Efficacy of Mrudweekadi Kashaya and Kalyanaka Ghrit in alcohol addiction.
Journal name: Ayushdhara
Original article title: Efficacy of mrudweekadi kashaya and kalyanaka ghrit nasya in the treatment of alcoholic addiction (madatyaya)
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Summary of article contents:
Introduction
Alcohol addiction, referred to as Madatyaya in Ayurvedic literature, is a significant public health issue in India, leading to various physical, mental, and economic problems. The study explored the efficacy of two Ayurvedic formulations—Mrudweekadi Kashaya and Kalyanaka Ghrita—in treating Alcohol Withdrawal Syndrome. Conducted at Anandvan De-Addiction and Rehabilitation Centre, the randomized clinical trial involved 100 male patients, divided into a trial group receiving the formulations and a control group receiving no medication. The study aimed to assess the clinical improvement in symptoms associated with alcohol addiction and evaluate the formulations’ effects on liver function and hemoglobin levels.
Efficacy of Ayurvedic Formulations
One significant finding from the study was that Mrudweekadi Kashaya and Kalyanaka Ghrita effectively alleviated many of the symptoms associated with Alcohol Withdrawal Syndrome. The trial group exhibited a notable reduction in symptoms such as Daurbalya (weakness), Aruchi (loss of appetite), and Murcha (fainting). These medications increased the overall nutritional status and improved appetite, supporting physical recovery. The improvement in patients' conditions was attributed to the deepana (appetizer), rasayana (rejuvenation), and srotoshodhaka (cleansing) properties of the formulations, which facilitated detoxifying the toxic effects of alcohol on the body.
Impact on Pathological Parameters
In addition to symptom alleviation, the study highlighted significant changes in pathological parameters among the trial group. Notable improvements were observed in hemoglobin levels, SGOT, SGPT, and alkaline phosphatase values, indicating enhanced liver function. Mrudweekadi Kashaya and Kalyanaka Ghrita showed a statistically significant increase in hemoglobin levels and reductions in liver function test results, which are essential indicators of liver health. These findings suggest that the aforementioned Ayurvedic treatments may offer an effective alternative for detoxifying and restoring patients’ health suffering from alcohol addiction.
Conclusion
The research underlines the potential of Ayurvedic approaches, specifically Mrudweekadi Kashaya and Kalyanaka Ghrita, in managing alcohol addiction and its withdrawal symptoms. By contributing to the reduction of both physiological and psychological symptoms while simultaneously improving important physiological parameters, these formulations demonstrate a promising alternative to conventional treatments. As alcohol addiction remains a pervasive issue, integrating Ayurvedic practices into treatment protocols may provide a holistic and effective strategy for recovery in affected individuals.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
*Syam B
Asst Professor, Dept. of Agada Tantra and Vyavahara Ayurveda, Parassinikadavu Ayurvedic Medical College, Kerala
A.B Patil
Professor, Dept. of Agada Tantra and Vyavahar Ayurveda, Bharathi Vidyapeeth College of Ayurveda, Pune
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Efficacy of mrudweekadi kashaya and kalyanaka ghrit nasya in the treatment of alcoholic addiction (madatyaya)
Year: 2016
Copyright (license): CC BY-NC-SA 4.0
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FAQ section (important questions/answers):
What are the key ingredients in Mrudweekadi Kashaya?
Mrudweekadi Kashaya contains various ingredients like Draksha, Yashtimadhu, Pippali, and Chandana. Each plays a role in improving digestion and detoxifying the body, which is beneficial in treating conditions like Alcoholic Addiction.
How effective is Kalyanaka Ghrita for treating alcohol addiction?
Kalyanaka Ghrita, known for its psychological and nutritional support, significantly reduces symptoms associated with Alcohol Withdrawal Syndrome. Its action on Manovaha Srotas helps in alleviating mental stresses and improving overall well-being for patients.
What methods were used to assess the treatment's effectiveness?
The trial used randomized clinical study methods, including subjective assessments, psychological scales, and objective parameters like Liver Function Tests to evaluate the efficacy of Mrudweekadi Kashaya and Kalyanaka Ghrita in treating Alcoholic Addiction.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy of Mrudweekadi Kashaya and Kalyanaka Ghrit in alcohol addiction.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Lakshana (Laksana):
In Ayurveda, 'Lakshana' refers to symptoms or signs of a disease. In the context of Madatyaya, Lakshanas like Agnimandya, Hrullas, and Chardi are significant indicators of alcohol withdrawal symptoms observed and treated during the study.
