A review on treatment of tuberculosis by using phytomedicine

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Journal name: World Journal of Pharmaceutical Research
Original article title: A review on treatment of tuberculosis by using phytomedicine
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Dr. Mohd Wasiullah, Piyush Yadav, Richa Yadav and Shivanand Yadav


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: A review on treatment of tuberculosis by using phytomedicine

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20231-26754

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Tuberculosis (TB) is a highly infectious disease caused by the bacterium Mycobacterium tuberculosis, which can lead to severe health complications and is known for its potential to develop drug resistance. Traditional synthetic medications used for TB treatment have been associated with significant adverse effects, prompting a growing interest in alternative treatments, particularly those derived from medicinal plants. This article explores various phytomedicines that can potentially offer effective and safer anti-tubercular activity, leveraging the longstanding historical knowledge within traditional healing practices.

The Burden of Tuberculosis and Its Forms

Tuberculosis manifests in two primary forms: latent and active. Latent TB occurs when individuals are infected with the tuberculosis bacteria but do not exhibit symptoms and are not contagious; however, there is a potential for the disease to progress to its active form, which poses significant health risks and the ability to spread to others. Active TB symptoms include prolonged cough, chest pain, fatigue, fever, and unintended weight loss. Understanding these stages is crucial for controlling the spread of TB and highlighting the need for effective treatment solutions.

The Role of Phytomedicine in TB Treatment

Phytomedicine, derived from medicinal plants, serves as a promising alternative to synthetic drugs due to its potential to alleviate TB symptoms with fewer side effects. The review discusses the pharmacological activity and therapeutic potential of specific plants' extracts, which have demonstrated inhibitory effects against Mycobacterium tuberculosis. For instance, plants like Piper nigrum (black pepper), Glycyrrhiza glabra (licorice), and Withania somnifera (ashwagandha) have been studied for their phytochemical compositions and corresponding anti-tubercular activities, providing a foundation for further research and exploration in herbal medicine.

Key Phytomedicinal Plants and Their Impact

The review provides detailed descriptions of several key plants known for their anti-tubercular properties. Piper nigrum showed promising results in inhibiting Mycobacterium tuberculosis due to its rich chemical composition, which includes compounds like piperine. Similarly, Glycyrrhiza glabra has a history of medicinal use and contains various active components that exhibit anti-tubercular activities. Other plants, such as Withania somnifera, also displayed significant anti-mycobacterial effects, suggesting a diverse range of natural remedies capable of complementing traditional TB treatments.

Conclusion

In conclusion, tuberculosis continues to pose a severe health threat globally, necessitating the development of effective treatment strategies. The exploration of phytopharmaceuticals offers a hopeful path forward, notably due to their potential to reduce the adverse effects prevalent with synthetic drugs. The research compiled in this review underscores the medicinal value of various plants and their bioactive compounds, paving the way for future pharmacological studies and potentially revolutionizing TB treatment protocols with safer, natural alternatives.

FAQ section (important questions/answers):

What is tuberculosis and how is it transmitted?

Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis, spreading through microscopic droplets when an infected person coughs or sneezes. It can affect the lungs and other body parts, making it highly infectious.

What are the main symptoms of active tuberculosis?

Symptoms of active tuberculosis include persistent cough, fever, night sweats, weight loss, fatigue, chest pain, and coughing up blood. If untreated, it can spread to others and lead to severe health issues.

How can medicinal plants be beneficial in treating tuberculosis?

Medicinal plants offer alternatives to synthetic drugs, providing potential anti-tuberculosis properties with fewer adverse effects. Plants like Piper nigrum and Glycyrrhiza glabra show promising efficacy against Mycobacterium tuberculosis.

What are some significant medicinal plants reviewed for tuberculosis treatment?

The review discusses several plants including Piper nigrum (black pepper), Glycyrrhiza glabra (licorice), Withania somnifera (ashwagandha), and Aloe vera, all showing potential anti-tuberculosis activities.

What are common adverse effects of synthetic anti-tuberculosis therapy?

Adverse effects can include nausea, vomiting, headache, liver toxicity, and skin reactions. These negative impacts highlight the need for safer therapeutic alternatives, such as herbal medicine.

What is the significance of phytomedicine in healthcare today?

Phytomedicine is gaining attention for its ability to treat various infections effectively, with fewer side effects compared to conventional treatments, thereby offering hope for patients with complicated ailments.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “A review on treatment of tuberculosis by using phytomedicine”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Tuberculosis:
Tuberculosis is a highly infectious bacterial disease caused by Mycobacterium tuberculosis, primarily affecting the lungs but also impacting other body parts. It can manifest in latent or active forms, with serious symptoms and risks. The advent of multi-drug resistant strains complicates treatment, making research into alternative therapies, including phytomedicine, essential.

2) Activity:
In the context of this article, 'activity' refers to the biological effects and therapeutic potential of various medicinal plants against tuberculosis. The anti-tubercular activity observed in those plants is critical for developing alternative treatment methodologies that may mitigate the side effects associated with conventional synthetic drugs.

3) Liquorice (Licorice):
Licorice, particularly Glycyrrhiza glabra, is noted for its medicinal properties and has been utilized historically in various traditional systems of medicine. Its active components, including glycyrrhizin, exhibit pharmacological activities that can support the immune response and may possess anti-tubercular effects, making it a subject of interest in tuberculosis treatment research.

4) Pharmacological:
Pharmacological pertains to the branch of medicine that focuses on the study of drug action. Understanding the pharmacological properties of medicinal plants helps researchers uncover their therapeutic potentials, particularly in treating diseases like tuberculosis, where conventional treatments may have debilitating side effects.

5) Disease:
Diseases are pathological conditions characterized by specific symptoms and functional disturbances. Tuberculosis exemplifies a serious infectious disease presenting clinical challenges and stimulating interest in research for alternative treatment options, including natural medicinals that can address the limitations of conventional therapies.

6) Family:
In botanical classification, family refers to a group of related plants sharing common characteristics. For instance, Piperaceae is the family of black pepper, which has demonstrated anti-tubercular activity. Understanding family classifications aids in the identification and study of medicinal plants for their therapeutic uses.

7) India:
India has a rich history of traditional medicine systems like Ayurveda and Siddha. Given its biodiversity, many medicinal plants sourced from India have been identified for potential therapeutic applications, including tuberculosis treatment, thereby contributing to global efforts in phytochemistry and alternative medicine.

8) Pain:
Pain is a symptom associated with various diseases, including tuberculosis. Effective management of pain is essential for improving the quality of life for affected individuals. Phytomedicines, like licorice and withania, might offer alternative pain relief strategies with fewer side effects compared to conventional analgesics.

9) Drug:
Drugs encompass substances that alter biological processes for therapeutic purposes. In the treatment of tuberculosis, both synthetic drugs and natural remedies like herbal extracts are considered. The exploration of combination therapies with plant-derived drugs represents a significant research focus aimed at optimizing treatment outcomes.

10) Substance:
Substances refer to distinct materials with unique chemical compositions. In pharmacology, inquiries into plant-derived substances are essential for discovering new therapeutic agents, particularly in treating bacterial infections like tuberculosis, where effective alternatives to traditional drugs are urgently needed.

11) Medicine:
Medicines refer to substances used for diagnosing, treating, or preventing diseases. The exploration of traditional and herbal medicines is increasingly relevant in treating conditions like tuberculosis, where research into their efficacy offers new avenues for combating drug-resistant infections.

12) Species:
Species is a fundamental classification in biological taxonomy. It identifies specific groups of organisms capable of interbreeding. In the context of medicinal plants, identifying species like Withania somnifera is essential for research into their therapeutic properties and potential applications in treating conditions like tuberculosis.

13) Genu:
The term 'genu' appears to relate to genus, which is a classification for taxonomic categorization in biology. It signifies a group of related species under the same family, essential for botanical studies and understanding the medicinal properties of related plants in treating diseases like tuberculosis.

14) Flavonoid:
Flavonoids, a subgroup of phytochemicals, exhibit significant antioxidant and anti-inflammatory effects. These compounds are found in various plants and have demonstrated potential in research as supportive agents in combating infections like tuberculosis, thereby enhancing the effectiveness of standard treatments.

15) Sugar:
In the context of medicinal plants, sugar refers to carbohydrates that may have various physiological roles, including energy provision. Some plants, such as those mentioned in herbal medicine, have sugar compounds that may contribute to their overall bioactivity, supporting immune health system functionality in patients with tuberculosis.

16) Antibiotic (Antibacterial):
Antibacterial refers to substances that kill or inhibit the growth of bacteria. This property is crucial for the treatment of bacterial infections, such as tuberculosis, prompting extensive research into phytomedicines that may offer alternative antibacterial agents with fewer adverse effects compared to traditional antibiotics.

17) Phytochemical:
Phytochemicals are bioactive compounds derived from plants providing various health benefits. Their role in modern medicine, particularly in treating diseases like tuberculosis, has garnered interest, as many traditional remedies contain phytochemicals that exhibit significant pharmacological activities and could serve as complementary treatments.

18) Siddha:
Siddha is a traditional system of medicine originating from South India, which employs natural remedies. It emphasizes healing through herbal medicines and other therapies, including the potential use of various plants that exhibit anti-tubercular activity, thus contributing to alternative medical practices.

19) Water:
Water serves as a fundamental solvent in biological systems and the primary component of numerous plant extracts. Understanding the role of water in the extraction of bioactive compounds from plants is essential for evaluating their medicinal properties, particularly compounds with potential anti-tubercular activity.

20) Withania somnifera:
Withania somnifera, commonly known as Ashwagandha, is a medicinal herb noted for its adaptogenic properties. Research indicates its potential efficacy against Mycobacterium tuberculosis, highlighting its relevance in exploring traditional herbal therapies in the context of modern medical challenges posed by tuberculosis.

21) Science (Scientific):
Scientific endeavors in medicine involve systematic investigation of substances, processes, and effects. Research in pharmacology, especially pertaining to anti-tubercular agents, requires rigorous scientific methodology to validate the efficacy and safety of medicinal plants compared to conventional synthetic treatments.

22) Account:
In academic contexts, account refers to a detailed description or narrative regarding a specific subject. The article provided accounts of various plants with anti-tubercular properties, aiming to present scientific information that encourages research and integration of traditional treatments into modern medicine.

23) Mineral:
Minerals play vital roles in various physiological processes of the human body. Many medicinal plants are rich in essential minerals, which contribute to overall health. Understanding these mineral compositions can enhance the pharmacological activities of plant extracts used in treating diseases like tuberculosis.

24) Indian:
Indian refers to anything related to India, including its diverse culture, traditional medicinal systems, and rich biodiversity of medicinal plants. This context emphasizes the significance of Indian herbal knowledge and practices in contemporary research on potential therapies for tuberculosis and other diseases.

25) Fever:
Fever is a common symptom of infections, including tuberculosis. Understanding and managing fever is crucial in patient care, and many medicinal plants exhibit antipyretic properties, providing avenues for further research into natural ways to alleviate symptoms associated with diseases.

26) Blood:
Blood is a vital fluid in the body, essential for transporting nutrients and oxygen. In tuberculosis, the involvement of blood cells or the presence of bacteria in the bloodstream emphasizes the disease’s severity and complexity, guiding research towards effective therapeutic interventions.

27) Sign:
In clinical terms, a sign refers to an objective indication of a disease or condition as observed by a healthcare professional. Symptoms of tuberculosis such as coughing or fever serve as critical signs that inform diagnosis, treatment, and research into effective therapies.

28) Ripe:
Ripe typically describes the state of fruits when they are fully developed and ready for consumption. In the context of medicinal plants, ripe fruits may possess concentrated bioactive compounds, which can be harvested for research into their therapeutic properties, including anti-microbial activities.

29) Salt (Salty):
Salt, or sodium chloride, is a mineral critical for various physiological functions. In herbal medicine, salt compounds might be explored in formulations to enhance therapeutic effects or address particular health issues related to diseases like tuberculosis, necessitating research on their integrative use.

30) Male:
In botanical terms, 'male' refers to the sex of reproductive organs that produce pollen. In the context of medicinal plants, understanding both male and female plant characteristics can be important for cultivation and maximizing the yields of compounds with potential therapeutic effects.

31) Inflammation:
Inflammation is a biological response to harmful stimuli, which is often a symptom of infections like tuberculosis. Medicinal plants with anti-inflammatory properties can provide alternative treatments that reduce inflammation associated with diseases, thereby alleviating discomfort and improving patient quality of life.

32) Afghanistan:
Afghanistan has a rich history of traditional medicine and diverse flora, with several plants noted for their medicinal properties. Research focusing on Afghan plants may yield new insights into potential treatments for diseases like tuberculosis, contributing to global medicinal knowledge.

33) Depression:
Depression is a mental health disorder that can occur alongside chronic illnesses such as tuberculosis. Understanding the interplay between physical health and mental well-being highlights the importance of holistic approaches, including the use of medicinal plants that may alleviate symptoms of both conditions.

34) Himalaya (Hima-alaya):
The Himalaya region is known for its biodiversity and the presence of numerous medicinal plants. The unique climatic conditions foster the growth of plants with therapeutic properties, making it an important area for research in finding natural remedies for diseases like tuberculosis.

35) Vomiting:
Vomiting is a distressing symptom often associated with various medical conditions and medications. Research into herbal remedies that can alleviate nausea and vomiting, particularly in patients undergoing treatment for tuberculosis, underscores the need for effective natural therapies with fewer side effects.

36) Vertigo:
Vertigo refers to a sensation of spinning or dizziness, which can be a side effect of certain drugs or conditions. Exploring natural treatments that may alleviate vertigo can be beneficial in holistic approaches to managing the overall health of patients with tuberculosis.

37) Greece:
Greece's historical context in the development of herbal medicine and pharmacognosy illustrates the long-standing human reliance on plants for therapeutic benefits. This legacy highlights the importance of research into traditional remedies, contributing additional insights into natural anti-tubercular agents.

38) Punjab:
Punjab, a region in India, is noted for its agricultural practices and diversity of medicinal plants. Researching the local flora of Punjab offers potential insights into traditional remedies and their applications for treating tuberculosis and potentially improving patient outcomes.

39) Cancer:
Cancer represents a significant health challenge characterized by uncontrolled cell growth. Research into plant-based treatments continues to explore how phytomedicine, including both prevention and supportive care for cancer patients, can address complications arising from conditions like tuberculosis, emphasizing the need for alternative therapies.

40) Nausea:
Nausea is a common symptom of many medical conditions and treatments. Identifying herbal remedies that can alleviate nausea enhances patient comfort and improves compliance with tuberculosis treatments, reinforcing the importance of exploring phytochemicals that offer relief without significant side effects.

41) Bitter:
Bitter compounds in herbal medicine often signify the presence of active phytochemicals, contributing to therapeutic effects such as digestive aid and anti-inflammatory properties. The role of bitter plants warrants investigation for their potential use in treating conditions like tuberculosis.

42) Medium:
In scientific research, 'medium' often refers to the environment in which cells or microorganisms are cultured. Utilizing appropriate growth media is crucial in evaluating the efficacy of medicinal plants against specific pathogens, including testing their anti-tubercular properties.

43) Thirst:
Thirst is a physiological response indicating fluid deficiency. Some medicinal plants have properties that may help alleviate excessive thirst or dehydration symptoms, contributing to overall patient care. Understanding this aspect may complement treatment strategies for individuals suffering from infections like tuberculosis.

44) Table:
In research literature, a table is a structured format for presenting data concisely. Tables organize complex information, such as the pharmacological activities or adverse effects of various plant extracts, facilitating easier understanding and comparison, particularly crucial in studies addressing tuberculosis treatment.

45) Field:
Field refers to the area of study or research. In the context of medicine, field studies on medicinal plants provide insights into their real-world applications, efficacy, and safety, particularly regarding potential treatments for tuberculosis and other infectious diseases.

46) Death:
Death reflects the ultimate outcome of diseases like tuberculosis if left untreated. Understanding mortality rates emphasizes the urgency for effective therapeutic interventions and motivates research into alternative treatments, particularly the efficacy of phytomedicine and traditional remedies in combating serious infections.

47) Fight:
Fight pertains to the strategies employed to combat diseases. In the context of scientific research, it refers to the ongoing efforts to develop effective treatments for tuberculosis using both conventional and alternative medicinal approaches, highlighting the need for innovative solutions against this global health threat.

48) Study (Studying):
Study involves systematic investigation into specific subjects. Research studies focusing on the medicinal properties of plants provide insights into their potential anti-tubercular effects, guiding the development of effective treatment strategies and contributing to the broader understanding of herbal medicine.

49) Sweating (Sweat):
Sweat is a physiological process often associated with fever in infectious diseases like tuberculosis. Monitoring sweat production can provide insights into disease progression. Understanding how herbal treatments may affect sweating could inform complementary approaches alongside conventional therapies.

50) Cina:
China has a longstanding tradition of using herbal medicine and traditional systems like Traditional Chinese Medicine. Researching Chinese medicinal plants for their therapeutic properties offers valuable insights into potential treatments for diseases such as tuberculosis, fostering a global exchange of medical knowledge.

51) Tree:
The term 'tree' signifies a tall perennial plant crucial for producing various medicinal components used in herbal medicine. Trees may serve as sources for compounds with therapeutic potential, inspiring research focused on their roles in treating diseases such as tuberculosis.

52) Egypt:
Egypt's historical practices in herbal medicine illustrate ancient knowledge of plants' therapeutic properties, contributing to today's understanding of phytomedicine. Researching Egyptian medicinal plants could uncover new insights into treatments for diseases like tuberculosis, thus enhancing global herbal medicine knowledge.

53) Beta:
Beta often denotes a classification related to chemical compounds or molecular structure. Understanding the beta forms of various phytochemicals can provide insights into their bioactivity and therapeutic potential, particularly in the context of treating bacterial infections like tuberculosis.

54) Ras (Rash):
Rash refers to skin changes that can occur due to various conditions, including allergic reactions or infections. Identifying plant-based treatments that can soothe or alleviate rashes might represent an important aspect of holistic approaches for patients with tuberculosis.

55) Rice (Rce):
Rice is a staple food in many cultures and may appear in discussions about dietary considerations for patients. Understanding nutrition's role, including traditional food sources, can improve care strategies for individuals battling infections like tuberculosis, emphasizing the holistic treatment approach.

56) Bell:
Bell can refer to specific plant forms or products derived from those plants. In herbal medicine, understanding how certain parts of plants, like bell-shaped flowers, contribute to the overall therapeutic efficacy is essential for harnessing their properties in treating ailments, including tuberculosis.

57) Soil:
Soil represents the foundation for plant growth, influencing the phytochemical properties of medicinal plants. Understanding the relationship between soil health and the bioactive compounds produced by plants is critical for agricultural practices, especially in cultivating species used for treating diseases like tuberculosis.

58) Life:
Life signifies the existence of living organisms. Understanding how various factors influence health and longevity is essential in medical research. In the context of tuberculosis, addressing life quality through effective treatments illustrates the importance of advancing both conventional and alternative therapeutic approaches.

59) Oil:
Oils derived from plants possess diverse therapeutic properties, including anti-inflammatory and antibacterial effects. Investigating the efficacy of essential oils in treating infections like tuberculosis provides a foundation for broader application of natural remedies, emphasizing their potential role in integrated healthcare solutions.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘A review on treatment of tuberculosis by using phytomedicine’. Further sources in the context of Science might help you critically compare this page with similair documents:

Glycyrrhiza glabra, Withania somnifera, Aloe vera, Medicinal plant, Adverse effect, Herbal medicine, Immune system, Pharmacological activity, Antioxidant property, Treatment of tuberculosis, Anti-tubercular activity, Phytomedicine, Multi drug resistant tuberculosis, Substance abuse, Chemical constituent, Piper nigrum, Synthetic drug, Physiological Effect, Active tuberculosis, Weakened immune system.

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