Karamardādi Yoga vs. diclofenac for post-op pain: A trial

| Posted in: Scientific

Journal name: Ancient Science of Life
Original article title: Effect of Karamardādi Yoga versus diclofenac sodium in post-operative pain management: A randomized comparative clinical trial
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.

Summary of article contents:

Introduction

Post-operative pain is an unavoidable physiological response resulting from tissue trauma, typically managed with analgesics like Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and opioids, which may have side effects. The study explores the efficacy of Karamardādi Yoga, an Ayurvedic remedy known for its analgesic properties, in comparison to Diclofenac sodium, a conventional NSAID, in managing pain after hemorrhoidectomy procedures. The aim was to assess the comparative impact of these two treatments on post-operative pain relief and associated side effects.

Efficacy of Karamardādi Yoga

The study incorporated a randomized clinical trial design involving 60 patients undergoing hemorrhoidectomy. Participants were divided into two groups: one receiving Diclofenac sodium and the other receiving Karamardādi Yoga. Pain levels were assessed using the Visual Analog Scale (VAS) at regular intervals post-surgery. Results indicated that although Karamardādi Yoga displayed analgesic properties, its effectiveness in pain management was inferior to that of Diclofenac sodium. Patients in the Karamardādi Yoga group required rescue analgesics approximately three times more frequently than those in the control group, emphasizing the need for further exploration into enhancing the potency of this Ayurvedic formulation.

Conclusion

Karamardādi Yoga demonstrates analgesic effects without significant toxicities or undesirable side effects, making it a potential supplementary treatment in pain management. However, its analgesic capacity is less potent than that of Diclofenac sodium when used alone, indicating that it may not sufficiently control post-operative pain without additional support. This study underscores the importance of characterizing the specific compounds responsible for the analgesic properties in Karamardādi Yoga, which could lead to the development of a more potent alternative for managing post-operative pain in clinical settings.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Rahul Hegana, Hemant Devaraj Toshikhane, Sangeeta Toshikhane, Hetal Amin


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Effect of Karamardādi Yoga versus diclofenac sodium in post-operative pain management: A randomized comparative clinical trial

Year: 2016

Copyright (license): CC BY-NC-SA


FAQ section (important questions/answers):

What is the purpose of the study on Karamardādi Yoga?

The study aimed to compare the effectiveness of Karamardādi Yoga and Diclofenac sodium in managing post-operative pain, particularly following hemorrhoidectomy procedures under local anesthesia.

What were the main criteria for assessing pain relief?

Pain relief was assessed using the Visual Analog Scale (VAS), alongside monitoring vital signs, the requirement for rescue analgesics, and any undesirable side effects experienced by patients.

What were the findings regarding Karamardādi Yoga's effectiveness?

Karamardādi Yoga demonstrated analgesic properties but was less effective than Diclofenac sodium. Patients in the Karamardādi group required more rescue analgesics, indicating higher pain levels than those in the control group.

Did Karamardādi Yoga cause any serious side effects in patients?

The study found that Karamardādi Yoga did not produce any serious or undesirable side effects in patients, suggesting it may be a safer alternative for pain management in this context.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Karamardādi Yoga vs. diclofenac for post-op pain: A trial”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Post:
Post refers to the period following a surgical procedure. In this context, it highlights the significance of managing 'post-operative pain,' which is crucial for recovery. Effective pain relief can enhance the patient’s experience, facilitate faster healing, and reduce complications associated with inadequate pain management.

2) Drug:
A drug is a substance used for medical treatment, particularly in alleviating pain. In this research, Diclofenac sodium and Karamardādi Yoga are highlighted. The comparison illustrates the efficacy and safety of these compounds in post-operative care, underscoring the importance of selecting appropriate analgesics for patients.

3) Yoga:
Yoga is a term here used to refer to a specific Ayurvedic formulation, Karamardādi Yoga, which is employed for its alleged analgesic properties. It plays a vital role in traditional medicine, contributing to pain management, and embodies the holistic approach of combining different natural ingredients for therapeutic effects.

4) Ayurveda (Ayus-veda):
Ayurveda, a traditional Indian system of medicine, emphasizes balance in the body and mind. It incorporates natural substances and therapeutic practices for healing. This context highlights its relevance in pain management, presenting Karamardādi Yoga as an alternative to contemporary pharmaceutical options like NSAIDs.

