Mercury and copper distribution post-Aarogyavardhini Vati in CCl4 rats.

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Tissue distribution of mercury and copper after Aarogyavardhini Vati treatment in rat model of CCl4 induced chronic hepatotoxicity
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Shrirang Jamadagni, Pallavi Jamadagni, Binita Angom, Dhirendranath Mondal, Sachchidanand Upadhyay, Sudesh Gaidhani, Jayram Hazra


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Tissue distribution of mercury and copper after Aarogyavardhini Vati treatment in rat model of CCl4 induced chronic hepatotoxicity

Year: 2020 | Doi: 10.1016/j.jaim.2019.09.005

Copyright (license): CC BY-NC-ND 4.0


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Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Mercury and copper distribution post-Aarogyavardhini Vati in CCl4 rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Vati:
Vati refers to a traditional Ayurvedic dosage form, typically a tablet or pill made from herbs and minerals. Used for therapeutic purposes, Vati is significant in promoting health and healing within Ayurveda. It illustrates the fusion of herbal and mineral resources aimed at treating specific ailments, particularly chronic conditions like liver diseases.

2) Table:
A table in the context of research presents data clearly and systematically. It organizes results from experiments, showing relationships between variables such as mineral content in 'Aarogyavardhini Vati'. Tables facilitate easier understanding of complex data and allow for straightforward comparisons and analyses vital in scientific studies.

3) Study (Studying):
The study refers to a research investigation aimed at understanding the effects and safety of 'Aarogyavardhini Vati'. It involves experimental procedures, data collection, and analysis, engaging scientific principles to evaluate how the formulation impacts chronic hepatotoxicity. Studies are fundamental in validating therapeutic claims in traditional medicine.

4) Animal:
In pharmacological research, animal models are often used to simulate human diseases. Animal studies allow researchers to observe the biological effects of herbal formulations like 'Aarogyavardhini Vati' in a controlled environment. This is crucial for understanding potential toxicity and efficacy before considering human applications.

5) Drug:
A drug in this context is a substance used to diagnose, treat, or prevent diseases. 'Aarogyavardhini Vati', an Ayurvedic formulation, combines specific medicinal plants and minerals aimed at healing liver ailments. Studying its effects and side effects is vital for assessing its therapeutic potential.

6) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. In studying 'Aarogyavardhini Vati,' toxicity levels of its mercury and copper constituents are scrutinized to ensure safety for prolonged use in humans, especially in treating chronic conditions, addressing safety concerns from traditional herbal medicine usage.

7) India:
India is the birthplace of Ayurveda, a holistic approach to health that utilizes herbal formulations like 'Aarogyavardhini Vati' for therapeutic purposes. The cultural and historical context of India emphasizes the significance of traditional medicine, thus necessitating thorough scientific studies to validate and ensure the safety of such practices.

8) Medicine:
Medicine refers to the science and practice of diagnosing and treating diseases. Ayurvedic medicine, specifically, encompasses a system using various natural ingredients for healing. 'Aarogyavardhini Vati' falls under this category, making it essential to study its biochemical and toxicological effects in research to ensure safe medicinal use.

9) Accumulation (Accumulating, Accumulate):
Accumulate refers to the gathering and buildup of substances in tissues over time, particularly regarding total elemental content in 'Aarogyavardhini Vati' in relation to its mercury and copper components. Understanding accumulation mechanisms is key in evaluating potential toxicity and safety in therapeutic contexts.

10) Bhasma (Bhasman):
Bhasma refers to a calcinated form of metals or minerals in Ayurveda, believed to enhance therapeutic efficacy while minimizing toxicity. Bhasma preparation techniques play a pivotal role in the formulation of 'Aarogyavardhini Vati,' emphasizing safety in using traditionally toxic metals like mercury within Ayurvedic treatments.

11) Powder:
Powder refers to a fine substance formed by crushing or grinding materials into small particles. In Ayurvedic formulations like 'Aarogyavardhini Vati', powders from specific herbs and minerals are essential for effective dosage forms. Their preparation affects the bioavailability and therapeutic action of the medicine.

12) Disease:
Disease represents a pathological condition affecting the body, which is often treated using medicinal formulations. 'Aarogyavardhini Vati' is particularly indicated for chronic liver diseases, showcasing Ayurveda's role in addressing health challenges. Understanding disease context is critical in evaluating treatment efficacy and safety.

