Quality control parameters for Tamra (copper) Bhasma

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Journal name: Ancient Science of Life
Original article title: Quality control parameters for Tamra (copper) Bhasma
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Chandrashekhar Yuvaraj Jagtap, Pradeepkumar Prajapati, Biswajyoti Patgiri, Vinay J. Shukla


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Quality control parameters for Tamra (copper) Bhasma

Year: 2012

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study focuses on establishing quality control parameters for Tamra Bhasma (copper Bhasma), a significant component in Ayurvedic medicine known for its therapeutic properties. The rising demand for Ayurvedic preparations has led to concerns about the standardization and quality of these products, as the preparation of metallic Bhasmas is a complex and time-consuming process that requires precise methodologies. With advancements in analytical techniques, the study aims to combine classical Ayurvedic tests with modern scientific methods to ensure the efficacy and safety of Tamra Bhasma.

Quality Control Parameters: A Comprehensive Approach

One of the central aspects of the research is the application of classical Ayurvedic tests alongside advanced analytical methods such as scanning electron microscopy (SEM) and inductively coupled plasma atomic emission spectrometry (ICP-AES). The study details the preparation of Tamra Bhasma from high-purity copper wire, emphasizing the importance of purification processes to eliminate impurities. An analysis of the final product revealed a particle size distribution indicating that the majority of the material consists of particles much smaller than 2 μm, which supports better bioavailability. Additionally, elemental analysis showed the presence of approximately 56.24 wt % copper and 23.06 wt % sulfur, further confirming the therapeutic potential of the Bhasma. The methods employed for testing not only verify the classical parameters but also provide a scientific basis for establishing quality standards.

Conclusion

In conclusion, the research establishes robust quality control parameters for Tamra Bhasma, demonstrating a successful integration of traditional Ayurvedic practices with modern analytical techniques. The findings suggest that Tamra Bhasma not only complies with classical tests but also possesses characteristics that enhance its effectiveness as a therapeutic agent. The study underscores the necessity of standardizing Ayurvedic formulations to ensure safety and efficacy, ultimately contributing to the growing field of Ayurvedic pharmaceuticals and their acceptance in modern healthcare.

FAQ section (important questions/answers):

What is the significance of Tamra Bhasma in Ayurveda?

Tamra Bhasma is an Ayurvedic preparation of copper used for treating various diseases. Its properties include purgative, rejuvenator, and wound healing, making it valuable in Ayurvedic formulations for ailments like peptic ulcers and skin disorders.

What processes are involved in the preparation of Tamra Bhasma?

The preparation of Tamra Bhasma involves several classical procedures including Shodhana (purification), Marana (calcination), and Amritikarana (final refinement), ensuring the quality and efficacy of the final product through specific heating cycles and other traditional methods.

How was the quality of Tamra Bhasma assessed in the study?

Quality control parameters for Tamra Bhasma were established using classical Ayurvedic tests and advanced analytical techniques. Methods included particle size distribution analysis, scanning electron microscopy, and inductive coupled plasma spectrometry to analyze composition and properties.

What were the findings regarding the composition of Tamra Bhasma?

The analysis showed Tamra Bhasma contained approximately 56.42% copper and 23.06% sulfur, confirming its composition as primarily cupric sulfide. The absence of heavy metals such as cadmium and selenium highlighted its safety for consumption.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Quality control parameters for Tamra (copper) Bhasma”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Bhasma (Bhasman):
Bhasma refers to a specific type of Ayurvedic preparation of metals and minerals that are processed in a particular manner to transform them into a fine powder or ash-like form. Bhasma is known for its therapeutic benefits in Ayurvedic medicines, where it enhances bioavailability and potency, making it a critical component in Ayurvedic formulations and treatments.

2) Tamra:
Tamra is the Sanskrit word for copper, a metal used in traditional Ayurvedic practices. Tamra is processed into Tamra Bhasma, where it undergoes various purification and transformation techniques to be used as a therapeutic agent, illustrating its importance in Ayurvedic medicines.

3) Tamrabhasma (Tamra-bhasma):
Tamra Bhasma represents the processed form of copper in Ayurvedic medicine, where copper is subjected to traditional methods of purification and incineration to produce a potent therapeutic ash. The significance of Tamra Bhasma lies in its health benefits and its application in treating various disorders, showcasing the ancient practices of Ayurveda in melding materials for medicinal uses.

