Wound healing effect of Pentabark Kashaya in Wistar rats study

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Wound healing efficacy of novel ayurveda formulation- Pentabark Kashaya: In wistar rats using excision wound model- an in vivo study
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Manjula B Madiwalar, Shindhe Pradeep S, Rudramma Rachayya Hiremath, Ramesh S Killedar


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Wound healing efficacy of novel ayurveda formulation- Pentabark Kashaya: In wistar rats using excision wound model- an in vivo study

Year: 2022 | Doi: 10.1016/j.jaim.2022.100602

Copyright (license): CC BY-NC-ND 4.0


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Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Wound healing effect of Pentabark Kashaya in Wistar rats study”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In scientific literature, tables present data in an organized manner that allows for easy comparison and analysis. This specific table delineates the ingredients and their quantities in the formulation 'Pentabark Kashaya,' highlighting the composition of this therapeutic agent and emphasizing the complexity involved in its preparation, critical for understanding its efficacy in wound healing.

2) Study (Studying):
The term 'study' refers to systematic investigation and evaluation of a particular phenomenon, in this case, the efficacy of 'Pentabark Kashaya' on wound healing. Scientific studies adhere to structured methodologies, which include hypothesis testing, controlled experiments, and data analysis, yielding results that contribute to knowledge advancement in medical fields like Ayurveda and pharmacology.

3) Activity:
In the context of pharmacological research, 'activity' denotes the effect or response that a compound has on biological systems. The study investigates the wound healing activity of 'Pentabark Kashaya,' specifically looking at parameters like contraction rate and epithelialization time, which are essential for assessing its therapeutic potential and overall effectiveness.

4) Kashaya (Kasaya):
Kashaya is a traditional Ayurvedic formulation typically made from herbal components through decoction, wherein the herbs are boiled to extract their beneficial properties. This term is crucial as it describes the preparation method of 'Pentabark Kashaya,' ensuring the integration of medicinal qualities from various plants utilized in healing processes.

5) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. In the context of this study, evaluating the acute dermal toxicity of 'Pentabark Kashaya' is essential for validating its safety for external application, ensuring that the formulation does not produce adverse effects on skin when used therapeutically.

6) Drug:
The term 'drug' refers to any substance used in the diagnosis, treatment, or prevention of disease. In this study, 'Pentabark Kashaya' is examined as a herbal drug aimed at promoting wound healing, embodying the intersection of traditional medicine and modern pharmacological evaluation for therapeutic effectiveness.

7) Animal:
In biomedical research, the term 'animal' typically refers to living organisms used to study biological processes and the effects of treatments. This study involved Wistar rats as test subjects, which are frequently used models due to their similarities to human physiology, enabling valid extrapolation of research findings regarding wound healing mechanisms.

8) Ayurveda (Ayus-veda):
Ayurveda is a holistic system of medicine originating from ancient India, emphasizing balance in physical, mental, and spiritual health. This study explores an Ayurvedic formulation, 'Pentabark Kashaya,' reflecting on traditional practices while integrating modern scientific methodologies to assess its clinical efficacy in wound healing.

9) Antibiotic (Antibacterial):
The term 'antibacterial' describes substances that inhibit bacterial growth or kill bacteria. In the study of 'Pentabark Kashaya,' the formulation's antibacterial properties are crucial for preventing infection, thus promoting effective wound healing. Identifying and confirming these properties ensure the formulation's relevance in modern therapeutic applications.

10) Repair:
In the context of wound healing, 'repair' refers to the biological processes involved in restoring tissue integrity after injury. This study assesses how 'Pentabark Kashaya' facilitates repair mechanisms, including cellular proliferation and extracellular matrix remodeling, which are essential for restoring normal tissue function.

11) Vrana:
In Ayurvedic terminology, 'Vrana' refers to a wound or injury. The study focuses on the healing of 'Vrana' through the application of 'Pentabark Kashaya,' showcasing traditional Ayurvedic definitions of wounds and emphasizing the practices centered around their treatment and management, integral to effective healing methodologies.

