"Study of alepa for managing rheumatoid arthritis"
Journal name: World Journal of Pharmaceutical Research
Original article title: “a clinical study to evaluate effect of alepa in the management of rheumatoid arthritis”
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Sudhanva Koodur, Dr. Niranjan Rao and Dr. Padmakiran C.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: “a clinical study to evaluate effect of alepa in the management of rheumatoid arthritis”
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20242-31100
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints, now increasingly prevalent worldwide, particularly among women who are three times more likely to be affected than men. This condition leads to joint destruction and functional disability over time, manifesting in symptoms such as morning stiffness, joint pain, swelling, and tenderness. The disease is closely correlated with the Ayurvedic concept of Amavata, which is primarily attributed to impaired digestion (Agni dushti). In Ayurveda, the treatment approach emphasizes correcting the doshas involved, particularly vitiated Vata, and aims to eliminate Ama, the toxic byproduct of digestion.
Efficacy of Alepa in Rheumatoid Arthritis
Alepa, a traditional Ayurvedic treatment, was assessed for its effectiveness in managing rheumatoid arthritis. The study involved 20 diagnosed patients who underwent a regimen of external application of Alepa and oral administration for seven days. The preparation contained a blend of ten herbs, comprising five fresh wet drugs and five dry drugs, linked to therapeutic properties that facilitate the treatment of RA symptoms. The results indicated that Alepa significantly improved several symptoms related to rheumatoid arthritis, such as joint swelling and stiffness, as well as inflammatory markers like CRP, RA, ASO, and ESR.
Mechanism of Action: Balancing Doshas
The therapeutic action of Alepa is primarily attributed to its Ushna (hot) and Teekshna (sharp) qualities, which aid in reducing Vata and promoting the digestion of Ama. According to Ayurvedic principles, vitiated Vata leads to the deposition of Ama in the joints, exacerbating symptoms. The ingredients used in Alepa are known for their Kaphavatahara properties, which help eliminate excess Vata and remove accumulated Ama, thus relieving joint pain, swelling, and stiffness. This treatment aligns with the Ayurvedic strategies of Langhana and Swedana, focusing on the reduction of Ama while not compromising the individual’s strength (Bala).
Observations During Treatment
During the study, notable side effects included itching experienced by a minority of patients, attributed to the balancing of Pitta dosha. To mitigate this reaction, a mild antipyretic agent was administered. Furthermore, patients were advised on dietary changes to support their treatment goals by avoiding foods that could aggravate Agni and Pitta. These observations underscore the holistic approach in Ayurvedic therapy, focusing not just on symptom relief but also on maintaining overall balance and wellness.
Conclusion
The findings from this clinical study suggest that Alepa, through its unique formulation and application, is effective in alleviating the symptoms and inflammatory markers associated with rheumatoid arthritis. By leveraging Ayurvedic principles of dosha balance and Ama elimination, Alepa can be integrated into the modern treatment protocols for RA. These encouraging results pave the way for further research into Ayurvedic treatments, offering potential avenues for innovative therapies that enhance patient care within the field of rheumatology.
FAQ section (important questions/answers):
What is the focus of the clinical study on Alepa?
The study evaluates the effect of Alepa on managing rheumatoid arthritis symptoms and inflammatory markers, including ESR, CRP, ASO, and RA factor.
How many patients participated in the Alepa study?
A total of 20 patients diagnosed with rheumatoid arthritis were selected for this clinical study.
What methods were used to evaluate the effectiveness of Alepa?
The study employed a single-blind clinical design, assessing objective parameters before and after treatment to determine Alepa's impact.
What were the significant results from using Alepa treatment?
Alepa treatment showed significant improvements in symptoms like joint pain, swelling, and inflammatory markers such as CRP and ESR.
What are the key components of the Alepa treatment?
Alepa consists of five wet and five dry Ayurvedic herbal ingredients, applied externally and administered internally for optimal results.
What recommendations were given to patients during the treatment?
