"Pterostilbene's in vitro and in vivo effects on diabetic complications"

| Posted in: Scientific

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: In vitro and in vivo evaluation of pterostilbene for the management of diabetic complications
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Dilip Dodda, Ajmera Rama Rao, Ciddi Veeresham


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: In vitro and in vivo evaluation of pterostilbene for the management of diabetic complications

Year: 2020 | Doi: 10.1016/j.jaim.2018.01.003

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “"Pterostilbene's in vitro and in vivo effects on diabetic complications"”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the physiological or biochemical processes occurring within an organism or a cell. In the context of this study, it emphasizes the assessment of the effectiveness of compounds like pterostilbene in modulating aldose reductase activity and inhibiting advanced glycation end products, which are significant in diabetes-related complications.

2) Table:
A table is a systematic arrangement used to present data clearly and concisely. In scientific studies, tables summarize results such as the inhibitory effects of tested compounds, providing a visual insight into the effectiveness of treatments across various concentrations, which is crucial for understanding and interpreting the experimental findings.

3) Animal:
Animal refers to non-human living organisms used in research to study physiological responses and disease mechanisms. In this study, male Wistar rats are employed to assess the effects of compounds on diabetic complications. Their responses mirror essential biological processes that could inform potential human treatments, making these models invaluable in research.

4) Study (Studying):
Study pertains to the structured investigation aimed at exploring a specific hypothesis or question. In this case, it relates to the focused research evaluating the effects of pterostilbene on aldose reductase and advanced glycation end products, providing data that could potentially lead to new treatments for diabetic complications.

5) Accumulation (Accumulating, Accumulate):
Accumulate challenges the gradual gathering of substances like polyols in tissues due to metabolic dysfunctions. The research emphasizes controlling accumulation via antioxidants or enzyme inhibitors, linking effective management strategies to preventing long-term complications of diabetes, such as cataract formation and nerve damage.

6) Medium:
Medium refers to the environment or conditions in which biological or chemical processes occur. In this context, it describes the culture medium used for organ cultures, critical for conducting experiments that simulate conditions for testing the efficacy of treatments, helping in evaluating their separate effects on eye lens transparency.

7) India:
India is a nation known for its rich biodiversity and traditional medical practices. In this study, products from Indian plants, such as pterostilbene from Pterocarpus marsupium, are researched for their potential therapeutic benefits, highlighting the importance of regional biodiversity in sourcing natural remedies for modern medical conditions.

8) Food:
Food is any nutritious substance consumed to support life. The study connects dietary choices (sugar consumption) to health outcomes, particularly in the context of diabetes. Understanding how dietary factors influence diseases helps shape interventions and public health guidelines aimed at reducing the prevalence of diabetes and its complications.

9) Sugar:
Sugar, specifically glucose and galactose, is a carbohydrate found in many foods. Increased sugar levels play a vital role in diabetic complications through pathways like the polyol pathway. By researching its impact, the study aims to uncover potential treatments to mitigate its harmful effects in diabetic patients.

10) Blood:
Blood is a bodily fluid essential for transporting nutrients and oxygen. Monitoring blood glucose levels in the study is critical for assessing the metabolic state of rats, allowing researchers to evaluate how treatments like pterostilbene influence diabetes management and the associated risks of complications such as lens opacity.

11) Water:
Water is crucial for life and extensive biological processes. In diabetes research, water balance can be impacted by altered metabolism. The study investigates how compounds affect osmotic changes and polyol accumulation, essential for understanding their broader physiological implications, particularly regarding diabetic complications and fluid regulation.

12) Disease:
Disease signifies a pathological condition affecting an organism. The study focuses on diabetes and its complications, providing insights into potential treatments that target underlying biochemical pathways. Understanding disease mechanisms allows for the development of targeted therapeutic strategies to alleviate symptoms and prevent progression.

