Anti-histaminic effects of Gandhaga Chunnam in animal model
Journal name: World Journal of Pharmaceutical Research
Original article title: Anti- histaminic activity of siddha herbo mineral formulation gandhaga chunnam in animal model
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Om Sakthi T, Mohamed Musthafa M
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Anti- histaminic activity of siddha herbo mineral formulation gandhaga chunnam in animal model
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The Siddha system of medicine, originating in Tamil Nadu, India, is known for its efficacy in treating chronic auto-immune disorders through herbo-mineral formulations. This study examines the anti-histaminic action of a specific formulation called Gandhaga Chunnam (GC). The formulation primarily consists of Gandhagam (Sulphur), coconut oil, cucumber, and egg white, with honey used as a vehicle to enhance its effects. Gandhagam is traditionally regarded for its astringent properties and potential benefits for skin health, particularly in inflammatory skin diseases like psoriasis.
Anti-Histaminic Action of Gandhaga Chunnam
The study employed the hind paw method using albino rats to assess the anti-histaminic effects of GC. The results demonstrated that GC exhibited significant anti-histaminic activity in both acute and chronic models. The test involved administering different doses of GC alongside histamine to evaluate its efficacy in reducing paw edema, a marker of inflammation. The findings indicate that GC is effective in mitigating the effects of histamine, suggesting beneficial implications for treating allergic skin conditions.
Preparation and Dosage of Gandhaga Chunnam
The preparation of GC involves a traditional method where Gandhagam is purified using cucumbers and then combined with egg white and coconut oil. The final product is processed into pills and administered at a dose of 65 mg twice daily over a period of 48 days. This method not only preserves the active components of the formulation but also enhances its therapeutic properties through specific preparation steps outlined in Siddha literature.
Pharmacological Evidence of Efficacy
Statistical analysis supports the efficacy of GC, revealing a significant reduction in paw volume due to its anti-histaminic effects. The results affirm the pharmacological validity of the formulation, indicating that GC can offer a viable alternative treatment for skin ailments associated with histamine activity. This highlights the potential of traditional herbal medicines in modern pharmacotherapy.
In conclusion, Gandhaga Chunnam shows promise as a treatment for psoriasis and other allergic skin diseases, exhibiting notable anti-histaminic properties. Further research is warranted to explore its clinical efficacy and contribute to the development of novel therapeutic agents derived from Siddha medicine to address chronic health issues.
FAQ section (important questions/answers):
What is the focus of the study regarding Gandhaga Chunnam?
The study aims to evaluate the anti-histaminic activity of the Siddha herbo-mineral formulation Gandhaga Chunnam in animal models.
What are the main ingredients of Gandhaga Chunnam?
Gandhaga Chunnam consists of Gandhagam (Sulphur), coconut oil, cucumber, and egg white, with honey used as a vehicle to enhance efficacy.
How was the anti-histaminic activity tested in the study?
The anti-histaminic activity was assessed using the hind paw edema method in albino rats, measuring paw volume before and after histamine injection.
What were the results of administering Gandhaga Chunnam?
Gandhaga Chunnam showed significant anti-histaminic action, effectively reducing paw volume in treated animals compared to controls.
What was the conclusion about Gandhaga Chunnam's effectiveness?
Gandhaga Chunnam is concluded to be effective in treating psoriasis and other allergic skin diseases, showcasing pharmacological anti-histamine properties.
Who guided the research study on Gandhaga Chunnam?
Dr. M. Mohamed Musthafa, HOD of the PG Department of Sirappu Maruthuvam, provided guidance for the study and its publication.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-histaminic effects of Gandhaga Chunnam in animal model”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'drug' refers to the active therapeutic agent or formulation under investigation, particularly the Siddha herbo-mineral formulation Gandhaga Chunnam (GC) in this context. It plays a critical role in evaluating its anti-histaminic activity, especially concerning skin diseases like psoriasis and other allergic conditions. Understanding its mechanism aids in potential clinical applications.
2) Siddha (Siddhā):
Siddha is an ancient Indian healthcare system originating in Tamil Nadu, characterized by its unique blend of herbal, mineral, and spiritual practices. This system emphasizes holistic treatment, focusing on balancing the body's elements. The research highlights Siddha's approach to treating chronic ailments, showcasing its relevance and efficacy in contemporary medicine.
3) Sakthi:
Om Sakthi T is the lead researcher and PG Scholar involved in this study, representing the contribution of individual practitioners within the Siddha medical community. His work aims to explore and validate the therapeutic properties of Siddha formulations, furthering their acceptance and application in modern clinical settings. Author identity lends credibility to the research.
4) Activity:
In this study, 'activity' refers to the biological effects produced by the Siddha herbo-mineral formulation, specifically its anti-histaminic action. This term is crucial as it signifies the formulation's potential to mitigate allergic reactions and skin conditions, thereby validating its use in effective treatment protocols derived from Siddha medicine.
5) Coconut (Cocoanut):
Coconut oil, one of the ingredients in Gandhaga Chunnam, plays a prominent role as a vehicle for the drug. Its moisturizing properties contribute to the formulation's efficacy in promoting skin health. The inclusion of coconut oil underscores the integration of natural ingredients in Siddha formulations, enhancing their therapeutic effectiveness for skin ailments.
6) Pharmacological:
'Pharmacological' pertains to the study of drug action on biological systems. In this research, it encapsulates the evaluation of Gandhaga Chunnam's effectiveness in altering histamine-induced reactions in animal models. The pharmacological investigations are key to understanding the active components and their mechanisms, providing a bridge between traditional Siddha practices and modern medicine.
7) Discussion:
The 'Discussion' section of the study offers critical analysis and interpretation of the results. It connects the findings of the anti-histaminic activity of Gandhaga Chunnam with existing literature, invites further inquiry, and emphasizes the implications of Siddha formulations in clinical practice. This section is essential for understanding the broader context of the research.
8) Honey:
Honey serves as the adjuvant in the preparation of Gandhaga Chunnam, acting as a vehicle to enhance the absorption and efficacy of the active ingredients. It also possesses its own health benefits, such as anti-inflammatory properties. This inclusion showcases the holistic approach of Siddha medicine, utilizing natural substances for therapeutic enhancements.
9) Edema (Oedema):
Edema refers to the swelling caused by the accumulation of fluid in body tissues, which is a key focus in the anti-histaminic study of Gandhaga Chunnam. Understanding the formulation's effects on histamine-induced edema is crucial for validating its use against allergic reactions and skin disorders prevalent in conditions like psoriasis.
10) Cow dung:
Cow dung plays a unique role in the preparation process of Gandhaga Chunnam, specifically during the incineration phase, where it is used as a fuel source. This traditional practice in Siddha medicine highlights the integration of natural materials not only for medicinal benefits but also for cultural and ritualistic significance.
11) Purification:
Purification is a critical step in the preparation of Gandhaga Chunnam, ensuring that the active ingredients, such as Gandhagam (sulphur), are free from impurities. This process is essential in Siddha medicine to uphold the integrity and efficacy of medicinal formulations, underscoring the importance of meticulous preparation in traditional healing.
12) Science (Scientific):
The term 'scientific' reflects the methodological approach taken in this study to evaluate the anti-histaminic effects of the Siddha formulation. By employing rigorous experimental techniques and statistical analysis, the research aims to substantiate the traditional claims of efficacy, thereby integrating Siddha practices with contemporary scientific standards for validation.
13) Inference:
Inference refers to the conclusions drawn from the statistical analyses conducted during the study. This aspect is vital for establishing the significance of the results, indicating the effectiveness of Gandhaga Chunnam in the observed anti-histaminic action, and guiding future research directions in both Siddha and broader herbal medicine applications.
14) Medicine:
The term 'medicine' encompasses the study and practice of diagnosing, treating, and preventing diseases. In this context, it underscores the role of Siddha as a traditional medical system with unique formulations like Gandhaga Chunnam. It highlights the ongoing validation and integration of herbal medicine into modern healthcare practices.
15) Debility:
Debility refers to a state of weakness or incapacity often addressed in traditional medicine. In Siddha, conditions of debility may be treated using formulations that enhance overall vitality and wellness. This research emphasizes the potential of Gandhaga Chunnam to address such chronic ailments, thereby promoting a holistic approach to health restoration.
16) Post:
'Post' in this context relates to the post-administration assessment of the effects of Gandhaga Chunnam on the test subjects. This phase is crucial for understanding the duration and efficacy of the formulation's anti-histaminic properties, contributing to the overall evaluation and potential for clinical application in treating allergic conditions.