Tadalafil’s gastroprotective effect on stress ulcers in rats
Journal name: World Journal of Pharmaceutical Research
Original article title: The gastroprotective effect of tadalafil on stress-induced ulcer in wistar rat model
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Doris N. Ajibo, Udeme O. Georgewill and Owunari A. Georgewill
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: The gastroprotective effect of tadalafil on stress-induced ulcer in wistar rat model
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20234-27145
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The prevalence of gastric lesions and ulcers, particularly due to stress, excessive NSAID usage, and infections like Helicobacter pylori (H. pylori), has increased in West Africa. Traditional African medicine, leveraging the vast biodiversity of medicinal plants, has been a vital approach to treating these conditions. With approximately 5,000 plant species used for medicinal purposes in Africa, the World Health Organization (WHO) supports integrating traditional practices into health systems, acknowledging the significance of herbal remedies. This review investigates the gastroprotective and cytoprotective effects of various plant-derived compounds, focusing on their application in managing gastric ulcer diseases.
Phytochemical Constituents and Their Role in Cytoprotection
Cytoprotection involves mechanisms that protect the gastric mucosa from injury, primarily due to the modulation of gastric acid secretion and enhancement of mucosal defenses. Secondary metabolites like flavonoids, saponins, and alkaloids contribute significantly to these protective effects. Plants such as Cassia siberiana and Moringa oleifera exhibit these properties by promoting the production of mucus and bicarbonate, reducing oxidative stress, and stimulating gastroprotective factors like prostaglandins. The antioxidant properties of these phytochemicals play a crucial role in preventing mucosal damage and promoting ulcer healing.
The Mechanism of Action of Prostaglandins
Prostaglandins are critical in maintaining gastric mucosal integrity through their role as chemical messengers that enhance mucosal defenses. They stimulate the secretion of mucus and bicarbonate while inhibiting gastric acid production. Exogenous prostaglandins like PGE₂ have been shown to promote the release of viscous mucus, thereby providing a barrier against acid damage. This mechanism is essential in mitigating injuries caused by irritants such as NSAIDs and H. pylori. The ongoing production of prostaglandins sustains the blood flow to the gastric mucosa, further enhancing its resiliency against ulceration.
Impact of Herbal Medicine on Gastroprotection
Herbal medicines have gained traction as alternative treatments for peptic ulcer disease due to rising resistance to conventional therapies, including proton pump inhibitors and antibiotics for H. pylori. Studies on various plants such as Zingiber officinale (ginger) and Guiera senegalensis have shown they can effectively reduce gastric ulcers. These plants exhibit anti-inflammatory actions and enhance mucosal healing through their active phytoconstituents. The comparative safety, accessibility, and affordability of these herbal remedies make them potent candidates for addressing gastric health conditions, especially in regions where conventional pharmaceuticals may have limited efficacy.
Conclusion
The exploration of gastroprotective plants and their phytochemicals highlights their potential as effective treatments for gastric ulcers. Their mechanisms of action, primarily through the enhancement of mucosal defenses and antioxidant activities, underscore the importance of integrating traditional herbal remedies into modern healthcare practices. As antibiotic resistance continues to challenge conventional therapies, the prevailing evidence supports the increased utilization and further research of plant-based treatments in the management of gastric ulcers, reinforcing the value of indigenous knowledge and biodiversity in pharmaceutical innovation.
FAQ section (important questions/answers):
What are the major causes of gastric ulcers?
Major causes of gastric ulcers include stress, poor diet, Helicobacter pylori infection, and the use of non-steroidal anti-inflammatory drugs (NSAIDs), leading to an imbalance between gastric acid secretion and mucosal defenses.
How do medicinal plants help manage peptic ulcers?
Medicinal plants provide cyto-protective effects by increasing mucus and bicarbonate secretion, promoting healing, and mitigating oxidative stress. They often contain phytochemicals like flavonoids and alkaloids that exhibit anti-ulcer properties.
What is the significance of mucosal defense in gastric health?
Mucosal defense is crucial for gastric health as it protects the stomach lining from acid and prevents injury. Factors like increased blood flow, mucus secretion, and prostaglandin production enhance this protective barrier.
What are some common medicinal plants used for gastric ulcer treatment?
Common medicinal plants for gastric ulcers include Moringa oleifera, Zingiber officinale (ginger), and Cassia siberiana. They exhibit gastro-protective and anti-inflammatory properties, supporting gastric mucosa health.
What are the roles of flavonoids in gastric mucosal protection?
Flavonoids are important secondary metabolites that scavenge free radicals, reduce inflammation, and enhance mucus secretion, thus protecting the gastric mucosa from ulceration and promoting healing.
Are there any side effects associated with traditional herbal treatments?
While traditional herbal treatments are generally considered safe, they can cause side effects and interactions with conventional medications. It's important to consult healthcare professionals before use.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Tadalafil’s gastroprotective effect on stress ulcers in rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ulcer:
Ulcers refer to various lesions that can occur in the digestive tract, primarily caused by factors such as infection with Helicobacter pylori, excessive NSAID use, or stress. They can lead to severe complications if untreated, emphasizing the need for effective prevention and treatment strategies.