13) Water:
Water serves as a solvent and critical component in many Ayurvedic preparations. It is involved in the extraction and administration of herbal components in treatments like 'Phalatrikadi kvatha'. The quality and purity of water can impact the overall efficacy of herbal medicines significantly.

14) Mineral:
Minerals in Ayurveda, such as mercury and copper, are integral to formulations like 'Aarogyavardhini Vati'. They enhance therapeutic potential but raise safety concerns regarding toxicity. Understanding the role of minerals is crucial for evaluating the safety and efficacy of herbomineral medicines in traditional practices.

15) Indian:
Indian refers to the cultural and geographical origin of Ayurvedic practices. This term highlights the traditional practices, herbs, and formulations unique to India, such as 'Aarogyavardhini Vati'. This context is vital for understanding the historical development of herbal medicine and its significance in modern research.

16) Kajjali:
Kajjali is a specific Ayurvedic preparation combining mercury and sulfur into a black powder form, emphasized in medicinal formulations like 'Aarogyavardhini Vati'. It is believed to enhance therapeutic properties while minimizing toxicity risks. The process of making kajjali is crucial in ensuring its safe use.

17) Tamra:
Tamra refers to copper in Ayurvedic texts, often used in the preparation of formulations like 'Aarogyavardhini Vati' for its healing properties. Understanding its role and potential toxicity is critical for evaluating the safety of herbal medicines, particularly in treatments involving heavy metals.

18) Kumar:
Kumar is mentioned as an author in the research studies associated with 'Aarogyavardhini Vati'. The inclusion of specific researchers highlights the credibility and scholarly efforts behind the evaluation of Ayurvedic formulations, ensuring scientific rigor in assessing their safety and efficacy.

19) Tamrabhasma (Tamra-bhasma):
Tamra-bhasma is a specific Ayurvedic preparation of calcined copper, used in 'Aarogyavardhini Vati' to provide therapeutic benefits. It highlights how Ayurveda processes minerals to enhance safety and efficacy, underlining the importance of rigorous preparation methods that minimize potential toxicity.

20) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating in India, emphasizing balance and holistic healing. It uses a variety of natural substances including 'Aarogyavardhini Vati' for treating illnesses. The study of its formulations integrates traditional knowledge with modern scientific research, proving essential in addressing health challenges.

21) Delhi:
Delhi represents the urban context where significant Ayurvedic research and practice occur. The city is home to various institutions and regulatory bodies overseeing herbal medicine safety and efficacy, highlighted in the study of 'Aarogyavardhini Vati', underscoring the blend of traditional and contemporary medical practices.

22) Blood:
Blood analysis is critical in evaluating the biochemical effects of formulations like 'Aarogyavardhini Vati'. Assessing changes in blood chemistry helps determine the health implications of administered drugs, particularly regarding liver function. Such evaluations are essential in ensuring safety in pharmacological studies related to Ayurveda.

23) Observation:
Observation refers to monitoring and recording data in scientific studies. In the context of 'Aarogyavardhini Vati', observations of clinical signs and biochemical parameters are essential for understanding dosage effects and evaluating the safety and efficacy of treatments in animal models.

24) Shuddha (Suddha):
Shuddha translates to 'pure' in Ayurveda, referring to the purification processes applied to ingredients. It emphasizes that formulations like 'Aarogyavardhini Vati' are made from purified ingredients to enhance safety and potency, reflecting Ayurvedic principles aimed at minimizing toxicity.

25) Line:
In a scientific context, 'line' might refer to data presentation or a specific methodology. In research involving formulations like 'Aarogyavardhini Vati', maintaining clarity throughout every line of methodology is vital for reproducibility and understanding of findings, ensuring scientific rigor.

26) Science (Scientific):
Scientific refers to research that utilizes systematic methodologies to investigate questions about efficacy and safety. In studying 'Aarogyavardhini Vati', scientific approaches validate traditional knowledge, ensuring that long-established practices are rigorously tested for their health benefits and potential risks.

27) Rules:
Rules in scientific research refer to established guidelines and protocols that must be followed during experimentation. They ensure integrity and reproducibility of studies focusing on herbal formulations like 'Aarogyavardhini Vati', which are vital for validating efficacy and safety claims.

28) Post:
Post refers to activities or evaluations taking place after a specific intervention. In the study of 'Aarogyavardhini Vati', post-treatment analyses help assess physiological effects and the safety profile of treatments, critical in verifying the formulation's protective or hazardous impacts on health.

