Natural radioprotective and anti-cancer plants from Uttarakhand.

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Prospects in the development of natural radioprotective therapeutics with anti-cancer properties from the plants of Uttarakhand region of India
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Sakshi Painuli, Navin Kumar


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Prospects in the development of natural radioprotective therapeutics with anti-cancer properties from the plants of Uttarakhand region of India

Year: 2016 | Doi: 10.1016/j.jaim.2015.09.001

Copyright (license): CC BY-NC-ND 4.0


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Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Natural radioprotective and anti-cancer plants from Uttarakhand.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth and division. It can affect various parts of the body and is closely linked to DNA mutations due to factors like radiation. Radioprotective agents, discussed in this context, aim to reduce the risk of radiation-induced cancers.

2) Activity:
Activity in the context of biomedicine usually refers to the biological effects exhibited by certain substances, including plant extracts and phytochemicals. This can include anti-cancer properties, antioxidant effects, or radioprotective capabilities, highlighting their role in health and disease prevention.

3) Line:
In cancer research, the term 'line' often refers to cell lines used in experiments to study the effects of drugs and treatments. They are derived from human or animal tissues and allow for controlled studies of anti-cancer and radioprotective properties in a laboratory setting.

4) Flavonoid:
Flavonoids are plant-derived compounds known for their antioxidant properties. They play a significant role in protecting cells from oxidative stress and have potential radioprotective and anti-cancer effects, making them valuable in the search for natural therapeutics from plants like those discussed in the review.

5) Family:
In botanical classification, 'family' refers to a ranked category that groups together related plants sharing common characteristics. For instance, various anti-cancer agents derived from plants belong to specific families, which can provide insights into their properties and potential uses in medicine.

6) Indian:
The term 'Indian' refers to the geographical and cultural context relating to India, a region rich in biodiversity. Many traditional medicines, including those derived from local plants in India, are explored for their radioprotection and anti-cancer potential, as highlighted in the reviewed literature.

7) India:
India is a country known for its vast array of medicinal plants and traditional healthcare practices. The review emphasizes plant-based therapies for chemotherapy and radioprotection originating from India, showcasing its relevance in finding natural solutions to combat cancer and the effects of radiation.

8) Kumar:
Kumar is a common surname in India, often associated with individuals in academic and scientific fields. In the context of the text, it may refer to researchers who contribute to studies on medicinal plants, cancer therapies, and radioprotective agents, reflecting the collaborative nature of scientific inquiry.

9) Blood:
Blood plays a crucial role in the overall health of an organism and is often studied in relation to cancer and radiation effects. The review discusses the protection of blood cells (like lymphocytes) from damage caused by radiation, demonstrating the need for effective radioprotective agents.

10) Garlic:
Garlic, or Allium sativum, is known for its numerous health benefits, including antioxidant and anti-cancer properties. The text mentions garlic extracts as having radioprotective capabilities, highlighting its potential role in mitigating radiation effects and strengthening the body's defenses against various conditions.

11) Drug:
A drug is a chemical substance used for medical purposes, including the treatment, prevention, or diagnosis of diseases. The review discusses natural compounds from plants as potential drugs, focusing on their use in radioprotection and cancer therapy, expanding the therapeutic options available for patients.

12) Medicine:
Medicine encompasses a broad field focusing on health care practices, including the study and application of medicinal plants. The review highlights the importance of exploring herbal remedies as effective treatments for cancer and radiation-induced damage, emphasizing the value of traditional medicine.

13) Disease:
Disease refers to a pathological condition that disrupts normal bodily functions. The text discusses various diseases, particularly cancer, in the context of radiation exposure and the potential role of plant-based radioprotective agents in preventing or mitigating disease progression.

14) Sharman (Sarma, Sharma, Sarman):
Sharma is a common surname in India and may indicate contributors to research in the field of medicinal plants and radioprotection. Collaboration among researchers, often represented by different surnames, helps enhance the understanding of natural therapeutics and their applications in modern medicine.

15) Aegle marmelos:
Aegle marmelos, or Bael, is a plant known for its medicinal properties. The review discusses its components and significant effects in cancer treatment and radioprotection, emphasizing the plant's potential as a natural therapeutic agent derived from traditional medicine.

16) Phytochemical:
Phytochemicals are bioactive compounds found in plants that contribute to their therapeutic properties. In the review, the focus is on various phytochemicals from studied plants, emphasizing their roles in anti-cancer and radioprotective activities, supporting their potential as natural remedies in medicine.