Patients were advised to avoid spicy and fried foods and drink plenty of fluids to support the treatment process.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “"Study of alepa for managing rheumatoid arthritis"”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Alepa:
Alepa refers to a topical application in Ayurveda, often made from a combination of herbal ingredients. It is used in treatments for various ailments, particularly in conditions like Rheumatoid arthritis, where it is applied externally to provide relief from symptoms such as pain and inflammation.
2) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic autoimmune condition characterized by inflammation of the joints, leading to pain, stiffness, and potential joint damage. It is considered a significant health problem globally, affecting millions and requiring ongoing management to improve quality of life for patients.
3) Study (Studying):
The study is a clinical evaluation aimed at assessing the impact of Alepa on patients with Rheumatoid arthritis. Through systematic observation and analysis of results, it seeks to affirm the therapeutic benefits of Ayurvedic treatments in managing chronic inflammatory diseases.
4) Drug:
Drugs refer to the specific herbal components used in the preparation of Alepa. Each drug possesses unique properties that contribute to the treatment efficacy, such as anti-inflammatory and analgesic effects, aimed at alleviating the symptoms of Rheumatoid arthritis and restoring balance in the body.
5) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine based on the balance of bodily systems and the use of herbal treatments. Its holistic approach emphasizes prevention, health, and well-being, utilizing natural remedies like Alepa to address diseases, including chronic ailments like Rheumatoid arthritis.
6) Vata:
Vata is one of the three doshas in Ayurveda, representing elements of air and space. It's responsible for movement and physiological functions, and its imbalance is thought to contribute to various health issues, including Rheumatoid arthritis, where it is often seen as a primary pathogenic factor.
7) Amavata (Ama-vata):
Amavata is an Ayurvedic term for a condition similar to Rheumatoid arthritis, characterized by joint pain, stiffness, and swelling due to the presence of Ama (toxins). It emphasizes the need for targeted treatments that address both symptoms and the underlying causes of the disease.
8) Agni:
Agni refers to the digestive fire in Ayurveda, essential for maintaining health. Impaired Agni leads to the formation of Ama and various diseases. In the context of this study, enhancing Agni is crucial for treating Rheumatoid arthritis and facilitating the elimination of toxins from the body.
9) Stiffness:
Stiffness, particularly morning stiffness, is a primary symptom of Rheumatoid arthritis. It represents reduced flexibility and mobility in joints, often resulting in difficulty performing daily activities. The study aims to assess changes in stiffness following the application of Alepa as part of the treatment.
10) Swelling:
Swelling in joints, caused by inflammation, is a hallmark of Rheumatoid arthritis. The study evaluates the effect of Alepa on reducing this swelling, providing insights into the efficacy of traditional Ayurvedic treatments in managing inflammatory responses in chronic conditions.
11) Disease:
In this context, disease refers to Rheumatoid arthritis, a chronic condition marked by inflammation and progressive joint damage. The text discusses its symptoms, causes, and traditional Ayurvedic approaches to manage it, emphasizing the need for effective treatment strategies.
12) Angamarda (Amgamarda, Anga-marda):
Angamarda refers to body pain or aching in Ayurveda, often a symptom of Vata imbalance. It is significant in the study as one of the symptoms of Rheumatoid arthritis that Alepa aims to alleviate, contributing to the overall improvement of patient well-being.
13) Dosha (Dosa):
Dosha represents the three fundamental energies in Ayurveda—Vata, Pitta, and Kapha. Their balance is essential for health, and understanding how each dosha affects the body helps in diagnosing and treating conditions like Rheumatoid arthritis in a holistic manner.
14) Ushna (Usna):
Ushna means warm or hot in Ayurveda. Since Rheumatoid arthritis is characterized by pain and stiffness, Ushna properties of Alepa are beneficial as they counteract cold qualities, helping to relieve inflammation, improve circulation, and support healing of affected joints.
15) Pain:
Pain is a central symptom of Rheumatoid arthritis, affecting the patient's quality of life. This study focuses on assessing pain levels using VAS criteria before and after treatment with Alepa, aiming to demonstrate its effectiveness in reducing discomfort related to the condition.
16) Aruci:
Aruchi signifies loss of appetite in Ayurveda, often accompanying chronic conditions like Rheumatoid arthritis. It is included in the study parameters to evaluate the overall health of participants, as nutrition plays a critical role in managing inflammation and supporting recovery.
