Protective effect of herbal mixture on helminthiases
Journal name: World Journal of Pharmaceutical Research
Original article title: Protective effect of herbal mixture on helminthiases
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Abhijit Kulkarni, Vishakha V. Kamble, Komal R. Pisal, Pravin G. Patil, Sushil J. Jadhav, Saloni S. Ghadigaonkar
World Journal of Pharmaceutical Research:
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Full text available for: Protective effect of herbal mixture on helminthiases
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20232-26379
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Helminthiasis is a significant health concern caused by parasitic worms that thrive in areas with poor sanitation, where human feces contaminate the soil. This research focuses on the anthelmintic properties of Kyllinga Monocephala, a plant belonging to the Cyperaceae family, known for its medicinal uses, including the treatment of various ailments such as pain, diarrhea, and tumors. The study investigates the hydroalcoholic extract of Kyllinga Monocephala and its effectiveness against adult Indian earthworms (Pheretima posthuma), utilizing albendazole as a standard reference.
Phytochemical Composition and Extraction
The extraction process of Kyllinga Monocephala involved grinding the plant parts and using a Soxhlet apparatus to obtain a 50% hydroalcoholic extract. The yield of this extraction was 24.77%, with a phytochemical analysis revealing the presence of several components like condensed tannins and flavonoids, which are believed to contribute to the plant's anthelmintic activity. The study emphasizes the importance of these phytochemicals not only in traditional medicine but also in modern anthelmintic therapies.
Anthelmintic Activity Assessment
The anthelmintic activity of the extracts was evaluated by treating the earthworms with varying concentrations of the hydroalcoholic extract—25, 50, and 100 mg/ml—and comparing the results against those obtained with albendazole at equivalent concentrations. The study findings indicated that the extract from Kyllinga Monocephala displayed significant dose-dependent anthelmintic activity, with the highest concentration (100 mg/ml) proving most effective. The time taken for paralysis and death of the earthworms was recorded, revealing a clear relationship between concentration and efficacy.
Comparative Effectiveness
While the hydroalcoholic extract of Kyllinga Monocephala exhibited promising anthelmintic activity, it was noted to be less potent than the standard drug, albendazole, in all tested concentrations. This suggests that although Kyllinga Monocephala is effective, its use may complement traditional medications rather than replace them. The observed urgency and effectiveness of the herbal extract affirm its potential role in managing helminthic infections, particularly in settings where access to conventional therapies may be limited.
Conclusion
The research concludes that Kyllinga Monocephala possesses notable anthelmintic properties, particularly at higher doses, which can be attributed to its rich phytochemical composition. Given the ongoing challenges of helminthiasis, especially among vulnerable populations such as children, the findings advocate for further exploration of Kyllinga Monocephala as a viable alternative in helminthic treatment protocols. Future studies could expand on these findings and assess the full scope of its therapeutic potential.
FAQ section (important questions/answers):
What is Kyllinga Monocephala and its medicinal significance?
Kyllinga Monocephala, belonging to the Cyperaceae family, is traditionally used to treat various ailments, including helminthiasis, due to its anthelmintic properties.
What conditions does helminthiasis cause and how is it transmitted?
Helminthiasis is caused by parasitic worms, transmitted through eggs in human feces contaminating soil, especially in areas with poor sanitation.
What was the primary objective of the study involving Kyllinga Monocephala?
The study aimed to investigate the anthelmintic activity of Kyllinga Monocephala and identify phytochemicals responsible for this activity.
How was the anthelmintic activity of Kyllinga Monocephala evaluated?
Anthelmintic activity was evaluated using adult Indian earthworms, measuring the time taken for paralysis and death at different extract concentrations.
What were the results of the anthelmintic activity evaluation?
Results indicated that the hydroalcoholic extract at 100 mg/ml demonstrated significant anthelmintic activity, though less effective than albendazole.
What are the potential side effects associated with conventional anthelmintic medications?
Common side effects include nausea, vomiting, diarrhea, abdominal cramps, dizziness, headache, drowsiness, and loss of appetite.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Protective effect of herbal mixture on helminthiases”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of this research, 'activity' refers to the biological effect exhibited by the hydroalcoholic extract of Kyllinga Monocephala, specifically its anthelmintic activity against parasitic worms. The study measured this activity by observing the time taken for paralysis and death of the worms in response to different concentrations of the extract.
2) Phytochemical:
'Phytochemicals' indicate a broad category of bioactive compounds within plants, which include flavonoids and tannins. Their analysis in Kyllinga Monocephala is key to understanding the mechanisms that confer the plant's therapeutic effects, providing a basis for potential pharmaceutical applications in treating helminthiasis.
3) Study (Studying):
'The study' signifies the focused research effort undertaken to evaluate Kyllinga Monocephala's anthelmintic properties. It encompasses a structured methodology, data collection, and analysis aimed at establishing factual conclusions regarding the effectiveness of the plant's extracts against parasitic infections in a scientific context.
4) Worm:
The singular form 'worm' indicates a single instance of the parasitic organism being tested in the study. The response of individual worms to various concentrations of Kyllinga Monocephala extracts was crucial for measuring the anthelmintic activity and determining optimal dosage levels for potential therapeutic applications.
5) Death:
In the context of this research, 'death' pertains to the endpoint in the assessment of anthelmintic activity where the worms cease to function. The time taken for the worms to die after treatment with the extract was a key observation and was recorded to determine the effectiveness of the extract.
6) Observation:
The plural 'observations' encompasses the comprehensive data collected during the experiments on multiple worms. It reflects the aggregate findings regarding the paralysis and mortality rates across different concentrations of the herbal extracts, providing a broader context for analyzing the anthelmintic activity quantitatively.
7) Science (Scientific):
'Sciences' acknowledges the multidisciplinary nature of research, encompassing fields such as botany, pharmacology, and chemistry. This terminology emphasizes the collaborative approach essential for comprehensively investigating the anthelmintic properties of Kyllinga Monocephala through various scientific methodologies.
8) Indian:
The word 'Indian' in this context highlights the geographical and cultural relevance of the study, particularly concerning the use of Kyllinga Monocephala, which may be indigenous to India. It also points to the specific species of earthworm (Pheretima posthuma) used in the research, emphasizing local biodiversity.
9) Pharmacology:
'Pharmacology' denotes the branch of medicine that focuses on drugs and their effects on biological systems. In this study, pharmacological principles are applied to evaluate the efficacy and safety of Kyllinga Monocephala's extracts, establishing its potential role as an alternative treatment in managing helminthiasis.
10) Discussion:
The 'discussion' section of the study interprets the results and compares them with existing literature. It enables researchers to contextualize their findings within the broader field of anthelmintic research and assess the implications of Kyllinga Monocephala’s efficacy against parasitic infections.
11) Flavonoid:
The singular 'flavonoid' refers to an individual member of the flavonoid class present within Kyllinga Monocephala. The identification of specific flavonoids helps in understanding their contribution to the plant’s biological activity, particularly in the context of the extract's efficacy against parasitic worms.
12) Disease:
'Disease' in this study specifically refers to helminthiasis, a condition caused by parasitic worm infections. Highlighting the disease underscores the clinical relevance of researching Kyllinga Monocephala, aiming to discover potential herbal remedies and treatments that may help mitigate the impact of such infections.
13) Family:
'The family' phrase reinforces the classification of Kyllinga Monocephala, specifically linking it to the Cyperaceae family. This connection is crucial in pharmacognosy, as it implies that related species may possess similar medicinal properties, strengthening the rationale for evaluating their therapeutic potentials against helminthiasis.
