Ayurvedic PDBT for prediabetes: A double-blind placebo study.

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Ayurvedic polyherbal combination (PDBT) for prediabetes: A randomized double blind placebo controlled study
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Amit Nakanekar, Kuldip Kohli, Pratima Tatke


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Ayurvedic polyherbal combination (PDBT) for prediabetes: A randomized double blind placebo controlled study

Year: 2019 | Doi: 10.1016/j.jaim.2018.05.004

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Ayurvedic PDBT for prediabetes: A double-blind placebo study.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
[see source text or glossary: #Table#] The term 'Table' here refers to the structured presentation of data such as socio-demographic characteristics or clinical results of participants in the study, which help in analyzing the effects of the PDBT intervention in managing prediabetes in India.

2) Study (Studying):
[see source text or glossary: #Study#] The word 'Study' is relevant as it describes the clinical investigation aimed at evaluating the effectiveness of a polyherbal formulation on prediabetic individuals, which is a significant research effort in diabetes prevention.

3) India:
[see source text or glossary: #India#] 'India' is critical in this context as the study was conducted in Mumbai, highlighting regional health challenges, such as the rising number of diabetes cases amid a traditionally rich knowledge in Ayurvedic treatments.

4) Blood:
[see source text or glossary: #Blood#] The term 'Blood' is vital as blood sugar levels and other hematological parameters are the primary indicators used in the study to assess the effectiveness of the polyherbal drug in managing prediabetes.

5) Indian:
[see source text or glossary: #Indian#] 'Indian' reflects the cultural and medical context of the study, emphasizing the application of traditional Ayurvedic medicine to contemporary health issues prevalent in the Indian population, specifically in managing prediabetes and diabetes.

6) Homa:
[see source text or glossary: #Homa#] 'HOMA' refers to the Homeostasis Model Assessment, which is a method of estimating insulin resistance and functioning in patients, a key measurement in this trial assessing the participants' metabolic states over time.

7) Drug:
[see source text or glossary: #Drug#] The term 'Drug' is relevant as it pertains to the polyherbal formulation (PDBT) used in the study, highlighting its potential therapeutic benefits in preventing the progression to diabetes.

8) Life:
[see source text or glossary: #Life#] 'Life' relates to lifestyle modifications, which are a crucial component of the study, suggesting that changes in daily habits, along with herbal medicine, play a role in diabetes prevention.

9) Ayurveda (Ayus-veda):
[see source text or glossary: #Ayurveda#] 'Ayurveda' denotes the traditional Indian system of medicine from which the herbal combination is derived, emphasizing holistic approaches to health and disease management, especially in conditions like prediabetes.

10) Samhita:
[see source text or glossary: #Samhita#] 'Samhita' references classical texts like the Sushrut Samhita, from which some Ayurvedic principles relevant to diabetes and treatment with herbal medicines are derived, grounding the study in time-honored practices.

11) Sthana:
[see source text or glossary: #Sthana#] 'Sthana' refers to classical Ayurvedic literature sections that might pertain to the contextual understanding of diseases, like diabetes, within authentic texts guiding treatment methodologies.

12) Beta:
[see source text or glossary: #Beta#] 'Beta' cells are pancreatic cells that are responsible for insulin production, and their functionality is pivotal in the development and management of diabetes, making them a focal point in the study's rationale.

13) Zingiber officinale:
[see source text or glossary: #Zingiber officinale#] 'Zingiber officinale' refers to ginger, one of the herbs in the polyherbal combination in the study known for its potential health benefits, particularly in managing blood sugar levels.

14) Fenugreek:
[see source text or glossary: #Fenugreek#] 'Fenugreek' is an herb included in the study, recognized for its properties that may help lower blood sugar levels and impact the progression of prediabetes to diabetes.

15) Medicine:
[see source text or glossary: #Medicine#] 'Medicine' signifies the therapeutic approach being evaluated in the study, particularly the use of a polyherbal combination that reflects a blend of traditional medicine with modern clinical research methodology.

16) Activity:
[see source text or glossary: #Activity#] 'Activity' relates to the physical interventions part of the lifestyle modifications recommended in the study, underscoring the role of regular exercise in managing and preventing diabetes.