4) Quality:
Quality in the context of Bhasma refers to the standards and parameters established to ensure its efficacy and safety for medicinal use. The quality control measures for Tamra Bhasma are crucial for ensuring that the final product meets the classical Ayurvedic standards of potency and safe consumption, reflecting the meticulous processes involved in Ayurvedic preparations.

5) Puta:
Puta refers to the series of heating processes applied to the raw materials during the preparation of Bhasma. Each Puta is a specific heating stage that contributes to the transformation of a material’s physical and chemical properties, essential for developing effective Ayurvedic medicines, especially in the formulation of Tamra Bhasma.

6) Shodhana (Sodhana):
Shodhana is a purification process used in Ayurveda to detoxify and prepare raw materials before their use in formulations like Tamra Bhasma. It is a critical step that ensures the elimination of impurities, thereby ensuring that the final product is safe and effective for medicinal use, emphasizing the importance of proper preparation in Ayurvedic practices.

7) Pariksha (Pariksa):
Pariksha means examination or testing in Sanskrit and is a vital concept in Ayurveda that refers to the evaluation of Bhasma to determine its quality and efficacy. Proper Pariksha ensures that the prepared Tamra Bhasma complies with the classical standards and is suitable for therapeutic use, demonstrating the systematic approach of Ayurvedic practitioners.

8) Drug:
In Ayurveda, a drug can refer to herbal formulations or processed minerals like Tamra Bhasma that are used for therapeutic benefits. The effective formulation and quality of drugs are crucial for achieving the desired health outcomes, emphasizing the role of scientific processes and traditional knowledge in developing effective treatments.

9) Rasashastra (Rasa-shastra, Rasasastra):
Rasashastra is an ancient Indian science focused on the study of metals and minerals used in Ayurvedic medicine. It encompasses techniques for preparation, processing, and examination of medicinal substances like Tamra Bhasma, illustrating the intricate knowledge and skills involved in crafting effective remedies within the Ayurvedic tradition.

10) Dadhi:
Dadhi, or curd, is used in the final testing of Bhasma, specifically in the Dadhi Pariksha, to check the quality and safety of Tamra Bhasma. An effective Bhasma should not alter the appearance of curd during this test, showing its transformation into a harmless and therapeutic form, reflecting the ancient scientific methods employed in Ayurveda.

11) Curd:
Curd, referred to as Dadhi in Ayurveda, serves as a medium for the Dadhi Pariksha, a test to evaluate the quality of prepared Bhasma. The interaction between Tamra Bhasma and curd during this test is crucial in affirming its safety and effectiveness for therapeutic uses, demonstrating the importance of traditional testing methods in Ayurvedic formulations.

12) Bhaishajya (Bhaisajya):
Bhaishajya means medicine in Sanskrit and is a cornerstone concept in Ayurveda that signifies the practice of preparing medicinal forms, including Bhasma preparations like Tamra Bhasma. The development of Bhaishajya involves meticulous scientific techniques and adherence to traditional standards, emphasizing the blend of art and science in Ayurveda.

13) Gandhaka (Gamdhaka):
Gandhaka is purified sulfur used in the preparation of Tamra Bhasma, where it acts as a critical ingredient during the Puta process. Its role in the preparation is significant as it helps transform the properties of copper into a therapeutic form, demonstrating the collaborative effect of various materials in Rasashastra practices.

14) Kalpana:
Kalpana refers to the method of preparation in Ayurvedic medicine. In the context of Tamra Bhasma, Kalpana encompasses the various processes such as Shodhana, Marana, and Amritikarana used to produce a safe and effective final product, underscoring the systematic approach followed in traditional medication preparation.

15) Shukla (Sukla):
Shukla, likely referring to Vinay J. Shukla, one of the authors of the study on Tamra Bhasma. The contributions of specific researchers like Shukla are essential in advancing the understanding of Ayurvedic formulations through scientific investigation and analysis, bridging ancient wisdom and modern techniques in quality control practices.

16) Visheshashodhana (Visesasodhana, Vishesha-shodhana):
Vishesha Shodhana is a specialized purification process distinct from Samanya Shodhana, used to prepare materials like Tamra better. It involves more rigorous detoxification methods ensuring that raw materials are adequately purified, which directly influences the quality and efficacy of the final Bhasma product in Ayurveda.

17) Shuddhagandhaka (Suddhagandhaka, Shuddha-gandhaka):
Shuddha Gandhaka, or purified sulfur, is essential in the preparation of Tamra Bhasma, serving as a crucial component during the Puta stages. Ensuring the purity and quality of Shuddha Gandhaka is vital in achieving the desired therapeutic effects of the final product, indicating the importance of raw material integrity in Ayurvedic practices.