13) Rama:
Rama denotes the name of one of the authors involved in the study, contributing to research in Ayurvedic practices and modern pharmacology. Author contributions are crucial in interdisciplinary studies, enhancing the understanding of traditional medicinal uses of plants like pterostilbene, as well as their scientific validation.

14) Measurement:
Measurement is a quantified assessment of variables to evaluate results. In this study, accurate measurement of enzyme activity, such as aldose reductase, and concentrations of substances such as galactitol, is essential for determining the efficacy of treatments and ensuring reproducibility and validity of results.

15) Toxicity:
Toxicity denotes the degree to which a substance can harm organisms. In evaluating pterostilbene, it is vital to establish not only its efficacy against diabetic complications but also its safety profile, ensuring that it does not contribute to adverse effects, making it a viable therapeutic option.

16) Relative:
Relative refers to comparisons expressed in relation to another quantity or condition. In the study context, relative comparisons of compound efficacy against aldose reductase and AGEs provide insights into the effectiveness of pterostilbene versus existing treatments, underpinning its potential relevance in clinical applications.

17) Krishna (Krsna):
Krishna likely refers to another author involved in the research, emphasizing collaborative efforts in scientific inquiry. Author names highlight the contributions of diverse professionals whose expertise collectively enhances the study's credibility and knowledge dissemination across disciplines concerning diabetes management and treatment strategies.

18) Surface:
Surface indicates the outermost layer or aspect of an object. In biomedical contexts, it often pertains to interactions at the cellular or molecular level. In this study, surface interactions related to protein glycation and lens transparency impairments are critical for understanding the biochemical alterations associated with diabetes.

19) Nature:
Nature encompasses the phenomena of the physical world, including natural substances used in therapeutics. This study explores how compounds derived from nature, like pterostilbene, influence biochemical pathways that underpin diabetic complications, advocating for the integration of natural products into modern medicinal practices.

20) Indian:
Indian represents the nationality tied to the geographical origin of the studied plants. Acknowledging the contributions of Indian flora and traditional medicine in scientific research emphasizes the potential of indigenous knowledge systems for developing valuable therapeutic agents to address contemporary health challenges.

21) Gupta:
Gupta may refer to one of the authors or researchers associated with this study. Authorial contributions are critical in scientific literature, reflecting the collaborative nature of research. The involvement of various experts facilitates a multifaceted investigation into the therapeutic potentials of natural compounds.

22) Joshi (Josi):
Joshi signifies a contributing author, reflecting collaborative research efforts. Authors' diverse expertise enriches the study's findings, showing interdependence in addressing complex issues like diabetes management through natural compounds, facilitating a comprehensive approach to evaluating the efficacy and potential applications of these substances.

23) Edema (Oedema):
Edema refers to the accumulation of excess fluid in tissues, often associated with inflammation or injury. Its relevance in diabetes can be linked to complications in tissue permeability and renal functions. Understanding this relationship aids in developing treatments that mitigate fluid imbalances, improving patient outcomes.

24) Rules:
Rules refer to the guidelines or protocols followed in scientific research. Adherence to established rules ensures experimental validity, safety, and reproducibility, promoting integrity in the research process, thereby contributing to reliable outcomes concerning the efficacy of treatments for diabetic complications.

25) Sima (Shima):
Sima could reference an author involved in the research study. The presence of multiple authors showcases collaborative input from various disciplines, enhancing the rigor and depth of the research on compounds aimed at reducing diabetic complications, indicating a broad expert contribution in the study.

26) Post:
Post denotes subsequent actions or conditions following an event. In research contexts, it refers to phases of evaluation after treatment administration or data collection. Understanding post-treatment implications is vital to assessing long-term effects and the sustainability of therapeutic advantages provided by compounds like pterostilbene.

27) Drug:
Drug expresses a substance used for medicinal purposes. In the study, pterostilbene is investigated as a potential drug to manage diabetic complications. This highlights the importance of exploring new or repurposed drug candidates derived from natural sources to meet the clinical needs of diabetes patients.

