Medicinal oleogum resin – guggulu a review

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Journal name: Ancient Science of Life
Original article title: Medicinal oleogum resin – guggulu a review
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.

Summary of article contents:

Introduction

Guggulu, an oleogum resin derived from the bark of the Commiphora wightii tree, is a significant medicinal substance within Ayurveda. This tree, native to the arid regions of Central India, produces a resin through intentional incisions made by local collectors. Guggulu has been recognized for its various health benefits, as noted in classical Ayurvedic texts such as those by Caraka and Susruta. The resin is characterized by its complex composition, including steroids, diterpenoids, and other bioactive compounds, making it versatile in treating various ailments, including arthritis, obesity, and heart diseases.

Pharmacological Significance: Anti-Inflammatory and Hypolipidemic Activities

Guggulu is particularly noted for its potent anti-inflammatory and hypolipidemic properties. Research has demonstrated that its oleoresin is more effective than standard anti-inflammatory drugs like hydrocortisone when tested on induced arthritic models in rats. It also shows significant effects in reducing inflammation and pain in humans suffering from conditions such as rheumatoid arthritis. In addition to its anti-inflammatory benefits, guggulu has been shown to lower serum cholesterol and triglyceride levels, effectively combating hyperlipidemia. Clinical studies support its efficacy in reducing total serum cholesterol and promoting overall cardiovascular health, suggesting a valuable role in managing weight and associated metabolic disorders.

Conclusion

Although guggulu has gained attention primarily for its anti-inflammatory and hypolipidemic effects, the broader pharmacological uses detailed in Ayurvedic literature warrant further investigation. The potential applications of guggulu, along with its traditional uses for a range of health conditions, could lead to new therapeutic avenues. Continued research elucidating its modes of action may enhance its integration into contemporary medicinal practices, thereby bridging Ayurvedic and modern scientific approaches to health care.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

E. Sukumar, K. Balakrishna


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Medicinal oleogum resin – guggulu a review

Year: 1985

Copyright (license): CC BY-NC-SA


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FAQ section (important questions/answers):

What is Guggulu and how is it obtained?

Guggulu is an oleogum resin exuded from the bark of the Commiphora wightii tree. The resin is harvested by making incisions on the trunk and branches, allowing the gum to exude and harden.

What are the main chemical components of Guggulu?

Guggulu contains a complex mixture of steroids, diterpenoids, aliphatic esters, carbohydrates, and amino acids. Specific compounds include guggulsterones and new sterols like guggulsterol-IV and guggulsterol-V.

What are the medicinal uses of Guggulu in Ayurveda?

In Ayurveda, Guggulu is used for heart diseases, obesity, tumors, urinary infections, skin diseases, arthritis, and more, highlighting its diverse utility.

What are the reported pharmacological effects of Guggulu?

Guggulu has demonstrated anti-inflammatory, antiarthritic, and hypolipidaemic activities, as well as potential in reducing cholesterol and aiding in weight loss.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Medicinal oleogum resin – guggulu a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Guggulu:
Guggulu is an oleogum resin derived from the tree Commiphora wightii, noted for its medicinal properties in Ayurveda. It is used to treat various ailments, including inflammation and obesity. The resin is harvested from incisions made on the tree and is rich in bioactive compounds, including steroids and diterpenoids.

2) Activity:
Activity refers to the physiological effects or therapeutic actions of a substance or drug. In the context of guggulu, its activity encompasses various pharmacological effects such as anti-inflammatory, hypolipidemic, and analgesic actions, contributing to its use in treating conditions like arthritis and heart diseases.

3) Drug:
A drug is a chemical substance used for treating, curing, or preventing diseases and medical conditions. Guggulu is classified as a drug in Ayurveda, utilized for its therapeutic effects. It combines multiple phytoconstituents that exert synergistic actions against various health issues.

4) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is an ancient Indian system of medicine emphasizing balance in bodily systems and the use of natural substances. Guggulu is a significant component in Ayurvedic practice, cited extensively in ancient texts for its therapeutic uses, highlighting its value in holistic health approaches.

5) Pharmacological:
Pharmacological pertains to the study of drugs and their effects on living organisms. Guggulu's pharmacological properties include its anti-inflammatory, analgesic, and hypolipidemic actions. Understanding these properties enables clinicians to utilize guggulu effectively in modern therapeutic contexts while adhering to traditional practices.

6) Swelling:
Swelling, a common symptom of inflammation, involves the increase in size of tissues due to fluid accumulation. Guggulu is recognized for its ability to reduce swelling associated with rheumatoid arthritis and other inflammatory conditions, making it an important therapeutic agent in Ayurvedic medicine.