17) Upanaha:
Upanaha refers to a therapeutic procedure in Ayurveda involving the application of a medicated paste or poultice. Alepa, as used in this study, serves as a form of Upanaha treatment, designed to penetrate the skin and provide localized relief from joint pain and inflammation.
18) Alasya:
Alasya translates to lethargy or fatigue, often associated with Rheumatoid arthritis patients. It reflects the impact of the disease on energy levels, included in the assessment to evaluate overall treatment effectiveness and its role in improving patient vitality and daily functioning.
19) Lepa:
Lepa indicates the herbal paste applied externally for therapeutic purposes in Ayurveda. In the context of this study, Lepa is used as Alepa to alleviate symptoms of Rheumatoid arthritis by facilitating absorption of medicinal properties through the skin to provide relief.
20) Rasa (Rasha):
Rasa refers to tissue fluid or humor in Ayurveda, and maintaining its balance is crucial for health. The study seeks to address issues related to Rasa in Rheumatoid arthritis, recognizing its importance in nourishment and inflammation processes within the body.
21) Shri (Sr, Sri):
Shri signifies respect or a name often associated with wellness and holistic practices. In this study, it underscores the traditional Ayurvedic affiliation and the cultural importance of the healing practices being examined, representing a connection to heritage and therapeutic knowledge.
22) Sama (Shama):
The Sama represents a balanced state of health in Ayurveda. The study aims to achieve a Sama condition in patients with Rheumatoid arthritis through targeted treatments like Alepa, ensuring that symptoms are managed effectively and overall well-being is restored.
23) Observation:
An individual observation refers to a specific measurement or assessment made during the study, such as changes in pain levels or swelling. Each observation contributes to the comprehensive understanding of the treatment's effectiveness and aids in refining Ayurvedic therapeutic approaches.
24) Langhana (Lamghana):
Langhana refers to a therapeutic approach in Ayurveda aimed at reducing excesses in the body, often through dietary changes or treatments. It plays a significant role within the context of managing Rheumatoid arthritis by eliminating Ama and restoring balance.
25) Svedana:
Svedana denotes the process of sweating induced through external treatments to promote detoxification and relieve symptoms. In treating Rheumatoid arthritis, it aids in alleviating stiffness and inflammation, thus forming an important part of the holistic Ayurvedic management approach.
26) Itching:
Itching refers to a common side effect experienced by patients during treatment. This study reports cases of itching in response to Alepa, highlighting the importance of monitoring and managing treatment reactions for patient comfort and therapy success.
27) Dravya:
Dravyas references the various herbal substances used in Ayurvedic formulations. In the study, an understanding of the different Dravyas employed in Alepa is vital for grasping the therapeutic actions they impart related to the treatment of Rheumatoid arthritis.
28) Sandhi (Shandhi, Samdhi):
Sandhi refers to joints in Ayurveda. This term emphasizes the focus of the study on joint-related symptoms and conditions. The treatment aims to address the issues at the Sandhi level, targeting pain and inflammation associated with disorders like Rheumatoid arthritis.
29) Ruksha (Ruksa):
Ruksha denotes dry or astringent qualities in Ayurvedic treatment. When applied in the context of Alepa, Ruksha properties help optimize treatment for Rheumatoid arthritis by helping to balance excess moisture and relieve associated swelling and inflammation in the joints.
30) Pitta:
Pitta is one of the three doshas representing fire and transformation. Imbalances in Pitta can affect digestion and impact conditions like Rheumatoid arthritis. Monitoring and managing Pitta is critical in the treatment plan to ensure holistic healing and restore balance.
31) Asthi (Ashthi):
Asthi refers to bone tissue in Ayurveda. It is significant in cases of Rheumatoid arthritis, as it highlights the potential impact on the skeleton. This connection informs treatment strategies focused on maintaining joint health and preventing further degeneration.
32) Dhatu:
Dhatus represent the fundamental tissues in Ayurveda, each playing critical roles in health. In Rheumatoid arthritis, understanding the interplay of Dhatus illuminates strategies for restoring balance among them and ensuring overall bodily function.