18) Vishesha (Visesa):
Vishesha is an adjective indicating special or specific characteristics, often associated with processes in Ayurveda like Vishesha Shodhana. It signifies the need for specialized techniques or conditions to enhance the purification and effectiveness of Bhasma preparations such as Tamra Bhasma, indicating the nuanced understanding required in this traditional practice.

19) Samanya:
Samanya refers to general or common, particularly in the context of Samanya Shodhana, a general purification process applied to raw materials like copper in Tamra Bhasma preparation. This initial step is crucial to eliminate basic impurities, setting the foundation for subsequent specialized processes necessary for developing effective Ayurvedic drugs.

20) Vomiting:
Vomiting is a common adverse effect associated with improperly prepared Bhasma, indicating the significance of quality control in the production of Tamra Bhasma. Ensuring that the Bhasma does not instigate symptoms such as vomiting underlines the importance of strict adherence to preparation protocols in achieving safe medicinal products.

21) Marana:
Marana refers to the incineration or calcination phase in the preparation of Bhasma, including Tamra Bhasma. This crucial step transforms the raw materials into a finer, medicinal ash, emphasizing the technical expertise involved in Ayurveda for optimizing the therapeutic properties of the final product.

22) Amritikarana (Amrtikarana, Amriti-karana):
Amritikarana is a specific process following the preparation of Bhasma intended to enhance its therapeutic qualities. This final transformation ensures that the Bhasma serves as a safe and effective medicinal form for use in health treatments, demonstrating the complex interactions within Ayurvedic drug preparations.

23) Purification:
Purification in Ayurveda refers to the processes applied to raw materials to eliminate impurities, such as in the Shodhana and Vishesha Shodhana methods for preparing Tamra Bhasma. This is critical for ensuring that the final Bhasma is therapeutically effective and safe for consumption, highlighting the foundational principles underlying Ayurvedic practices.

24) Science (Scientific):
Science refers to the systematic study and application of knowledge, including modern analyses in the field of Ayurveda. The integration of scientific methods in evaluating substances such as Tamra Bhasma illustrates the evolving understanding of traditional practices, benefiting both practitioners and patients.

25) Kajjali:
Kajjali refers to the black sulfide of mercury, a key ingredient used in the preparation of Tamra Bhasma. Its role as a catalyst in the process underscores the importance of using specific materials in Ayurvedic formulations to achieve desired therapeutic outcomes, enhancing the effectiveness of Bhasma preparations.

26) Nausea:
Nausea is a potential side effect of consuming improperly prepared Bhasma, highlighting the critical importance of quality control measures in the preparation of Tamra Bhasma. Understanding the adverse effects related to dosage and preparation methods is essential for ensuring patient safety in Ayurvedic treatments.

27) Shula (Sula):
Shula refers to spasmodic pain or abdominal discomfort that can be treated with remedies involving Tamra Bhasma. Its significance in the context of Ayurvedic treatments illustrates the therapeutic use of various preparations in managing specific health conditions and the holistic approach of Ayurveda to patient care.

28) Blood:
Blood may refer to hematological effects observed with the use of certain Bhasma preparations. Understanding the impact of Tamra Bhasma on blood-related conditions signifies the importance of clinical evaluations in confirming the medicinal benefits and safety of Ayurvedic practices.

29) Burning sensation:
Burning sensation is a symptom that may indicate adverse reactions to improperly prepared Bhasma. Ensuring that Tamra Bhasma adheres to quality standards is crucial to avoid such side effects, reinforcing the emphasis on careful and knowledgeable preparations in Ayurveda.

30) Citrus limon:
Citrus limon, or lemon, plays a vital role in the preparation process of Tamra Bhasma, especially during the Bhavana process where it is used for trituration. The acidic properties of lemon help in enhancing the efficacy of the preparations, illustrating the interconnectedness of plant materials in Ayurvedic formulations.

31) Rasaushadhi (Rasa-aushadhi, Rasausadhi):
Rasaushadhi refers to medicinal substances derived from metals and minerals in Ayurveda, specifically emphasizing preparations like Tamra Bhasma. The field explores how these substances interact within the body, indicating the importance of understanding both traditional wisdom and contemporary scientific validation in their use.

32) Discussion:
Discussion of the results in the context of quality control for Tamra Bhasma highlights the importance of critically evaluating the outcomes of various analytical techniques applied to Ayurvedic preparations. The discourse facilitates the integration of traditional practices with modern scientific understanding, ultimately advancing Ayurvedic medicine.