29) Male:
Male refers to the gender of the rats used in the study involving 'Aarogyavardhini Vati'. Gender-specific responses to treatments can vary in physiological and biochemical contexts, indicating the necessity for understanding and documenting the differences in reaction to herbal formulations across genders.

30) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Srivastava indicates the involvement of a researcher or author connected with studies, contributing to investigations surrounding 'Aarogyavardhini Vati'. Acknowledging individual contributions in research helps ensure accountability and recognizes collaborative efforts that drive scientific inquiries in traditional medicine.

31) Sharman (Sarma, Sharma, Sarman):
Sharma is another author listed in the research pertaining to 'Aarogyavardhini Vati', indicative of the collaborative nature within scientific research. Recognizing individual researchers enhances the transparency of collective efforts aimed at understanding and validating Ayurvedic medicinal applications.

32) Gupta:
Gupta is mentioned as part of the research team investigating 'Aarogyavardhini Vati'. This naming highlights the importance of scientific contributors in establishing foundational research that assesses the safety and effectiveness of Ayurvedic formulations within modern pharmacological contexts.

33) Rasa (Rasha):
Rasa translates to 'essence' or 'taste' in Ayurveda and often refers to formulations like 'Aarogyavardhini Vati' that incorporate mineral content. Understanding 'Rasa Yoga' reflects how elemental properties are perceived to enhance therapeutic properties, linking traditional practices to the scientific exploration of herbal medicines.

34) Milk:
Milk, particularly cow milk, plays a role in the preparation and purification of some Ayurvedic formulations. It highlights the importance of specific traditional practices in refining substances used in 'Aarogyavardhini Vati', ensuring components are adequately processed for safety and effectiveness.

35) Shilajit (Silajit, Shila-jit):
Shilajit is a mineral-rich composition utilized in Ayurvedic medicine, often included in formulations like 'Aarogyavardhini Vati'. Its inclusion serves both therapeutic purposes and addresses concerns regarding mineral toxicity, emphasizing the need for careful consideration in the preparation and application of herbal medicines.

36) Activity:
Activity refers to the effects or actions of a drug or treatment, particularly in scientific research. In studies involving 'Aarogyavardhini Vati', evaluating its activity against various health markers determines its efficacy and potential as a therapeutic agent in managing liver disorders.

37) Sign:
In research, 'sign' often pertains to observable effects of treatment. In the context of 'Aarogyavardhini Vati', signs observed in experimentations help indicate biological outcomes, particularly concerning serum biochemical parameters that determine the safety and effectiveness of Ayurvedic drugs.

38) Emblica officinalis:
Emblica officinalis, commonly known as Amla, is a vital ingredient in Ayurvedic formulations. This herb contributes to the health benefits of ‘Aarogyavardhini Vati’, especially in enhancing liver health, emphasizing the interdependence of traditional herbal remedies with pharmacological science in therapeutic contexts.

39) Azadirachta indica:
Azadirachta indica, also known as Neem, is significant in Ayurvedic formulations for its therapeutic properties. In 'Aarogyavardhini Vati', Neem’s inclusion reflects traditional understandings of herb efficacy in treating ailments, reinforcing the need to validate such claims through scientific evidence.

40) Terminalia chebula:
Terminalia chebula, recognized as Haritaki, is another crucial herb in 'Aarogyavardhini Vati'. Its properties are noted for supporting digestive health and detoxification, emphasizing the importance of traditional herbal knowledge in modern research aiming to authenticate and study the therapeutic application of plant-based treatments.

41) Commiphora wightii:
Commiphora wightii, or Guggul, is frequently utilized in Ayurvedic formulations like 'Aarogyavardhini Vati' for its anti-inflammatory and lipid-lowering properties. Its role underlines the significance of understanding each ingredient’s therapeutic potential within the broader context of herbal medicine and holistic health.

42) Terminalia bellirica:
Terminalia bellirica is an important Ayurvedic herb, contributing to the formulation of 'Aarogyavardhini Vati'. Known for its potential health benefits, its presence enhances the holistic efficacy of traditional medicines, which are increasingly validated through scientific exploration of their active compounds.

43) Ricinus communis:
Ricinus communis, or Castor oil plant, is utilized in Ayurvedic practices for its therapeutic uses, which include anti-inflammatory and laxative effects. In studying 'Aarogyavardhini Vati', its inclusion represents the integration of various plant components to achieve holistic healing outcomes.