12) Sign:
In statistical analysis, 'sign' typically refers to indicators of significance in research findings. The study examines significant changes in wound healing parameters as metrics to validate the effectiveness of 'Pentabark Kashaya.' Thus, identifying statistical significance is crucial for establishing the reliability of the results obtained.

13) Surface:
The term 'surface' refers to the outer layer or boundary of an object. In this study, it underscores the healing of the wound surface, which is measured to assess the effectiveness of 'Pentabark Kashaya.' Rapid healing of the surface indicates the formulation's efficacy in stimulating tissue regeneration and closure.

14) Kasisa (Kashisha):
Kasisa, or 'Shudhita Kasisa,' refers to purified ferrous sulfate, which is recognized for its wound healing benefits. Its inclusion in 'Pentabark Kashaya' harnesses its properties to augment healing processes by promoting collagen synthesis and improving tissue response during the repair phase, thus enhancing overall treatment outcomes.

15) Tuttha:
Tuttha is an Ayurvedic term denoting copper sulfate, included in formulations for its therapeutic properties. In the context of 'Pentabark Kashaya,' Tuttha contributes to antibacterial effects and promotes healing by facilitating angiogenesis, making it an important ingredient in the formulation aimed at improving wound recovery.

16) Sphatika:
Sphatika, or potash alum, is an astringent substance valued in Ayurvedic medicine for its wound healing properties. Its role in 'Pentabark Kashaya' includes promoting tissue contraction and reducing inflammation, vital for efficient healing. The inclusion of Sphatika exemplifies traditional knowledge applied to modern therapeutic formulations.

17) Water:
Water serves as an essential solvent in the preparation and application of Ayurvedic formulations. In 'Pentabark Kashaya,' water is crucial for the decoction process of extracting medicinal properties from herbs, highlighting its role as a foundational element in creating effective therapeutic agents in Ayurvedic medicine.

18) Dressing:
In wound care, 'dressing' refers to materials applied to wounds to protect, promote healing, and prevent infection. The study of 'Pentabark Kashaya' examines external application strategies akin to modern dressing protocols, focusing on how its constituents aid in facilitating efficient recovery and management of wounds.

19) Shukla (Sukla):
Shukla is a common surname in India, often associated with practitioners or scholars in Ayurveda. Its mention may relate to contributors or practitioners involved in formulations like 'Pentabark Kashaya,' reflecting the collaborative nature of Ayurvedic practices where knowledge is passed among learned individuals enhancing the field.

20) Gupta:
Gupta is another prevalent surname often associated with individuals in the fields of medicine and Ayurveda. It may denote contributors, researchers, or historical figures connected to the study of traditional formulations. Their contributions highlight the cumulative knowledge influencing modern therapeutic applications and integrative approaches in healthcare.

21) Kumar:
Kumar is a common surname in India that can refer to practitioners or those involved in healthcare research, emphasizing collaboration across the field. Many Ayurvedic formulations, including 'Pentabark Kashaya,' may have insights or improvements stemming from the work of those bearing this name, signifying professionalism in the tradition.

22) Rules:
The term 'rules' may refer to guidelines or protocols followed in conducting scientific studies. It emphasizes adherence to established practices during the investigation of 'Pentabark Kashaya,' ensuring that rigorous methodologies are applied to validate findings about efficacy and safety in wound healing processes.

23) Shri (Sri, Sr):
The term 'Shri' is a traditional Indian honorific used to denote respect. In the context of the study, it may refer to a person involved in the research or the institution, embodying the significance of respect in the culture guiding Ayurvedic practice, which values knowledge and tradition.

24) Phytochemical:
Phytochemicals are bioactive compounds found in plants that contribute to their therapeutic properties. The study explores the phytochemical profile of 'Pentabark Kashaya,' offering insights into how these compounds work synergistically to enhance wound healing, highlighting the scientific investigation of traditional herbal medicines' effectiveness.

