Antidiabetic effects of Passiflora foetida extracts in diabetic rats.
Journal name: World Journal of Pharmaceutical Research
Original article title: Antidiabetic activity of aqueous and ethanolic extracts of passiflora foetida l. in alloxan induced diabetes rats
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Summary of article contents:
Introduction
Diabetes mellitus is identified as a significant endocrine disorder and a growing health concern globally, notably in India, which is often referred to as the diabetic capital of the world. The condition is characterized by chronic hyperglycemia stemming from insulin deficiency or reduced tissue sensitivity to insulin. This leads to a range of metabolic complications and increased oxidative stress due to enhanced free radical production. Traditional synthetic treatments, while effective, often come with undesirable side effects, prompting a search for safer alternatives through herbal medicines. The study focuses on the antidiabetic properties of Passiflora foetida, a plant traditionally used in various medicinal applications.
Antidiabetic Activity of Passiflora foetida
The research investigates the effectiveness of both aqueous and ethanolic extracts of Passiflora foetida against diabetes induced in Wistar albino rats using alloxan. The study administered these extracts at a dosage of 200 mg/kg orally for 14 days, measuring their impact on blood glucose levels and other biochemical markers. Results indicated that the aqueous extract exhibited superior antidiabetic activity compared to the ethanolic extract, with both showing significant reductions in blood glucose levels. Additionally, the treatment led to marked improvements in body weight among the diabetic rats, suggesting a protein-sparing effect.
Biochemical Improvements in Diabetic Rats
The study further addresses the beneficial effects of P. foetida extracts on hepatic and renal parameters in diabetic rats. Elevations in serum markers such as SGOT and SGPT in diabetic groups indicated liver damage, which were significantly restored towards normal levels upon treatment with the extracts. Similarly, serum levels of urea and creatinine, indicators of renal function, were markedly reduced, thereby demonstrating the nephroprotective potential of P. foetida. The findings underscore the plant’s capability to mitigate organ damage associated with diabetes, supporting its use in traditional medicine.
Impact on Protein Levels
Another critical finding of the research is the effect of P. foetida on serum protein levels in diabetic rats. The study discovered a significant decrease in serum protein levels in untreated diabetic rats, a condition attributed to enhanced protein catabolism in the hyperglycemic state. Conversely, treatment with the extracts of P. foetida resulted in a restoration of protein levels, indicating that the plant may play a role in enhancing protein synthesis or reducing degradation. This reinforces the overall therapeutic potential of P. foetida in managing diabetic conditions by improving protein metabolism.
Conclusion
In conclusion, the investigation into Passiflora foetida establishes its promising antidiabetic properties, as evidenced by significant reductions in blood glucose levels and improvements in hepatic and renal functions. The plant extracts not only contribute to the regulation of glucose metabolism but also enhance overall health conditions in diabetic rats by normalizing body weight and protein levels. These findings advocate for further studies into the therapeutic applications of P. foetida and its potential to serve as a viable alternative or complementary treatment for diabetes, emphasizing the growing need for safe, natural remedies in healthcare.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
P. Joseph Asir, S. Hemmalakshmi, S. Priyanga and K.Devaki
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antidiabetic activity of aqueous and ethanolic extracts of passiflora foetida l. in alloxan induced diabetes rats
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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FAQ section (important questions/answers):
What was the purpose of the study on Passiflora foetida?
The study aimed to evaluate the antidiabetic efficacy of aqueous and ethanolic extracts of Passiflora foetida against alloxan-induced diabetes in rats.
How was diabetes induced in the experimental rats?
Diabetes was induced in Wistar albino rats through a single intraperitoneal injection of alloxan monohydrate at a dosage of 100 mg/kg.
What were the key findings regarding glucose reduction?
Aqueous extracts of Passiflora foetida showed the highest percentage reduction in blood glucose levels compared to ethanolic extracts and other plant parts.
How did the extracts affect serum hepatic markers?
The treatment with both aqueous and ethanolic extracts significantly reversed elevated serum SGOT and SGPT levels, indicating supportive liver effects.
What impact did the extracts have on body weight?
The aqueous and ethanolic extracts significantly improved body weight loss in diabetic rats, suggesting a protein-sparing effect.
Were there any observed effects on renal markers?