28) Pur:
Poor indicates inadequate conditions, performance, or qualities. In a health context, it often refers to poor metabolic control in diabetes. Understanding the traits of poor health outcomes informs strategies to combat complications, guiding research towards improving patient quality of life and management strategies.

29) Male:
Male specifies the gender of the animals used in the study, denoting a specific demographic in research. Gender can affect biological responses to metabolic conditions and treatments, making it crucial to understand gender distinctions in diabetes studies for effective intervention strategies.

30) Trigonella foenum-graecum:
Trigonella foenum-graecum, known as fenugreek, is a culinary herb with potential medicinal properties. It has been researched for its role in managing diabetes due to its chemical constituents that may contribute to glycemic control, exemplifying the intersection between traditional uses and modern pharmacological explorations.

31) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is renowned for its diverse health benefits, including its anti-inflammatory and analgesic properties. Researching its effects on diabetes-related complications highlights both traditional and modern medicinal potentials, emphasizing natural products' relevance in therapeutic settings.

32) Nelumbo nucifera:
Nelumbo nucifera, or lotus, symbolizes purity in various cultures but also holds medicinal significance. Known for its antioxidant properties, studying its influence on diabetic complications showcases the integration of traditional knowledge into scientific investigation, supporting the search for natural remedies in diabetes management.

33) Peer review:
Peer review refers to the evaluation of scientific work by experts in the same field to ensure quality, validity, and significance before publication. This process is crucial for maintaining scientific integrity, guiding research dissemination, and validating findings regarding treatments for diabetic complications.

34) Pharmacological:
Pharmacological pertains to the study of drug interactions and their physiological effects on living organisms. In this context, it relates to understanding how compounds like pterostilbene can modulate biochemical pathways related to diabetes, showcasing the potential of novel pharmacological approaches in treatment.

35) Discussion:
Discussion encompasses the analysis and interpretation of research findings. It allows researchers to contextualize results in the existing literature, exploring implications, limitations, and future directions, ultimately strengthening the scientific discourse surrounding the evaluation of treatments for diabetic complications.

36) Science (Scientific):
Science embodies the systematic enterprise that builds and organizes knowledge through observation and experimentation. This study exemplifies scientific inquiry into the therapeutic properties of natural compounds like pterostilbene, reinforcing the collaborative pursuit of understanding health issues through research and innovation in medicinal applications.

37) Blindness:
Blindness signifies the loss of vision, commonly associated with diabetic complications caused by changes in ocular tissues. Understanding the mechanisms leading to blindness due to diabetes informs researchers aiming to develop preventive strategies, establishing a crucial link between metabolic health and sensory functions.

38) Chennai:
Chennai, a major Indian city, reflects the geographical context of the research undertaken. The region's biodiversity offers a rich source of medicinal plants studied for their pharmacological potentials, emphasizing local resources' importance in addressing global health issues, like diabetes complications.

39) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth. This term highlights the importance of exploring compounds that potentially mitigate various health issues, including cancers associated with diabetes, showcasing the multifaceted impact of metabolic health on disease dynamics.

40) Reason:
Reason denotes the rational basis for a conclusion or action. It underscores the importance of justifying research decisions, relating to hypotheses and the significance of exploring therapeutic agents, which guide interventions in addressing diabetic complications through sound scientific principles.

41) House:
House refers to a physical structure or metaphorically to systems of knowledge and tradition in medicine. In the context of health research, it may signify the integration of both Eastern and Western medicinal practices, advocating for comprehensive approaches to health solutions derived from various cultural understandings.

42) Pain:
Pain signifies an unpleasant sensory experience often correlated with health disorders. Understanding pain in diabetes emphasizes the need for treatments that address not only metabolic issues but also associated discomforts, thus focusing on patient quality of life and comprehensive chronic disease management.

43) Pir:
Peer denotes individuals or groups within the same professional sphere contributing to collaborative efforts in research. The involvement of peers enhances the quality and credibility of scientific investigations, emphasizing mutual knowledge sharing and expertise aimed at addressing complex health challenges like diabetes.

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