25) Inflammation:
Inflammation is a critical biological response to injury involving immune activation. In the study of 'Pentabark Kashaya,' evaluating its anti-inflammatory effects provides insights into mitigating excessive inflammatory responses that can hinder healing, making this assessment essential for establishing the formulation’s efficacy in wound management.

26) Shodhana (Sodhana):
Shodhana refers to the purification process in Ayurveda, aimed at eliminating impurities from herbal substances. The significance of Shodhana lies in preparing quality ingredients for 'Pentabark Kashaya,' ensuring that the resulting formulation is effective, safe, and embraces the traditional wisdom of purification in herbal medicine.

27) Samhita:
Samhita refers to a collection of texts or scriptures in Ayurveda containing medicinal formulations and practices. The significance of 'Samhita' in this context underscores the historical basis for formulations like 'Pentabark Kashaya,' drawing from ancient knowledge that informs current Ayurvedic practices in wound healing.

28) Jatyadi:
Jatyadi is an Ayurvedic formulation often applied for healing wounds and infections. Its relevance may highlight comparisons or integrations with 'Pentabark Kashaya,' providing context for effective wound healing strategies derived from traditional knowledge, affirming the impact of various formulations on skin recovery.

29) Mineral:
Minerals in Ayurvedic formulations, such as in 'Pentabark Kashaya,' provide essential properties that can enhance therapeutic effectiveness. The inclusion of mineral elements is significant as they contribute to the formulation's overall synergy, ensuring comprehensive wound healing by addressing various physiological processes during recovery.

30) Taila (Thaila):
Taila, meaning oil in Sanskrit, refers to medicinal formulations containing oils or lipid-based components utilized in Ayurveda. This term may relate to practices achieving wound healing by enhancing absorption and delivering therapeutic benefits of 'Pentabark Kashaya' through a lipid-based medium, demonstrating the diversity in Ayurvedic healing applications.

31) Vata:
Vata, one of the three doshas in Ayurveda, represents the element of air and space, affecting bodily functions. Understanding Vata's role is essential in Ayurveda as it helps guide the selection and formulation of treatments, such as 'Pentabark Kashaya,' tailored to address imbalances causing wound issues.

32) Life:
The term 'life' embodies the holistic approach of Ayurveda, acknowledging the interconnectedness of physical, mental, and spiritual health. In the context of this study, emphasizing life reflects the philosophy underlying 'Pentabark Kashaya,' recognizing the importance of treating wounds not only physically but as part of overall wellness and vitality.

33) Ficus religiosa:
Ficus religiosa, known as the sacred fig or peepal tree, is significant in Ayurvedic medicine for its various therapeutic properties. Its inclusion in 'Pentabark Kashaya' enhances the formulation's efficacy through documented effects on healing, showcasing the integration of specific plant species into holistic health practices.

34) Vranashodhana (Vranasodhana, Vrana-shodhana):
Vranashodhana translates to the cleansing and treatment of wounds in Ayurveda. Its emphasis in this study underscores the aim of 'Pentabark Kashaya' to not only promote healing but also to purify the wound area, integrating traditional knowledge with modern therapeutic evaluation for comprehensive wellness.

35) Pancavalkala (Panca-valkala, Pancan-valkala, Pamcavalkala):
Pañcavalkala is a traditional Ayurvedic formulation made from the barks of five sacred trees, recognized for its wound healing properties. Its significance in 'Pentabark Kashaya' showcases the incorporation of deeply rooted Ayurvedic traditions that utilize herbal combinations to create effective remedies for wound care and management.

36) Pomegranate:
Pomegranate is known for its rich antioxidant properties, contributing positively to wound healing. Its inclusion or reference in studies like that of 'Pentabark Kashaya' signifies the exploration of various naturally occurring compounds derived from fruits that promote healing mechanisms, reflecting the potential of botanical ingredients in formulations.

