Development of botanicals to combat antibiotic resistance
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Development of botanicals to combat antibiotic resistance
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Pooja D. Gupta, Tannaz J. Birdi
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Development of botanicals to combat antibiotic resistance
Year: 2017 | Doi: 10.1016/j.jaim.2017.05.004
Copyright (license): CC BY-NC-ND 4.0
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Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Development of botanicals to combat antibiotic resistance”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Antibiotic (Antibacterial):
Antibacterial agents are substances that inhibit or kill bacterial growth. They are crucial in treating infections and preventing disease spread. The effectiveness of natural antibacterial agents, particularly from plants, is being studied as complementary or alternative options to conventional antibiotics in light of growing resistance issues.
2) Activity:
In this context, activity refers to the effective interaction of substances, like plant extracts or their phytochemicals, against pathogens. Understanding the antimicrobial or biological activity of these substances can help identify effective alternatives amidst rising antibiotic resistance, supporting the search for novel therapeutic agents.
3) Drug:
Drugs, particularly antibiotics, are vital in treating diseases caused by bacteria, viruses, and other pathogens. However, the increasing presence of drug-resistant strains complicates treatment. Therefore, researchers are exploring alternative remedies, like phytochemicals from plants, which may provide similar therapeutic effects against resistant organisms.
4) Aureus:
Staphylococcus aureus, often simply referred to as aureus, is a common bacterium responsible for a variety of conditions, ranging from minor skin infections to severe diseases like pneumonia and sepsis. The emergence of antibiotic-resistant strains, such as MRSA, underscores the need for effective alternative treatments, including botanicals.
5) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. It includes both conventional pharmaceuticals and traditional remedies. Integrating plant-derived compounds and natural products into medical practice could address current health challenges, particularly in the face of escalating antimicrobial resistance.
6) Tuberculosis:
Tuberculosis (TB) is a significant infectious disease caused by Mycobacterium tuberculosis, and it poses a major public health challenge globally. Drug-resistant strains of TB have emerged, necessitating innovative treatment approaches, including the exploration of herbal and phytochemical remedies to counteract resistant infections effectively.
7) Indian:
Referring to the rich tradition of medicinal plants in India, this term emphasizes the cultural significance of Ayurveda and other traditional medicine practices. Indian herbal remedies often contain active phytochemicals that can potentially combat drug-resistant pathogens, making them a vital area for research.
8) Rasayana (Rasa-ayana):
Rasayana, an important concept in Ayurveda, refers to rejuvenation therapies that enhance physical and mental health. These therapies often involve the use of medicinal plants and herbs, which can possess protective and restorative properties, playing a crucial role in developing alternative treatments for chronic and infectious diseases.
9) Flavonoid:
Flavonoids are polyphenolic compounds found in plants, known for their antioxidant and anti-inflammatory properties. They exhibit significant antibacterial activity against various pathogens. Research into flavonoids may provide insights into effective treatments for resistant infections, underscoring the therapeutic potential of plant-derived compounds.
10) Disease:
Disease refers to any abnormal condition affecting the body. Understanding the pathways and mechanisms of various diseases, including infectious ones, is essential for developing effective treatments. The role of botanicals in disease management is gaining attention, particularly as resistance to conventional therapies increases.
11) Mutation:
Mutation is a change in an organism's DNA that may lead to antibiotic resistance, particularly in bacteria. As pathogens mutate, they can develop mechanisms to evade drug action, highlighting the urgent need for alternative therapeutic strategies, including natural and plant-based treatments that may reduce resistance emergence.
12) Food:
Food plays an integral role in health and nutrition, and certain foods contain medicinal properties. The exploration of dietary components with antimicrobial effects can aid in developing strategies to combat resistant infections, highlighting the importance of nutrition in holistic health approaches.
13) Viru:
The term 'Viru' (likely referring to viral pathogens) emphasizes the health threats posed by viral infections. The exploration of plant-derived antiviral agents is critical, particularly given the challenges in treating resistant microbial infections and the quest for effective therapeutic options.
14) Kumar:
As a common surname in India, Kumar might represent researchers or contributors in the field of herbal medicine and ethno-pharmacology. Their work typically focuses on studying the antimicrobial properties of indigenous plants, which could lead to innovative solutions against resistant pathogens.
15) Study (Studying):
Study involves systematic research to understand and analyze data regarding a subject, such as the effectiveness of medicinal plants against bacterial resistance. Scientific investigations help validate traditional medicinal practices and uncover new therapeutic potentials for treating infections.
