Formulation and Evaluation of Herbal Chocolate for Deworming Therapy

formulation and evaluation of herbal medicated chocolate in treatment of intestinal worms and related problems

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Review on
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: lyophilization process of pharmaceuticals

Original source:

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Author:

Siddhi Pandhare, Mallinath Harwalkar, N.B Mahale, S.R. Chaudhari


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Review on

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

The study aims to develop and evaluate a polyherbal medicated chocolate designed for the treatment of intestinal worms and related issues. The focus is on creating a formulation that offers improved bioavailability and patient compliance compared to conventional treatments. This effort involves using a chocolate base combined with herbal components, promoting an easier and faster onset of action. The formulations are assessed through various parameters, including shape, size, taste, texture, and stability, to ensure they meet the necessary standards for an oral drug delivery system.

Benefits of Medicated Chocolate

Medicated chocolate serves as an innovative delivery system for herbal remedies. The characteristics of chocolate disguise unpleasant flavors and provide a smooth texture, making it an appealing option, especially for children. Additionally, chocolate’s anhydrous properties prevent microbial growth and the degradation of sensitive active ingredients. This delivery method has the potential to bypass first-pass metabolism and prevent pre-systemic elimination within the gastrointestinal tract, enhancing the therapeutic effect of the herbal extracts incorporated into the chocolate.

Herbal Components and Their Efficacy

The formulation includes various herbal ingredients known for their anthelmintic properties, like S. chirata and Ferula asafetida. These herbs possess beneficial phytochemical constituents that can combat parasitic worms effectively. Evidence from traditional medicine suggests that these components can help in deworming and alleviating associated gastrointestinal issues. The study also highlights other herbal extracts' pharmacological uses, emphasizing their collective potential to improve therapeutic outcomes against intestinal parasites.

Methodology of Formulation

The formulation process involves extracting bioactive compounds from fruits like banana and apple peels, along with selected herbs. The extracts are obtained using methods such as maceration and Soxhlet extraction with solvents like methanol and chloroform. Once the extracts are prepared, they are incorporated into a melted chocolate base, resulting in a unique medicinal product. Various evaluations, including moisture content, viscosity, and hardness, were conducted to assess the quality of the chocolate formulation, ensuring it meets the required standards for medicinal use.

Conclusion

The research concludes that the developed polyherbal medicated chocolate effectively combines the benefits of herbal medicine with the palatability of chocolate, providing a promising alternative for treating intestinal worms. The evaluation results indicated that the chocolate maintained desirable physical properties and demonstrated an ability to mask unpleasant tastes while delivering therapeutic benefits. Therefore, this innovative formulation could significantly enhance patient compliance and safety in treating gastrointestinal issues associated with helminths.

FAQ section (important questions/answers):

What is the objective of developing herbal medicated chocolate?

The main goal is to create a polyherbal chocolate formulation for treating intestinal worms, enhancing bioavailability and patient compliance compared to standard treatment options.

What herbs are included in the medicated chocolate formulation?

The formulation includes banana peel, apple peel, S. chirata, and Ferula asafoetida, known for their anthelmintic properties and potential health benefits.

How is the herbal chocolate prepared?

The chocolate base is melted, mixed with specific herbal extracts, and poured into molds to solidify, following a meticulous extraction and formulation process.

What parameters were evaluated for the formulated chocolate?

The evaluation included tests for appearance, dimensions, moisture content, viscosity, weight variation, hardness, bloom test, and stability to ensure quality.

What are the benefits of using chocolate as a delivery system?

Chocolate acts as a pleasant vehicle for drugs, masking unpleasant flavors and improving palatability, particularly beneficial for children and enhancing patient compliance.

What were the findings related to the stability of the formulation?

The formulated chocolate demonstrated satisfactory stability, maintaining its physical, chemical, and therapeutic properties during the testing period, indicating its efficacy.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Formulation and Evaluation of Herbal Chocolate for Deworming Therapy”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs denote the chemical substances that alter physiological functions in the body. The polyherbal chocolate formulation aims to deliver these therapeutic substances effectively while improving patient compliance with a palatable option.

2) Water:
The water refers to its use in the extraction processes of the herbal components. Its significance lies in its role as a solvent that helps release the active constituents of the herbs to be incorporated into the chocolate.