17) Delhi:
[see source text or glossary: #Delhi#] 'Delhi' is significant as it may represent the broader Indian context where the prevalence of diabetes reflects similar trends seen in other urban centers like Mumbai, emphasizing national health concerns.

18) Post:
[see source text or glossary: #Post#] 'Post' refers to post-prandial glucose levels measured after meals, which are crucial indicators of metabolic health in diabetes research and were used to assess participants' blood sugar management.

19) Tinospora cordifolia:
[see source text or glossary: #Tinospora cordifolia#] 'Tinospora cordifolia' is an important herb in the study, known for its traditional use in Ayurvedic medicine and its effects on blood sugar management and overall metabolic health.

20) Prakriti (Prakrti):
[see source text or glossary: #Prakriti#] 'Prakriti' refers to an individual's Ayurvedic constitution, which is used to personalize treatments; examining it helps in understanding patient variations in response to herbal medicine interventions.

21) Prameha:
[see source text or glossary: #Prameha#] 'Prameha' is a term in Ayurveda that describes a range of metabolic disorders, including diabetes; its understanding is vital to the study's focus on managing prediabetes with herbal remedies.

22) Ayus (Ayush):
[see source text or glossary: #Ayush#] 'Ayush' refers to the Indian system encompassing traditional medicine practices, integrating Ayurveda into mainstream health discourse and emphasizing alternative therapeutic approaches to manage diabetes.

23) Sugar:
[see source text or glossary: #Sugar#] 'Sugar' denotes the glucose levels being monitored in participants; managing blood sugar is crucial in preventing diabetes, which is the prime focus of the study.

24) New Delhi:
[see source text or glossary: #New Delhi#] 'New Delhi' denotes the capital city, potentially broadening the study's context in relation to diabetes and health care systems in urban India; health initiatives may need adaptation here.

25) Momordica charantia:
[see source text or glossary: #Momordica charantia#] 'Momordica charantia' refers to bitter gourd, another herb in the study known for its hypoglycemic effects and beneficial role in traditional medicine for diabetes management.

26) Maharashtra (Maharastra, Maha-rashtra):
[see source text or glossary: #Maharashtra#] 'Maharashtra' is the state where the study occurs, linking regional health practices with broader national health issues related to diabetes and providing insights into local health challenges.

27) Varanasi (Varanashi):
[see source text or glossary: #Varanasi#] 'Varanasi' may connect the study's cultural and spiritual heritage as an ancient city known for Ayurveda, reinforcing the roots of traditional medicine in modern dietary and lifestyle practices.

28) Sanskrit:
[see source text or glossary: #Sanskrit#] 'Sanskrit' references the language of many Ayurvedic texts, which forms the basis of the knowledge system used to derive and understand the implications of herbal treatments in the study.

29) Disease:
[see source text or glossary: #Disease#] 'Disease' relates to diabetes as the primary condition addressed in this study, aiming to develop preventative measures through herbal treatments combined with lifestyle modifications.

30) Science (Scientific):
[see source text or glossary: #Science#] 'Science' emphasizes the research approach taken in the study as it evaluates the efficacy of Ayurvedic practices, signifying the intersection between traditional knowledge and scientific inquiry.

31) Ambika:
[see source text or glossary: #Ambika#] 'Ambika' refers to editor Datta Shastri Ambika's role in compiling Ayurvedic literature, contributing to the knowledge base that informs this research in diabetes management.

32) Nashik:
[see source text or glossary: #Nashik#] 'Nashik' is relevant as it is the location associated with Maharashtra, providing a geographical context for health issues like diabetes that are under investigation in the study.

33) Pitta:
[see source text or glossary: #Pitta#] 'Pitta' characterizes one of the three doshas in Ayurveda and reflects the individualized treatment approaches in managing health, relevant to participants’ Ayurvedic assessments.

34) Kapha:
[see source text or glossary: #Kapha#] 'Kapha' is another dosha in Ayurveda, underlining the holistic assessment of participants within the study, which considers physical constitutions in treatment approaches.

35) Rules:
[see source text or glossary: #Rules#] 'Rules' may refer to the adherence to clinical protocols and ethical guidelines outlined during the study, ensuring fairness and scientific integrity in the trial’s execution.