Yes, both extracts significantly reduced elevated levels of urea and creatinine in diabetic rats, indicating potential renal protective effects.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antidiabetic effects of Passiflora foetida extracts in diabetic rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Animal:
In the context of the study, 'animal' refers to the Wistar albino rats used as experimental subjects to induce and evaluate diabetes through alloxan administration. Animal models are pivotal in preclinical research to understand disease mechanisms and assess the efficacy of potential treatments.
2) Blood:
'Blood' is a critical biological fluid monitored in the study to measure glucose levels, serum markers, and overall physiological health of the rats. Changes in blood composition are key indicators of metabolic disease progression and therapeutic efficacy in experimental settings.
3) Devaki (Devakī):
Devaki is the name of one of the authors contributing to the research. Author names provide attribution and acknowledgment of intellectual contributions in academic work, which is essential for accuracy in scientific communication and for giving credit to researchers involved.
4) Activity:
'Activity' in this context refers to the biological effects observed in the study, particularly the antidiabetic effects of the extracts from Passiflora foetida. Understanding the activity of extracts helps in elucidating their potential therapeutic benefits and mechanisms of action.
5) Study (Studying):
'Study' denotes the research investigation conducted to assess the antidiabetic properties of Passiflora foetida extracts. The term represents the scientific inquiry aimed at generating knowledge and validating hypotheses pertaining to diabetes treatment using herbal remedies.
6) India:
'India' is significant as the location of the study. It reflects the regional interest in diabetes research due to the high prevalence of diabetes in the country, underscoring the relevance of locally sourced medicinal plants in addressing public health challenges.
7) Table:
'Table' refers to a method of data presentation used in the study to summarize and compare experimental results systematically. Tables enhance clarity and allow quick reference to vital findings regarding biochemical parameters and treatment outcomes.
8) Disease:
'Disease' refers to diabetes mellitus in this study, which poses serious health challenges globally. The term encompasses the pathological state being investigated, its etiology, symptoms, and impact on bodily functions, highlighting the need for effective treatments.
9) Species:
'Species' pertains to Passiflora foetida, the plant studied for its medicinal properties. Understanding the species is critical in pharmacognosy and pharmacology, as each species can possess unique phytochemicals affecting its therapeutic potential and biological activity.
10) Medicine:
'Medicine' in this context refers to the therapeutic interventions aimed at managing diabetes, including herbal remedies derived from Passiflora foetida. This highlights the search for alternative treatments in the face of the limitations and side effects of synthetic pharmaceuticals.
11) Water:
'Water' is a fundamental solvent in the extraction process of plant materials. Its presence in the study signifies its role as a medium for preparing aqueous extracts, essential for exploring the bioactive compounds that exert antidiabetic effects.
12) Tamil (Tamiḻ):
'Tamil' refers to the language and cultural context relevant to the study conducted in Tamil Nadu, India. It emphasizes the linguistic and regional aspects that may influence traditional medicine practices and the use of local flora in healthcare.
13) Drug:
'Drug' denotes the bioactive components derived from Passiflora foetida evaluated for their medicinal efficacy. The term is crucial in pharmacological research as it underscores the focus on potential therapeutic agents derived from natural sources.
14) Tamilnadu (Tamil-nadu, Tamilnāḍu):
'Tamilnadu' serves as an alternative spelling for Tamil Nadu, reiterating the geographical significance of the study’s context. Correct spelling and regional recognition are important in academic writing for precision and clarity.
15) Container:
'Container' denotes the storage method for the dried plant material and extracts used in the study. Proper preservation in airtight containers is essential to maintain the integrity of bioactive compounds and ensure reliable research results.
16) Nadu (Nāḍu):
'Nadu' is part of 'Tamil Nadu,' indicating the cultural and regional aspect of the study. This term highlights the importance of localization in research and the relevance of regional medicinal plants in traditional healing practices.
17) Genu (Geṇu):
'Genu' refers to the genus of Passiflora species, emphasizing the taxonomical classification relevant to botanical and pharmacological studies. Understanding genus-level characteristics aids in comparing species and assessing their potential uses in medicine.
18) Pharmacological:
'Pharmacological' pertains to the study of drug action and effect on biological systems. This term is essential for understanding the mechanisms through which Passiflora foetida exerts its antidiabetic effects, contributing to the body of pharmacotherapy knowledge.
