Influence of nanotechnology on herbal drugs

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Influence of nanotechnology on herbal drugs
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Jogeshwari N. Gunjal and Minal S. Patil


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Influence of nanotechnology on herbal drugs

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20241-30849

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

1) Introduction

Herbal medicines have gained significant popularity worldwide as safer and more economical alternatives to modern conventional medicines. These herbal remedies boast a wide array of health benefits due to their multidimensional approach, wherein a single herb can target multiple diseases. However, their limitations in absorption, distribution, and bioavailability often necessitate larger doses, leading to decreased effectiveness. The integration of nanotechnology into herbal drug formulations presents a promising solution to these challenges by enhancing the delivery and bioactivity of phytochemicals.

2) Enhancing Bioavailability through Nanotechnology

Nanotechnology-based delivery systems function as efficient drug carriers that can improve the bioavailability and bioactivity of herbal components. By utilizing nanotechnology, researchers aim to develop advanced herbal formulations that can effectively overcome the limitations faced by conventional herbal medicines. Various strategies have emerged, such as phytosomes, solid lipid nanoparticles, and nano emulsions, which are designed to improve the pharmacokinetic properties of herbal drugs. The ability of nano-sized systems to enhance therapeutic effects leads to increased efficiency in phytotherapy, particularly for poorly absorbed and unstable substances.

3) Advantages of Nanoparticle Delivery Systems

The utilization of nanoparticle delivery systems offers numerous advantages in herbal medicine, prominently featuring the enhanced permeation and retention (EPR) effect. This effect facilitates improved drug delivery to target sites, particularly in cases such as tumor targeting, while minimizing side effects and reducing the required dosage. Additionally, these systems allow direct delivery of herbal formulations to the affected area, increasing their efficacy and therapeutic index. Enhanced stability via encapsulation is another significant benefit, leading to improved pharmacokinetic effects compared to traditional drug formulations.

4) Techniques for Preparing Nanoparticles

Various techniques have been developed for the preparation of herbal nanoparticles, each with unique methodologies and advantages. Methods such as complex coacervation, co-precipitation, and salting-out processes facilitate the creation of nanoscale drug delivery systems. Other innovative methods include nanoprecipitation, supercritical fluid techniques, and high-pressure homogenization. These preparation techniques are crucial in achieving the desired particle size, stability, and drug release profiles necessary for effective herbal treatment.

5) Conclusion

The integration of nanotechnology in herbal medicine represents a significant advancement towards enhancing drug delivery systems with improved bioavailability and reduced toxicity. By bridging the gap between traditional herbal practices and modern technological approaches, nanotechnology holds the promise for developing more effective and safer herbal medicines. This synergy could minimize the reliance on harmful chemical applications, fostering a sustainable relationship between plant sciences and technological innovation for the future of health and wellness.

FAQ section (important questions/answers):

What is the main focus of the study by Gunjal et al.?

The study investigates the influence of nanotechnology on herbal drugs, highlighting how nano-sized drug delivery systems can enhance the bioavailability and activity of phytochemicals in herbal medicines.

How do herbal medicines compare to conventional allopathic treatments?

Herbal medicines are often considered safer, more economical, and possess a wide range of health benefits due to their multifaceted approach, targeting various diseases simultaneously.

What limitations do phytochemical constituents in herbal medicine face?

Phytochemical constituents often have low bioavailability, low target specificity, and may require large doses for efficacy, and some compounds are sensitive to acidic conditions, impacting their stability.

What advantages do nanoparticle delivery systems provide for herbal formulations?

Nanoparticle delivery systems enhance drug efficacy, reduce side effects, increase stability, and provide a targeted approach to delivering herbal formulations directly to the site of action.

What are some methods used for the preparation of nanopharmaceuticals?

Common methods include complex coacervation, nanoprecipitation, salting-out method, supercritical fluid methods, and high-pressure homogenization, each enabling the creation of effective nano-sized drug delivery systems.