33) Water:
Water is essential for health and plays a vital role in supporting bodily functions. In the context of the study, the role of hydration is emphasized, especially during treatment with Alepa to enhance detoxification and overall wellness in patients with Rheumatoid arthritis.
34) Bala:
Bala signifies strength or vitality in Ayurveda. It is crucial in assessing treatment outcomes, as preserving or enhancing Bala is important for individuals undergoing therapies for chronic conditions like Rheumatoid arthritis, ensuring they maintain their energy and functioning.
35) Food:
Food is central to Ayurvedic philosophy, impacting Agni, Doshas, and overall health. Dietary recommendations often accompany treatment plans, emphasizing the need for balanced nutrition to support healing and improve the outcomes in patients with Rheumatoid arthritis.
36) Sign:
Sign refers to the observable indicators of health or disease. In the study, signs of Rheumatoid arthritis, such as swelling, pain, and stiffness, are assessed to evaluate the effectiveness of the Alepa treatment and contribute to clinical understanding of the condition.
37) Post:
In a clinical study, 'Post' indicates measurements or assessments taken after treatment. It is a crucial component for evaluating the effectiveness of interventions like Alepa on symptoms of Rheumatoid arthritis, allowing comparisons between pre-treatment and post-treatment states.
38) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha embodies the combination of earth and water elements, contributing to stability and lubrication. Imbalance in Kapha can lead to increased stiffness and swelling in conditions like Rheumatoid arthritis, making it essential to manage this dosha effectively in treatment.
39) Ashraya (Asraya):
Ashraya relates to the essential foundations or support systems in Ayurvedic practices. In the context of treatments like Alepa, understanding where the treatment acts and how it supports affected systems is crucial for achieving effective therapeutic outcomes.
40) Field:
Field denotes the area of study or research domain. In the context of this study, it represents the exploration of Ayurvedic practices and their application in treating Rheumatoid arthritis, bridging traditional knowledge with modern scientific inquiry.
41) Nidraviparyaya:
Nidraviparyaya refers to disturbed sleep patterns often experienced by individuals with chronic conditions. It is relevant in this study as sleep disturbances can impact the overall quality of life and healing, highlighting the need for comprehensive treatment approaches.
42) Tiktadravya (Tikta-dravya):
Tikta-dravya pertains to bitter substances in Ayurveda, known for their detoxifying and anti-inflammatory properties. Incorporating Tikta-dravya in Alepa is beneficial for managing conditions like Rheumatoid arthritis by regulating doshas and promoting healing within the body.
43) Agnidushti (Agnidusti, Agni-dushti):
Agni-dushti indicates a compromised digestive fire, contributing to the formation of Ama and subsequent disease. This condition is particularly significant in diagnosing and treating Rheumatoid arthritis, emphasizing the importance of restoring Agni through appropriate dietary and therapeutic interventions.
44) Majjadhatu (Majja-dhatu):
Majja-dhatu refers to bone marrow and nervous tissue in Ayurveda. It plays a vital role in supporting overall body function. Understanding the health of Majja-dhatu is crucial in conditions like Rheumatoid arthritis, as it can impact joint and nerve health.
45) Pittadosha (Pittadosa, Pitta-dosha):
Pitta-dosha denotes the fiery element within the body, responsible for metabolism and transformation processes. An imbalance in Pitta can exacerbate symptoms in Rheumatoid arthritis, which necessitates careful management to ensure successful treatment outcomes.
46) Rasadhatu (Rasa-dhatu):
Rasa-dhatu refers to the lymphatic and blood circulation system in Ayurveda. Understanding its role is vital for managing conditions like Rheumatoid arthritis since it involves the flow of nutrients essential for healing and reducing inflammatory processes within the joints.
47) Katutikta (Katu-tikta):
Katu-tikta refers to the bitter and pungent properties of certain herbs. These substances are recognized in Ayurveda for their effectiveness in alleviating inflammation and managing symptoms of diseases, including Rheumatoid arthritis, by influencing dosha balance and enhancing digestion.