3) Worm:
Worm refers specifically to a single parasitic worm that can infect the human body. The study's focus on developing a medicated chocolate demonstrates an innovative approach to combat these organisms, enhancing patient compliance with a more palatable treatment option.

4) Medicine:
Medicines encompass all therapeutic agents, including the herbal extracts specifically formulated in the chocolate. The study highlights how these medicines can be effectively delivered in a palatable form to enhance therapeutic effects.

5) Activity:
Activity refers to the effectiveness of the herbal components in the medicated chocolate in achieving the desired therapeutic outcomes. In this case, it highlights the medicinal properties of the ingredients in combating intestinal worms and promoting digestive health.

6) Ferula asafoetida (Ferula assa-foetida):
Ferula asafoetida is a plant known for its medicinal properties, particularly its anthelmintic effects. This herb is included in the chocolate formulation, contributing to the overall effectiveness against intestinal parasites and aiding in stomach health.

7) Asafoetida:
Asafoetida, a resin from Ferula species, possesses various medicinal benefits including anti-helminthic properties. Its inclusion in the chocolate formulation enhances the therapeutic profile, allowing it to be used effectively against parasitic infections.

8) Powder:
Powder refers to the form in which the herbal extracts are processed and added to the chocolate base. The powdered extracts ensure that the bioactive compounds are evenly distributed in the formulation for optimal efficacy.

9) Study (Studying):
The study focuses on developing and evaluating the effectiveness of a polyherbal chocolate formulation targeting intestinal health. It examines various parameters like formulation techniques and pharmacological properties to support its therapeutic claims.

10) Pharmacological:
Pharmacological relates to the effects and mechanisms of action of drugs and medicinal compounds. In this context, it denotes how the ingredients in the chocolate formulation interact with the body's biological systems to exert their medicinal effects.

11) Flavonoid:
Flavonoid is a specific type of flavonoid compound that functions as a bioactive ingredient in the chocolate. Its inclusion enhances the health benefits associated with the chocolate, particularly in terms of antioxidant effects.

12) Container:
Container refers to the packaging used to store the formulated chocolate. Proper containers are vital for maintaining the product's stability and ensuring the preservation of its chemical and physical properties over time.

13) Honey:
Honey serves as a natural sweetener and contributes to the overall flavor profile of the medicated chocolate. Additionally, it has its own medicinal properties, including antimicrobial and anti-inflammatory effects that complement the herbal ingredients.

14) Human body:
The human body is the physiological system impacted by the intake of the formulated chocolate. The ingredients are designed to bring about health benefits, specifically targeting intestinal health and combating infections from parasitic worms.

15) Antibiotic (Antibacterial):
Antibiotic describes substances that inhibit bacterial growth. While the focus of the study is on deworming, the herbal ingredients may provide additional health benefits, reinforcing the multifaceted therapeutic potential of the chocolate formulation.

16) Disease:
Disease refers to abnormal physiological conditions that the formulated chocolate aims to address, particularly helminthiasis caused by parasitic worms. The chocolate serves as a therapeutic intervention for such diseases.

17) Raigad:
Raigad is a geographic location that provides the context for the study, identifying the institution behind the research. It emphasizes the regional relevance of developing herbal medicines tailored to local health issues.

18) Fever:
Fevers can be a symptom of infections, including those caused by parasites. The study's formulation aims to address this symptom along with deworming, thereby providing a multifaceted approach to treating gastrointestinal health issues.

19) Blood:
Blood refers to the fluid in the body that delivers necessary substances. The health implications of parasitic infections can affect blood quality; hence, the study aims at improving overall bodily function through herbal treatment.

20) Substance:
Substance refers to any individual component included in the formulation, emphasizing the importance of each herbal extract in the combined effect of the polyherbal chocolate against intestinal worms.

21) Citrus medica:
Citrus medica, or citrons, are among the herbal ingredients with potential anthelmintic properties used in the formulation. Its inclusion adds to the overall therapeutic potential of the chocolate mix for treating worm infections.

22) Phytochemical:
Phytochemical refers to biologically active compounds derived from plants. The study emphasizes the importance of various phytochemicals in the herbal ingredients that contribute to the medicinal properties of the polyherbal chocolate.

23) Measurement:
Measurement is the process of determining specific attributes of the chocolate formulation, such as viscosity or moisture content. It validates the quality and consistency of the product, which is crucial in pharmaceutical preparations.