2) Karsha (Karsa):
'Karsa' is a unit of measurement used in Ayurvedic texts for ingredients. For example, the Kalyanaka Ghrita contains various ingredients measured in Karsas, such as Amalaki and Bibhitaka, indicating the precise quantity required for the formulation.
3) Ghrita (Ghrta):
In Ayurveda, 'Ghrita' stands for ghee or clarified butter. It is used as a base for various Ayurvedic formulations. Kalyanaka Ghrita is an example where ghrita is used for its therapeutic properties to alleviate psychological symptoms of Madatyaya.
4) Kalyanaka:
'Kalyanaka' is part of the term Kalyanaka Ghrita. It refers to the auspicious or beneficial nature of the formulation aimed at promoting mental health and well-being in patients suffering from conditions like alcohol addiction.
5) Kalyanakaghrita (Kalyanakaghrta, Kalyanaka-ghrita):
Kalyanaka Ghrita is an Ayurvedic formulation used in the treatment of Madatyaya. It includes ingredients like Haritaki, Bibhitaka, and Manjistha, and acts on Manovaha srotas, alleviating psychological symptoms and improving mental clarity.
6) Drug:
In the study, drugs like Mrudvikadi Kashaya and Kalyanaka Ghrita were used to treat Madatyaya. These Ayurvedic drugs are formulated with natural ingredients and aim to alleviate both physical and psychological withdrawal symptoms.
7) Madatyaya (Mada-atyaya):
Madatyaya is the Ayurvedic term for alcoholic addiction or Alcohol Withdrawal Syndrome. It describes the detrimental physical and psychological effects of excessive alcohol consumption and outlines treatment methodologies using Ayurvedic principles.
8) Kashaya (Kasaya):
Kashaya refers to a decoction or herbal preparation in Ayurveda. Mrudvikadi Kashaya, used in this study, is formulated with ingredients like Draksha and Yashtimadhu and helps alleviate symptoms of Madatyaya by enhancing nutritional status and detoxifying the liver.
9) Pitta:
In Ayurvedic medicine, 'Pitta' is one of the three doshas. Pitta represents the fire element and governs digestion and metabolism. Imbalances in Pitta can lead to symptoms like Daha, a burning sensation, commonly noted in Madatyaya.
10) Vata:
Vata is another dosha in Ayurveda, representing air and space elements. Vata dosha governs movement and communication. Imbalances in Vata due to alcohol consumption can lead to symptoms like anxiety and insomnia seen in Madatyaya.
11) Food:
The study notes the impact of food intake on alcohol consumption. It was found that consuming alcohol with or without food can influence the severity of Madatyaya symptoms, indicating the importance of dietary considerations in treatment.
12) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine from India that uses natural remedies and holistic approaches for treatment. This study on Madatyaya showcases Ayurveda's effectiveness in treating alcohol withdrawal symptoms using formulations like Mrudvikadi Kashaya.
13) Haritaki:
Haritaki is an ingredient in both Mrudvikadi Kashaya and Kalyanaka Ghrita. It is known for its detoxifying and rejuvenating properties and is effective in balancing Vata and Pitta doshas, essential in treating Madatyaya.
14) Depression:
'Depression' is a psychological symptom observed in Madatyaya. The study found Kalyanaka Ghrita to be effective in alleviating depression among alcoholic patients, thereby improving their overall mental health.
15) Daha:
Daha refers to a burning sensation, a symptom often associated with Pitta imbalance in Madatyaya. Ingredients like Chandana in Mrudvikadi Kashaya have cooling properties that help alleviate Daha, providing relief to patients.
16) Daurbalya:
Daurbalya means weakness or debility. The study found that Mrudvikadi Kashaya and Kalyanaka Ghrita significantly reduce Daurbalya in patients with Madatyaya by enhancing nutritional status and boosting overall health.
17) Aruci:
Aruchi refers to loss of appetite, a common symptom in Madatyaya. Mrudvikadi Kashaya, with its deepana (digestive) properties, helps stimulate appetite and improve digestion, thus alleviating Aruchi in patients.
18) Dosha (Dosa):
Dosha refers to the three biological energies in Ayurveda: Vata, Pitta, and Kapha. Imbalance in these doshas due to excessive alcohol use causes various symptoms of Madatyaya. Treatment aims at balancing these doshas to restore health.