What role does nanotechnology play in the future of herbal medicines?

Nanotechnology offers a promising avenue for improving the bioavailability and therapeutic potential of herbal medicines, enabling them to be more effective while potentially reducing toxicity.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Influence of nanotechnology on herbal drugs”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs are substances that modify physiological functions in living organisms. They can be synthetic or derived from natural sources, such as plants used in herbal medicines. The development of nanotechnology-based drug delivery systems can significantly alter how drugs are absorbed and utilized by the body, increasing their effectiveness.

2) Medicine:
Medicines are substances used to prevent or treat disease and relieve pain. They can be derived from various sources, including plants (herbal medicines) and synthetics. The integration of nanotechnology in the formulation of medicines aims to enhance their effectiveness, safety, and user compliance, especially in herbal products.

3) Activity:
Activity refers to the physiological or pharmacological effects of a compound or substance. In herbal medicine, the activity of phytochemicals is crucial for therapeutic benefits. Enhanced activity can be achieved through nanotechnology, which aids in improving the solubility and bioavailability of herbal drugs, thereby optimizing their therapeutic potential.

4) Phytochemical:
Phytochemicals are compounds produced by plants, contributing to their color, flavor, and disease resistance. In herbal medicine, phytochemicals play a vital role in providing health benefits. Utilizing nanotechnology can help enhance the bioavailability of these compounds, optimizing their therapeutic effects and expanding their applications in health care.

5) Water:
Water serves as an essential solvent in many biochemical processes and is fundamental for the bioavailability of phytochemicals in herbal medicine. The solubility of active compounds often influences their effectiveness. Utilizing nanotechnology can enhance herbal properties, facilitating better interactions with water and improving absorption in the body.

6) Patil:
Patil refers to Minal S. Patil, a researcher involved in the study of herb-based formulations at DCS’s A. R. A. College of Pharmacy. Collaborating with colleagues, Patil contributes to exploring the intersection of herbal medicine and nanotechnology, providing insights into innovative drug delivery methods and enhancing herbal therapy's potency.

7) Disease:
Diseases encompass various health conditions that may disrupt normal functioning. Herbal remedies are increasingly recognized for their ability to target multiple diseases due to their complex phytochemical compositions. The application of nanotechnology in herbal formulations holds promise for enhancing therapeutic responses to various diseases, improving patient health outcomes.

8) Performance:
Performance in this context refers to the effectiveness of a drug or treatment in achieving its intended pharmacological effects. The performance of herbal drugs can be significantly improved through nanotechnology, which enhances bioavailability and targeted action, making these natural therapies more competitive with conventional medicinal approaches.

9) Surface:
Surfaces of nanoparticles are key factors influencing their behavior in biological systems. The surface chemistry and morphology of nanomaterials can affect how they interact with cells. Modifying the surfaces of herbal nanoparticles through nanotechnology can improve their targeting and effectiveness, enhancing the therapeutic benefits of herbal formulations.

10) Cancer:
Cancer describes a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Herbal medicines are being researched for their anticancer properties due to their rich array of phytochemicals. Nanotechnology may improve the delivery and efficacy of these herbal treatments in oncology.

11) Sahu:
Sahu refers to Alakh N. Sahu, a researcher cited in the article on herbal drug formulations and nanotechnology. Sahu contributes to the scientific understanding of how nanotechnology can bolster the effectiveness of herbal drugs, exploring innovative approaches to enhance their therapeutic profiles in modern pharmacotherapy.

12) Terminalia chebula:
Terminalia chebula is a medicinal herb used for various health benefits, including antioxidant properties. Understanding its bioactive compounds is essential for enhancing its therapeutic potential. The application of nanotechnology can aid in formulating effective delivery systems for this herb, improving its interaction with biological systems and overall efficacy.

13) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India, home to numerous herbal plants used in traditional medicine. The region's diverse flora supports the study and development of herbal remedies. Researchers in Maharashtra explore the integration of nanotechnology in herbal medicine formulation, aiming to enhance therapeutic outcomes and bioavailability of local herbal products.

14) Flavonoid:
A flavonoid is a type of phytochemical with antioxidant and health-promoting properties, commonly found in plant-based foods. Many herbal medicines contain flavonoids, which contribute to their therapeutic effects. Nanotechnology can enhance the solubility and bioavailability of flavonoids, making them more effective in treating various health conditions.

15) Kashaya (Kasaya):
Kashaya is a traditional herbal formulation, often consisting of a mixture of various medicinal plants. The activity and therapeutic benefits of Kashaya rely on its phytochemical constituents. The application of nanotechnology may enhance the pharmacokinetic properties of Kashaya, improving its efficacy and stability as a traditional herbal remedy.

16) India:
India is rich in biodiversity, hosting a vast array of medicinal plants used in traditional medicine systems. The country's historical reliance on herbal therapies leads to ongoing research in combining herbal medicine with modern technology, such as nanotechnology, to enhance treatment efficacy and patient outcomes in health care.

17) Dhule:
Dhule is a city in Maharashtra, India, where DCS’s A. R. A. College of Pharmacy is based. Research conducted here focuses on integrating traditional plant medicine with advanced technologies like nanotechnology. This local context supports the exploration of enhancing herbal drug formulations to improve therapeutic effectiveness.

18) Field:
The field of herbal medicine and nanotechnology emphasizes their intersection, focusing on how integrating these areas can improve health outcomes. This combination allows for a comprehensive approach to treatment, aiming to enhance the effectiveness of traditional herbal remedies, thereby broadening their application in contemporary healthcare.

19) Agra:
Agra, a city in India, might not be directly related to the core subject but serves as a geographical reference in broader discussions surrounding herbal medicine and traditional practices in the country. Understanding regional variations in herbal applications can inform the integration of science and tradition in medicine.

20) Pur:
Poor refers to inadequate conditions, often relating to the low bioavailability and solubility of certain herbal compounds. Enhancing these properties through nanotechnology can help overcome the limitations posed by poorly soluble and unstable substance forms in herbal medicines, ultimately improving therapeutic efficacy and patient compliance.

21) Emblica officinalis:
Emblica officinalis, also known as Amla, is revered in traditional medicine for its high vitamin C content and antioxidative properties. Research into its phytochemicals highlights their health benefits. Nanotechnology can enhance the delivery and effectiveness of compounds derived from Emblica officinalis, aiding in the development of more potent herbal treatments.

22) Adhatoda vasica:
Adhatoda vasica is known for its medicinal properties, especially in treating respiratory ailments. The bioactive compounds within this herb need to be effectively delivered to the target site. Advancements in nanotechnology may optimize the therapeutic applications of Adhatoda vasica, enhancing its bioavailability and efficacy in conventional treatment practices.

23) Food:
Food encompasses substances consumed for nourishment, which can also include herbal ingredients. The integration of herbal phytochemicals and nanotechnology into food products may enhance nutritional profiles and health benefits. Awareness of this relationship can improve public health initiatives focusing on integrating traditional herbal wisdom into contemporary dietary practices.

24) Pharmacotherapy:
Pharmacotherapy involves the use of medications to manage or treat diseases. The incorporation of herbal medicines into pharmacotherapy seeks to optimize treatment outcomes through natural substances. Employing nanotechnology in this context can significantly boost the bioavailability and efficiency of these herbal formulations, enhancing their therapeutic effectiveness.

25) Transformation (Transform, Transforming):
Transformation refers to the biochemical changes that herbal substances undergo, impacting their pharmacological activity. Understanding these changes is crucial for formulating effective herbal medicines. The application of nanotechnology can facilitate beneficial transformations, optimizing the release and absorption of bioactive compounds, ultimately enhancing their therapeutic potential.

