Antiurolithiatic activity of coleus Aromaticus Benth. In Rats
Journal name: Ancient Science of Life
Original article title: Antiurolithiatic activity of coleus Aromaticus Benth. In Rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Summary of article contents:
Introduction
Urinary stone disease, a prevalent condition affecting approximately 12% of the population, presents a significant challenge due to its high rate of recurrence, particularly in males. The most common components of these stones are calcium oxalate and magnesium ammonium phosphate. In traditional Indian medicine, the leaves of Coleus aromaticus Benth. are employed for treating urinary stones, although systematic pharmacological studies supporting their use are sparse. This study aimed to assess the efficacy of the water extract of Coleus aromaticus leaves in reducing calcium oxalate stone formation in male albino rats.
Effectiveness of Coleus Aromaticus
The research involved inducing urolithiasis in male Wistar rats by feeding them a diet supplemented with sodium oxalate, followed by administration of the water extract of Coleus aromaticus for a period of 30 days. The results indicated a significant reduction in calcium and oxalate deposition in the kidneys of rats treated with the extract. Specifically, doses of 0.5 g/kg and 1.0 g/kg of the extract demonstrated a decrease in calcium deposition by 23% and 9%, and oxalate deposition by 24% and 28%, respectively, compared to the untreated group. Notably, the extract did not adversely affect phosphates, suggesting that its mechanism of action may involve inhibition of calcium and oxalate absorption in the intestines.
Conclusion
The findings of this study support the traditional use of Coleus aromaticus leaves in Ayurvedic medicine for treating urinary stone disease. The significant reduction of calcium oxalate deposition in the kidneys among the treated rats reinforces the notion that Coleus aromaticus possesses antiurolithiatic properties. This study contributes valuable data to the limited body of pharmacological evidence regarding the therapeutic applications of this plant, suggesting potential implications for its use in human treatments for urinary stones.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
R.B. Ghosh, T.K. Sur, L.N. Maity, S.C Chakraborty
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Antiurolithiatic activity of coleus Aromaticus Benth. In Rats
Year: 2000
Copyright (license): CC BY-NC-SA
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FAQ section (important questions/answers):
What is the purpose of the study on Coleus aromaticus?
The study aimed to assess the antiurolithiatic activity of Coleus aromaticus leaves against calcium oxalate stones in male albino rats, evaluating its potential therapeutic effects in preventing urinary stone formation.
How was urolithiasis induced in the rats?
Urolithiasis was induced by feeding the rats a calculi-producing diet containing 3% sodium oxalate mixed with commercial rat feed for 30 days before starting the treatment with Coleus aromaticus extract.
What were the outcomes of using Coleus aromaticus extracts?
The administration of Coleus aromaticus water extract significantly reduced the deposition of calcium and oxalate in the kidneys of CPD-treated rats, indicating its effectiveness in preventing stone formation.
What dosages of Coleus aromaticus were tested in the study?
The study evaluated two dosages of Coleus aromaticus: 0.5 g/kg and 1.0 g/kg, given orally for 30 days to assess their impact on calcium oxalate deposition in rats.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antiurolithiatic activity of coleus Aromaticus Benth. In Rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Water:
Water is a crucial component in the extraction process of the coleus aromaticus leaves for testing their antiurolithiatic properties. The study used an aqueous extract to assess effectiveness against calcium oxalate stones in rats. Its role emphasizes the importance of fluid in both medicinal applications and metabolic functions in living organisms.
2) Activity:
Activity in this context refers to the biological effect that coleus aromaticus has on combating urolithiasis or kidney stone formation. The extract’s efficacy is measured in terms of its ability to reduce calcium and oxalate deposition in the kidney, thereby reflecting its therapeutic potential in clinical settings.
3) Medicine:
Medicine connects to the holistic approaches in treating health conditions, including the use of traditional herbal remedies like coleus aromaticus. The research contributes to the understanding of potentially effective treatments for urinary stones and highlights the intersection of ancient practices with modern scientific inquiry.
4) Diet:
Diet refers to the specific feeding regimen employed to induce urolithiasis in male Wistar rats using a calculi producing diet mixed with sodium oxalate. This diet is fundamental to the experiment as it establishes the conditions under which the antiurolithiatic properties of coleus aromaticus can be evaluated.
5) Pharmacological:
Pharmacological relates to the study of the biochemical and physiological effects of substances in the body. This research looks into the pharmacological action of coleus aromaticus, contributing valuable insights into its potential mechanisms of action for preventing kidney stone formation through plant-based therapies.
6) Pharmacology:
Pharmacology is the discipline that studies drug action and interaction within biological systems, laying the scientific groundwork for evaluating the effects of coleus aromaticus. The investigation into its properties sheds light on medicinal uses, dosing, and the effects of herbal remedies on human health conditions.
7) Discussion:
Discussion in scientific research encapsulates the analysis and interpretation of results. It evaluates the implications of findings from the antiurolithiatic activities observed, correlating them with existing knowledge and offering insights into potential future research directions and clinical applications for urinary stone treatments.
8) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is an ancient Indian system of medicine advocating the use of natural substances for health benefits. The study highlights the relevance of traditional practices in modern scientific contexts by investigating coleus aromaticus as a remedy for kidney stones, thus bridging both worlds of health care.
9) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. This research exemplifies the scientific method by investigating the antiurolithiatic potential of coleus aromaticus, aiming to validate traditional knowledge with empirical evidence.