5) Karamarda (Kara-amarda, Kara-marda):
Karamarda, also known as Carissa carandas, is a plant whose unripe fruit is utilized in Ayurvedic medicine for its pain-relieving properties. Its inclusion in Karamardādi Yoga enhances the formulation’s analgesic potential, making it pertinent in exploring non-conventional pain management options in post-operative care.

6) Kanji (Kamji):
Kāñji is a sour gruel made from fermented rice, used in Ayurvedic preparations. It acts as a medium for enhancing the properties of the other components in Karamardādi Yoga. The fermentation process is believed to augment the therapeutic benefits of the herbs combined with it.

7) Jati (Jatin):
Jāti refers to the plant Jasmine (Jasminum officinale). In traditional medicine, it is valued for its healing qualities, including its role in alleviating pain. Understanding the role of Jāti in Karamardādi Yoga illustrates how specific plants contribute to the formulation's overall efficacy.

8) Water:
Water is a fundamental solvent in medicinal formulations, facilitating the ingestion and absorption of active substances. Its inclusion in the preparation of Karamardādi Yoga aids in the extraction and enhancement of the medicinal properties of its herbal components, making it essential for consumption.

9) Vatahara (Vata-ahara):
Vātahara discusses the classification of herbal substances that mitigate 'vāta' imbalances in Ayurvedic medicine, which are believed to contribute to pain. Karamardādi Yoga's vātahara properties underline its role in alleviating pain by addressing the root cause of discomfort as per Ayurvedic principles.

10) Curna:
Cūrṇa signifies powdered herb preparations in Ayurveda. The usage of cūrṇa in Karamardādi Yoga refers to the powdered form of Karamarda and Jāti, emphasizing the Ayurvedic process of preparing medicines that enhance bioavailability and efficacy when consumed, particularly in pain relief scenarios.

11) Blood:
In medical contexts, blood circulation plays a vital role in healing and response to pain. The study investigates the effect of Karamardādi Yoga on vital parameters, including blood pressure, reinforcing the importance of monitoring cardiovascular stability while treating post-operative pain.

12) Shalyatantra (Salyatantra, Shalya-tantra, Shalyatamtra):
Shalyatantra is an Ayurvedic branch focusing on surgical procedures and the management of surgical conditions. Its relevance in this study lies in bridging traditional surgical practices with modern research methodologies, demonstrating how ancient sciences can inform contemporary medical practices, particularly in pain management.

13) Bhavana (Bha-vana):
Bhāvanā refers to a traditional Ayurvedic process involving the treatment of herbal powders with a liquid medium to enhance their therapeutic effects. In preparing Karamardādi Yoga, bhāvanā with kāñji indicates the cultural practices aimed at maximizing the effectiveness of medications through specific preparation techniques.

14) Shulaprashamana (Sulaprasamana, Shula-prashamana):
Śūlapraśamana describes substances that relieve pain or discomfort. This term emphasizes the goal of Karamardādi Yoga, which is to act as a pain reliever. Understanding its properties is crucial in the quest for effective alternative therapies alongside conventional drugs in post-operative care.

15) Siddhanta (Siddha-anta, Siddhamta):
Siddhanta denotes the principles or doctrines in Ayurveda upon which treatments are based. These guidelines help justify the use of Karamardādi Yoga and provide a framework within which practitioners understand and apply traditional treatments for pain management, emphasizing a systematic approach to healing.

16) Pancanga (Pancan-anga, Panca-anga, Pamcamga):
Pañcāṅga translates to the five parts of a plant or herbal medicine utilized in Ayurveda, enhancing their therapeutic effects. In Karamardādi Yoga, the concept of pañcāṅga reinforces the idea of utilizing multiple components to achieve comprehensive medicinal benefits, especially in pain alleviation.

17) Samhita:
Samhita refers to classic Ayurvedic texts that compile medical knowledge and formulate treatment protocols. Its relevance in this study is crucial, as it provides foundational knowledge for understanding the use of traditional formulations like Karamardādi Yoga in modern medical research, especially regarding analgesics.

18) Dravya:
Dravya means substance or material in Ayurvedic terminology. It encompasses the herbs or ingredients used in formulations like Karamardādi Yoga. Understanding dravya is vital for comprehending drug properties, dosages, and effects in the context of treatment, particularly for pain relief.

