Pharmaceutical prep and evaluation of acne vanishing cream.
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmaceutical preparation and evaluation of acne vanishing cream with special reference to bhaishajya ratnawali mukhdushikahar lepa.
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Kajal Govindkumar Dargad, Dr. R. K. Ingole and Dr. Nalini Hedaoo
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Pharmaceutical preparation and evaluation of acne vanishing cream with special reference to bhaishajya ratnawali mukhdushikahar lepa.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20241-30879
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The article outlines a study on the pharmaceutical preparation and evaluation of an Acne Vanishing Cream, which incorporates a significant concentration of herbal constituents aimed at providing an effective treatment for acne vulgaris. Acne vulgaris is widely recognized as a prevalent condition that affects individuals' quality of life, particularly among adolescents. While there are numerous modern treatments for acne, many come with adverse effects. In response to this challenge, the authors propose an herbal alternative believed to be safer and effective, utilizing extracts from traditional Ayurvedic ingredients like Dhanyak, Vacha, and Lodhra in the formulation.
Significance of Herbal Constituents
One of the key concepts presented in the study is the importance of herbal constituents in formulating the Acne Vanishing Cream. The cream is made primarily from the aqueous extracts of Dhanyak, Vacha, and Lodhra, alongside other ingredients including stearic acid and cetyl alcohol, which serve as emulsifying agents. The formulation utilizes a simple method of preparation and aims to capitalize on the therapeutic properties of these herbal ingredients, which are believed to possess antimicrobial and anti-inflammatory properties. This highlights a growing trend in the cosmetic industry toward natural and herbal formulations due to their minimal side effects compared to conventional synthetic products.
Formulation Process
The study also describes the meticulous formulation process behind creating the Acne Vanishing Cream. The preparation involves two main phases: an oil phase and an aqueous phase. The oil phase is prepared by heating stearic acid and cetyl alcohol, while the aqueous phase consists of herbal extracts, glycerine, and other components like triethanolamine and isopropyl alcohol. These two phases are then combined through continuous stirring at 70°C, leading to a stable oil-in-water emulsion. The rigorous methodological approach ensures a uniform mixture and addresses the challenges of stability associated with emulsions.
Evaluation of Cream Characteristics
The Cream’s effectiveness and safety were assessed through various physical evaluations, including organoleptic characteristics, pH measurement, homogeneity, and patch tests for skin irritation. The results indicated that the cream maintained a pH around 7.1 to 8.5, signifying a balanced formulation. Additionally, the cream exhibited good washability, homogeneity, and emollient properties, making it a suitable option for consumers concerned about skin health. The patch tests demonstrated no irritation, indicating the cream’s compatibility with skin and suggesting it as a potential alternative treatment for acne vulgaris.
Conclusion
In conclusion, the study demonstrates the feasibility of creating an effective Acne Vanishing Cream using traditional herbal ingredients as a viable alternative to synthetic creams, emphasizing the potential benefits of herbal formulations in skin care. The positive results from the evaluation of the cream’s physical characteristics suggest that it can provide a soothing and hydrating effect with minimal adverse reactions. Future clinical trials are recommended to further validate the efficacy and safety of this herbal cream, solidifying its role in contemporary skincare routines targeting acne treatment.
FAQ section (important questions/answers):
What is the primary aim of the Acne Vanishing Cream study?
The study aims to prepare and evaluate an herbal acne vanishing cream with high herbal constituent concentration, offering advantages over synthetic creams and minimizing side effects.
What are the key ingredients in the Acne Vanishing Cream?
Key ingredients include stearic acid, cetyl alcohol, glycerin, isopropyl alcohol, and herbal extracts of Dhanyak, Vacha, and Lodhra, making the formulation rich in beneficial properties for skin health.
How was the Acne Vanishing Cream prepared in this study?
The cream was prepared by creating an oil phase with stearic acid and cetyl alcohol, and an aqueous phase with herbal extracts and glycerin, then mixed at 70°C with constant stirring.
What evaluation methods were used for the Acne Vanishing Cream?