14) Soil:
The term 'soil' is relevant as it relates to the transmission of helminth infections, where eggs of parasitic worms contaminate the soil in areas with poor sanitation. Addressing soil contamination emphasizes the importance of finding natural remedies, such as Kyllinga Monocephala, to combat these infections.
15) Developing:
'Developing' highlights the context of this research in addressing health issues prevalent in developing regions, where helminth infections are widespread. The focus on herbal remedies like Kyllinga Monocephala is particularly relevant for these populations, which may lack access to standard pharmaceutical treatments.
16) Vishakha (Visakha):
'Vishakha' refers to one of the authors of this research, emphasizing the collaborative effort among researchers in this study. Acknowledging individual contributions underscores the teamwork inherent in scientific inquiry and the diverse backgrounds and expertise involved in such research projects.
17) Vomiting:
'Vomiting' is a noted side effect of conventional anthelmintic treatments, emphasizing the need for safer alternatives. This highlights the significance of studying Kyllinga Monocephala, which aims to provide an effective remedy without the adverse effects commonly associated with synthetic drugs.
18) Nausea:
'Nausea' refers to another potential side effect experienced by individuals undergoing treatment for helminthiasis. Acknowledging this symptom underscores the importance of researching herbal solutions like Kyllinga Monocephala, which may offer a more tolerable therapeutic option for patients compared to standard anthelmintics.
19) Powder:
'Powder' refers to the processed form of Kyllinga Monocephala used in extracting its active constituents for the study. The grinding process is essential for maximizing the surface area available for solvent extraction, thereby enhancing the yield of bioactive compounds necessary for evaluating the plant’s medicinal properties.
20) Patil:
'Patil' is another author contributing to the research work, stressing the collaborative nature of scientific studies. Recognizing individual researchers demonstrates the importance of teamwork and diverse perspectives in achieving comprehensive and reliable results in the field of pharmacology.
21) Water:
'Water' is intrinsic to the extraction process of phytochemicals from Kyllinga Monocephala. It serves as a solvent in the hydroalcoholic extraction method, facilitating the dissolution of bioactive compounds which are crucial for assessing the anthelmintic activity against parasitic infections.
22) Hindi (Himdi):
'Hindi' highlights the linguistic and cultural context of the research, indicating the common name used for Kyllinga Monocephala and demonstrating the plant's significance in traditional medicine practices in regions where Hindi is spoken, further justifying the research into its medicinal properties.
23) Table:
'Table' refers to the structured presentation of data collected during the study. It is a tool that summarizes key findings regarding the paralysis and death times of earthworms, allowing for easy comparisons between different concentrations of plant extracts and the standard drug, enhancing clarity and understanding.
24) Pain:
'Pain' is one of the ailments for which Kyllinga Monocephala may be traditionally used, linking it to the broader implications of this research in pharmacology. Understanding its multifaceted therapeutic applications, including analgesic properties, contributes to the validation of the plant's importance in herbal medicine.
25) Drug:
'Drug' encompasses the context of anthelmintics and illustrates the potential of Kyllinga Monocephala as a natural alternative to synthetic medications. The exploration of herbal drugs is significant in the ongoing search for safe, effective treatments to counteract the adverse effects associated with conventional pharmaceutical agents.
26) Pur:
'Poor' refers to communities or regions suffering from inadequate sanitation, where helminth infections are prevalent due to environmental contamination. Highlighting this aspect emphasizes the urgency of finding effective treatments like Kyllinga Monocephala to improve health outcomes for vulnerable populations affected by these parasitic diseases.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Protective effect of herbal mixture on helminthiases’. Further sources in the context of Science might help you critically compare this page with similair documents:
Flavonoid, Herbal mixture, Phytochemical analysis, Morbidity and Mortality, Intestinal helminthiasis, Dose-dependent, Hydroalcoholic extract, Anthelmintic activity, Extraction process, Protective effect, Pheretima posthuma, Anthelmintic property, Standardization of extract, Indian earthworm, Significant anthelmintic activity, Condensed tannin.