33) Salivation:
Salivation is an indicator of the physical reaction to potent substances, including improperly prepared Bhasma. The relevance of salivation during testing, particularly in Dadhi Pariksha, underscores the need for thorough quality assessments in determining the safety and effectiveness of Tamra Bhasma.

34) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine that emphasizes holistic health approaches, incorporating various therapies including the use of Bhasmas like Tamra Bhasma. Its foundational principles guide the preparation of medicines and their application in treating diverse health conditions, representing a comprehensive healing tradition.

35) Brimhana (Brmhana):
Brimhana refers to rejuvenating practices within Ayurveda, which can be a characteristic of certain Bhasmas such as Tamra Bhasma. The role of Brimhana emphasizes the restorative effects of these preparations, focusing on enhancing overall health and vitality through medicinal use.

36) Parinama:
Parinama means transformation and is often associated with the changes that occur during the preparation of substances like Tamra Bhasma. Understanding Parinama is crucial in Ayurevda as it explains the efficacy and appropriate applications of Bhasmas in treatments, illustrating the depth of knowledge in ancient practices.

37) Niruttha (Nir-uttha):
Niruttha indicates the ability to overcome challenges, including adverse effects that could arise from using improperly prepared Bhasma. The focus on achieving Niruttha highlights the emphasis on quality and safety in Ayurvedic medicines, ensuring that preparations like Tamra Bhasma are effective and beneficial.

38) Fainting (Fainted):
Fainting can be a result of improper usage of drugs or medications like Bhasma. Monitoring and controlling the quality of Tamra Bhasma is essential in preventing such adverse effects, underlining the importance of traditional and scientific evaluation methods within Ayurveda.

39) Lekhana:
Lekhana indicates a scraping or reducing effect on excessive fat, which may be a therapeutic use of specific Bhasmas. Understanding the role of Tamra Bhasma in promoting Lekhana illustrates its applications in various health conditions, reinforcing the functional benefits of Ayurvedic preparations.

40) Murccha:
Murccha signifies a form of fainting or dizziness potentially caused by improper medication use. The occurrence of Murccha highlights the necessity of rigorous standards in the preparation of Bhasma, including Tamra Bhasma, to prevent adverse reactions and ensure safety in treatments.

41) Bhavana (Bha-vana):
Bhavana refers to the process of trituration used in Ayurveda to enhance the potency of substances such as Tamra Bhasma. This process, which may involve the addition of mediums like lemon juice, is critical for achieving effective herbal and mineral preparations, emphasizing careful technique in Ayurvedic practices.

42) Kushtha (Kustha):
Kushtha refers to a range of skin diseases that may be treatable through Ayurvedic remedies, including formulations like Tamra Bhasma. The relationship between such diseases and the therapeutic application of Bhasma highlights the relevance of Ayurvedic knowledge in addressing complex health conditions.

43) Ropana:
Ropana means healing or wound healing in Ayurveda, often a property attributed to certain Bhasmas like Tamra Bhasma. Recognizing the Ropana effects of such preparations illustrates their therapeutic potential in treating injuries and enhancing healing processes, demonstrating Ayurveda's holistic approach to health.

44) Vaidya:
Vaidya refers to a practitioner of Ayurveda, skilled in the art of healing through herbal and mineral preparations like Tamra Bhasma. The knowledge and expertise of Vaidyas are fundamental in implementing Ayurvedic treatments effectively, ensuring that practices are aligned with traditional wisdom and patient needs.

45) Uttama:
Uttama means the best or superior quality, emphasizing the importance of ensuring that preparations like Tamra Bhasma are of the highest standard for therapeutic use. Striving for Uttama quality reflects the rigorous standards upheld within Ayurvedic practices, fostering trust and efficacy in treatments.

46) Bhrama:
Bhrama signifies a state of confusion or disorientation potentially linked to adverse reactions from improper Bhasma preparations. Monitoring and ensuring the quality of Tamra Bhasma is essential to preventing Bhrama, underlining the importance of safety in Ayurveda treatments.

47) Surana (Shurana):
Surana refers to the specific vessel or container used in the preparation of Bhasma. Understanding the materials and methods associated with Surana highlights the technological aspects of Ayurvedic practices and emphasizes the careful craftsmanship required to ensure the quality of preparations like Tamra Bhasma.