Evaluation methods included pH measurement, homogeneity, patch tests for sensitivity, washability, and irritancy assessments to ensure safety and effectiveness.
What were the observed results of the Acne Vanishing Cream?
The cream was white with a non-greasy, smooth texture, acceptable pH, and demonstrated good emollience, washability, and non-irritating properties upon testing.
What conclusions were made about the Acne Vanishing Cream?
The cream, with 70% herbal extracts, was found effective, safe, and advantageous over chemical alternatives, suggesting the need for further clinical evaluation to validate its efficacy.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmaceutical prep and evaluation of acne vanishing cream.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Lodhra:
Lodhra refers to a medicinal plant known scientifically as Symplocos racemosa, traditionally used in Ayurvedic medicine for its therapeutic properties. It is recognized for its balancing effects on the body's doshas and is specifically valued for its skin benefits in treating acne, thus being relevant in the formulation of the herbal cream.
2) Vaca:
Vacha, or Acorus calamus, is an important herb in Ayurvedic medicine. It is known for its digestive properties and is often used in formulations for its skin benefits. In the context of the acne vanishing cream, Vacha acts as an active component providing anti-inflammatory and soothing effects, enhancing the cream's effectiveness.
3) Water:
Water is a crucial solvent used in the preparation of creams and emollients. In the context of the acne vanishing cream, water serves as the medium for dissolving other ingredients, facilitating the emulsification process. Its quality directly affects the texture, consistency, and stability of the final product.
4) Arka:
Arka refers to an herbal extract obtained through distillation from various medicinal plants. In the context of the study, Arka is notably used from plants like Dhanyak and Vacha. Its inclusion in formulations plays a pivotal role in delivering the natural therapeutic qualities of the herbs, particularly in skincare applications.
5) Hand:
Hand plays a significant role in the context of applying creams or pharmaceuticals. In the preparation and application stages of the acne vanishing cream, the use of hands is essential for mixing, measuring, and testing the product. Hands are also involved in conducting patch tests for irritation assessment on human skin.
6) Hindi (Himdi):
Hindi is one of the primary languages spoken in India and is of significance in the context of the study as many Ayurvedic texts and commentaries are available in Hindi. It aids in disseminating knowledge about the herbal preparations like acne vanishing cream to a broader audience, particularly in India.
7) Indradeva:
Indradeva refers to an author or contributor noted for providing commentaries on Ayurvedic texts. His work on the Arkaprakasa signifies the importance of scholarly contributions in documenting traditional herbal knowledge and supporting the formulation processes, thus linking historical Ayurvedic practices to contemporary applications such as the vanishing cream.
8) Delhi:
Delhi, the capital city of India, serves as a significant cultural and educational hub. Its relevance in this context can be attributed to being a central location for Ayurvedic research and publishing. Many Ayurvedic resources and practitioners are found here, contributing to the dissemination of knowledge related to herbal formulations.
9) Saha (Shaha):
Saha refers to a surname, possibly of one of the authors or contributors involved in the Ayurvedic literature cited in the study. The inclusion of works by Saha highlights collaborative efforts in advancing Ayurvedic understanding, particularly regarding cosmetic formulations like the acne vanishing cream.
10) Gyana (Gyan):
Gyan, meaning knowledge or wisdom in Hindi, is an important concept in Ayurveda. It emphasizes the understanding required to formulate effective herbal treatments. The process of creating Vanishing Cream entails integrating traditional knowledge (Gyan) with modern scientific principles, ensuring efficacy and safety in the end product.
11) Arkaprakasha (Arkaprakasa, Arka-prakasha):
Arka-prakasa refers to a traditional Ayurvedic text that describes methods for preparing herbal distillates (Arka). Its relevance lies in providing foundational knowledge and techniques for extracting medicinal properties from plants, thereby supporting the formulation of effective skincare products like the acne vanishing cream.
12) Drug:
Drugs in this context imply the active constituents derived from plants used for their medicinal properties. The study focuses on evaluating the efficacy of herbal drugs in the formulation of an acne vanishing cream, thus signaling a shift toward using natural remedies in cosmetic products for skin health.