19) Vaidya:
Vaidya is the term for Ayurvedic physicians. Their expertise is pivotal in utilizing traditional medicines and assessing their effectiveness. This study reflects the integration of their knowledge with clinical research, showcasing the potential of Ayurvedic treatments like Karamardādi Yoga in contemporary medical practices.

20) Shri (Sri, Sr):
Shri is an honorific prefix used in Indian culture that denotes respect or auspiciousness. In this context, it reflects the reverence associated with traditional practices and institutions, emphasizing the cultural significance of Ayurvedic medicine and its formulations in health care.

21) Vata:
Vāta represents one of the three doshas in Ayurveda, associated with movement and physiological processes. It is believed that an imbalance in vāta may lead to pain and discomfort. Understanding vāta’s role reinforces the rationale behind using Karamardādi Yoga for pain management.

22) Gana:
Gaṇa refers to a group or category of items, especially in the context of herbs or effective treatments in Ayurveda. Recognizing gaṇa is important for categorizing the efficacy and characteristics of various plants or substances for therapeutic purposes, particularly in pain relief formulations.

23) Sour gruel:
Sour gruel typically refers to a fermented food product that has been traditionally used in various cultures. In Ayurveda, it serves as a vehicle for delivering medicinal properties of herbs, enhancing efficacy in formulations like Karamardādi Yoga, pinpointing the importance of fermentation.

24) Vedanasthapana (Vedana-sthapana):
Vedanāsthāpana denotes pain relief in Ayurveda. The term encapsulates the aim of Karamardādi Yoga to alleviate pain, highlighting the significance of traditional methods of managing physical discomfort in patients undergoing surgery and its relevance in holistic health practices.

25) Pharmacology:
Pharmacology is the study of drugs, their actions, and effects. Understanding pharmacology is essential to evaluate the efficacy and safety of substances like Karamardādi Yoga, allowing integration of historical knowledge with scientific evidence to demonstrate their potential in modern medical practices.

26) Tridoshahara (Tridosahara, Tridosha-hara):
Tridoṣahara refers to substances that balance the three doshas in Ayurveda: vāta, pitta, and kapha. This concept illustrates the holistic nature of Ayurvedic medicine, where a formulation like Karamardādi Yoga aims to alleviate pain while restoring overall balance in the body.

27) Perception:
Perception, in the context of pain management, relates to how individuals experience and interpret pain. Understanding this concept helps in evaluating the subjective experiences of patients receiving Karamardādi Yoga versus a standard drug like Diclofenac sodium, assessing the effectiveness in altering pain perception.

28) Discussion:
Discussion refers to the evaluative analysis of study results. This section synthesizes findings on the effectiveness of Karamardādi Yoga compared to Diclofenac sodium, allowing for critical assessment and reflection on the implications of the research for both traditional and modern medicinal approaches to pain management.

29) Irritation:
Irritation refers to a state of discomfort that can signify underlying pain or emotional distress. Recognizing its association with physical ailments is crucial for devising holistic treatments like Karamardādi Yoga that address both physical symptoms and emotional well-being in patients post-surgery.

30) Depression:
Depression is a major mental health concern that may accompany pain conditions. Acknowledging its relationship with post-operative recovery reinforces the need for comprehensive pain management strategies that incorporate physical and psychological aspects, as seen in traditional practices like Karamardādi Yoga.

31) Shothahara (Sothahara, Shotha-hara):
Śothahara signifies treatment targeted at reducing inflammation and swelling in Ayurvedic medicine. This aspect is critical in managing post-surgical pain where both pain relief and reduction of swelling are desired outcomes, highlighting Karamardādi Yoga's multifaceted therapeutic approach in patient care.

32) Vitiation (Vitiated):
Vitiation refers to the disturbance of balance among the doshas in Ayurveda. Understanding vitiation is critical in diagnosing and treating pain conditions; Karamardādi Yoga aims to restore balance and alleviate pain by addressing the root cause embedded in this concept.

33) Prabhava:
Prabhāva refers to the specific effects or powers of a drug in the Ayurvedic context. Identifying prabhāva is essential for understanding how Karamardādi Yoga achieves its therapeutic action, allowing for improved formulations in alleviating pain and enhancing patient outcomes.

34) Sandhana (Samdhana):
Sandhāna refers to a method of preparation, particularly with respect to herbal formulations. This concept is crucial in Ayurveda for ensuring the efficacy and safety of treatments, emphasizing the need for traditional knowledge in crafting effective formulations like Karamardādi Yoga.

35) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing disease. In this context, it highlights the significance of integrating traditional and modern approaches in developing effective treatments for pain management, as demonstrated in the application of Karamardādi Yoga.

36) Vomiting:
Vomiting is a common physical response that may occur due to various ailments, including postoperative recovery. Recognizing its potential causes in patients receiving treatments highlights the importance of comprehensive care strategies that address potential side effects of pain management options, including Karamardādi Yoga.

37) Swelling:
Swelling is an inflammation response, often accompanying pain, especially post-surgery. Managing swelling is crucial for recovery, where formulations like Karamardādi Yoga aim to alleviate pain and reduce inflammation, underlining its dual purpose in enhancing patient health outcomes.

38) Kalpana:
Kalpanā refers to the conception or formulation of medicinal substances in Ayurveda. This notion is central to the development of Karamardādi Yoga, showcasing the intricate processes involved in preparing effective traditional medicines for ailments like pain, enhancing the understanding of its formulation.

39) Habitat:
Habitat indicates the natural environment where plants grow. Understanding the habitat of medicinal plants utilized in Karamardādi Yoga is essential for ensuring quality and potency, supporting sustainable practices in sourcing ingredients for traditional medicines and preserving biodiversity.

40) Science (Scientific):
Science refers to the systematic study of the physical and natural world through observation and experimentation. This context emphasizes the need for evidence-based approaches in evaluating traditional medicines like Karamardādi Yoga, promoting a dialogue between scientific research and classical Ayurvedic practices.

41) Vipaka:
Vipāka signifies the post-digestion effect of a substance in Ayurveda. Understanding vipāka is important for determining how Karamardādi Yoga interacts with the body after its consumption, influencing its pain-relieving efficacy and ensuring that therapeutic benefits align with Ayurvedic principles.

42) Nausea:
Nausea is a feeling of discomfort that often precedes vomiting. In the context of post-operative recovery, it serves as an important symptom to monitor. Consideration of nausea is significant in assessing patient outcomes for those receiving pain management interventions, like Karamardādi Yoga.

43) Danta (Damta):
Danta signifies teeth in Ayurveda. This term may underscore the relevance of dental health in the broader spectrum of pain management and the potential applications of Karamardādi Yoga in treating or alleviating pain related to dental issues as informed by Ayurvedic literature.

44) Mukha:
Mukha means mouth in Sanskrit. Its relevance in Ayurveda embodies the connection between oral health, digestion, and overall well-being. Understanding this connection helps practitioners consider holistic approaches in treating pain, especially in formulations like Karamardādi Yoga, which can aid oral ailments.

45) Virya:
Vīrya denotes the potency or strength of a substance in Ayurveda. Understanding vīrya is essential for evaluating how effective Karamardādi Yoga is in alleviating pain, providing insights into the balance of ingredients that contribute to its overall efficacy in post-operative treatment strategies.

46) Shiras (Siras, Siro, Shirash):
Śiras means head in Ayurveda. The significance of this term relates to understanding various pain types and their anatomical origins, emphasizing the need for specific formulations like Karamardādi Yoga to effectively address head-related ailments or discomfort, aligning treatment with Ayurvedic principles.

47) Rasa (Rasha):
Rasa signifies taste or essence in Ayurveda. Acknowledging rasa is pivotal in formulating Karamardādi Yoga, as it encompasses the medicinal properties derived from the taste profile of its ingredients, influencing their therapeutic actions and patient acceptance during treatment.

48) Sira (Shira):
Śira refers to the upper part of the neck or head. This anatomical context emphasizes the exploration of pain management pertaining to these regions, underlining the applicability of Karamardādi Yoga in alleviating pain associated with conditions involving the head or neck.

49) Rice (Rce):
Rice, particularly in the form of kāñji, serves as a fermentation base for herbal preparations in Ayurveda. It plays an essential role in the preparation of Karamardādi Yoga, highlighting the ancient practice of combining staple foods with medicinal herbs to enhance therapeutic effects.

50) Sour:
Sour taste, often linked to the presence of acids, is an important aspect in Ayurvedic formulations. It enhances digestive processes and may signify the presence of medicinal properties in substances like kāñji, reinforcing its role in preparations like Karamardādi Yoga aimed at pain relief.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Consider supporting this website: