Study on nishamalaki vs. elaadi churna in madhumeha (NIDDM).
Journal name: World Journal of Pharmaceutical Research
Original article title: A comparitive clinical study on the effect of nishamalaki churna and elaadi churna in madhumeha w.s.r. to niddm
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Shubham Ladkat (B.A.M.S), G. Vinay Mohan M.D (Ayu.), Ishwarayya S. Mathapati M. D. (Ayu.), G. S. Dharmannavar M. D. (Ayu.) and Punit P. M. D. (Ayu)
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A comparitive clinical study on the effect of nishamalaki churna and elaadi churna in madhumeha w.s.r. to niddm
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20242-30890
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Madhumeha, identified as a variant of vataja prameha, is one of the eight significant diseases in Ayurveda, commonly correlating with diabetes mellitus, specifically non-insulin-dependent diabetes mellitus (NIDDM). It arises from the vitiation of Vata and Kapha doshas that influence the dhatus (tissues) and ojas (vital energy), ultimately affecting the urinary system. With an alarming increase in diabetes prevalence, particularly in India, there is a pressing need for effective herbal treatments that are accessible and have minimal side effects. This comparative clinical study investigates the efficacy of two herbal formulations: Nishamalaki Churna and Elaadi Churna, in managing Madhumeha.
Efficacy of Nishamalaki Churna
Nishamalaki Churna is heralded in Ayurvedic medicine for its potent therapeutic properties in treating Madhumeha due to its ability to balance the deteriorated doshas, particularly Vata and Kapha. The study shows that patients treated with Nishamalaki Churna reported significant symptomatic relief across various parameters such as excessive urination (Prabhoota Mutrata), sleep disturbances (Svapna Sheela), and increased thirst (Atitrushna). The results indicated an approximate 88.88% reduction in symptoms for Nishamalaki Churna, suggesting it may be a highly effective intervention compared to other treatments.
Benefits of Elaadi Churna
While Nishamalaki Churna demonstrated notable effectiveness, Elaadi Churna also provided beneficial outcomes in managing Madhumeha. Formulated with ingredients such as Ela and Pashanabhedha, Elaadi Churna showed moderate relief across various symptoms, surviving as a viable alternative treatment option. For instance, patients using Elaadi Churna achieved about 68.18% relief from sleep-related issues. Despite inferiority in efficacy compared to Nishamalaki Churna, Elaadi Churna's therapeutic properties, particularly in reducing Vata and Kapha, underline its relevance in diabetes management.
Clinical Observations and Comparative Results
The study's clinical observations reveal that the therapeutic interventions were effective in lowering the mean scores of symptoms in both groups treated with either Nishamalaki Churna or Elaadi Churna. The comparative analysis indicated that Nishamalaki Churna led to a substantial decrease in symptomatic scores across multiple parameters, highlighting its superior efficacy. Various subjective assessments, such as increased hunger (Atikshudha) and lesser urinary sweetness (Mutra Madhuryatha), corroborated the effectiveness of Nishamalaki in contrast to Elaadi Churna.
Conclusion
This clinical study concludes that Madhumeha represents a significant metabolic disorder that significantly impacts the quality of life. Both Nishamalaki Churna and Elaadi Churna show potential in alleviating the symptoms of Madhumeha, but Nishamalaki Churna emerged as the more effective treatment option based on the observed outcomes. The promising results advocate for further research into these herbal treatments to enhance diabetes management practices, offering hope for long-term, natural therapeutic strategies in the face of rising diabetes prevalence in populations at risk.
FAQ section (important questions/answers):
What is the main study focus of the research?
The study focuses on comparing the effects of Nishamalaki Churna and Elaadi Churna in managing Madhumeha, specifically concerning non-insulin dependent diabetes mellitus (NIDDM).
What are the key properties of Nishamalaki Churna?
Nishamalaki Churna is known for its vata-kapha hara properties and is considered an effective treatment for Prameha due to its Rasayana (rejuvenating) attributes.
What inclusion criteria were used for patient selection?
Patients aged 24 to 60 diagnosed with Madhumeha were included, without discrimination of sex, race, or caste.
What is the duration of the study treatment?
The study treatment lasted for 28 days, with each group receiving their respective Churna twice daily before meals.
Which group showed better results in the study?
Nishamalaki Churna demonstrated significantly better results compared to Elaadi Churna, showcasing greater improvements in symptoms related to Madhumeha.
What were some common symptoms assessed in the study?
Symptoms assessed included Prabhoota Mutrata, Svapna Sheela, Atikshudha, and Avila Mutrata, among others, to evaluate treatment efficacy.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study on nishamalaki vs. elaadi churna in madhumeha (NIDDM).”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
Study refers to a systematic investigation conducted to evaluate the effectiveness of Nishamalaki Churna and Elaadi Churna in managing Madhumeha, particularly NIDDM. It involves assessing the intervention's effects on various clinical parameters, thereby contributing to the understanding of Ayurvedic treatment's role in diabetes management.
2) Shri (Sr, Sri):
Shri is a respectful honorific often used in Indian culture, denoting reverence. In the context of the study, it precedes the name of the institution, Shri Shivyogeshwar Rural Ayurvedic Medical College, indicating its importance and the integrity associated with scholarly research conducted therein.
3) Daurbalya:
Daurbalya signifies weakness or lack of strength. In the study's context, it represents a clinical symptom associated with Madhumeha. Understanding and assessing Daurbalya helps gauge the impact of treatment on patients' overall vitality and energy levels, crucial for evaluating the efficacy of the interventions.
4) Mutra:
Mutra translates to urine in Ayurvedic terminology. The research assesses various urinary features, such as frequency and quality, as part of Madhumeha diagnosis. A thorough evaluation of Mutra is essential for understanding how diabetes affects kidney function and overall metabolic health.
5) Tanu:
Tanu refers to thinness or emaciation, often experienced by patients with prolonged diabetes due to metabolic disturbances. Evaluating Tanu enables clinicians to assess the overall nutritional status of patients, helping determine the effectiveness of treatments in managing symptoms associated with Madhumeha.
6) Atikshudha (Atiksudha, Ati-kshudha):
Atikshudha denotes excessive hunger, a common symptom associated with diabetes. The study evaluates this parameter among participants to assess how well the treatments can control hyperglycemia symptoms. Managing Atikshudha is vital for improving patients' quality of life and overall health outcomes.
7) Discussion:
Discussion is a critical element in research, examining collected data and interpreting findings. In this context, it focuses on comparing clinical outcomes of both treatment groups while contextualizing results within Ayurvedic frameworks and the existing body of research on diabetes management.
8) Prameha:
Prameha refers to a group of urinary disorders within Ayurveda, with Madhumeha being a subtype characterized by excess urine and sugar. Understanding Prameha is key in Ayurveda to effectively categorize and treat various forms of diabetes, highlighting its relevance in the study.
9) Sign:
Sign refers to observable clinical manifestations of a condition. In this study, various signs of Madhumeha such as polydipsia and polyuria are monitored to evaluate treatment effectiveness. Proper identification and interpretation of these signs are crucial for accurate diagnosis and management.
10) Drug:
Drugs refer to therapeutic agents used in healthcare. In this context, the study evaluates the effectiveness of Ayurvedic drugs like Nishamalaki Churna and Elaadi Churna in managing symptoms of Madhumeha, enhancing understanding and acceptance of traditional herbal remedies in contemporary medicine.
11) Observation:
Observation encompasses the careful monitoring of patients’ responses to treatment throughout the study. It plays a pivotal role in clinical research, providing valuable insights about the effectiveness of Nishamalaki and Elaadi Churna, informing practitioners about treatment outcomes and necessary adjustments.
12) Suffering:
Suffering refers to the distress experienced by individuals living with chronic conditions like Madhumeha. The study aims to alleviate this suffering through effective Ayurvedic treatments, ultimately improving the quality of life for patients and providing an alternative to conventional diabetes management.
13) Shilajatu (Silajatu, Shila-jatu):
Silajatu is a mineral-based Ayurvedic substance reputed for numerous therapeutic benefits, particularly in treating Madhumeha. Its inclusion in Elaadi Churna highlights its relevance in enhancing efficacy, illustrating Ayurvedic medicine's holistic approach towards diabetes through natural and readily available bioactive compounds.
14) Svapna:
Svapna translates to sleep in Ayurvedic contexts. Its assessment in the study aids in identifying sleep disturbances among patients with Madhumeha, as poor glycemic control can affect sleep quality. Addressing Svapna issues is vital for overall well-being in diabetes management.
15) Kapha:
Kapha is one of the three Ayurvedic doshas, representing earth and water elements. In Madhumeha, Kapha vitiation can contribute to obesity and metabolic disorders. Understanding Kapha's role is integral to tailoring treatment approaches that restore balance and address diabetes-related symptoms.
16) Sukha:
Sukha denotes happiness or comfort, representing a state of well-being. In the realm of diabetes management, achieving Sukha is crucial for improving life quality. Effective treatments aim to restore Sukha by managing symptoms and ensuring holistic health for diabetic patients.
17) Avila:
Avila refers to turbidity or unclear urine, an important symptom in Madhumeha diagnosis. Monitoring Avila provides insights into a patient's metabolic state, aiding healthcare providers in assessing the severity of diabetes and the impacts of Ayurvedic treatments on urinary clarity.
18) India:
India, referred to as the expected diabetes capital, emphasizes the importance of addressing diabetes through effective and culturally relevant strategies. The study underscores the need for accessible Ayurvedic treatments to manage the rising rates of NIDDM among the Indian population.
19) Asana (Ashana):
Asana translates to posture or attitude, significant in Ayurvedic evaluations. Assessing Asana helps understand the physical state of patients, which can be affected by diabetes. Incorporating Asana assessments in the study provides a holistic framework for evaluating patient well-being and function.
20) Hara:
Hara indicates the act of regulating or controlling. In Ayurvedic context, it often refers to balancing doshas like Vata and Kapha. Successful treatment of Madhumeha aims to Hara the imbalance caused by diabetes, restoring health through effective interventions that target metabolic pathways.
21) Vata:
Vata is another crucial dosha in Ayurveda, representing air and space elements. In Madhumeha, Vata imbalances can lead to various symptoms, including neurological disturbances. Understanding Vata's influence helps tailor treatments effectively, addressing the broader implications of diabetes on health and wellness.
22) Avil:
Avil denotes clarity or transparency, particularly in urine examination. In diabetes patients, assessing Avil allows clinicians to determine the impact of glycemic control on urinary health. Monitoring Avil helps gauge the effectiveness of treatments, ensuring better management of Madhumeha.
23) Food:
Food is pivotal in managing diabetes, influencing glycemic control and overall health. The study recognizes diet's role, emphasizing Ayurvedic dietary recommendations alongside medication as essential in managing Madhumeha, promoting lifestyle adjustments to enhance treatment outcomes.
24) Mental disorder:
Mental disorder refers to specific psychological conditions affecting individuals. In the study, excluding patients with such disorders ensures a clear focus on Madhumeha's physiological aspects and the evaluation of treatment efficacy, recognizing the complexity of comorbidity in diabetes care.
25) Nidana:
Nidana refers to causative factors or risk factors leading to diseases. Within the study, identifying the nidana linked with Madhumeha aids in crafting effective treatments. Understanding these causes underpins the Ayurvedic approach to proactively address issues before they manifest as chronic health conditions.
26) Similarity:
Similarity highlights the connections between Ayurvedic definitions of Madhumeha and modern diabetes classifications. Recognizing these overlaps enhances understanding and acceptance of Ayurvedic treatments in contemporary healthcare, illustrating the relevance of traditional wisdom in addressing prevalent diseases like diabetes.
27) Mathapati:
Mathapati is one of the authors contributing expertise to the study. Acknowledging collaborators like Mathapati emphasizes the collaborative nature of research and enhances credibility, as input from multiple professionals enriches the findings and recommendations presented within the study.
28) Blindness:
Blindness is a severe complication associated with uncontrolled diabetes, resulting from long-term retinal damage. The study highlights the importance of effective Madhumeha management to prevent such debilitating outcomes, stressing the need for timely intervention and optimized treatment strategies.
29) Vitiation (Vitiated):
Vitiation refers to the disturbance or imbalance of bodily systems. In Madhumeha, understanding vitiation of the doshas is crucial for accurate diagnosis and effective treatment, guiding practitioners to restore balance through Ayurvedic interventions tailored to individual patient needs.
30) Tridosha (Tridosa, Tri-dosha):
Tridosha refers to any singular dosha within Ayurveda, emphasizing its unique influence on health. Assessing the state of each tridosha is crucial in diabetes management, allowing for tailored treatment approaches that align with patient-specific imbalances and promoting overall well-being.
31) Relative:
Relative refers to the family history or genetic predisposition towards certain diseases, including diabetes. Understanding relatives' health conditions provides insights into patients' risks, guiding preventive strategies and personalized treatment plans aimed at managing Madhumeha more effectively.
32) Samhita:
Samhita, in singular context, refers to a specific Ayurvedic text. These texts serve as foundational resources that guide treatment protocols and diagnosis. Exploring relevant Samhita enhances the study's credibility and connects contemporary practices to ancient wisdom in managing Madhumeha.