24) Observation:
Observation refers to the systematic recording of data and characteristics during the study. It plays a critical role in analyzing the effectiveness and quality of the formulated chocolate for therapeutic use.

25) Discussion:
Discussion involves the analysis and interpretation of data collected during the study. It contextualizes the findings, comparing them to existing research and evaluating the implications for future studies and applications.

26) Education:
Education refers to informing patients and healthcare providers about the benefits and mechanisms of the polyherbal medicated chocolate. Increased awareness can lead to better healthcare practices and improved patient compliance in treatments.

27) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine that emphasizes the use of natural ingredients for therapeutic purposes. The study draws on Ayurvedic principles in selecting herbs with known benefits for treating worm infections.

28) Toxicity:
Toxicity refers to the degree to which a substance can cause harm to an organism. Understanding the toxicity of the herbal components ensures that the formulated chocolate is safe for consumption without adverse effects.

29) Mineral:
Mineral, singular, indicates a specific inorganic substance that might be found in some of the herbs used in the study. These minerals can play a role in supporting the overall health effects of the chocolate formulation.

30) Species:
Species refer to specific groups of plants or organisms used in the formulation of the chocolate. The selection of various species is crucial as each brings distinct pharmacological benefits essential for the efficacy of the treatment.

31) Hygiene (Hygienic):
Hygiene refers to practices that maintain health and prevent disease. The study highlights the role of good hygiene in preventing helminth infections, thus indicating the importance of education alongside medicinal treatments.

32) Garlic:
Garlic is a known herbal remedy with antibacterial and antifungal properties. Its potential role as an anthelmintic could be explored in future research within this formulation context as it may enhance the therapeutic effects.

33) Bitter:
Bitter refers to one of the basic tastes and is often characteristic of many medicinal herbs. The study may address how the formulation helps mask bitter flavors commonly found in herbal remedies, increasing patient compliance.

34) Nature:
Nature embodies the biological and botanical aspects of the ingredients used in the formulation. Understanding the natural properties of the herbs aids in leveraging their therapeutic potentials for effective medicinal outcomes.

35) Ulcer:
Ulcer in this context may refer specifically to lesions that can arise due to parasitic infections. Ingredients in the formulation may help treat or prevent ulcers, providing comprehensive gastrointestinal support.

36) Edema (Oedema):
Edema is swelling caused by fluid retention and can be associated with parasitic infections. The study addresses how the formulated chocolate may alleviate symptoms of edema caused by worms, reinforcing its therapeutic role.

37) Table:
Table likely refers to the tabulated data presenting the various components and properties of the formulated chocolate. It offers a clear and organized way to assess each ingredient's role and effectiveness.

38) Salt (Salty):
Salty is one of the basic tastes that can also be present in some herbs. The study may address how the chocolate formulation incorporates various flavors, including salty ones, to enhance consumer acceptability.

39) Rich (Rch):
Rich describes the abundance of bioactive compounds, vitamins, and minerals in the herbal ingredients used in the formulation. A rich profile contributes to the overall effectiveness and nutritional value of the chocolate product.

40) Milk:
Milk, while not a primary component of the study, represents a classic base for many formulations. The mention of milk highlights the broader context of creating palatable medicinal products for enhanced patient compliance.

41) Sour:
Sour is one of the basic tastes that can signal the presence of certain active compounds. The chocolate formulation thoughtfully addresses flavors to ensure that the final product is enjoyable to consume.

42) Dish (Dis):
Dish refers to the presentation or serving of the chocolate formulation, indicating an emphasis on how the product can be introduced to consumers in an appealing manner, enhancing its marketability.

43) Oil:
Oils can be integral to the formulation of medicated products due to their properties such as enhancing flavor and aiding in the absorption of active ingredients. The study's chocolate formulation may include oils for these reasons.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Formulation and Evaluation of Herbal Chocolate for Deworming Therapy’. Further sources in the context of Science might help you critically compare this page with similair documents:

Ferula asafoetida, Therapeutic effect, Helminthiasis, Bioavailability, Polyherbal formulation, Traditional use, Moisture content determination, Drug compliance, Stability testing, Weight variation, Anthelmintic activity, First Pass Metabolism, Nutritional evaluation, Pharmaceutical therapy, Patient compliance, Hardness test, Viscosity determination, Organic extract, Phytoconstituent, Intestinal worm.

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