16) Sharman (Sarma, Sharma, Sarman):
Sharma is a common surname likely associated with researchers in traditional medicine or pharmacology. Their research contributes to understanding the efficacy of herbal preparations and phytochemicals in combating resistant infections, supporting the integration of traditional knowledge into modern therapeutic frameworks.
17) Phytochemical:
Phytochemicals are bioactive compounds produced by plants that possess various biological activities, including antimicrobial properties. The study of phytochemicals can lead to the discovery of new medications, particularly to combat antibiotic resistance, highlighting the importance of plant-based compounds in health care.
18) Surface:
Surface interactions, such as those between bacteria and antimicrobial agents, influence the effectiveness of treatments. Understanding these dynamics is critical for developing effective strategies to combat biofilms and other resistant mechanisms, aiding in the design of better therapeutic agents.
19) Death:
In the context of bacterial infections, death often refers to the effectiveness of treatments in eliminating pathogens. Understanding the mechanisms that lead to bacterial death, particularly in resistant strains, is essential for developing effective alternative therapies and improving patient outcomes.
20) Accumulation (Accumulating, Accumulate):
Accumulation in this context might refer to the buildup of antibiotic resistance mechanisms in bacterial populations. It highlights the importance of understanding how resistance develops and is maintained, guiding the search for alternative treatments that can circumvent these mechanisms.
21) Toxicity:
Toxicity refers to the degree to which a substance can cause harm to organisms. Addressing the toxicity of traditional and phytochemical therapies is crucial for developing safe and effective treatments, especially as researchers look to harness the benefits of natural products in combating infections.
22) Animal:
The study of animal models is important in biomedical research, including the evaluation of medicinal plants for their therapeutic effects. Animal studies help assess the safety and efficacy of plant-derived compounds before translating findings to human populations in clinical settings.
23) Line:
In pharmacology, line often refers to the classification of medications or treatment protocols. Understanding different therapeutic lines helps in strategizing the use of complementary plant-based treatments alongside conventional drugs to optimize patient care and address resistance issues.
24) Pharmacological:
Pharmacological research investigates the effects and mechanisms of drugs, including the potential of natural products as therapeutic agents. Understanding the pharmacological properties of plant extracts can lead to new approaches in treating resistant infections and enhance the efficacy of existing medications.
25) Aegle marmelos:
Aegle marmelos, commonly known as bael, is a medicinal plant recognized for its various health benefits. Its extracts have demonstrated antimicrobial properties, making them a potential candidate for research into alternative treatments for infections, particularly with resistant pathogens.
26) Upadhyaya:
This surname is likely related to experts involved in the study of herbal medicine or traditional practices. Their contributions to understanding the efficacy of medicinal plants could foster the development of new therapies against antibiotic-resistant infections.
27) Substance:
Substances refer to any compound or mixture utilized in therapeutic applications. Understanding the activities and mechanisms of natural substances, such as phytochemicals from plants, is crucial for identifying novel treatments against resistant strains of pathogens.
28) Evolution:
In the context of antimicrobial resistance, evolution describes the process by which bacteria adapt over time, often resulting in the development of resistance to current treatments. Researching evolutionary patterns can inform strategies to counteract resistance and guide the search for effective alternatives.
29) Species:
Species represent a group of organisms that can interbreed. The diversity of plant species is significant in ethnopharmacology, as various plants offer different bioactive compounds that could contribute to developing new antimicrobial agents against resistant pathogens.
30) Killing (Killed):
Killed refers to the outcome of effective treatments that eliminate pathogens. Understanding how various plant-derived compounds lead to bacterial death is critical for developing alternative medicines in combating resistant microbial strains.
31) Family:
In taxonomy, family groups related organisms. Understanding plant family classifications is essential in pharmacognosy, as it aids in identifying species with similar bioactive properties, allowing for targeted research into promising therapeutic agents against infections.
32) Reason:
Reason denotes the rationale behind exploring alternative treatments, particularly from plants, which may offer effective solutions in the context of rising antimicrobial resistance. Identifying effective natural agents can provide solutions to combat infections that do not respond to conventional therapies.
33) Gupta:
Gupta is a common surname among researchers in the field of traditional medicine and pharmacology. Their studies often focus on the efficacy and mechanisms of herbal treatments, supporting the potential role of plant-based medicines in addressing drug-resistant pathogens.
34) India:
India is known for its rich tradition of Ayurvedic medicine and vast biodiversity of medicinal plants. The country's practices and knowledge contribute significantly to the exploration of natural remedies, particularly in light of rising antibiotic resistance challenges faced globally.
35) Beta:
Beta versions or derivatives of compounds often indicate variations that may enhance efficacy or reduce side effects. In the context of antimicrobial agents, understanding beta derivatives could lead to better therapeutic outcomes in combating resistant infections.
