetes. It provides a foundational framework for the herbal treatments discussed.
33) Relative:
Relative in this context refers to the comparative relationships between different herbal treatments and their effects on blood sugar levels. Establishing such relationships aids in determining the most effective interventions.
34) Channel:
Channel refers to biochemical pathways involved in insulin release and glucose metabolism. Understanding these channels is crucial for developing targeted therapies that can effectively regulate blood sugar levels in diabetic patients.
35) Aruna (Aruṇa, Aruṇā):
Aruna may refer to a contributor or researcher involved in diabetes research or herbal medicine advocacy. Such individuals play a role in bridging traditional practices with modern scientific understanding.
36) Maci (Mācī):
Machi does not have a widely recognized connotation in this context unless referring to a specific researcher or part of a name in relevant literature, emphasizing the geographical and cultural facets of studying herbal medicine.
37) Shri (Śri, Śrī, Śṝ, Sṛ, Sṝ):
Shri is an honorific title commonly used in Indian culture to denote respect. It emphasizes the cultural significance and reverence associated with traditional practices and herbal remedies in Indian society.
38) Musha (Musa, Musā, Mūṣā, Muṣā, Musá):
Musa refers to the genus of bananas, which are utilized in various forms in traditional diets. They may have roles in health maintenance, including potential regulatory effects on blood glucose.
39) Bari (Barī):
Bari is a geographical reference that may relate to regional practices or research in herbal medicine. Recognizing such locations enhances appreciation for local contributions to the field of diabetes management.
40) Pari:
Pari may reference individuals contributing to diabetes research or may stand as part of a larger nomenclature in the context of herbal formulations. It indicates the network of contributors to traditional medicine.
41) Withania somnifera:
Withania somnifera, or ashwagandha, is used in traditional medicine for its adaptogenic properties. Its inclusion in diabetes management reflects the holistic approach of Ayurvedic practices focusing on overall health.
42) Cuminum cyminum:
Cuminum cyminum, or cumin, has shown potential anti-diabetic properties. Its active components contribute to supporting metabolism and glucose regulation, making it a valuable dietary herb.
43) Bitter gourd:
Bitter gourd represents a crucial component in diabetes management due to its efficacy in lowering blood glucose levels. Its consumption and incorporation in herbal formulations highlight its traditional significance and modern therapeutic application.
44) Tamarindus indica:
Tamarindus indica, or tamarind, is recognized for various health benefits, including potential anti-diabetic effects. Its use in traditional medicine reflects its multifunctionality and relevance in dietary strategies for diabetes.
45) Ficus religiosa:
Ficus religiosa, also known as the sacred fig, is revered for its medicinal properties in various cultures. Its active compounds have demonstrated potential in managing blood glucose, linking spirituality with health practices.
46) Pharmacological:
Pharmacological refers to the scientific study of drug action. In the context of diabetes, it involves researching herbal constituents and their mechanisms to develop effective treatment strategies.
47) Aegle marmelos:
Aegle marmelos, or bael, is recognized for its anti-diabetic properties. Its use in traditional remedies emphasizes the importance of integrating cultural practices with scientific research for herbal treatment validation.
48) Allium sativum:
Allium sativum, or garlic, has demonstrated beneficial effects on blood glucose regulation. Its antioxidant properties accentuate the relevance of dietary components in preventing and managing diabetes.
49) Cocos nucifera:
Cocos nucifera, or coconut, is valued for its nutritional and health benefits. Its potential effects in managing blood glucose levels contribute to the breadth of dietary strategies in diabetes treatment.
50) Phytochemical:
Phytochemical refers to the chemical compounds produced by plants. Understanding these compounds’ roles and interactions in diabetes management is paramount for developing new therapeutic approaches and enhancing existing remedies.
51) Raghavendra (Rāghavendra):
Raghavendra is a common name that may refer to scientists or practitioners contributing to diabetes research. Individual contributions highlight the collaborative effort in advancing herbal medicine for diabetes management.
52) Ramalingam (Rāmaliṅgam):
Ramalingam is possibly a researcher involved in studying herbal remedies for diabetes. The name represents the cultural and scholarly contributions to our understanding of traditional medicine.
53) Science (Scientific):
Scientific pertains to the methodical study and research crucial for understanding the efficacy of herbal treatments in diabetes management. It emphasizes evidence-based approaches in validating traditional methods.