48) Shothahara (Sothahara, Shotha-hara):
Shothahara denotes substances or treatments that reduce swelling and inflammation in Ayurveda. By promoting detoxification and alleviating symptoms in conditions like Rheumatoid arthritis, Shothahara drugs play a critical role in restoring balance and enhancing a patient's overall health.
49) Vatadosha (Vatadosa, Vata-dosha):
Vata-dosha signifies the elemental force of air and space responsible for movement and communication within the body. Its imbalance is associated with various disorders, including joint issues in Rheumatoid arthritis, highlighting the need for therapeutic measures to restore Vata balance.
50) Discussion:
Discussion refers to the analysis of findings and interpretations related to the study of Alepa on Rheumatoid arthritis. It promotes understanding of how Ayurvedic approaches can be aligned with modern medicine, providing insights into effective management strategies for chronic inflammatory diseases.
51) Samprapti:
Samprapti represents the pathogenesis of a disease in Ayurveda, outlining the factors that lead to its manifestation. In the context of Rheumatoid arthritis, analyzing Samprapti is critical for developing effective treatments that address both symptoms and root causes of the condition.
52) Viparyaya:
Viparyaya refers to the reversal of natural order or balance in the body. It's relevant in contexts such as Rheumatoid arthritis, as understanding Viparyaya can help identify corrective measures to restore health and alleviate symptoms caused by dosha imbalances.
53) Pratiloma (Prati-loma):
Pratiloma indicates the upward direction in which hair grows and is often referenced in Ayurveda for specific therapeutic applications. For Alepa, the application direction is considered important for maximizing therapeutic effectiveness and ensuring optimal absorption of the treatment.
54) Attending:
Attending refers to the individuals seeking healthcare services. In this study, it highlights the patient population engaged in Ayurvedic treatments at the hospital, focusing on those who experience Rheumatoid arthritis and their responses to Alepa therapy.
55) Suffering:
Suffering highlights the struggles faced by patients dealing with chronic conditions like Rheumatoid arthritis. It underscores the necessity for effective treatment solutions, such as those explored in this study, aimed at alleviating pain and improving quality of life.
56) Lakshana (Laksana):
Lakshana, similar to Lakshanas, refers to the specific symptoms indicative of a particular condition. In the study, it plays a crucial role in tracing the effects of Alepa on patients suffering from Rheumatoid arthritis and supports clinical assessment of treatment outcomes.
57) Abhyanga (Abhyamga):
Abhyanga is an Ayurvedic massage technique using oil and herbal preparations. It enhances circulation and provides relief from various ailments. In the context of Rheumatoid arthritis, Abhyanga can complement treatments like Alepa, promoting relaxation and improving joint flexibility.
58) Ashtanga (Astanga, Ashtan-anga):
Ashtanga refers to the 'Eight Limbs' of Ayurveda, emphasizing holistic practices for health. The text connects Ashtanga principles to the treatment methodologies, reflecting the comprehensive approach to managing conditions like Rheumatoid arthritis through balanced lifestyle and therapeutic interventions.
59) Shleshma (Slesma):
Shleshma symbolizes the qualities of Kapha dosha, associated with lubrication and stability. An understanding of Shleshma's role helps inform treatment strategies in Rheumatoid arthritis by addressing mucous-related problems and improving joint function through effective management of the underlying dosha.
60) Medicine:
Medicine signifies the practice of treating and preventing disease. In this context, it emphasizes the importance of pharmacological and non-pharmacological approaches, including herbal preparations like Alepa, that are integral to managing chronic diseases such as Rheumatoid arthritis.
61) Vitiation (Vitiated):
Vitiated refers to an altered or imbalanced state of doshas in Ayurveda. In the study, recognizing vitiated states of Vata and Kapha is crucial for selecting appropriate treatments for Rheumatoid arthritis and restoring the body's natural equilibrium.
62) Prayoga:
Prayoga refers to the application or practice of specific therapeutic treatments in Ayurveda. This term underscores the importance of employing the right approach, such as the use of Alepa, thereby enhancing the effectiveness of treatment for conditions like Rheumatoid arthritis.