48) Reason:
Reasoning involves the analytical aspect of evaluating the processes and outcomes related to Ayurvedic preparations. Understanding the reasoning behind quality control measures for Tamra Bhasma supports the scientific validation of traditional practices, bridging gaps between ancient knowledge and contemporary research.

49) Aruci:
Aruchi denotes a lack of appetite that may arise from consuming improperly prepared medications, emphasizing the implications of quality in Tamra Bhasma preparation. Monitoring the effects of such preparations on appetite reflects the broader understanding of how Bhasma impacts physiological functions in patients.

50) Caraka:
Saraka refers to purgative properties, often associated with Bhasmas that are designed to facilitate detoxification in the body. The presence of Saraka effects in formulations like Tamra Bhasma illustrates their therapeutic applications in managing various health conditions and promoting overall wellness.

51) Dosha (Dosa):
Dosha refers to the three biological energies (Vata, Pitta, Kapha) recognized in Ayurveda, which govern physiological functions. Understanding the relationship between Dosha imbalances and the therapeutic properties of substances like Tamra Bhasma is fundamental to Ayurveda's holistic approach to patient health, directing treatment strategies accordingly.

52) Pitta:
Pitta is one of the three principal doshas in Ayurveda associated with heat and metabolism, and its balance is crucial for maintaining good health. The role of Tamra Bhasma in addressing Pitta-related disorders highlights the tailored approaches of Ayurveda in managing bodily functions and promoting wellness.

53) Kapha:
Kapha represents the dosha connected with structure and stability, and understanding its influence is vital in Ayurveda for formulating treatments. The utility of Tamra Bhasma in addressing Kapha imbalances showcases the personalized nature of Ayurvedic treatment methodologies, emphasizing the impact of natural substances.

54) Pandu (Pamdu, Pamde):
Pandu refers to a condition commonly known as anemia, for which remedies including Tamra Bhasma can be utilized. Addressing Pandu through Ayurvedic preparations underscores the effectiveness of such treatments in restoring health and vitality to those affected by blood-related disorders.

55) Varna:
Varna denotes the color and appearance of a substance, significant in the evaluation of Bhasma quality. Monitoring Varna, particularly for Tamra Bhasma, ensures that it aligns with classical descriptions, reflecting the attention to detail characteristic of Ayurvedic practices.

56) Glass:
Glass is relevant in terms of storage for Tamra Bhasma to maintain its quality and prevent contamination. Proper containment in glassware indicates the care involved in Ayurvedic preparations, ensuring that the therapeutic properties of Bhasma are preserved until required for use.

57) Water:
Water serves as a fundamental part of many Ayurvedic preparations and processes. Understanding the role of Water in the preparation of Tamra Bhasma, particularly during purification and testing phases, emphasizes the importance of elemental interactions in achieving effective medicinal formulations.

58) Avami:
Avami refers to a term indicating unwanted effects or impurities, particularly as related to improperly prepared Bhasma. Recognizing Avami outcomes underlines the significance of rigorous preparation standards in creating Tamra Bhasma, ensuring a product that supports health instead of causing adverse reactions.

59) Arshas (Arsa, Arsas, Arsha):
Arsha denotes conditions such as hemorrhoids, associated with certain Bhasmas like Tamra Bhasma for treatment. The significance of Bhasmas in managing conditions like Arsha demonstrates the therapeutic breadth of Ayurvedic formulations, highlighting their relevance in modern medicinal practices.

60) Ulcer:
Ulcer represents a type of condition treated in Ayurveda with formulations like Tamra Bhasma. Understanding the application of Bhasmas in addressing Ulcer conditions showcases the intricate relationship between traditional medicine and specific health challenges, emphasizing the healing properties of Ayurvedic treatments.

61) Lemon:
Lemon, or Citrus limon, is utilized in the preparation of Tamra Bhasma for its purifying and enhancing properties. The inclusion of lemon illustrates the synergy between various natural ingredients in Ayurvedic formulations, emphasizing the holistic approach to health and wellness overall.

62) Moha:
Moha refers to delirium or confusion that may arise as a side effect from consuming improperly prepared Tamra Bhasma. Monitoring Moha highlights the necessity of detailed quality assessments in Ayurvedic preparations, ensuring patient safety and the efficacy of treatments against all potential side effects.

63) Daha:
Daha, meaning burning, may be experienced due to reactions to improper Bhasma. It underscores the importance of stringent preparation protocols for Tamra Bhasma to mitigate adverse reactions, reinforcing the principles of safe and effective Ayurvedic practice.

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