19) Measurement:
'Measurement' involves quantifying biological parameters such as blood glucose, serum components, and body weight in the study. Accurate measurements are foundational for validating experimental hypotheses and ensuring the reliability of research findings.
20) Discussion:
'Discussion' refers to the section in research where findings are interpreted in relation to existing literature. It is crucial for contextualizing results, drawing conclusions, and suggesting implications for future research and clinical applications.
21) Flavonoid:
'Flavonoid' refers to a class of phytochemicals potentially present in Passiflora foetida, known for various health benefits, including antioxidant properties. The presence of flavonoids supports the exploration of their role in managing diabetes and enhancing overall health.
22) Epidemic:
'Epidemic' refers to the widespread occurrence of diabetes, particularly in India, highlighting the urgency for effective treatments and research like this study. The term signifies the public health challenge posed by the increasing prevalence of diabetes globally.
23) Relative:
'Relative' refers to a comparative assessment of results, important in understanding the impacts of treatments compared to control groups. This term emphasizes the importance of relative changes in parameters like blood glucose in evaluating treatment efficacy.
24) Family:
'Family' categorizes groups of related plants; in this context, Passifloraceae is pertinent. Understanding plant family relationships aids in identifying other species with potential therapeutic effects and contributes to bioprospecting efforts for natural remedies.
25) Cancer:
'Cancer' indicates a condition explored in relation to the properties of Passiflora foetida. Its mention underscores the broader therapeutic potential of the plant beyond diabetes, suggesting possible applications in oncology based on prior research.
26) Repair:
'Repair' relates to physiological processes aimed at restoring normal function post injury or disease. In the study, it suggests the ability of Passiflora foetida extracts to support recovery in diabetic rats, implicating its therapeutic role.
27) Powder:
'Powder' signifies the processed form of plant materials after drying and grinding, used for extraction. The physical form is critical in preparation methods, influencing the efficacy of bioactive compounds extracted during research.
28) Thirst:
'Thirst' refers to a common symptom in diabetic conditions observed in the rats during the study. It reflects the physiological effects of diabetes and highlights the need for effective antidiabetic treatments to mitigate such symptoms.
29) Campu (Campū, Cāmpu):
'Campu' likely relates to 'Campus,' referring to Karpagam University where the study took place. This indicates the institutional context, critical for ensuring ethical research practices and fostering academic collaboration in scientific inquiry.
30) Fever:
'Fever' relates to a symptom that may be associated with various diseases. Its mention in the context of traditional medicine indicates the broader scope of ailments addressed by herbal treatments and reflects on local healthcare practices.
31) Death:
'Death' signifies the potential severity and complications of untreated diseases like diabetes. This highlights the broader implications of the research, underscoring the importance of finding effective treatments to prevent fatal outcomes in diabetic patients.
32) House:
'House' refers to the animal house facility where the rats were kept for the study. Appropriate housing conditions are crucial for maintaining the health and well-being of experimental animals, helping to ensure the validity of research results.
33) Male (Mālē):
'Male' specifies the gender of the albino rats used in the study. Gender can influence the physiological responses to treatments, making it vital to specify in research to account for variations in drug efficacy and biological function.
34) Food:
'Food' denotes the diet provided to the experimental rats, which is essential for maintaining health during the study. The consistent provision of diet ensures that results attributed to treatments are not confounded by nutritional variables.
35) King:
'King' likely refers to the method of serum enzyme activity measurement (King's method) used in the study. Methodological accuracy is crucial for reliable results, ensuring that biochemical analyses adhere to established standards.
36) Ripe:
'Ripe' refers to the developmental stage of Passiflora foetida fruit used in the study. The ripeness of plant material can affect its chemical composition and therapeutic properties, emphasizing the need for careful selection in research.
37) Pose:
'Pose' relates to the challenges and risks associated with diabetes, highlighting the disease's impact on public health and quality of life. This term emphasizes the necessity for effective interventions capable of addressing these challenges.
38) Hand:
'Hand' signifies human involvement in the research process, from experimentation to data analysis. It underscores the role of researchers in actively engaging with the study material, interpreting results, and contributing to scientific knowledge.