19) Kapha:
Kapha is one of the three doshas in Ayurveda, representing water and earth elements. Excessive alcohol can imbalance Kapha, leading to symptoms like lethargy and heaviness, which need to be addressed in Madatyaya treatment.
20) Madya:
Madya refers to alcohol in Ayurveda. Consumption of Madya is both a therapeutic agent when taken judiciously and a poison when consumed excessively, leading to Madatyaya, characterized by various withdrawal symptoms.
21) Kasa (Kasha):
Kasa refers to cough, a possible symptom in Madatyaya. Ingredients like Pippali in Mrudvikadi Kashaya possess properties that alleviate Kasa, helping to reduce this respiratory symptom in alcoholic patients.
22) Pippali (Pippalin):
Pippali is an ingredient in Mrudvikadi Kashaya, known for its digestive and detoxifying properties. It helps in reducing symptoms like Aruchi and Hrullas in Madatyaya by enhancing metabolism and clearing toxins.
23) Craving (Crave, Craved):
Craving is a psychological symptom of alcohol withdrawal observed in Madatyaya. The study noted that Mrudvikadi Kashaya and Kalyanaka Ghrita help significantly reduce cravings, aiding in the recovery process from addiction.
24) Agnimandya (Agni-mandya, Agnimamdya):
Agnimandya refers to weak digestion, a common symptom in Madatyaya. Mrudvikadi Kashaya, with its Agni deepana properties, helps stimulate digestive fire, thereby improving digestion and alleviating Agnimandya.
25) Nidranasha (Nidranasa, Nidra-nasha):
Nidranasha means insomnia, a symptom often seen in Madatyaya. The use of Kalyanaka Ghrita in the study showed effectiveness in improving sleep quality and reducing Nidranasha in alcoholic patients.
26) Gandharva (Gamdharva, Gamdharvadurve):
Gandharva Haritaki is used as a premedication in the study for Madatyaya. It aids in Srotoshodhan (cleansing of channels) and Anuloman (downward movement of Vata), preparing the body for subsequent treatments [see source text or glossary: Gandharva].
27) Substance:
In the study, substances like alcohol cause Madatyaya, leading to physical and psychological dependence. Ayurvedic substances like Mrudvikadi Kashaya are used to counteract the negative effects of such dependencies [see source text or glossary: Substance].
28) Medicine:
Medicines used in this study, specifically Ayurvedic formulations like Mrudvikadi Kashaya and Kalyanaka Ghrita, were selected for their efficacy in treating Madatyaya by alleviating both physical and psychological symptoms [see source text or glossary: Medicine].
29) Trishna (Trsna):
Trishna refers to excessive thirst, a symptom observed in Madatyaya. Ingredients like Chandana in Mrudvikadi Kashaya help alleviate Trishna by addressing the underlying Pitta imbalance [see source text or glossary: Trishna].
30) Sariva (Shariva):
Sariva is an ingredient in Mrudvikadi Kashaya known for its cooling and detoxifying properties. It helps in alleviating symptoms like Daha and facilitating detoxification in the treatment of Madatyaya.
31) Dadima:
Dadima, or pomegranate, is included in Kalyanaka Ghrita for its Rasayana (rejuvenative) properties. It aids in improving appetite and digestion, crucial for treating Madatyaya symptoms like Aruchi and Agnimandya.
32) Kerala:
The preparations like Mrudvikadi Kashaya and Kalyanaka Ghrita used in the study were procured from Shankar Pharmacy in Kerala, known for their GMP certification and quality Ayurvedic medicines [see source text or glossary: Kerala].
33) Tandra (Tamdra):
Tandra refers to drowsiness, a symptom observed in Madatyaya. The study shows that Ayurvedic treatments like Mrudvikadi Kashaya help alleviate Tandra by balancing the affected doshas [see source text or glossary: Tandra].
34) Nasya (Nashya):
Nasya refers to the administration of medicinal drops through the nostrils. In the study, Kalyanaka Ghrita was used as Pratimarsha Nasya to deliver therapeutic benefits directly to the brain and nasal passages [see source text or glossary: Nasya].
35) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yashtimadhu, or licorice, is an ingredient in Mrudvikadi Kashaya, known for its soothing and anti-inflammatory properties, aiding in the treatment of Madatyaya symptoms like Hrullas and Chhardi [see source text or glossary: Yashtimadhu].