44) Abhrakabhasma (Abhraka-bhasma):
Abhraka-bhasma, or calcined Mica, is used in Ayurveda for its believed health benefits. Its incorporation in 'Aarogyavardhini Vati' exemplifies how traditional Indian medicine utilizes specific mineral preparations to potentially enhance efficacy while addressing toxicity concerns of minerals like mercury.

45) Amritikarana (Amrtikarana, Amriti-karana):
Amritikarana refers to a unique Ayurvedic processing technique for purification and preparation of metals and minerals, enhancing their safety and efficacy. This concept is critical in formulating 'Aarogyavardhini Vati', ensuring that the products align with Ayurvedic principles while minimizing toxicity risks.

46) Phalatrikadi (Phalatrika-adi):
Phalatrikadi is an Ayurvedic formulation that also addresses liver ailments. Its mention alongside 'Aarogyavardhini Vati' signifies the interconnectedness of different traditional medicines, promoting a comprehensive approach toward healing and the validation of their combined therapeutic potentials.

47) Toxicology:
Toxicology involves the study of adverse effects of substances on living organisms. It is crucial in assessing the safety profile of 'Aarogyavardhini Vati', particularly regarding the mineral content to ensure the formulation does not pose toxicity risks to users.

48) Rasayoga (Rasa-yoga):
Rasa-yoga defines a category in Ayurveda where medicinal preparations contain minerals. It signifies the philosophical and practical basis for formulating traditional medicines like 'Aarogyavardhini Vati', underpinning the systematic approach to combining herbs and minerals for therapeutic use.

49) Pesticide:
Pesticide analysis ensures that herbal formulations like 'Aarogyavardhini Vati' are free from harmful residues that could pose health risks. Assessing pesticide levels is crucial to maintaining safety standards and the therapeutic integrity of Ayurvedic medicines in clinical applications.

50) Teaching:
Teaching refers to the dissemination of knowledge related to Ayurvedic principles and practices. It is essential for educating practitioners and researchers about formulations like 'Aarogyavardhini Vati', ensuring that they understand both traditional uses and scientific validations for effective patient care.

51) Guggulu:
Guggulu, derived from the plant Commiphora wightii, is known for its medicinal benefits in Ayurveda, particularly in managing obesity and liver health. Its role in 'Aarogyavardhini Vati' highlights how traditional ingredients are carefully selected for their healing properties within Ayurvedic formulations.

52) Abhraka:
Abhraka signifies the use of calcined Mica in Ayurvedic medicine, contributing to the formulation of 'Aarogyavardhini Vati'. Understanding its application showcases the holistic ideology in Ayurveda, where minerals are traditionally seen as integral to enhancing therapeutic efficacy without causing harm.

53) Quality:
Quality assessment in research is essential for ensuring that formulations like 'Aarogyavardhini Vati' meet pharmacological standards. This encompasses evaluating the purity, potency, and safety of the ingredients, contributing to the overall credibility of Ayurvedic practices in modern healthcare.

54) Kalita:
Kalita is mentioned as a contributor in research related to 'Aarogyavardhini Vati.' Recognizing authors adds legitimacy to the studies, where collaborative efforts expand the understanding of Ayurvedic formulations, reflecting on the continual integration of traditional knowledge with scientific inquiry.

55) Vaidya:
Vaidya refers to a practitioner or physician of Ayurveda. Their expertise is essential for the application and administration of formulations like 'Aarogyavardhini Vati', bridging traditional knowledge with modern healthcare practices, thus ensuring that patients receive informed and effective treatments.

56) Kvatha:
Kvatha, or decoction, is a traditional preparation method in Ayurveda that extracts the medicinal properties of herbs. The computation of kvatha indicates its use in formulations like 'Aarogyavardhini Vati', which emphasize holistic therapeutic approaches through optimal extraction methods in Ayurvedic formulations.

57) Rashmi (Rasmi):
Rashmi is often mentioned as a collaborator or researcher involved in the study of 'Aarogyavardhini Vati.' Acknowledging individual contributions is important in scientific contexts as it maintains accountability and transparency within research, particularly when exploring traditional herbal medicine.

58) Arogya:
Arogya means health in Sanskrit, representing the core philosophy of Ayurveda which aims for holistic well-being. 'Aarogyavardhini Vati' directly connects to this concept, emphasizing preventive and therapeutic measures to enhance health, thereby supporting the efficacy of traditional Ayurvedic practices.

59) Rajput:
Rajput is another researcher associated with the study of 'Aarogyavardhini Vati,' representing the collaborative nature of scientific inquiries. Recognizing individual contributions fosters the credibility and integrity of the research process within the context of traditional herbal medicine.