37) Krimighna (Krmighna, Krimi-ghna):
Krimighna refers to substances with antimicrobial properties used to combat infections. This term is relevant in assessing the components of 'Pentabark Kashaya,' highlighting its role in preventing infections during wound healing, a critical aspect that enhances the therapeutic value of the formulation.

38) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant and anti-inflammatory properties. Their mention within the context of 'Pentabark Kashaya' is essential as it highlights these bioactive compounds' contribution to promoting healing processes, reflecting a deeper understanding of the formulation's components in traditional medicine.

39) Sadananda (Sadanamda, Sada-ananda):
Sadananda is a Sanskrit term often related to individuals or texts contributing to Ayurvedic knowledge. Its mention in the study underscores the collaborative development of Ayurvedic formulations like 'Pentabark Kashaya,' enshrining a legacy of knowledge passed through generations, reflecting the cultural richness of this medical tradition.

40) Varanasi (Varanashi):
Varanasi, a city in India, is renowned for its rich heritage in Ayurveda and traditional medicine. Referring to Varanasi in the context of 'Pentabark Kashaya' highlights the geographical roots of Ayurvedic practices, emphasizing the city's historical significance in the evolution and preservation of such medicinal formulations.

41) Narayana (Nara-ayana, Nara-yana):
Narayana typically refers to a revered figure in Hindu philosophy, signifying health and protection. Within the context of the study, it may pertain to cultural references or personalities associated with Ayurvedic traditions, linking the knowledge of 'Pentabark Kashaya' to spiritual dimensions of healing and well-being.

42) Udumbara:
Udumbara, or Ficus racemosa, is valued in Ayurveda for its health-promoting qualities. Its mention in the study of 'Pentabark Kashaya' signifies the inclusion of potent herbal ingredients recognized for enhancing therapeutic effects, thus supporting the study's focus on natural healing formulations derived from specific plant species.

43) Darvyadi (Darvi-adi):
Darvyadi refers to a specific Ayurvedic preparation known for its medicinal properties. Its connection to 'Pentabark Kashaya' may underscore comparative effectiveness or shared methodologies in formulating traditional remedies, emphasizing the cumulative insights within Ayurvedic practices aimed at addressing various health concerns, including wound care.

44) Mahanta (Mahamta):
Mahanta, often used as a title of respect in Indian culture, may refer to notable practitioners or scholars in Ayurvedic medicine. Its relevance within the framework of this study highlights the contributors' shared wisdom evident in forms of knowledge and practices contributing to formulations like 'Pentabark Kashaya.'

45) Parisa (Parisha):
Parisha is another species of Ficus esteemed in Ayurvedic formulations. Its presence in 'Pentabark Kashaya' signifies the use of various medicinal plants to create synergistic effects for wound healing, representing the holistic approach characteristic of Ayurvedic traditions that integrate multiple components for therapeutic efficacy.

46) Plaksha (Plaksa):
Plaksha, or Ficus infectoria, is utilized in traditional medicine for its healing properties. The mention of Plaksha in the context of 'Pentabark Kashaya' emphasizes the formulation's complexity by highlighting the specific contributions of each herb, showcasing the knowledge of synergistic effects in herbal preparations for enhanced therapeutic outcomes.

47) Nagappa:
Nagappa may refer to individuals involved in Ayurvedic medicinal practices or research. Its inclusion in the context of 'Pentabark Kashaya' signifies the collaborative efforts and accumulated expertise from various practitioners, emphasizing the tradition of knowledge-sharing vital for effective therapeutic formulation development in Ayurveda.

48) Harisha (Harisa):
Harisha refers to knowledgeable individuals in Ayurveda traditionally respected for their insights into medicinal practices. Its mention in the study of 'Pentabark Kashaya' reinforces the cultural importance of collective wisdom among practitioners, reflecting the ensemble of expertise that enhances the formulation of traditional medicine.