13) Lepa:
Lepa signifies a herbal paste or ointment applied to the skin. In Ayurvedic practice, Lepa is often used for various skin conditions, including acne. The study seeks to modernize the concept of Lepa by formulating a vanishing cream that combines traditional herbal ingredients with contemporary cosmetic technology.
14) Shri (Sr, Sri):
Shri is a respectful prefix often used before names in Indian culture. Its presence in the text signifies reverence for the Ayurvedic texts and their authors. This respect reflects the importance of tradition, heritage, and foundational works that inform modern practices, such as the formulation of herbal creams.
15) Activity:
Activity in this context refers to the pharmacological properties exhibited by the herbal constituents used in formulating the cream. Understanding the activity of ingredients like Lodhra, Vacha, and Dhanyak ensures that the cream effectively addresses acne vulgaris while minimizing potential side effects associated with synthetic alternatives.
16) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India where the study is conducted. Its relevance lies in the cultural background and biodiversity it offers, providing a rich source of herbal ingredients. Region-specific knowledge enhances the study's application by tapping into regional resources for Ayurvedic formulations like the acne vanishing cream.
17) Rasashastra (Rasa-shastra, Rasasastra):
Rasashastra is a branch of Ayurveda that deals with the science of herbal formulations and medicinal preparations. This discipline is essential in creating effective, safe pharmaceutical products, including creams. Its principles guide the formulation practices showcased in the study, reinforcing the traditional knowledge base in modern applications.
18) Bhaishajya (Bhaisajya):
Bhaishajya refers to the realm of therapeutic substances in Ayurveda. Its relevance to the study emphasizes the importance of understanding the medicinal properties of the ingredients used in the acne vanishing cream. This recognition allows practitioners to create formulations with specific therapeutic effects and benefits for users.
19) Collecting:
Collecting pertains to the process of gathering raw materials for herbal preparations. In the study, systematic collecting of herbs like Dhanyak, Vacha, and Lodhra is essential for ensuring the quality and efficacy of the final cream product, underscoring the significance of sourcing quality ingredients in herbal medicine.
20) Irritation:
Irritation refers to the adverse skin reactions that can occur from the application of topical products. The study highlights the importance of conducting patch tests to assess the irritation potential of the acne vanishing cream, ensuring safety and consumer acceptance in herbal skincare formulations.
21) Container:
Container refers to the vessel used to hold the formulated cream. Choosing the right container is crucial for preserving the cream's properties and preventing contamination. The relevance lies in ensuring that the packaging is suitable for maintaining the effectiveness and stability of the herbal components used in the formulation.
22) Quality:
Quality in this context refers to the standard of the ingredients and the formulation process itself. High-quality raw materials and methods are essential for creating a safe and effective acne vanishing cream. Ensuring quality control is fundamental in pharmaceutical preparations to achieve desired therapeutic outcomes.
23) Science (Scientific):
Science pertains to the systematic study of natural phenomena, which, in this case, includes the development and evaluation of herbal formulations like the acne vanishing cream. Incorporating scientific methodologies alongside traditional Ayurvedic knowledge ensures that the products are effective, safe, and evidence-based for users.
24) Yantra (Yamtra):
Yantra refers to a device or instrument used in the distillation process to prepare Arka from herbs. Its proper use is significant in ensuring the accurate extraction of medicinal properties. Understanding the yantra's significance showcases the blending of traditional Ayurvedic practices with modern formulation techniques for creating herbal creams.
25) Study (Studying):
Study refers to the systematic investigation into the formulation and evaluation of the acne vanishing cream. It embodies the research process aimed at validating the effectiveness of herbal ingredients while ensuring compliance with safety standards, thereby bridging the gap between traditional medicine and contemporary scientific approaches.
26) Daha:
Daha translates to burning sensation or heat in Sanskrit and is relevant in the context of measuring the effectiveness of herbal constituents aimed at alleviating heat-related conditions of the skin. Ingredients in the cream may possess properties to soothe and mitigate discomfort associated with acne, aligning with Ayurvedic principles.