60) Aureus:
Aureus refers to Staphylococcus aureus and is significant in microbiological evaluations of 'Aarogyavardhini Vati.' Understanding the presence of such pathogens helps ensure the safety and purity of herbal products, reinforcing the importance of rigorous testing to eliminate potential health hazards.

61) Garlic:
Garlic, or Allium sativum, is utilized in Ayurvedic medicine for its therapy-enhancing properties. Its inclusion in preparation methods emphasizes the holistic approach of Ayurveda, leveraging various natural ingredients for their synergetic effects alongside traditional formulations like 'Aarogyavardhini Vati.'

62) Panda (Pamda):
Panda indicates a researcher contributing to studies related to 'Aarogyavardhini Vati.' Acknowledging individuals involved in research strengthens the scientific credibility of the studies, providing a connection between traditional practices and contemporary scientific scrutiny.

63) Lauha:
Lauha refers to iron in Ayurvedic terminology, recognized for its medicinal properties. Its incorporation in 'Aarogyavardhini Vati' illustrates how Ayurvedic formulations use specific minerals for therapeutic benefits, reinforcing the importance of mineral supplementation in health and healing practices.

64) Mishra (Misra):
Misra is mentioned as part of a research team studying 'Aarogyavardhini Vati.' Recognizing the contributions of various scholars in Ayurvedic studies allows for a deeper understanding of the collective efforts made in evaluating and validating the effectiveness of traditional medicine.

65) Patil:
Patil denotes a researcher involved in the investigation of 'Aarogyavardhini Vati.' Mentioning collaborative efforts in studies showcases the integration of diverse expertise necessary to uphold the scientific integrity of research surrounding Ayurvedic formulations.

66) Nimba:
Nimba, or Neem, is widely recognized for its medicinal benefits in Ayurveda and is often included in formulations to enhance therapeutic effects. Its presence in 'Aarogyavardhini Vati' emphasizes the role of traditional herbs in promoting health and addressing chronic ailments.

67) Kadam:
Kadam represents a researcher involved in the scientific study of 'Aarogyavardhini Vati.' Recognizing contributions from various individuals is vital for collaborative research efforts, highlighting the intersection of traditional knowledge and modern scientific practices in evaluating herbal medicines.

68) Chang:
Chang is noted in the context of research studies, contributing to the investigation of formulations like 'Aarogyavardhini Vati.' Academic contributions reflect the importance of interdisciplinary collaboration in verifying the efficacy and safety of Ayurvedic medicines.

69) Camel:
Camel milk is sometimes referenced in traditional practices for its health benefits, potentially including its role in Ayurveda. Its mention illustrates the broader application of various natural resources within the realm of medicinal preparations alongside traditional formulations like 'Aarogyavardhini Vati.'

70) Doshin (Dosin, Dosi, Doshi):
Doshi is an individual mentioned in the research associated with 'Aarogyavardhini Vati.' Recognizing individual contributions shows the collaborative nature required in scientific inquiry, particularly when addressing complex subjects like the safety and efficacy of traditional herbal medicines.

71) Giri:
Giri is another researcher tied to the 'Aarogyavardhini Vati' study, illustrating the collaborative teamwork necessary in scientific investigations. Each contributor plays a critical role in ensuring comprehensive research output that upholds the integrity and understanding of traditional medicine applications.

72) Yoga:
Yoga is a fundamental concept in Ayurveda, referring to the integration and balance of body and mind in health practices. The term represents the holistic philosophy behind formulations like 'Aarogyavardhini Vati', aimed at achieving overall wellness through traditional healing systems.

73) Mica:
Mica is referenced as a mineral used in Ayurvedic treatments, particularly in 'Aarogyavardhini Vati' as Abhraka-bhasma. Understanding the role of various minerals expands knowledge of their therapeutic benefits while assessing their potential risks within Ayurvedic formulations.

74) Food:
Food references the nutritional aspects necessary for maintaining health. In investigations of 'Aarogyavardhini Vati', the relationship between nutrition and herbal treatments highlights the comprehensive nature of Ayurveda, where diet is integrated with medicinal practices to enhance overall well-being.

75) Burning (Burn, Burned, Burnt):
Burn in this context refers to the application or preparation methods concerning Ayurvedic medicines. Proper handling during the calcination of metals like Lauha in 'Aarogyavardhini Vati' is essential for ensuring safety and achieving desired therapeutic effects.

[Note: The above list is limited to 75. Total glossary definitions available: 115]

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