49) Quality:
The term quality in medicine refers to the standard of efficacy and safety in therapeutic formulations. In the study of 'Pentabark Kashaya,' ensuring the quality of ingredients and preparation processes is fundamental for establishing the formulation’s reliability in promoting wound healing, crucial for medical acceptance and use.

50) Disease:
In the medical context, 'disease' signifies any dysfunction in normal bodily processes that require treatment. The study of 'Pentabark Kashaya' addresses wound healing, highlighting its role in treating conditions associated with damage to the skin, thus emphasizing the formulation's relevance in clinical therapeutic applications.

51) Pandita (Pandit):
Pandita is an honorific title denoting scholars or learned individuals in traditional Indian texts. Its reference may suggest the scholarly foundation upon which Ayurvedic knowledge, including the study of 'Pentabark Kashaya,' builds, emphasizing the cultural significance of wisdom in formulating effective medicinal treatments.

52) Ropana:
Ropana translates to healing in Ayurvedic context, particularly focusing on wound healing. The term is critical in this study as it defines the goal of 'Pentabark Kashaya' to promote effective healing processes in wounds, reinforcing the relevance of ancient terms within modern medicinal evaluations.

53) Mishra (Misra):
Mishra is a common surname in India often associated with learned individuals in various fields, including Ayurveda. In the context of the study, it may refer to contributors or researchers involved in the examination of formulations like 'Pentabark Kashaya,' illustrating the collaborative nature of Ayurvedic research and practice.

54) Sthana:
Sthana refers to the location or place in Ayurvedic literature and can denote specific chapters or locations within texts that elaborate on particular medical principles. This term's relevance within the study emphasizes the connection between traditional texts and the exploration of formulations like 'Pentabark Kashaya' for wound healing.

55) Cancer:
Cancer signifies a serious group of diseases characterized by uncontrolled cell growth. While the main focus is on wound healing in this particular study, the mention of cancer underscores the broader context of herbal formulations like 'Pentabark Kashaya' potentially having applications in oncology, emphasizing the comprehensive utility of Ayurvedic medicine.

56) Sharman (Sarma, Sharma, Sarman):
Sharma is a common Indian surname often linked to learned figures in Ayurveda. It signifies individuals who contribute significantly to the collective knowledge, as is the case with practices and studies examining formulations like 'Pentabark Kashaya,' tying into the tradition of scholarly pursuit in Ayurvedic practice.

57) Varti (Vartin):
Varti refers to specifically designed Ayurvedic preparations for localized treatment, often in the context of applications like ointments or suppositories. In this context, it highlights the formulation of 'Pentabark Kashaya,' indicating methods of administration that enhance localized therapeutic effects, equipping practitioners with diverse treatment options.

58) Sidhu (Shidhu):
Sidhu is a surname in India, commonly affiliated with individuals in the field of Ayurveda and medicine. Its reference within this context serves to acknowledge those involved in research and contributions to Ayurvedic formulations like 'Pentabark Kashaya,' fostering a tradition of shared learning and knowledge advancement.

59) Delhi:
Delhi, being the capital of India, has historical significance in the spread and evolution of Ayurveda. Its mention contextualizes the study within the broader landscape of traditional medicine, helping to highlight the importance of location in the development, research, and application of formulations like 'Pentabark Kashaya.'

60) Ficus benghalensis:
Ficus benghalensis, also known as Banyan tree, is an important species in Ayurvedic practices recognized for its healing properties. Its reference in the formulation 'Pentabark Kashaya' underscores the significance of traditional herbal components that contribute to the efficacy of the treatment and enrich the diversity of Ayurvedic remedies.

61) Sushruta-samhita (Susruta-samhita):
Sushruta-samhita is a foundational Ayurvedic text authored by Sushruta, focusing on surgery and healing techniques. Its inclusion signifies the deep-rooted historical and intellectual legacy informing modern formulations like 'Pentabark Kashaya,' reflecting the wisdom that continues to influence contemporary approaches to wound healing in Ayurveda.

