Healing potential of Caralluma attenuata extract on diabetic ulcers
Journal name: Ancient Science of Life
Original article title: Ulcer healing potential of ethanolic extract of Caralluma attenuata on experimental diabetic rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Sunil Garg, Sajal Srivastava, Kisanpal Singh, Alok Sharma, Kavita Garg
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Ulcer healing potential of ethanolic extract of Caralluma attenuata on experimental diabetic rats
Year: 2016
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Diabetes mellitus (DM) is known to increase the risk and severity of gastric ulcers, necessitating effective treatment strategies for diabetic patients. The study focuses on the ulcer-healing properties of the ethanolic extract of Caralluma attenuata (CAEt) in experimental rats with aspirin-induced gastric ulcers and streptozotocin-induced DM. Given the compromised mucosal defenses in diabetic conditions, the research aimed to examine whether CAEt could enhance healing and alleviate ulceration in this vulnerable population.
Antioxidant Properties and Ulcer Healing
One of the critical findings of the study is that CAEt significantly decreases the ulcer index in diabetic rats, demonstrating its potential as an effective antiulcer agent. The results indicated that the administration of CAEt at doses of 100 mg/kg and 250 mg/kg notably reduced the ulcer index when compared to diabetic control, with the higher dose showing results comparable to the standard antiulcer medication omeprazole. Furthermore, CAEt exhibited remarkable antioxidant properties, enhancing the activity levels of superoxide dismutase and catalase while decreasing lipid peroxidation in the gastric mucosa of diabetic rats. This reinforces the idea that the protective effects of CAEt against ulceration may stem from its ability to combat oxidative stress and restore mucosal integrity.
Conclusion
The study concluded that Caralluma attenuata ethanol extract could be a promising treatment for aspirin-induced gastric ulcers in diabetic rats, primarily due to its antioxidant effects and restoration of mucosal defenses. The findings support the potential utilization of CAEt in developing novel therapeutic options for mitigating gastric ulcers in diabetic patients and suggest that further research may lead to identifying specific active compounds within CAEt that could enhance ulcer healing more effectively.
FAQ section (important questions/answers):
What was the aim of the study on Caralluma attenuata?
The study aimed to assess the ulcer healing potential of the ethanolic extract of Caralluma attenuata in experimental diabetic rats, evaluating its effectiveness against gastric ulcers induced by aspirin.
How was diabetes induced in the experimental rats?
Diabetes was induced in albino rats by injecting streptozotocin in citrate buffer, with effectiveness confirmed by measuring fasting blood glucose levels 72 hours post-injection.
What were the key findings regarding ulcer healing?
The results indicated that Caralluma attenuata significantly reduced the ulcer index in diabetic rats, demonstrating its potential as an effective antiulcer agent compared to standard drugs like omeprazole.
What implications do the findings have for diabetic ulcer treatment?
The findings suggest that Caralluma attenuata may provide a novel treatment option for gastric ulcers in diabetic patients due to its antioxidant properties and ability to enhance mucosal defenses.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Healing potential of Caralluma attenuata extract on diabetic ulcers”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ulcer:
Ulcer refers to a lesion on the skin or mucous membrane, characterized by the loss of tissue. In the context of this study, gastric ulcers, particularly in diabetic rats, are the focus, particularly how the ethanolic extract of Caralluma attenuata may aid in healing these ulcers.
2) Activity:
Activity in this context refers to the biological effects and potential therapeutic benefits of the ethanolic extract of Caralluma attenuata. The study specifically examines its antiulcer and antidiabetic activities, highlighting how it aids in healing gastric ulcers and regulating blood glucose levels in experimental models.
3) Blood:
Blood is the bodily fluid that circulates through the heart, arteries, and veins, carrying oxygen and nutrients to tissues and removing waste products. In this study, the focus is on blood glucose levels in diabetic rats, assessing the efficacy of Caralluma attenuata in regulating these levels.
4) Drug:
A drug is a chemical substance utilized in the diagnosis, treatment, or prevention of disease. Within this research, drugs like omeprazole and tolbutamide are used as positive controls to compare their effects with those of Caralluma attenuata on gastric ulcers and blood glucose management.
5) Sharman (Sarma, Sharma, Sarman):
Sharma refers to Alok Sharma, one of the authors and contributors to this study. The presence of multiple authors denotes collaborative research efforts in pharmacology, emphasizing the collective expertise in exploring the therapeutic potential of herbal extracts like Caralluma attenuata in managing diabetes and gastric ulcers.
6) Water:
Water, the essential solvent of life, is crucial for all biological processes. In this study, it is implicitly relevant as the animals were given free access to water and were kept overnight fasting to prepare for experimental assessments, impacting results in dehydration and hydration levels.
7) Inflammation:
Inflammation is the body's immune response to injury or infection, often causing redness, heat, swelling, and pain. In this study, chronic inflammation associated with diabetes significantly affects the healing of gastric ulcers, making it essential to explore anti-inflammatory properties of Caralluma attenuata for therapeutic applications.
8) Discussion:
Discussion refers to the section of the study where findings are interpreted and contextualized within existing literature. It allows researchers to analyze results, understand mechanisms, and suggest future directions for research concerning the efficacy of Caralluma attenuata in treating diabetic ulcers and antioxidant mechanisms.
9) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world. This research epitomizes the scientific inquiry into the medicinal benefits of Caralluma attenuata, contributing to the pharmacological understanding of herbal extracts in treating conditions like diabetes and gastric ulcers.