63) Trishna (Trsna):
Trishna indicates thirst or dehydration, often recognized as a symptom associated with underlying health issues. Assessing Trishna in patients may shed light on the overall hydration and wellness status, which is relevant when managing conditions such as Rheumatoid arthritis.
64) Gaurava:
Gaurava signifies heaviness or fatigue, often experienced by individuals with chronic conditions like Rheumatoid arthritis. It plays a critical role in evaluating the overall impact of the disease on daily functioning and is considered during treatment assessment and planning.
65) Avarana:
Avarana denotes a covering or obstruction, often related to the dosha imbalances in Ayurveda. In Rheumatoid arthritis, understanding Avarana helps inform treatment strategies aimed at unblocking or addressing impediments to natural healing processes within the body.
66) Pradeha:
Pradeha refers to a specific type of topical application in Ayurveda for releasing toxins and relieving pain. The use of Pradeha in treating symptoms of Rheumatoid arthritis highlights the significance of localized therapies responding to the body's needs.
67) Nidhana:
Nidhana signifies the underlying causes or sources of a disease. In the context of Rheumatoid arthritis, identifying Nidhana helps practitioners design appropriate treatment regimens that target both the manifestations and root causes of the condition.
68) Madhava:
Madhava refers to foundational texts in Ayurveda that provide insights into herbal therapies and treatment methodologies. The relevance of Madhava lies in its guidance for clinicians exploring Ayurvedic approaches to conditions like Rheumatoid arthritis, shaping contemporary practices.
69) Pacana:
Pacana pertains to the process of digestion and detoxification in Ayurveda. In the context of treating Rheumatoid arthritis, enhancing Pacana is essential to eliminate Ama and restore balance, effectively alleviating symptoms through dietary and herbal interventions.
70) Sthana:
Sthana refers to the location or site of disease manifestation in Ayurvedic medicine. Identifying the Sthana of symptoms in Rheumatoid arthritis is critical for targeted therapeutic applications, ensuring treatments like Alepa are effectively directed to where they are needed most.
71) Nidana:
Nidana means the root causes or factors contributing to a condition. Understanding the Nidana of Rheumatoid arthritis is crucial for developing focused treatment strategies that address the factors leading to Vata and Kapha imbalances and promote optimal health.
72) Kapha:
Kapha embodies the qualities of earth and water, representing structure and stability in the body. Its balance is paramount for health, and imbalances can lead to conditions like Rheumatoid arthritis, necessitating dietary and therapeutic interventions to restore equilibrium.
73) Laghu:
Laghu indicates lightness in Ayurveda and is often used in contrast to heavy qualities, particularly in food and therapies. Understanding Laghu is relevant in managing patients with Rheumatoid arthritis, as therapies that promote lightness can help alleviate symptoms.
74) Mamsa (Mamsha):
Mamsa refers to muscle tissue in Ayurveda. Its significance in conditions like Rheumatoid arthritis lies in its interaction with Vata, where imbalances can impact muscle integrity and overall joint function. Addressing Mamsa health is crucial for treatment efficacy.
75) Nidra:
Nidra refers to sleep or rest in Ayurveda, essential for health. The study recognizes how disturbances in Nidra can affect the well-being of patients with Rheumatoid arthritis, stressing the importance of comprehensive treatments that support healthy sleep patterns.
[Note: The above list is limited to 75. Total glossary definitions available: 88]
Other Science Concepts:
Discover the significance of concepts within the article: ‘"Study of alepa for managing rheumatoid arthritis"’. Further sources in the context of Science might help you critically compare this page with similair documents:
Dosha, Ama, Upanaha, Amavata, Agnidushti, Pachana, Panchakarma, Aruchi, Angamarda, Jwara, Rheumatoid arthritis, Chronic disease, External application, Internal administration, Significant result, Clinical study, Diagnostic criteria, Treatment Protocol, Statistical Significance, Swedana, Samprapti Vighatana, Subjective parameter, Ama formation, Objective parameter, Sandhishotha, Sandhishoola, Transdermal drug delivery, Gourava, Clinical parameter, Upanaha Swedana, Swedana effect, Sama stage, Inflammatory marker.