17) Radiotherapy:
Radiotherapy is a cancer treatment method that uses high doses of radiation to kill cancer cells. The text discusses the need for radioprotective agents, particularly during radiotherapy, to minimize damage to healthy tissues while targeting tumors effectively.

18) Water:
Water is vital for all living organisms, and its role in radiation biology is significant. The effects of radiation primarily arise from the radiolysis of water, generating reactive oxygen species that can damage cellular structures, thereby underscoring the need for effective radioprotective strategies.

19) Emblica officinalis:
Emblica officinalis, or Amla, is a plant recognized for its potent antioxidant properties. The review notes its effectiveness in both cancer prevention and as a radioprotector, supporting the relevance of plant-based solutions in addressing health challenges like radiation exposure and cancer.

20) Nelumbo nucifera:
Nelumbo nucifera, known as the Sacred Lotus, is mentioned for its potential in radioprotection. The review describes its bioactive components that may offer protective effects against radiation damage and highlights the plant's importance in traditional and modern healthcare contexts.

21) Curcuma longa:
Curcuma longa, or Turmeric, is widely known for its active compound curcumin. The review discusses its anti-cancer properties and radioprotective effects, illustrating turmeric's value as a natural therapeutic agent with applications in cancer treatment and protection against radiation damage.

22) Turmeric:
Turmeric is not only a popular spice but also a medicinal plant used in traditional medicine. The review highlights its active constituents and their role as anti-cancer and radioprotective agents, emphasizing the importance of incorporating such natural products into healthcare practices.

23) Animal:
In biomedical research, animal models are often used for studying disease mechanisms, therapy efficacy, and toxicity. The review frequently references studies conducted on animals to evaluate the effectiveness of various plant extracts in providing radioprotection and anti-cancer benefits.

24) Ocimum sanctum:
Ocimum sanctum, also known as Holy Basil, is a revered plant in traditional medicine. The review highlights its radioprotective and anti-cancer properties, indicating that its active components can mitigate damage from radiation exposure, showcasing its potential in integrative therapies.

25) Pharmacological:
Pharmacological pertains to the study of drugs and their effects on biological systems. The review discusses pharmacological properties of various plant extracts, focusing on their therapeutic applications in cancer treatment and radioprotection, underpinning the importance of natural products in drug development.

26) Himalaya (Hima-alaya):
The Himalaya region is home to a diverse range of medicinal plants. The review emphasizes the significance of this geographical area in providing plant species with potential anti-cancer and radioprotective properties, thus recognizing its role in traditional and modern herbal medicine.

27) Mutation:
Mutation refers to changes in the DNA sequence, which can lead to cancer. The review discusses radiation-induced mutations in normal cells, emphasizing the importance of radioprotective agents in preventing such changes and reducing the risk of malignancy in exposed tissues.

28) Samanta (Sama-anta, Samamta):
Samanta is a surname associated with researchers in plants' medicinal properties. The name appears in the context of studies highlighting the anti-cancer and radioprotective effects of various natural compounds, showcasing collaborative efforts in the field of biomedicine.

29) Study (Studying):
A study involves systematic investigation to establish facts or principles. The text reflects numerous studies regarding plant-based radioprotective and anti-cancer properties, indicating the scientific exploration required to validate traditional uses of herbal medicines and their efficacy in modern contexts.

30) Devi:
Devi is a common surname in India, often associated with researchers and academics. In the context of this review, it refers to contributors who have investigated the radioprotective and anti-cancer properties of various plants, contributing to a deeper understanding of herbal medicine.

31) Beta:
Beta refers to a type of radiation and may also denote beta-glucans found in some plant extracts with immunological benefits. The text discusses various radiation types and highlights compounds that exhibit protective activities against harmful radiation exposure, especially in cancer therapy contexts.

32) Life:
Life is fundamentally connected with the study of biology and medicine, particularly in understanding how organisms respond to diseases. The review discusses ways to enhance the quality and longevity of life through the use of natural compounds that can protect against cancer and radiation.

33) Allium sativum:
Allium sativum, or garlic, is well-known for its health benefits. The review highlights garlic's antioxidant properties and its role as a potential radioprotector, emphasizing how this widely available food may be leveraged in both traditional and modern therapeutic practices.

34) Developing:
Developing in the context of the review refers to the process of creating or formulating new treatments, particularly from natural sources. The emphasis is on developing effective and safe radioprotective agents and anti-cancer therapeutics based on traditional medicinal plants.

35) Substance:
A substance is any material with a definite chemical composition. In the context of the review, it refers to natural compounds derived from plants that exhibit promising pharmacological activities, such as radioprotection and anti-cancer effects, essential for therapeutic advancement.

36) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. The review emphasizes the importance of exploring plant-based therapies that are non-toxic and safe for humans, juxtaposed against conventional synthetic drugs that often come with adverse effects.

37) Species:
Species refer to distinct biological classifications of organisms that share common characteristics. The review mentions various plant species explored for their medicinal properties, emphasizing the rich biodiversity of the Uttarakhand region and its contributions to finding natural radioprotective agents.

38) Repair:
Repair relates to biological processes aimed at fixing cellular damage. The review highlights the significance of enhancing DNA repair mechanisms through radioprotective agents, which may safeguard cells from radiation-induced damage and mitigate cancer risk.

39) Kappa:
Kappa often refers to the kappa light chain in immunology, but in this context may relate to kappa protein signaling pathways involved in the cell response to damage. The review indicates the relevance of cellular mechanisms in relation to radiation effects and corresponding herbal protections.

40) Ranga (Ramga):
Ranga is a surname representing contributors to the field of plant-based medicine. In the review, it refers to researchers engaged in studies exploring the efficacy and safety of herbal extracts in radioprotection and cancer treatment, reflecting the collaborative nature of scientific research.

41) Gupta:
Gupta is a common surname in India, usually associated with individuals in academia and research. The text references researchers like Gupta who contribute to understanding healing properties of plants, particularly their anti-cancer and radioprotective effects in various experimental contexts.

42) Joshi (Josi):
Joshi is a surname linked to researchers contributing to studies on radioprotective agents. In the review, it features researchers who have compiled evidence regarding the efficacy of herbal extracts, emphasizing their collaborative efforts in advancing knowledge of plant-based therapies.

43) Patel:
Patel is a common surname in South Asian communities, often representing individuals involved in science and research. The review highlights collaborations in studying medicinal plants for their protective and therapeutic properties against cancer, underscoring the importance of community efforts in research.

44) Table:
A table is a systematic arrangement of data in rows and columns. In the text, it refers to a structured presentation of various plants with radioprotective and anti-cancer properties, encapsulating significant information to facilitate understanding and comparisons among studied plants.

45) Death:
Death signifies the end of life, often used in the context of illness or disease. The review discusses the role of cancer and radiation therapy in mortality rates, highlighting the importance of finding effective radioprotective agents to improve survival rates in affected populations.

46) Amla:
Amla, or Emblica officinalis, is a medicinal plant renowned for its health benefits, particularly in traditional Indian medicine. It is noted for its antioxidant and potential radioprotective properties, underscoring its relevance in cancer prevention and treatment through natural therapies.

47) Rana:
Rana is a common surname in India, potentially referring to researchers focused on traditional medicine and its applications. The context reveals how individuals in research contribute to expanding knowledge about plant-based treatments for cancer and radioprotection.

48) Babu:
Babu is a common name in South Asia, often used in academia. Within the text, it could represent a researcher involved in herbal medicine studies, emphasizing contributions to understanding effective natural treatments for cancer and the impact of radiation exposure.

49) Food:
Food refers to substances consumed for nutritional support and health benefits. The review touches on the medicinal properties of various plants, positioning them as potential dietary components that offer protective benefits against radiation and support anti-cancer therapy.

50) Rich (Rch):
Rich refers to abundance or high quantities of specific elements or nutrients. The review emphasizes that certain regions, like Uttarakhand, are rich in medicinal plants with promising anti-cancer and radioprotective properties, highlighting the potential for discovering new therapies from local biodiversity.

51) Southern India:
Southern India is a culturally diverse region known for its traditional medicine practices. The region's rich biodiversity includes numerous plant species used for healthcare, aligning with the review's focus on exploring local flora for effective natural remedies against cancer and radiation effects.

52) Human body:
The human body is often the subject of study in medical research, particularly regarding its response to diseases like cancer. The review discusses the need for protective agents to shield healthy tissues from radiation damage, underscoring the human body's biological complexities.

53) Chemotherapy:
Chemotherapy is a treatment method that utilizes chemical substances to combat cancer. The review discusses the importance of integrating radioprotective agents in chemotherapy to minimize adverse effects on healthy tissues, emphasizing a holistic approach to cancer treatment.

54) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Srivastava, much like Shrivastava, is a surname representing individuals involved in research. Their contributions to the studies of plant-based therapies for cancer and other conditions further enrich the knowledge base within the field of herbal pharmacology.

55) Science (Scientific):
Scientific refers to methods or principles based on systematic observation and experimentation. The review emphasizes the significance of scientific research in validating traditional uses of herbal remedies for cancer treatment and developing evidence-based natural therapies.