7) Rheumatoid arthritis:
Rheumatoid arthritis is an autoimmune disorder characterized by chronic inflammation of the joints. Guggulu has been studied for its efficacy in managing symptoms of rheumatoid arthritis, including pain and swelling, and its use in traditional medicines reflects its historical value in rheumatology.

8) Simhanada (Siṃhanāda, Simha-nada):
Simhanada is a compound formulation in Ayurveda, often incorporating guggulu. It is reputed for its efficacy in managing various health conditions, particularly inflammatory and joint disorders. The synergistic effects of its ingredients enhance its therapeutic potential, supporting traditional healing practices.

9) Triphala (Triphalā, Tri-phala):
Triphala is a traditional Ayurvedic formulation made from three fruits, valued for its detoxifying and rejuvenating properties. When combined with guggulu, it enhances the latter's therapeutic effects, particularly in digestive health and restoring balance within the body, essential in Ayurvedic medicine.

10) Bhasma (Bhasman):
Bhasma refers to calcined metals and minerals used in Ayurveda, believed to enhance bioavailability and therapeutic effects. The combination of guggulu with bhasma, such as Abhraka-bhasma, aims to increase the potency and effectiveness of treatments, showcasing Ayurvedic principles of synergistic healing.

11) Edema (Oedema):
Oedema is the medical term for swelling caused by fluid accumulation in tissues. Guggulu is heralded for its anti-oedematous properties, helping alleviate conditions associated with excess fluid, thus making it a valuable agent in managing inflammatory disorders in traditional and modern medicine.

12) Ulcer:
Ulcers are sores or lesions that develop on the skin or mucous membranes. Guggulu has traditionally been used in Ayurveda for treating ulcers, leveraging its healing properties to reduce inflammation and promote recovery, an essential aspect of holistic health approaches.

13) Diet:
Diet refers to the types of food consumed and plays a crucial role in health and disease management. In the context of guggulu, dietary recommendations, such as incorporating fiber-rich foods, support its efficacy in treating conditions like obesity and metabolic disorders.

14) Milk:
In Ayurveda, milk is considered a 'sattvic' or purifying food that nourishes the body and aids in digestion. The use of milk with guggulu in formulations emphasizes the synergy of traditional remedies, enhancing their therapeutic effects against various ailments.

15) Commiphora wightii:
Commiphora wightii is the botanical name for the tree from which guggulu is harvested. This plant, essential in Ayurvedic medicine, is renowned for its medicinal oleoresin known for anti-inflammatory and lipid-lowering properties, underscoring its importance in traditional healing practices.

16) Bitter gourd:
Bitter gourd, known for its hypoglycemic properties, is often used in Ayurvedic treatments. When combined with guggulu, it enhances metabolic health, particularly in managing obesity and diabetes, creating a powerful synergistic effect against these prevalent health issues.

17) Commiphora mukul:
Commiphora mukul is a synonym for Commiphora wightii. As a significant source of guggulu, this nomenclature highlights the importance of the plant in traditional medicine, emphasizing its use and recognition in various medicinal contexts and practices.

18) Sushruta-samhita (Suśruta-saṃhitā):
Susruta-samhita is an ancient Ayurvedic text that extensively documents surgical practices and medicinal formulations. Guggulu is mentioned in this treatise, underscoring its historical and medicinal significance in the treatment of various ailments as outlined in classical texts.

19) Abhrakabhasma (Abhraka-bhasma):
Abhraka-bhasma is a traditional Ayurvedic preparation of mica, used to augment health in various formulations. Its combination with guggulu is aimed at enhancing therapeutic outcomes, exemplifying the integrative nature of Ayurvedic remedies and bhasmas in clinical practice.

20) Cikitsasthana (Cikitsāsthāna, Cikitsa-sthana):
Cikitsasthana, a section of the Susruta-samhita, focuses on therapeutic treatments. The mention of guggulu emphasizes its relevance in Ayurvedic healing for various diseases, reinforcing the foundational role of traditional knowledge in the practice of medicine.

21) Pharmacology:
Pharmacology is the science of drugs and their actions on biological systems. The pharmacological studies of guggulu reveal its effectiveness, supporting its traditional use in Ayurveda. Continued research may deepen understanding of its mechanisms and broaden its applications in contemporary medicine.

22) Inflammation:
Inflammation is the body's response to injury, characterized by redness and swelling. Guggulu's potent anti-inflammatory properties make it a valuable treatment in conditions where inflammation plays a central role, like arthritis and skin diseases, promoting healing and symptom relief.