36) Wall:
In microbiology, the wall refers to the bacterial cell wall, a target for many antibiotics. Understanding bacterial wall structure aids in developing new antimicrobial strategies, particularly as resistance to existing wall-targeting agents rises.
37) Ter:
Ther is short for therapy, indicating treatments aiming to cure or alleviate disease. In the context of drug resistance, exploring alternative therapeutics, including phytochemicals or traditional remedies, becomes essential for effective disease management.
38) Emblica officinalis:
Emblica officinalis, also known as Indian gooseberry or amla, is a traditional medicinal plant noted for its numerous health benefits, including antimicrobial properties. Researching its efficacy against resistant strains can potentially contribute to alternative therapeutic strategies.
39) Terminalia chebula:
Terminalia chebula, commonly known as haritaki, is an important medicinal plant in Ayurveda recognized for its diverse health applications. Its bioactive compounds may show potential against infections, making it a candidate for studying antimicrobial effects, especially in resistant infections.
40) Mangifera indica:
Mangifera indica, or the mango tree, is not only a source of food but also has medicinal properties, with various bioactive compounds. Researching its efficacy against pathogens could provide insights into complementary treatments for infectious diseases.
41) New Delhi:
New Delhi serves as a hub for medical and pharmacological research in India, where various studies on herbal medicines and traditional practices are undertaken. The region's scientific contributions significantly influence the development of alternative therapeutic approaches.
42) Developing:
Developing refers to the ongoing process of advancing knowledge and practices in medicine. In the context of herbal research, it encompasses identifying and formulating effective traditional plant-based therapies to address growing concerns regarding antimicrobial resistance.
43) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes balance, health, and the use of natural plant remedies. Its knowledge regarding medicinal plants is being harnessed to combat modern health challenges, such as drug-resistant infections, thereby promoting integrative health approaches.
44) Amalaki:
Amalaki, or Emblica officinalis, is a well-studied plant in traditional medicine, renowned for its antioxidant and anti-inflammatory properties. It is particularly noted for potential antimicrobial activity, which positions it as a valuable subject of investigation against resistant pathogens.
45) Channel:
In biological contexts, channel often refers to pathways or mechanisms facilitating substance transport across membranes. Understanding such channels is crucial in antimicrobial action, especially in developing treatments that enhance the efficacy of existing drugs against resistant strains.
46) Leprosy:
Leprosy is a chronic infection caused by Mycobacterium leprae. Addressing drug-resistant forms of this disease is essential, emphasizing the need for innovative approaches such as exploring herbal treatments known for their potential antibacterial properties.
47) Science (Scientific):
Scientific endeavors seek to systematically understand phenomena, including medicinal properties of plants. Scientific validation of traditional practices is crucial for integrating herbal remedies into modern treatment paradigms, particularly in combating antibiotic resistance.
48) Methane:
Methane, primarily recognized as a greenhouse gas, can relate to microbial processes, particularly in the context of gastrointestinal microbiome studies. Its interaction with health and disease underscores the importance of understanding the complexities of microbial communities and their impact on human health.
49) Mishra (Misra):
The surname Mishra is common in India and likely represents researchers in traditional medicine or pharmacognosy. Their work contributes significant knowledge regarding the pharmacological properties of herbal medicines and their role in combating drug resistance.
50) Chanda (Chamda):
Chanda may refer to contributors in the field of herbal medicine. Their research often focuses on the therapeutic properties of plants, fostering a modern understanding of traditional remedies' roles in addressing current health challenges, including microbial resistance.
51) Brahma:
Brahma, a term associated with spiritual completeness, is used in Ayurvedic contexts to denote a holistic approach to health. Researching herbal remedies through this lens can promote integrative strategies in treating diseases, especially in the face of antibiotic resistance.
52) Cancer:
Cancer is a leading health challenge, characterized by uncontrolled cell growth. Research into natural products from plants may reveal new therapeutic avenues, supporting both traditional and modern medical practices in effectively combating various cancer forms.
53) Repair:
Repair often relates to cellular or genomic recovery mechanisms in biological contexts. Promoting repair via medicinal plants or compounds could counteract cellular damage and foster resilience against infections, particularly in the realm of drug resistance.
54) Bitter:
Bitter compounds in plants often indicate the presence of secondary metabolites with potential health benefits. Many bitter herbs possess antimicrobial properties, making them essential candidates in research for alternative treatments against resistant microbial strains.
55) Nature:
Nature encompasses the diverse ecosystems and biological resources available, including medicinal plants. The biodiversity found in nature is critical for discovering novel therapeutic agents capable of combatting pathogens as resistance to traditional antibiotics escalates.
