Luliconazole for the treatment of fungal infections
Journal name: World Journal of Pharmaceutical Research
Original article title: Luliconazole for the treatment of fungal infections
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Manoj Digambar Ingole, Nitin Namdev Fating and Unnati T. Rathod
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Luliconazole for the treatment of fungal infections
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20233-27156
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Luliconazole is an emerging antifungal agent belonging to the imidazole class, known for its unique structure that incorporates an imidazole moiety into a ketene dithioacetate framework. The active R-enantiomer of luliconazole exhibits a potent antifungal activity that surpasses that of lanoconazole. This review collates in vitro studies, animal research, and clinical trial findings on topical luliconazole, emphasizing its efficacy against common skin fungal infections, including dermatophytes and Candida albicans.
Potency Against Fungal Infections
Luliconazole has demonstrated superior antifungal efficacy, particularly in treating dermatophytosis and other fungal infections. Preclinical studies indicate strong antifungal activity against clinically relevant pathogens such as dermatophytes and Candida albicans. Clinical trials show that luliconazole exhibits a significant therapeutic effect compared to placebo treatments and outperforms terbinafine in antifungal action, particularly for skin conditions like tinea corporis and tinea cruris. Its documented success highlights its potential as a leading treatment option for various superficial fungal infections.
Clinical Trials and Safety Profile
Clinical studies have established luliconazole’s commendable local tolerability and minimal systemic side effects when used topically. The Phase I/II a trials confirm that luliconazole solution is well-tolerated, making it potentially suitable for a wide range of patients, including those with onychomycosis. The Phase III trials further indicate that the 1% luliconazole cream offers favorable clinical and mycological results, lending credibility to its approval in Japan since 2005 and subsequently in the United States for treating tinea infections caused by T. rubrum.
Application and Usage Instructions
Luliconazole is administered as a topical cream, prescribed for various fungal skin infections such as jock itch, ringworm, and athlete's foot. It is typically applied once daily for a specified duration, dependent on the condition being treated. Patients are instructed to apply a sufficient amount to cover the affected area and to wash their hands afterward to prevent accidental spread. Precautions are advised, including checking for allergies and discussing other medications with healthcare providers.
Conclusion
In conclusion, luliconazole presents a promising advancement in the treatment of fungal infections due to its potent antifungal properties, strong clinical evidence, and favorable safety profile. Its application as a topical solution offers an effective strategy for managing conditions like dermatophytosis, reinforcing its status as a valuable tool in the dermatological arsenal against fungal skin infections. As research and clinical experiences with luliconazole continue to evolve, its significance in antifungal therapy is expected to grow, establishing it as a preferred option for patients and healthcare providers alike.
FAQ section (important questions/answers):
What is Luliconazole and how does it work?
Luliconazole is an imidazole antifungal agent that treats fungal infections by slowing the growth of fungi. It is effective against dermatophytes and Candida albicans, demonstrating superior antifungal activity compared to some other agents.
How should Luliconazole cream be applied?
Apply Luliconazole cream once daily to the affected area and surrounding skin. Use it for one week for jock itch and ringworm, and for two weeks for athlete's foot, according to your doctor's instructions.
What are common side effects of Luliconazole?
Common side effects include irritation, itching, or stinging at the application site. If you experience severe or unusual side effects, contact your doctor immediately.
What precautions should I take before using Luliconazole?
Inform your doctor if you have allergies, are pregnant, or are breastfeeding. Discuss all medications you are taking, including over-the-counter drugs and supplements.
How should Luliconazole be stored and disposed of?
Store Luliconazole at room temperature, tightly closed, away from light and moisture. Dispose of unused medication properly to prevent accidental ingestion, ideally through a medication take-back program.
What brand name is Luliconazole sold under?
Luliconazole is commonly sold under the brand name Luzu. Always follow your healthcare provider's advice when using any medication.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Luliconazole for the treatment of fungal infections”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the effectiveness of luliconazole as an antifungal agent. It is measured through clinical trials and in vitro studies, illustrating how well the drug performs in inhibiting fungal growth and treating infections. Higher activity indicates better patient outcomes and recovery from fungal skin infections.
2) Pregnant:
Pregnant refers to the condition of carrying a developing fetus. In the context of luliconazole, it is crucial for patients to inform healthcare providers if they are pregnant or planning to become pregnant, as certain medications can affect fetal development or have other implications for maternal health.
3) Study (Studying):
Study pertains to research conducted to evaluate the safety and efficacy of luliconazole as an antifungal treatment. This includes clinical trials and preclinical studies that provide data supporting its use against various fungal infections, contributing to the overall understanding of its therapeutic benefits and potential side effects.
4) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India where the Ishwar Deshmukh Institute of Pharmacy is located. The significance of this geographical location highlights the local context in which the research on luliconazole is conducted, including available resources, patient demographics, and regional considerations in medicine and drug development.
5) Container:
Container refers to the packaging used to store luliconazole cream. Proper storage in its original container is essential to maintain the medication's effectiveness and prevent contamination. Awareness of storage instructions is vital for safe use, ensuring that the medication is kept out of reach of children.
6) Yavatmal:
Yavatmal is a district in Maharashtra, India, where the corresponding author of the study is based. Its mention contextualizes the research's geographical origin and highlights the local academic and medical community's engagement in addressing health issues, such as fungal infections prevalent in the region.
7) Medicine:
Medicine encompasses substances used to prevent, diagnose, or treat diseases, including luliconazole for fungal infections. The development, testing, and distribution of medications are critical for public health, signifying the advancements in pharmacotherapy and the importance of using evidence-based practices to ensure patient safety and efficacy of treatments.
8) Animal:
Animal refers to living organisms used in preclinical studies to evaluate the effectiveness and safety of luliconazole. Animal research helps in understanding drug interactions, metabolism, and potential side effects in biological systems before human trials. It plays a vital role in pharmaceutical development and safety assessments.
9) Wall:
Wall, in this context, relates to the fungal cell wall that is targeted by antifungal agents like luliconazole. Understanding the structure and function of the wall is crucial for developing effective treatments, as disrupting wall synthesis can kill fungi and prevent their growth, addressing skin infections effectively.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Luliconazole for the treatment of fungal infections’. Further sources in the context of Science might help you critically compare this page with similair documents:
Clinical trial, Clinical studies, Safety profile, Clinical trial data, Fungal infection, Tinea corporis, Dermatophytosis, Side effect, Department of Pharmaceutical Chemistry, Antifungal agent, Tinea Pedis.