23) Bhallataka (Bhallāṭaka, Bhallātaka):
Bhallataka, or Semecarpus anacardium, is a traditional Ayurvedic herb known for its therapeutic benefits. Combined with guggulu, it enhances treatment efficacy for conditions like osteoarthritis, showcasing the synergistic properties of Ayurvedic formulations in addressing complex health issues.

24) Irritation:
Irritation refers to an uncomfortable inflammatory response in tissues. Guggulu’s pharmacological actions help alleviate irritation experienced in conditions like arthritis, reinforcing its therapeutic value and relevance in managing inflammatory diseases within Ayurvedic medicine.

25) Punarnava (Punarnavā, Punarṇava, Punar-nava):
Punarnava, or Boerhavia diffusa, is an important herb in Ayurvedic medicine recognized for its diuretic and rejuvenating properties. Its combination with guggulu amplifies the latter's efficacy in treating urinary disorders and promoting overall health, illustrating Ayurvedic principles of synergy.

26) Picchila (Picchilā):
Picchila denotes a sticky or viscous property. Guggulu's picchila characteristic enhances its action in treating certain conditions in Ayurveda, facilitating its absorption and efficacy in alleviating ailments related to inflammation and excess bodily humors.

27) Toxicity:
Toxicity refers to the degree to which a substance can adversely affect an organism. Guggulu is noted for its low toxicity profile, making it a safe option for prolonged use in various treatments, underscoring the importance of safety in Ayurvedic medicine.

28) Nirgundi (Nirguṇḍī, Nirgumdi):
Nirgundi, or Vitex negundo, is an Ayurvedic herb known for its anti-inflammatory and analgesic properties. Its combination with guggulu enhances therapeutic outcomes in conditions like sciatica and arthritis, reflecting the holistic approach of Ayurveda to address complex health challenges.

29) Medicine:
Medicine encompasses practices for diagnosing, treating, and preventing diseases. Guggulu is a vital component in traditional medicine, especially in Ayurveda, where its diverse pharmacological properties make it crucial in managing various health conditions and promoting overall wellness.

30) Incision:
Incision refers to cutting into a tissue or organ. In the context of guggulu collection, incisions are made on the tree to extract the oleoresin. Understanding this process is essential for sustainable harvesting and preservation of the medicinal properties of guggulu.

31) Samhita (Saṃhitā, Saṃhita):
Samhita denotes a collection of texts in traditional Indian literature and medicine. Guggulu appears in these texts, particularly in Ayurveda, illustrating its foundational role in developing comprehensive medicinal knowledge and practices throughout history.

32) Abhraka:
Abhraka refers to mica used in various Ayurvedic formulations. Combined with guggulu, Abhraka enhances the therapeutic effects of the formulation, demonstrating the importance of minerals and metals in Ayurvedic pharmacotherapy and the complex interactions within herbal remedies.

33) Gokshura (Gokṣura, Go-kshura):
Goksura, or Tribulus terrestris, is another medicinal herb recognized for its benefits in Ayurveda, particularly in urinary and reproductive health. When used alongside guggulu, it enhances the overall efficacy of treatments targeting metabolic disorders and promoting vitality.

34) Vyoshadi (Vyoṣādi):
Vyosadi is a specific Ayurvedic formulation that incorporates guggulu, enhancing its therapeutic potential. Such combinations are designed to optimize treatment effects, emphasizing the holistic and integrative nature of Ayurvedic medicine with carefully crafted formulations for health benefits.

35) Pungent:
Pungent refers to a strong taste or odor. Guggulu’s pungent properties are believed to enhance digestion and metabolism, reflecting Ayurvedic principles where such qualities are considered beneficial for various health conditions and overall digestive health.

36) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions. The study of guggulu exemplifies the intersection of traditional knowledge and modern scientific inquiry, advancing understanding and applications in medicine.

37) Caraka (Cāraka, Cārāka):
Caraka is an ancient Ayurvedic physician and the author of the Caraka Samhita, a key text in Ayurvedic medicine. Guggulu is referenced in his works, underscoring its historical significance and the integration of traditional practices in holistic health.

38) Vaidya:
Vaidya refers to a practitioner of Ayurveda, important in diagnosing and treating ailments using traditional knowledge. Vaidyas utilize guggulu in their practices for its therapeutic benefits, showcasing the practical application of ancient wisdom in health care.

39) Katuki (Kaṭukī):
Katuki, or Picrorhiza kurroa, is valued in Ayurveda for its liver health benefits. When combined with guggulu, Katuki enhances effects on metabolic health, emphasizing the importance of herbal combinations in traditional medicine for treating complex health issues.

40) Shankha (Saṅkha, Śaṅkha, Śaṅkhā, Śāṅkha, Saṃkha, Shamkha, Shamkha, Saṅkhā, Sankha, Samkha, Samkha):
Sankha, or conch shell, is used in Ayurvedic medicine for its health benefits. Incorporating Sankha in formulations with guggulu may enhance the therapeutic effects, reflecting the holistic approach in Ayurveda that emphasizes the use of natural resources for health.

41) Garlic:
Garlic is recognized for its health-promoting properties, including cardiovascular benefits. Comparisons of guggulu's hypolipidemic effects to garlic showcase the breadth of natural remedies in Ayurveda, further enriching the therapeutic landscape of holistic medicine.

42) Bitter:
Bitter flavors are considered beneficial in Ayurveda for digestive health. The bitter properties of guggulu and other herbs, such as bitter gourd, promote detoxification and improve metabolic processes, highlighting the role of taste principles in Ayurvedic nutrition.

43) Kapha:
Kapha is one of the three doshas in Ayurveda, representing earth and water elements. Guggulu helps to balance Kapha dosha, alleviating symptoms related to excess Kapha, such as obesity and sluggishness, indicating its therapeutic role in maintaining dosha balance.

44) Rasna (Rāsnā, Rashna, Rasona, Rasa-una):
Rasna, or Alpinia galanga, is an herb valued for its anti-inflammatory actions in Ayurveda. Used with guggulu, it amplifies the therapeutic effects in managing conditions that involve pain and inflammation, highlighting the synergistic properties of traditional remedies.

45) Ushna (Uṣṇa, Uṣṇā):
Ushna refers to heat or warmth in Ayurvedic terminology. Guggulu’s ushna properties aid in digestion and metabolism, making it effective in treating conditions related to cold imbalances in the body, demonstrating the importance of thermal qualities in Ayurvedic treatments.

46) Gupta (Guptā):
Gupta denotes 'hidden' or 'revealed,' often associated with knowledge in Ayurveda. Studies conducted by researchers like Gupta on guggulu enhance our understanding of its pharmacological properties, bridging traditional wisdom with modern scientific exploration.

47) Aroma (A-roma):
Aroma relates to the distinctive fragrance of a substance. Guggulu’s aromatic properties are believed to contribute to its therapeutic efficacy, influencing appetite and digestion. The role of aroma in Ayurveda underscores the holistic approach to healing through sensory experiences.

48) Water:
Water is essential for life and is crucial in Ayurvedic treatments for its hydrating and detoxifying effects. Combining guggulu with water enhances its bioavailability and effectiveness, emphasizing the importance of hydration in the therapeutic process.

49) Vaca (Vācā, Vacā, Vāca):
Vaca, or Acorus calamus, is an herb known for its cognitive benefits. When paired with guggulu in Ayurvedic formulations, it enriches the therapeutic landscape, highlighting the diversity of plants utilized for enhancing health and wellness in traditional practices.

50) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
Vata is one of the three doshas in Ayurveda that embodies air and space elements. Guggulu is beneficial in balancing Vata, particularly in conditions associated with its excess, such as pain and dryness, illustrating its holistic application in managing doshic health.

51) Vayu (Vāyu):
Vayu represents the wind or air element in Ayurveda, associated with movement and physiological functions. Guggulu aims to balance Vayu, helping ease conditions arising from its imbalance, showcasing the integrative nature of Ayurvedic medicine and its focus on energy dynamics.

52) Rice (Ṛce):
Rice is a staple food in many cultures and is valued in Ayurveda for its nourishing properties. Consuming guggulu with rice enhances its therapeutic applications, supporting digestion and overall health, which is fundamental in traditional dietary practices.

53) Soup:
Soup is often used in Ayurveda as a nourishing and easily digestible meal. When taken with guggulu, it helps to enhance its effectiveness, particularly in treating conditions where digestive health is paramount, supporting the holistic dietary approach in Ayurveda.

54) Meat:
Meat is recognized for its protein content and is incorporated into some Ayurvedic diets for its nutritional benefits. Combining meat broth with guggulu emphasizes the holistic understanding of nutrition in Ayurveda, where foods enhance each other's therapeutic effects.

55) Worm:
Worms, referring to parasitic infections, are treated in Ayurveda with herbal formulations. Guggulu’s efficacy in managing conditions associated with helminthic infections highlights its role in comprehensive traditional medicine, where botanical remedies are leveraged to address diverse health issues.

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