36) Triphala (Tri-phala):
Triphala, a combination of three fruits, is used in Kalyanaka Ghrita. It has Rasayana properties, promoting overall health, improving digestion, and aiding detoxification, making it effective in treating Madatyaya [see source text or glossary: Triphala].
37) Rasayana (Rasa-ayana):
Rasayana refers to rejuvenative treatments in Ayurveda. Both Mrudvikadi Kashaya and Kalyanaka Ghrita have Rasayana properties, which enhance body strength, immunity, and overall well-being, crucial for treating Madatyaya [see source text or glossary: Rasayana].
38) Draksha (Draksa):
Draksha, or grapes, is a key ingredient in Mrudvikadi Kashaya. It is known for its antioxidant properties and ability to improve metabolism and nutritional status, making it beneficial in addressing symptoms of Madatyaya [see source text or glossary: Draksha].
39) Haridra:
Haridra, or turmeric, is included in Kalyanaka Ghrita for its anti-inflammatory and detoxifying properties. It helps alleviate symptoms like Aruchi and is beneficial in the overall treatment of Madatyaya [see source text or glossary: Haridra].
40) Srotas (Shrotas):
Srotas refers to channels in the body through which nutrients and waste products flow. Both Mrudvikadi Kashaya and Kalyanaka Ghrita work on clearing blockages in these channels, a critical aspect of treating Madatyaya [see source text or glossary: Srotas].
41) Kalpa:
In Ayurveda, 'Kalpa' refers to a specific preparation or prescription. Mrudvikadi Kashaya and Kalyanaka Ghrita are such Kalpas used in the study for treating Madatyaya, detailing the ingredients and their specific dosages [see source text or glossary: Kalpa].
42) Balya:
Balya refers to treatments that improve body strength and vitality. Mrudvikadi Kashaya has Balya properties, making it effective in alleviating symptoms like Daurbalya and enhancing overall health in patients with Madatyaya [see source text or glossary: Balya].
43) Agni:
Agni refers to the digestive fire in Ayurveda. Mrudvikadi Kashaya has Agni deepana properties, aiding in the stimulation of digestive fire to improve digestion and alleviate symptoms like Agnimandya in Madatyaya [see source text or glossary: Agni].
44) Vega:
In the context of symptoms like Chhardi (vomiting), Vega refers to the frequency or intensity of such symptoms. For example, Chhardi was measured in terms of Vega per day in the study [see source text or glossary: Vega].
45) Jala:
In the study, Jala (water) was mentioned as an Anupana (a liquid vehicle) used for taking Mrudvikadi Kashaya. This helps in proper assimilation and enhances the therapeutic effects of the medicine [see source text or glossary: Jala].
46) Kala:
Kala refers to time in Ayurveda. It is important for determining the timing of medicine administration, as seen with dosages like taking Mrudvikadi Kashaya Adhobhakta (after meals) to maximize its effectiveness [see source text or glossary: Kala].
47) Agadatantra (Agada-tantra, Agadatamtra):
Agada-tantra is a branch of Ayurveda dealing with toxicology and detoxification. Authors like Syam B and A.B Patil specialize in this field, focusing on managing toxic effects like those of alcohol in Madatyaya [see source text or glossary: Agada-tantra].
48) Vatapitta (Vata-pitta):
Vata-pitta is a common dual-dosha type found amongst patients in the study for Madatyaya. This combination includes characteristics and symptoms governed by both Vata and Pitta doshas, necessitating specific treatments [see source text or glossary: Vata-pitta].
49) Staimitya:
Staimitya refers to stiffness or rigidity, a symptom that was not significantly found in both the trial and control groups in the study of Madatyaya [see source text or glossary: Staimitya].
50) Kharjura:
Kharjura, or dates, is an ingredient in Mrudvikadi Kashaya known for its nourishing and tonic properties. It helps in enhancing the nutritional status and strength of the patients suffering from Madatyaya [see source text or glossary: Kharjura].
51) Gaurava:
Gaurava refers to a feeling of heaviness, a symptom associated with excess Kapha. Treatments in the study aimed at reducing Gaurava through ingredients like Pippali, Musta, and Mrudvikadi Kashaya [see source text or glossary: Gaurava].
52) Tantra (Tamtra, Tantrism):
Tantra in Ayurveda signifies a branch or system of treatments. Agada-tantra is one such branch focused on detoxification, vital for addressing conditions like Madatyaya caused by substance abuse [see source text or glossary: Tantra].