27) Dish (Dis):
Dish refers to the equipment used during the preparation stages of the cream. A suitable dish is essential for melting and mixing various components effectively. The choice of dish impacts the overall efficiency of the formulation process, ensuring that the ingredients are combined uniformly for a stable product.
28) Life:
Life in this context emphasizes the quality of life impacted by conditions like acne vulgaris. The study underscores the aim of improving individuals' lives through effective herbal creams that address common skin ailments, enhancing self-esteem and overall well-being while promoting the integration of natural remedies in skincare.
29) Acorus calamus:
Acorus calamus, commonly known as Vacha, is a significant herb in Ayurvedic medicine used for its therapeutic benefits. Its relevance in the acne vanishing cream stems from its anti-inflammatory and calming properties, making it an ideal ingredient for formulating effective treatments for skin conditions like acne vulgaris.
30) Antibiotic (Antibacterial):
Antibacterial refers to substances that combat bacterial infections. In the context of the acne vanishing cream, antibacterial properties play a crucial role in treating acne, which is often caused by bacterial proliferation. The inclusion of ingredients with antibacterial activity enhances the cream's efficacy for acne management.
31) Arkayantra (Arka-yantra):
Arka-yantra is the apparatus used in the distillation process to obtain Arka from raw herbs. Understanding the proper functioning and importance of the Arka-yantra allows for effective extraction of herbal constituents, which is essential in preparing high-quality ingredients for the acne vanishing cream.
32) Measurement:
Measurement refers to the quantitative assessment often utilized in formulating and evaluating creams. Accurate measurement of ingredients ensures the right proportions are used, which directly influence the cream’s efficacy, safety, and overall quality, making it a critical factor in pharmaceutical preparations.
33) Observation:
Observation involves the systematic watching and recording of effects or outcomes during study and evaluation processes. In this study, monitoring physical parameters and testing results are critical for assessing and validating the cream's quality and effectiveness, thereby ensuring consumer safety and product integrity.
34) Discussion:
Discussion refers to the part of the research where findings are interpreted and compared against existing literature. In the context of the study, it allows for critical analysis of the results, helping to draw conclusions about the cream's effectiveness and offering insights for future research in herbal formulations.
35) Cleansing:
Cleansing refers to the process of removing impurities and excess oils from the skin. In skincare, cleansing plays a crucial role in preparing the skin for treatment. The development of the acne vanishing cream seeks to incorporate cleansing aspects to complement its therapeutic effects on acne-prone skin.
36) Suffering:
Suffering describes the physical and emotional distress experienced by those with acne vulgaris. This condition can significantly impact a person's self-esteem and mental health. Recognizing the suffering associated with acne emphasizes the importance of developing effective, safe treatments, such as the herbal cream discussed in the study.
37) Kshudra (Ksudra):
Kshudra refers to minor ailments in Ayurvedic terminology. The study addresses Kshudra rogadhikara, which signifies the context in which the vanishing cream is formulated. This acknowledgment helps frame the herbal cream's use in addressing not just major but also common skin conditions like acne vulgaris.
38) Kalpana:
Kalpana translates to the concept of preparation or formulation in Ayurveda. It signifies the traditional methodologies used in creating herbal remedies. The study's focus on Kalpana reflects the integration of Ayurvedic wisdom in formulating the acne vanishing cream to address skin health effectively and safely.
39) Prakasha (Prakasa):
Prakasa means illumination or revelation and is often used in the context of knowledge dissemination. In the study, referring to texts like Arkaprakasa underscores the importance of historical Ayurvedic knowledge in guiding contemporary practices in herbal formulation and treatment methodologies.
40) Sheetal:
Sheetal means cool or soothing in Sanskrit. This term's relevance lies in its association with certain ingredients' therapeutic properties, which provide comfort to irritated or inflamed skin. The study aims to harness the cooling properties of the herbal components in crafting effective skincare solutions like the acne vanishing cream.