62) Punica granatum:
Punica granatum, or pomegranate, is renowned for its antioxidants and therapeutic benefits. Its mention within the context of 'Pentabark Kashaya' highlights the integration of protective and enhancing properties offered by such fruit-derived compounds, reflecting Ayurvedic principles that employ nature’s bounty in formulated remedies for healing.

63) Calculation:
Calculation in scientific research denotes the process of quantifying data and results to derive meaningful analysis. In this context, it could refer to statistics of healing progression or therapeutic outcomes observed during the study of 'Pentabark Kashaya,' highlighting the rigor applied in evaluating the formulation’s effectiveness.

64) Surrounding:
Surrounding refers to the area around a wound, which can influence healing. In the context of 'Pentabark Kashaya,' understanding the surrounding environment is vital to ensure the formulation's efficacy. Factors like hygiene, wound care practices, and the application of the medicinal agent significantly impact recovery.

65) Measurement:
Measurement relates to quantifying parameters such as wound size, healing rate, and microbial load. In research involving 'Pentabark Kashaya,' accurate measurement is crucial for evaluating its impact on wound healing, establishing the formulation's effectiveness, and facilitating comparisons against control and standard treatments.

66) Observation:
Observation is a fundamental practice in scientific research where data are collected through noted behaviors and changes over time. This study closely incorporates systematic observations on the effects of 'Pentabark Kashaya' on wound healing, reinforcing the importance of empirical evidence in validating traditionally used formulations.

67) Discussion:
Discussion in a research context is where authors interpret results and provide context. In this study, the discussion surrounding 'Pentabark Kashaya' will highlight findings, compare with existing literature, and explore potential implications for practice, allowing for critical analysis that can drive future research directions.

68) Salivation:
Salivation refers to the secretion of saliva by salivary glands. While it may seem tangential, in studies assessing drug effects, it can be an indicator of well-being or toxicity. Addressing such physiological responses ensures a comprehensive examination of the safety profile of formulations like 'Pentabark Kashaya.'

69) Substance:
Substance denotes any chemical matter involved in medical formulations. In the context of 'Pentabark Kashaya,' understanding the various substances that comprise the formulation is vital for evaluating its therapeutic effectiveness and safety, emphasizing the significance of component interactions in promoting wound healing.

70) Container:
A container in a research context is any vessel used to hold or transport samples, drugs, or solutions. In the study of 'Pentabark Kashaya,' maintaining proper containment is crucial for preventing contamination and ensuring that the medicinal properties of the formulation remain intact through storage and application.

71) Cleansing:
Cleansing in the context of wound management refers to the practice of cleaning wounds to promote healing and prevent infection. 'Pentabark Kashaya' may function as a cleansing agent while also promoting healing, embodying the dual role of many Ayurvedic formulations that focus on safety and efficacy.

72) Kaviraja (Kavi-raja):
Kaviraja is a title in Ayurveda denoting a physician or expert. It refers to the knowledgeable individuals responsible for creating and validating formulations like 'Pentabark Kashaya.' This term highlights the cultural importance of learned practitioners in developing effective traditional remedies and promoting holistic health practices.

73) Lighting:
Lighting refers to illumination and may pertain to the environmental conditions under which the research and observations occur. Adequate lighting in research settings ensures accurate visibility for procedures and assessments, contributing to the meticulous recording of data while studying the effects of 'Pentabark Kashaya.'

74) Relative:
Relative may denote the relation or comparison between different groups or treatments in a study. In the context of 'Pentabark Kashaya,' examining relative effects against control and standard groups allows for robust conclusions regarding the formulation’s efficacy in wound healing.

75) Hygiene (Hygienic):
Hygienic practices are vital in medical and research settings to prevent contamination and infection. Maintaining hygienic conditions during the application of 'Pentabark Kashaya' is essential for ensuring the safety and efficacy of the formulation as it is tested on animal subjects.

[Note: The above list is limited to 75. Total glossary definitions available: 117]

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