53) Ushira (Usira):
Ushira, or Vetiver, is an ingredient in Mrudvikadi Kashaya. It helps in cooling and purifying the blood, which is crucial for alleviating symptoms like Daha (burning sensation) caused by Pitta imbalance in Madatyaya [see source text or glossary: Ushira].
54) Chardi:
Chardi means vomiting, a primary symptom of Madatyaya. Mrudvikadi Kashaya effectively alleviates Chardi by using ingredients with deepana and Vatanuloman properties to address the underlying causes [see source text or glossary: Chardi].
55) Family:
Alcohol addiction significantly impacts not just the individual but also their family, leading to social and economic losses. This study underscores the importance of family support in the treatment of Madatyaya [see source text or glossary: Family].
56) Farmer:
Occupation-wise, some patients in the study were farmers. The prevalence of Madatyaya among different occupational groups like farmers highlights the widespread nature of alcohol addiction [see source text or glossary: Farmer].
57) Agada:
'Agada' refers to antidotes or treatments for poisoning and toxicological conditions, an essential aspect of the Agada-tantra branch used in treating conditions like Madatyaya caused by excessive alcohol use [see source text or glossary: Agada].
58) Karma (Karman):
Karma in Ayurveda means action or therapeutic procedure. For example, Snehana and Swedana are preparatory karmas performed before administering Nasya with Kalyanaka Ghrita in the treatment of Madatyaya [see source text or glossary: Karma].
59) Musta (Mushta):
Musta, or Cyperus rotundus, is an ingredient in Mrudvikadi Kashaya known for its digestive and detoxifying properties. It effectively alleviates symptoms like Hrullas and Tandra in patients with Madatyaya [see source text or glossary: Musta].
60) Matra:
Matra refers to the quantity or dosage of a medicinal substance. In the study, the Matra for Mrudvikadi Kashaya was 80 ml in divided doses to maximize therapeutic benefits for Madatyaya symptoms [see source text or glossary: Matra].
61) Hikka:
Hikka refers to hiccups, a symptom that was not significantly observed in the study of Madatyaya in both the trial and control groups [see source text or glossary: Hikka].
62) Guna:
Guna refers to qualities in Ayurveda. For example, Mrudvikadi Kashaya has Deepana (digestive) and Rasayana (rejuvenative) gunas which help alleviate symptoms of Madatyaya by improving digestion and overall vitality [see source text or glossary: Guna].
63) Pratimarshanasya (Pratimarsanasya, Pratimarsha-nasya):
Pratimarsha-nasya is a type of Nasya (nasal administration) where medicated ghee or oil is administered in small doses. In the study, Kalyanaka Ghrita was used as Pratimarsha-nasya to treat psychological symptoms of Madatyaya [see source text or glossary: Pratimarsha-nasya].
64) Daruharidra (Daru-haridra):
Daruharidra, or Berberis aristata, is an ingredient in Kalyanaka Ghrita. Its anti-inflammatory and detoxifying properties make it useful in treating symptoms associated with Madatyaya, like liver dysfunction [see source text or glossary: Daruharidra].
65) Meditation:
Meditation was part of the supplementary treatment for alcohol addiction in the control group. It helps in calming the mind and reducing psychological symptoms like anxiety and depression in Madatyaya [see source text or glossary: Meditation].
66) Kaphaghna (Kapha-ghna):
Kaphaghna refers to qualities or actions that reduce Kapha dosha. Ingredients like Pippali in Mrudvikadi Kashaya have Kaphaghna properties, helping to alleviate symptoms like Gaurava (heaviness) associated with excess Kapha in Madatyaya [see source text or glossary: Kaphaghna].
67) Vyavahara:
Vyavahara Ayurveda is a branch of Ayurveda dealing with jurisprudence and psychology. The study authors frequently referenced this specialization for insights into managing the psychological symptoms of Madatyaya [see source text or glossary: Vyavahara].
68) Manjishtha (Manjistha, Mamjishtha):
Manjistha, or Rubia cordifolia, is an ingredient in Kalyanaka Ghrita known for its blood-purifying and anti-inflammatory properties. It helps in detoxifying the liver and alleviating symptoms of Madatyaya [see source text or glossary: Manjistha].
[Note: The above list is limited to 75. Total glossary definitions available: 151]