36) Visit:
[see source text or glossary: #Visit#] 'Visit' denotes the scheduled follow-ups participants had throughout the study, which were crucial for monitoring health outcomes and adjusting the treatment as needed.

37) Kaphapitta (Kapha-pitta):
[see source text or glossary: #Kapha-pitta#] 'Kapha-pitta' describes a specific Ayurvedic constitution that influences how individuals respond to treatment in the study, essential in personalizing management strategies.

38) Developing:
[see source text or glossary: #Developing#] 'Developing' pertains to the progression of diseases like diabetes from prediabetes states; understanding this process is a crucial aim of the study to prevent future complications.

39) Gopinatha (Gopinath, Gopi-natha):
[see source text or glossary: #Gopinath#] 'Gopinath' is relevant in the context of authorship and contributions in Ayurvedic literature, potentially influencing the incorporation of traditional knowledge in clinical practices.

40) Family:
[see source text or glossary: #Family#] 'Family' signifies the relevance of a family history of diabetes, considered a significant factor in assessing individual risk and guiding preventative strategies in the study.

41) Saxena (Saksena, Sakshena):
[see source text or glossary: #Saxena#] 'Saxena' may refer to the authorship cited for prior research relevant to the efficacy of herbs used in the study, contributing to its foundational knowledge base.

42) Desire:
[see source text or glossary: #Desire#] 'Desire' relates to the aspects of thirst and hunger, which are key symptoms observed in individuals with metabolic disorders, informing the clinical assessment in the study.

43) Galla:
[see source text or glossary: #Galla#] 'Galla' can refer to contributors in the context of fenugreek research, highlighting its role when used in combination with other herbs in managing diabetes.

44) Kumar:
[see source text or glossary: #Kumar#] 'Kumar' signifies authors in the Ayurveda domain whose works might support the findings of this study based on prior investigations of herbal treatments in metabolic conditions.

45) Agni:
[see source text or glossary: #Agni#] 'Agni' represents the digestive fire in Ayurveda, crucial in determining an individual's metabolic health, and is essential to understanding treatment efficacy in the study.

46) Katu:
[see source text or glossary: #Katu#] 'Katu' refers to the bitter and pungent taste associated with certain herbs, embodying key principles in Ayurveda that impact the patient’s therapeutic approach explained in the study.

47) Vata:
[see source text or glossary: #Vata#] 'Vata' is the third dosha in Ayurveda, which, like Kapha and Pitta, creates a complete profile of an individual's health condition relevant to the study's holistic approach.

48) Hand:
[see source text or glossary: #Hand#] 'Hand' may convey the physical observation of participants, important for assessing symptoms such as burning sensations in patients, linked to diabetes complications considered in the study.

49) Male:
[see source text or glossary: #Male#] 'Male' denotes the gender distribution in the study's demographic profile, pivotal in analyzing how diabetes risk factors might differ across genders within the Indian context.

50) Peer review:
[see source text or glossary: #Peer review#] 'Peer review' signifies the process that validates the study’s integrity and findings, underscoring the importance of scientific evaluation prior to publication.

51) Madhurasyata:
[see source text or glossary: #Madhurasyata#] 'Madhurasyata' reflects the desire for sweet taste observed in patients, a symptom indicative of possible imbalances in metabolism relevant to diabetic conditions addressed in the study.

52) Observation:
[see source text or glossary: #Observation#] 'Observation' relates to the process of monitoring participants' health parameters over the study's duration, essential to ascertain the effectiveness and safety of the intervention.

53) Apanavayu (Apana-vayu):
[see source text or glossary: #Apana-vayu#] 'Apana-vayu' indicates a specific energy principle in Ayurveda believed to govern excretion and digestion, contributing to the understanding of participants' digestive health in the study.

54) Kaphavata (Kapha-vata):
[see source text or glossary: #Kapha-vata#] 'Kapha-vata' describes a dual dosha state that may be relevant for personalized participant assessments in the study, guiding tailored treatment responses depending on an individual's constitution.

55) Discussion:
[see source text or glossary: #Discussion#] 'Discussion' signifies the evaluative section of the study where findings are interpreted in context with existing research, drawing conclusions about the effectiveness of the PDBT formula.