54) Narasimha (Narasiṃha, Nārasiṃha, Narasingha, Nara-simha):
Narasimha may refer to an author or researcher within diabetes studies. Such individuals contribute to the collective knowledge base concerning the application of traditional herbal methods in treating chronic diseases.
55) Colouring (Coloring):
Colouring in the context of herbal medicine can refer to the pigments or compounds in plants that contribute to their therapeutic efficacy. Understanding these attributes relates to the effectiveness and appeal of herbal preparations.
56) Thanjavur:
Thanjavur is a city with a rich cultural heritage in India, known for its contributions to traditional medicine. Recognizing its historical significance aids in the appreciation of regional herbal practices in diabetes management.
57) Flavonoid:
Flavonoids are plant-derived compounds known for their antioxidant effects. They play a vital role in supporting metabolic health and combating oxidative stress, relevant in preventing and managing diabetes.
58) Nirupama (Nirupamā, Nir-upama):
Nirupama is a name possibly associated with scholars or researchers in diabetes research, highlighting individual contributions to the collective understanding of herbal remedies' role in treatment.
59) Bhavani (Bhavāni, Bhavānī):
Bhavani may indicate a contributor to research in the field of herbal medicine for diabetes. This representation underscores the importance of individual expertise in fostering advancements in this area.
60) Venkata (Veṅkaṭa, Vemkata):
Venkata may refer to an individual involved in diabetes research, highlighting the importance of personal contributions in enhancing the theoretical and practical applications of herbal medicine.
61) Gokharu (Gōkharū, Gokharū):
Gokharu, or Tribulus terrestris, is recognized for its potential benefits in regulating blood sugar levels. Its relevance in traditional medicine underscores the integration of herbal remedies in diabetes management strategies.
62) Chandra:
Chandra may refer to an individual contribution within diabetes research or traditional medicine advocacy. This highlights the personal efforts in advancing the understanding and application of herbal treatments.
63) Murugan (Murukan):
Murugan often represents a contributor to the study of herbal remedies in diabetes. Recognizing individuals engaged in research exemplifies the collaborative nature of advancing herbal medicine.
64) Mustard:
Mustard refers to plants like Brassica nigra that have been studied for their anti-diabetic properties. Their potential benefits in managing blood glucose underscore the therapeutic relevance of common culinary herbs.
65) Species:
Species in a botanical context refers to the various types of plants researched for their therapeutic potential against diabetes. Understanding these species helps in identifying effective herbal treatments.
66) Coconut (Cocoanut):
Coconut, recognized for its nutritional value, is often included in dietary strategies for diabetes management. Its components may support better metabolic health and assist in maintaining balanced blood sugar levels.
67) Camara (Cāmara, Camará):
Camara likely refers to Lantana camara, known for its potential anti-diabetic effects. Its inclusion in herbal studies highlights the broad range of plants being examined for diabetes treatment.
68) Kalita (Kālita):
Kalita may indicate a contributor to herbal medicine research, representing individual efforts in examining the therapeutic applications of plants in managing diabetes and other health conditions.
69) Tamala (Tamāla):
Tamala may refer to Cinnamomum tamala, a plant noted for its medicinal properties. Such references underscore the diversity of herbal remedies studied for their potential anti-diabetic effects.
70) Castor:
Castor refers to Ricinus communis, whose oil has demonstrated various health benefits, including potential anti-diabetic effects, contributing to the exploration of plant-based therapies against diabetes.
71) Karela (Karēlā, Karelā):
Karela, or bitter gourd, is extensively used for its significant anti-diabetic properties. Its incorporation in various forms within diets and herbal formulations highlights its prominence in diabetes management.
72) Family:
Family signifies the classification of plants in botanical taxonomy. Understanding the family relationships among herbal plants aids researchers in categorizing and studying their medicinal properties.
73) Nausea:
Nausea can be a side effect associated with synthetic diabetes medications, emphasizing the importance of exploring herbal alternatives that may present fewer side effects for managing blood glucose.
74) Garlic:
Garlic, or Allium sativum, is celebrated for its diverse health benefits, including potential anti-diabetic effects. Its active compounds have shown promise in improving insulin sensitivity and controlling blood sugar.
75) Bitter:
Bitter often describes the taste profile of certain anti-diabetic plants like bitter gourd. The bitterness is correlated with pharmacological actions that can lower blood sugar levels, enhancing therapeutic effectiveness.
[Note: The above list is limited to 75. Total glossary definitions available: 103]