56) Surendra (Sura-indra, Suremdra):
Surendra is a surname often associated with professionals in scientific research. The individuals with this surname may participate in studies exploring the efficacy of herbal extracts, contributing to the understanding and advancement of natural medicine in combating diseases.

57) Vomiting:
Vomiting is a physiological response often induced by toxicity or illness, including reactions to cancer treatments. The review highlights the side effects of conventional radioprotective agents, emphasizing the need for safe herbal alternatives that minimize adverse reactions like vomiting.

58) Lakshmi (Laksmi):
Lakshmi, used as a surname, often refers to individuals in research or academic settings. The context suggests contributions to studies on beneficial plants that may lead to better understanding and development of effective anti-cancer and radioprotective agents.

59) Solanki:
Solanki is a surname associated with individuals likely contributing to the medicinal plants field. The presence of this name in scholarly work indicates collaborative efforts in exploring the medicinal properties of various plants, particularly for their healing potentials against cancer.

60) Nirmala:
Nirmala is a common name and potentially refers to researchers involved in the study of pharmacological properties of plants. Contributions in the field of natural medicine often enhance the overall understanding of plant extracts' roles in disease prevention and treatment.

61) Shridevi (Sridevi, Shri-devi):
Sridevi is a commonly recognized name in South Asia, often linked to individuals in research. The mention in the review emphasizes participation in studies focusing on plants with promising anti-cancer effects, reinforcing scientific efforts in exploring natural alternatives for treatment.

62) Balhara:
Balhara is a surname potentially linked to researchers exploring the health benefits of various medicinal plants. The context reflects the collective effort towards recognizing and validating traditional remedies for modern health challenges like cancer and radiation exposure.

63) Vijaya:
Vijaya is a common name often associated with contributions to research in the field of herbal medicine. The context indicates the involvement of individuals with this name in studies concerning radioprotective agents derived from plants and their potential therapeutic applications.

64) Maurya:
Maurya is a surname representing individuals in the scientific community. In the context of this review, it may refer to researchers focusing on the study of medicinal plants and their potential roles in enhancing health through anti-cancer and radioprotective properties.

65) Humana:
Humana refers to the Latin term for human, often used in healthcare contexts. The review forges a connection between human health and the therapeutic potential of natural compounds derived from plants, highlighting how they protect humans against diseases and radiation damage.

66) Behera:
Behera is a surname likely representing researchers contributing to the study of medicinal plants. Their inclusion in the review emphasizes the collaborative nature of scientific inquiry and the growing interest in herbal therapies for therapeutic applications.

67) Nausea:
Nausea is a common side effect of various medical treatments, including chemotherapy and radiotherapy. The review highlights herbal remedies that might mitigate treatment-induced nausea, emphasizing the need for integrative approaches to patient care in oncology.

68) Nature:
Nature in this context refers to the environment and its resources, particularly the diverse medicinal plants that provide therapeutic benefits. The review emphasizes the ecological richness that can offer solutions for health issues, particularly from traditional medicine perspectives.

69) Patra:
Patra is a surname that may represent individuals in academic fields, particularly those focusing on pharmacological research. In the context of the review, contributions to the understanding of plant-based remedies enhance knowledge related to combating diseases like cancer.

70) Panda (Pamda):
Panda is a surname that could indicate researchers in the field of herbal medicine. This association signifies collaboration among professionals researching the efficacy of various plant extracts, particularly their roles in protecting against radiation and treating cancer.

71) Sagar (Sagár):
Sagar is a surname often linked to individuals in scientific research. The connection to the review underscores the collaborative nature of studies examining the properties of various plants known for their radioprotective and anti-cancer effects.

72) Malik:
Malik is a common surname in South Asia and often relates to researchers involved in studies focusing on natural products. The mention in the review indicates the importance of collaborative research efforts for the discovery and validation of herbal pharmacologies.

73) Kadam:
Kadam is a surname indicative of individuals engaged in research, particularly in the biomedicine field. The mention signifies contributions to the exploration of plant-derived compounds and their potential application in medical treatments, highlighting the collaborative nature of such efforts.

74) Chang:
Chang is a surname that may represent researchers, particularly in pharmacology and herbal medicine. The connection underscores the diverse backgrounds of scientists working on understanding the interactions and effects of plant-based therapies in health and disease management.

75) Ulcer:
Ulcers are painful sores that develop on the lining of the digestive system, often associated with diseases or stress. While the review does not emphasize ulcers, it relates to the overall health issues where herbal remedies may provide therapeutic benefits and enhance healing.

[Note: The above list is limited to 75. Total glossary definitions available: 86]

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