26) Biodegradable:
Biodegradable refers to materials capable of being broken down by biological means. In the context of nanotechnology for herbal medicines, utilizing biodegradable nanoparticles can enhance drug delivery systems by ensuring that herbal compounds are released in a controlled manner, minimizing side effects while improving their therapeutic applications in medicine.

27) Antibiotic (Antibacterial):
Antibacterial agents inhibit the growth of bacteria and are crucial in treating infections. Many herbal medicines possess antibacterial properties due to the phytochemicals they contain. Employing nanotechnology can optimize the delivery of these herbal antibacterial compounds, improving their bioavailability and effectiveness in combating bacterial diseases.

28) Purification:
Purification is a critical step in extracting and isolating bioactive compounds from herbal sources. This process ensures that the active ingredients retain their medicinal properties. Utilizing advanced purification techniques combined with nanotechnology can enhance the quality and efficacy of herbal medicines, ensuring they are safe and effective in therapeutic applications.

29) Science (Scientific):
Science represents the systematic pursuit of knowledge about the natural world. In addressing health issues, scientific inquiry into herbal medicine and its compounds enhances understanding of their mechanisms. The application of nanotechnology represents a significant advancement in the scientific study of herbal formulations, aiming at improving their therapeutic efficacy.

30) Substance:
A substance refers to a specific chemical or compound in herbal medicines. Each substance may exhibit unique biological activities contributing to overall therapeutic effects. Investigating these substances through nanotechnology can enhance their release and bioavailability, optimizing their role in treating various health conditions effectively.

31) Triphala (Tri-phala):
Triphala is a traditional Ayurvedic formulation composed of three fruits: Emblica officinalis, Terminalia chebula, and Terminalia bellirica. It is used for its health benefits, including digestive health and detoxification. The synergy among its components can be enhanced through nanotechnology, improving the delivery and absorption of its active ingredients for better outcomes.

32) Toxicity:
Toxicity refers to the harmful effects a substance can have on living organisms. Understanding the toxicity of herbal compounds is essential for their safe usage in medicine. Nanotechnology can play a role in reducing toxicity by improving the targeting and bioavailability of herbal medicines, leading to safer therapeutic applications.

33) Dealing:
Dealing refers to the methods used to address or manage challenges related to herbal medicine. Utilizing innovative approaches, such as nanotechnology, can effectively deal with issues like low bioavailability and stability of phytochemicals, ultimately improving the quality and effectiveness of herbal therapies in the medical field.

34) Powder:
Powder refers to the physical form of many herbal medications, providing an accessible way to deliver phytochemicals. The processing of herbs into powder allows for easier formulation. Nanotechnology can be used to create nanoparticles from these powders, improving their solubility, absorption, and overall effectiveness in therapeutic applications.

35) Table:
Table may refer to tabulated data in scientific literature presenting findings related to herbal medicines and their formulations. Such tables provide a clear overview of research results, making it easier to understand the effects of herbal nanoparticles and the methodologies used, facilitating knowledge dissemination and clinical applications.

36) Tree:
Tree may refer to medicinal plants classified under various species. The study and conservation of these medicinal trees play a crucial role in herbal medicine. Utilizing scientific approaches, including nanotechnology, can aid in the extraction and effective delivery of their bioactive compounds, ensuring traditional knowledge supports modern health practices.

37) Rich (Rch):
Rich describes the abundance of valuable nutrients or compounds in a substance. Many herbal medicines are rich in phytochemicals that provide health benefits. Enhancing the formulation of these rich herbal compounds through nanotechnology aims to optimize their therapeutic potential and address health concerns more effectively.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Influence of nanotechnology on herbal drugs’. Further sources in the context of Science might help you critically compare this page with similair documents:

Active ingredient, Phytotherapeutics, Herbal drug, Solid lipid nanoparticle, Phytosome, Phytochemical compound, Phytochemical constituent.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Consider supporting this website: