Floating drug delivery system

an updated review

| Posted in: Health Sciences Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Floating drug delivery system
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Subtitle: an approach to gastro retention

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Rupali S.Wagh, Poonam A. Salunke, Sheetal V.Patil, Shital S. Patil, Amit Ratnaparkhi, Mayur Pawar, Swati Rathod, Dr. S.D. Barhate


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Floating drug delivery system

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Copyright (license): WJPR: All rights reserved


Summary of article contents:

Introduction

The review article highlights the advancements and significance of floating drug delivery systems (FDDS) in pharmaceutical research. These systems are engineered to enhance drug retention in the stomach, addressing challenges such as short gastric residence times and variable gastric emptying. By optimizing the delivery and absorption of therapeutic agents, FDDS aim to improve patient compliance, minimize adverse effects, and maximize therapeutic efficacy. The review encompasses the mechanisms, classifications, evaluation techniques, and applications of floating drug delivery systems in enhancing drug bioavailability.

Mechanisms and Classification of Floating Drug Delivery Systems

Floating drug delivery systems operate on the principle of achieving buoyancy in the gastric environment, allowing the formulation to remain afloat in the stomach’s contents. This buoyancy aids prolonged gastric retention, facilitating the controlled release of medication at the absorption site. FDDS can be categorized into single-unit and multiple-unit systems, which include non-effervescent and effervescent systems, as well as raft-forming systems. Each category presents unique characteristics and manufacturing challenges. For instance, high-density systems maintain their position in the stomach due to their density, while mucoadhesive systems promote adhesion to the gastric lining, thereby prolonging retention.

Evaluation Techniques of Floating Drug Delivery Systems

The evaluation of floating drug delivery systems encompasses various parameters to ensure their effectiveness and quality. Important tests include thickness, hardness, weight variation, and friability assessments. Tablet density specifically is crucial because it determines whether a formulation will float or sink in gastric fluids. The angle of repose is also measured to evaluate the flow properties of the granules used in tablet formation. These quality control measures are pivotal in ensuring that the final product maintains its intended performance during storage and usage.

Applications of Floating Drug Delivery Systems

FDDSs have numerous applications that enhance therapeutic outcomes for drugs requiring prolonged gastric retention or localized action in the stomach. They significantly improve bioavailability for drugs that are absorbed in the upper gastrointestinal tract, such as riboflavin and furosemide. These systems are particularly beneficial in minimizing drug concentration fluctuation and reducing adverse reactions by controlling the delivery of medications and ensuring that unwanted drug activity in the colon region is minimized. Additionally, FDDS formulations can provide sustained drug release, ensuring a steady therapeutic effect over time.

Conclusion

In conclusion, floating drug delivery systems represent a promising approach for improving drug retention and bioavailability within the gastrointestinal tract. The review emphasizes the importance of developing these innovative dosage forms to enhance therapeutic efficacy while addressing the challenges associated with traditional drug delivery methods. The increasing focus from pharmaceutical companies on FDDS indicates a growing recognition of their potential in delivering effective patient care. Continued research and development in this field are essential for optimizing gastro-retentive technologies and bringing them to commercial viability.

FAQ section (important questions/answers):

What is the purpose of floating drug delivery systems?

Floating drug delivery systems aim to improve gastric retention to enhance bioavailability and therapeutic effectiveness, reducing dosing frequency and adverse effects associated with drug delivery.

Which drugs are suitable for gastro-retentive drug delivery systems?

Drugs locally active in the stomach, those with narrow absorption windows, and those unstable in the colon, like antacids and riboflavin, are suitable for these systems.

What are the advantages of floating drug delivery systems?

FDDS provide prolonged gastric retention, enhance drug absorption, improve patient compliance, and are beneficial for drugs that require local action in the stomach or are unstable in the colon.

What are some disadvantages of floating drug delivery systems?

Disadvantages include challenges with drug solubility in gastric fluids, the need for sufficient stomach fluid, and issues with drugs that irritate the gastric mucosa.

What types of floating drug delivery systems are there?

Floating drug delivery systems can be classified into single unit and multiple unit systems, including non-effervescent and effervescent systems, as well as raft-forming systems.

What is the significance of gastric retention time?

Gastric retention time is crucial as it determines how long a drug remains in the stomach, impacting its absorption and therapeutic effectiveness, especially for drugs targeting upper GIT.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Floating drug delivery system”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drugs refer to multiple substances used for medical purposes. In floating drug delivery systems, the formulation aims to improve the pharmacokinetics of drugs by prolonging gastric residence times. The review emphasizes various characteristics of drugs suited for gastro-retentive delivery, such as solubility and stability in gastric fluids.

2) Bhavana (Bha-vana):
Bhavana is the name of the lead author of the review article discussing floating drug delivery systems. This individual, along with co-authors, contributed to the research and compilation of data on effective dosage forms, highlighting their specific roles within pharmaceutical research and development initiatives.

3) Heap:
In pharmaceutical contexts, a heap refers to a pile or an accumulation of granules or powder. The angle of repose method mentioned assesses the flow properties of powder formulations, which is critical for ensuring uniformity and consistency in tablet production, impacting dosage and efficacy.

4) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India, known for its contributions to education and industry, including pharmaceutical research. The authors of the reviewed article are affiliated with institutions in Maharashtra, signifying the state's role in advancing drug delivery systems and producing innovative pharmaceutical technologies.

5) Irritation:
Irritation refers to the adverse reaction that some drugs can cause upon contact with biological tissues. The review discusses how floating drug delivery systems can mitigate gastrointestinal irritation caused by certain medications, enhancing patient tolerability and compliance, particularly with acidic drugs like aspirin.

6) Swelling:
Swelling occurs when a material absorbs water and expands, a critical mechanism in the function of some floating drug delivery systems. Systems like superporous hydrogels utilize swelling to increase volume and ensure prolonged gastric retention time, which is essential for effective drug delivery.

7) Surface:
In the context of floating systems, the 'surface' refers to the area of contact between the drug formulation and the gastric wall. Improved adhesion of these formulations to the gastric mucosa can extend gastric retention time, allowing for more effective drug absorption.

8) India:
India is the country where the research is conducted, particularly in the field of pharmacy and drug delivery. The country has a vibrant pharmaceutical industry, playing a key role in the innovation and commercialization of advanced drug delivery systems, such as floating systems discussed in the review.

9) Patil:
Patil refers to Dada Patil, an individual associated with the college where the research took place. This name signifies the connection to the educational institution that is involved in pharmaceutical sciences and contributes to the teaching and research landscape in drug delivery.

10) Shri (Sr, Sri):
Shri is an honorific prefix used in Indian names, signifying respect. In this context, it is part of the name of the college where the research authors work, reflecting the institution's commitment to education and research in the field of pharmacy.

11) Pune:
Pune is a city in Maharashtra, India, recognized for its educational and research institutions, especially in the pharmaceutical field. The authors’ affiliation with Pune highlights the city's importance in fostering innovations in drug delivery systems and enhancing pharmaceutical education.

12) Wall:
Walls pertain to the gastric walls in this context. Drug formulations that successfully adhere to these walls can enhance retention time and absorption, which is a fundamental objective of floating drug delivery systems, improving therapeutic outcomes for medications.

13) Tata:
Dada in this context likely refers to the founder or person of honor associated with the college. It indicates the historical connection and respect associated with the institution where research on floating drug delivery systems is being conducted.

14) Performance:
Performance in this context relates to how well floating drug delivery systems function in terms of drug release, bioavailability, and sustained action. The review examines the efficacy of these systems, intending to present data supporting their clinical applications and effectiveness.

15) Antibiotic (Antibacterial):
An antibiotic is a type of drug that combats bacterial infections. The review mentions antibiotic formulations, emphasizing how floating systems can enhance their therapeutic efficacy, especially in promoting targeted delivery to the stomach where local action is needed.

16) Science (Scientific):
Scientific refers to the systematic approach to understanding phenomena, particularly in the context of research and development in pharmaceuticals. The review aims to present scientifically gathered evidence regarding the advancements in floating drug delivery systems.

17) Substance:
A substance is any material or compound, especially those used in pharmacology. In floating drug delivery systems, the characterization of substances is crucial as their physicochemical properties directly influence the effectiveness of formulations.

18) Activity:
Activity, in pharmacological terms, refers to the effect of a drug on biological systems. The review highlights how floating drug delivery systems can maintain consistent drug activity over extended periods, improving therapeutic outcomes and patient compliance.

19) Entering:
Entering typically refers to the process whereby a drug formulation moves from one area of the body into another, such as from the stomach into the intestines. Understanding this process is vital for designing effective gastro-retentive systems that optimize drug delivery.

20) Writing:
Writing is the process of compiling information into a coherent format, which in this case refers to the preparation of a scientific review. The authors of the study engaged in writing to share findings and advancements in floating drug delivery systems with the scientific community.

21) Nature:
Nature refers to the inherent qualities or characteristics of substances. In the review, the nature of both drugs and formulations is analyzed to understand how these attributes affect their behavior in the gastrointestinal tract and overall therapeutic effectiveness.

22) Medium:
Medium typically describes the environment in which biochemical processes occur, such as the gastric fluid in the stomach. The properties of this medium affect the solubility and stability of drugs, which are crucial factors in the development of effective drug delivery systems.

23) Powder:
Powder refers to a solid substance finely ground into particles. In pharmaceutical formulations, the properties of powders influence tablet production, the angle of repose, and flowability, which are critical for ensuring uniformity and efficacy in floating drug formulations.

24) Water:
Water is a universal solvent and critical component in many pharmaceutical formulations. In floating drug delivery systems, the absorption of water by the formulation leads to swelling, which is essential for maintaining prolonged gastric retention and optimizing drug delivery.

25) Field:
Field refers to the area of study or profession, such as pharmaceutical sciences. The review represents contributions to the field of drug delivery systems, particularly in advancing knowledge and technologies for improving therapeutic strategies in medication delivery.

26) Blood:
Blood is vital for transporting drugs throughout the body. The pharmacokinetics of drug delivery systems influence how drugs enter the bloodstream, thus determining their overall efficacy and safety. Floating systems aim to optimize this process by enhancing gastric retention and absorption.

27) Salt (Salty):
Salt can refer to various ionic compounds used in drug formulations. The behavior of drugs in salt form, including solubility and stability, is essential for the design of effective floating drug delivery systems that can endure the harsh gastric environment.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Floating drug delivery system’. Further sources in the context of Science might help you critically compare this page with similair documents:

Oral route of administration, Controlled drug delivery, Floating drug delivery system, Floating tablet, Gastro retentive drug delivery system, Enhanced Bioavailability, Evaluation technique.

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