56) Kaphaghna (Kapha-ghna):
[see source text or glossary: #Kaphaghna#] 'Kaphaghna' references the Ayurvedic principle describing substances that reduce excess Kapha, reinforcing the study's holistic approach towards treating prediabetes effectively.

57) Vitiation (Vitiated):
[see source text or glossary: #Vitiation#] 'Vitiation' explains the conceptual framework in Ayurveda related to the disturbance of doshas, particularly relevant to the understanding of diabetes pathophysiology discussed in the study.

58) Relative:
[see source text or glossary: #Relative#] 'Relative' pertains to the comparative analysis of results from the intervention group versus the control group, focusing on differences in outcomes related to diabetes onset.

59) Sweating (Sweat):
[see source text or glossary: #Sweating#] 'Sweating' refers to a symptom linked to metabolic disturbances and imbalances addressed in the study, such as in the Ayurvedic assessment of participants' conditions.

60) Koshtha (Kostha):
[see source text or glossary: #Koshtha#] 'Koshtha' indicates the gastrointestinal constitution in Ayurveda, which might affect digestion and metabolic health, relevant to prediabetes management strategies provided in the study.

61) Vishama (Visama):
[see source text or glossary: #Vishama#] 'Vishama' denotes irregularities in bodily functions, a concept being explored in the context of metabolic conditions typical of participants involved in the study.

62) Tikshna (Tiksna):
[see source text or glossary: #Tikshna#] 'Tikshna' refers to sharpness or intensity, potentially characterizing certain symptoms evaluated in the research, especially regarding participants' metabolic responses.

63) Burning (Burn, Burned, Burnt):
[see source text or glossary: #Burning#] 'Burning' is a symptom analyzed in participants, often indicating neuropathic or metabolic changes that are vital for assessing the intervention’s effectiveness in diabetes management.

64) Madhya:
[see source text or glossary: #Madhya#] 'Madhya' symbolizes balance, which is critical in achieving health goals and is essential in both Ayurvedic philosophy and the study's holistic treatment strategy.

65) Amrita (Amrta):
[see source text or glossary: #Amrita#] 'Amrita' defines the essence of life and vitality, paralleling the study’s goal to restore health and prevent disease through balanced food, lifestyle, and herbal therapies.

66) Indore:
[see source text or glossary: #Indore#] 'Indore' is notable as the location of the herbal preparation facility, emphasizing collaboration in producing the study’s polyherbal formulation used for the trial.

67) Nidra:
[see source text or glossary: #Nidra#] 'Nidra' represents sleep in Ayurveda, revealing the importance of rest in overall health and its role in managing metabolic conditions evaluated in this research.

68) Tikta:
[see source text or glossary: #Tikta#] 'Tikta' refers to the bitter taste associated with some herbs, particularly significant in their therapeutic qualities assessed in the study as effective components of diabetes management.

69) Ushna (Usna):
[see source text or glossary: #Ushna#] 'Ushna' indicates heating properties of herbal medications relevant for manipulating metabolic processes, considered in the context of Ayurvedic assessments within the study.

70) Vyana:
[see source text or glossary: #Vyana#] 'Vyana' refers to the vata dosha influencing circulation; understanding its role is necessary for addressing metabolic syndromes and guiding treatment approaches discussed in the study.

71) Virya:
[see source text or glossary: #Virya#] 'Virya' signifies the potency of the herbal components, which is a key factor in determining the effectiveness of therapies used in the study's evaluation of diabetes management.

72) Manda (Mamda):
[see source text or glossary: #Manda#] 'Manda' refers to the slow or weak digestive fire, indicating digestive health as a crucial aspect to consider in participants' metabolic health explored in the study.

73) Apana:
[see source text or glossary: #Apana#] 'Apana' correlates to one of the bodily functions in Ayurveda related to excretion, relating to the metabolic processes discussed in the context of diabetes prevention in the study.

74) Water:
[see source text or glossary: #Water#] 'Water' addresses the importance of hydration in metabolism, essential for maintaining chemical balances in the body, emphasized in lifestyle recommendations throughout the trial.

75) Aahar:
[see source text or glossary: #Aahar#] 'Aahar' refers to dietary habits, a critical element in managing health, particularly in diabetes, and is discussed in terms of changes needed for controlling prediabetes in the study.

[Note: The above list is limited to 75. Total glossary definitions available: 80]

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