33) Disease:
Disease signifies a pathological condition affecting the body's functionality. In this context, Madhumeha as a disease demonstrates the complexities of managing metabolic disorders. The study aims to elucidate Ayurvedic treatment efficacy, addressing diseases holistically through integrated therapeutic modalities.
34) Pippali (Pippalin):
Pippali, or Indian long pepper, is an important herb known for its medicinal properties, particularly in aiding digestion and respiratory health. Its inclusion in Elaadi Churna reflects Ayurvedic approaches that leverage herbal synergism to enhance therapeutic effects in managing diabetes and related symptoms.
35) Indian:
Indian pertains to anything associated with India, including its rich cultural heritage and traditional medical practices like Ayurveda. The study reinforces Indian Ayurvedic texts and practices, emphasizing their relevance and applicability to addressing modern health issues like diabetes.
36) Ghrita (Ghrta):
Ghrita, which means clarified butter, is an important substance in Ayurveda known for its numerous health benefits. It is often used in Ayurvedic formulations. Recognizing its role within treatments like Nishamalaki Churna aids in the understanding of traditional methods and their significance in managing Madhumeha.
37) Srotas (Shrotas):
Srotas refers to the channels through which bodily fluids and energies flow in Ayurvedic physiology. Understanding Srotas is vital in the context of Madhumeha, as diabetes affects these channels. Effective treatments aim to restore their function, contributing to improved metabolic health.
38) Vataja (Vata-ja):
Vataja designates conditions influenced primarily by Vata dosha. Within the context of Madhumeha, recognizing Vataja characteristics aids practitioners in determining the specific type of diabetes and tailoring treatment strategies that address variegated symptoms resultant from this dosha's vitiation.
39) Vyadhin (Vyadhi):
Vyadhi translates to disease or disorder within Ayurvedic terminology. The study focuses on Madhumeha as a specific vyadhi to explore treatment efficacy. Understanding vyadhi ensures appropriate therapeutic interventions that cater to both symptomatic relief and underlying health deficiencies.
40) Dhatu:
Dhatu translates to tissue in the body. Identification of specific dhatus affected by Madhumeha can help guide treatment strategies. Recognizing the modifications in dhatus during disease progression enhances the understanding of metabolic disorders and their implications for holistic health.
41) Medas (Meda, Medash):
Meda, referring to fat tissue or body mass, plays a significant role in Ayurvedic understanding of health. In diabetes management, assessing the state of Meda involves evaluating the relationship between obesity and metabolic dysfunction, crucial in tailoring appropriate interventions for Madhumeha.
42) Water:
Water is crucial for maintaining hydration and metabolic balance. The relationship between water intake and diabetes control is significant. The study recognizes the importance of hydration in Madhumeha management, emphasizing that adequate water consumption contributes to overall health and well-being.
43) Meha:
Meha indicates urinary disorders, with Madhumeha being a prominent type characterized by excessive urination and sweetness in urine. The study's focus on Meha illustrates its significance in Ayurveda and modern medical research, drawing connections between symptoms and effective treatment modalities.
44) Ojas:
Ojas represents vital essence or strength in Ayurveda, necessary for health and vitality. The study highlights the importance of preserving Ojas in diabetes management, emphasizing how effective treatments contribute to maintaining overall energy and wellness in Madhumeha patients.
45) Asya (Ashya):
Asya indicates the mouth, playing a key role in digestion and intake of food. The study recognizes the importance of dietary habits and oral health in managing Madhumeha, suggesting that understanding Asya relates directly to the overall treatment success and disease management.
46) Ashta (Asta, Astan, Ashtan):
Asta refers to 'eight' in Sanskrit, indicating the eight most serious diseases in Ayurveda. United under the classification of Asta-Mahagada, understanding Asta solidifies the importance of addressing Madhumeha as a critical health issue requiring effective interventions and management strategies.
47) Coma:
Coma denotes a state of prolonged unconsciousness, which can occur due to severe diabetes complications such as diabetic ketoacidosis. The study emphasizes the importance of effective Madhumeha management to prevent such critical outcomes, underscoring the necessity of timely and appropriate interventions.
48) Life:
Life refers to the existence of individuals and the quality of that existence. The study focuses on improving the quality of life for Madhumeha patients through effective Ayurvedic treatments, emphasizing a holistic approach that addresses both physical and emotional health needs.
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