41) Heating:
Heating is an essential process in the preparation of creams, allowing for the melting and blending of components. It ensures that the ingredients are adequately incorporated for a smooth and stable texture. In the study, proper heating techniques are emphasized to maintain the integrity of the herbal extracts used.
42) Surface:
Surface refers to the outer layer of skin where the cream is applied. The effectiveness of topical products is often dependent on how well they interact with the skin surface. Understanding the skin's surface properties is crucial for creating a formulation that effectively penetrates and delivers therapeutic benefits.
43) Nalini (Nalini°):
Nalini possibly refers to one of the authors involved in the study. Her contribution emphasizes the importance of collaboration in research, especially in integrating Ayurvedic practices. Noting individual researchers highlights the diverse expertise brought into the herbal formulation process of the acne vanishing cream.
44) Mohini:
Mohini is another author mentioned in the study, relevant for her involvement in the research of herbal formulations. The presence of team members like Mohini showcases the collaborative nature of scientific exploration, emphasizing contributions toward enhancing traditional practices with modern techniques in formulations like the acne vanishing cream.
45) Mishra (Misra):
Mishra signifies an authorial name tied to the Ayurvedic texts used in the study. The recognition of Mishra's work reflects the reliance on scholarly sources that inform and validate contemporary formulations based on ancient wisdom, contributing to the credibility and depth of knowledge in the acne vanishing cream's development.
46) Nashik:
Nashik is a city in Maharashtra known for its herbal pharmacies and traditional medicine practices. Its significance is marked by the sourcing of raw materials for the preparation of the acne vanishing cream. The city embodies the intersection of traditional knowledge and modern application in skincare product development.
47) Adhman:
Adhman refers to a condition characterized by abdominal distension in Ayurveda. While primarily associated with digestive issues, its relevance emphasizes the holistic approach of Ayurveda in treating multiple bodily ailments. The development of the cream aims to extend knowledge from systemic conditions to skincare treatments.
48) Edema (Oedema):
Oedema denotes swelling caused by excess fluid trapped in tissues. Its mention in the study relates to the evaluation of the cream's efficacy in reducing skin inflammation associated with acne. Understanding and addressing conditions like oedema is vital for ensuring comprehensive treatment of skin issues.
49) Nature:
Nature in this context signifies the source of ingredients used in the formulation. Emphasizing natural constituents aligns with contemporary consumer preferences for herbal and organic products. The study aims to highlight the benefits of utilizing nature's resources in developing effective, non-synthetic solutions for skincare challenges.
50) Filling (Filled):
Filled pertains to the action of placing the prepared cream into suitable containers. This step is essential for storage and preservation, maintaining the cream's integrity and efficacy. Proper filling techniques help prevent contamination, ensuring that the final product is safe for consumer use.
51) Grahin (Grahi):
Grahi refers to a property of substances in Ayurveda that indicates the ability to absorb or retain. Ingredients with Grahi properties are significant in skin formulations as they facilitate better uptake of active compounds, enhancing the efficacy of the cream in treating acne and improving skin texture.
52) Vata:
Vata is one of the three doshas in Ayurveda, representing air and life force. In the context of skincare, balancing Vata is crucial as excessive Vata can lead to dry skin, making it relevant in the formulation process of the cream. Ingredients are selected to harmonize and balance the doshas for optimal skin health.
53) Pune:
Pune is a city in Maharashtra, India, and serves as a center for education and research in Ayurveda. Its relevance to the study lies in the availability of resources, expertise, and herbal pharmacies that aid in the formulation of herbal products like the acne vanishing cream.
54) Food:
Food signifies nourishment and is critical for overall health. In the context of skincare, proper nutrition impacts skin health directly. The study acknowledges dietary influences on skin conditions like acne, promoting a holistic approach where skincare products complement healthy eating habits for optimal skin wellness.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Pharmaceutical prep and evaluation of acne vanishing cream.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Pharmaceutical preparation, Clinical studies, Acne vulgaris, Research article, Morphological properties, Bhaishajyaratnawali, Glycerine, Vacha Arka, Triethanolamine, Patch test, Physical characteristic, Herbal constituents.