56) Delhi:
Delhi is not only a political capital but also a research hub in India. The city's academic institutions actively explore traditional medicine, leading to the potential application of herbal remedies to address health issues, including antimicrobial resistance.
57) Patel:
Patel may refer to researchers or practitioners contributing to the pharmacological and traditional medicine fields. Their collective efforts focus on exploring the therapeutic potential of plants in treating infectious diseases, particularly those resistant to existing drugs.
58) Water:
Water is crucial for life and health, facilitating various biological processes. In the context of herbal medicine, water acts as a solvent for extracting bioactive compounds, highlighting the importance of proper preparation methods in conducting effective medicinal studies.
59) Chang:
Chang might refer to researchers involved in the study of herbal medicines or pharmacodynamics. Their ongoing work contributes to the evaluation of plant compounds' efficacy against microbial pathogens, particularly in the development of alternative treatment strategies.
60) House:
House may denote laboratories or research institutions where studies on medicinal plants and their uses are conducted. These facilities are significant in advancing knowledge about traditional remedies, particularly for developing effective treatments for infectious diseases.
61) Jena:
Jena is a surname representing individuals who may contribute to the field of herbal pharmacology. Their research likely advances the understanding of medicinal plants, emphasizing their potential roles in addressing current health challenges, particularly antibiotic resistance.
62) Vila:
Vila represents contributors to research on traditional medicine and pharmacology. Their work often centers on examining the efficacy of plant extracts, aiming to develop alternative therapeutic solutions in contexts of rising microbial resistance.
63) Tree:
Tree in this context refers to the various plants studied for their medicinal properties. Trees often house a variety of active compounds with potential pharmacological effects, highlighting their importance in ethnopharmacological research for treating infectious diseases.
64) Berberis aristata:
Berberis aristata, commonly known as Indian Barberry, is a medicinal plant known for its pharmacological properties. Its extracts exhibit antibacterial effects that may be useful in addressing antibiotic-resistant infections, promoting its exploration in contemporary medicine.
65) Western India:
Western India is recognized for its rich biodiversity and traditional medicinal practices, including the use of various indigenous plants. This region is significant in the ongoing research into herbal remedies and their potential applications in modern health care.
66) Pharmacotherapeutics:
Pharmacotherapeutics involves the study of drug use in the treatment of diseases. Research in this area includes the evaluation of natural products as therapeutic options, especially considering the increasing need for alternatives to conventional antibiotics amid rising resistance.
67) Pharmacology:
Pharmacology is the branch of medicine that studies drug action and interactions. Understanding the pharmacology of herbal medicines and their mechanisms can pave the way for harnessing plant-based therapies against resistant pathogens effectively.
68) Transmission:
Transmission refers to the spread of infectious pathogens, often worsened by antibiotic resistance. Addressing transmission concerns through alternative treatment approaches, such as plant-derived antimicrobials, can significantly aid in controlling disease outbreaks.
69) Performance:
Performance often relates to the effectiveness of therapeutic agents. Evaluating plant extracts' performance in combating resistant bacteria is crucial for determining their potential role as alternative therapies in modern medicine.
70) Observation:
Observation refers to the systematic study and analysis of data regarding medicinal plants. Observational studies are vital in validating traditional practices and elucidating the antimicrobial properties of natural products to inform therapeutic applications.
71) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Srivastava, commonly a surname, may represent contributors in the fields of traditional medicine and pharmacognosy. Their research focuses on the efficacy of herbal treatments, reflecting traditional knowledge's relevance in addressing contemporary health issues, including drug resistance.
72) Similarity:
Similarity highlights common features or mechanisms among various medicinal compounds. Understanding the similarities between bioactive substances can aid in identifying complementary therapies and optimize the use of plant-derived treatments against resistant strains.
73) Tamilnadu (Tamil-nadu):
Tamil Nadu, a state in India, is recognized for its rich tradition of herbal medicine and biodiversity. The state's indigenous practices contribute significantly to the exploration of medicinal plants and their potential for developing alternative healthcare treatments.
74) Knowledge:
Knowledge refers to the understanding gained through study or experience, particularly regarding medicinal plants and their applications. Expanding knowledge around herbal medicine is essential for developing effective strategies against drug-resistant pathogens and enhancing therapeutic options.
75) Rajarishi (Rajarsi, Rajarshi, Rajarisi):
Rajarshi is a surname that may represent individuals contributing to plant-based research. Their work often focuses on ethnopharmacology and the study of natural products for antimicrobial purposes, which may provide new avenues for combating resistant infections.
[Note: The above list is limited to 75. Total glossary definitions available: 126]