2) Flavonoid:
Flavonoids, a subclass of polyphenols, are vital plant metabolites that contribute to the color, flavor, and disease resistance in plants. In human health, they exhibit beneficial biological effects, including cardioprotective, neuroprotective, and anti-cancer activities, making them critical in dietary sources for health promotion.
3) Activity:
Activity, in the context of pharmacology, refers to the biological effects that a substance has on living organisms. This can pertain to the efficacy of drugs in treating diseases, or plants in providing protective effects. Understanding the activity of compounds is essential for drug development and medicinal research.
4) Rat:
Rats are commonly used animals in scientific research, particularly in pharmacology and toxicology studies. Their physiology and genetics are similar to humans, allowing researchers to draw parallels in studies of disease, drug effects, and treatment methodologies, significantly contributing to our understanding of human health.
5) Surface:
Surfaces refer to the outermost layer of a material or object. In medical contexts, the surfaces of tissues, such as the gastric lining, are critical as they interact with drugs and other substances, influencing their effectiveness and uptake.
6) Blood:
Blood is the vital fluid that circulates in the body, carrying oxygen, nutrients, and waste products. Its role is crucial in physiological processes, including immune responses and healing mechanisms. The interaction of blood components with drugs or plant compounds is essential for therapeutic efficacy.
7) Disease:
Diseases are pathological conditions characterized by a specific set of symptoms or abnormalities. Understanding diseases is vital for developing effective treatment strategies and improving health outcomes, highlighting the importance of ongoing research in medicine.
8) Study (Studying):
The study refers to systematic research aimed at understanding specific phenomena. In medicine, studies contribute to advancements in knowledge, guiding treatment protocols and improving patient care through evidence-based practice.
9) Drug:
Drugs are substances that cause a physiological change in the body. This broad category encompasses a variety of pharmaceutical agents used for therapeutic purposes, requiring comprehensive research to discern their effects, interactions, and potential benefits to health.
10) Fever:
Fevers are elevated body temperatures often indicative of an underlying infection or illness. Understanding the biological mechanisms behind fevers and their management is crucial for treating various health conditions.
11) Pain:
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. It is a key symptom in many diseases and prompts individuals to seek medical attention, necessitating the development of effective pain management strategies, both pharmaceutical and herbal.
12) Inflammation:
Inflammation is the body's immune response to injury or infection, leading to redness, swelling, heat, and pain. Chronic inflammation is associated with various diseases, emphasizing the importance of managing inflammation through both lifestyle choices and medical interventions.
13) Family:
The family, in this context, often refers to a group of related organisms. Knowledge of family classifications aids researchers in identifying potential medicinal plants with similar therapeutic properties, promoting effective drug discovery efforts.
14) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is a flowering plant whose rhizome is widely used in culinary and medicinal applications. It has anti-inflammatory and antioxidant properties, making it a popular choice for treating nausea, digestive issues, and inflammatory conditions.
15) Asparagus racemosus:
Asparagus racemosus, also known as shatavari, is a plant valued in traditional medicine for its potential benefits in enhancing fertility and managing digestive disorders. Its active compounds may support various therapeutic functions, illustrating the importance of studying traditional medicinal plants.
16) Repair:
Repair refers to the process of healing or restoring tissue that has been damaged. In the gastrointestinal context, understanding the mechanisms that promote repair can inform the development of treatment strategies for conditions such as ulcers and inflammation.
17) Medicine:
Medicines are substances used to cure or alleviate symptoms of diseases. The study of different medicines, including traditional herbal remedies, expands potential treatment options and informs best practices for patient care.
18) Species:
Species refers to a group of organisms that can interbreed and produce fertile offspring. In medicinal research, understanding plant species helps identify those with therapeutic potentials, guiding discoveries of new drugs and treatment methodologies.
19) Sugar:
Sugar is a type of carbohydrate that serves as a key energy source for the body. It has implications in various health conditions, including diabetes and obesity. Its role in inflammation and ulcer development necessitates careful dietary considerations.
20) Food:
Food consists of substances consumed to provide nutritional support to the body. The choice of food can significantly impact health, including the prevention and management of diseases such as ulcers and inflammation, highlighting the importance of dietary research.
21) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth and division. Research into natural compounds that exhibit anti-cancer properties is crucial as it helps identify potential therapies that may complement traditional cancer treatments.
22) Ghana:
Ghana is a west African country rich in biodiversity, where many traditional medicinal plants are utilized. Understanding local plants and their pharmacological properties enhances the development of region-specific treatments and contributes to global pharmacotherapy.
23) Azadirachta indica:
Azadirachta indica, commonly known as neem, is a powerful plant known for its medicinal properties, including antimicrobial and anti-inflammatory effects. Its diverse applications in traditional medicine make it a subject of interest in phytochemical research.
24) Pharmacological:
Pharmacological studies involve the examination of drugs and their effects on biological systems. Understanding pharmacology allows for the optimal use of medications and the discovery of new therapies derived from natural products.
25) Phytochemical:
Phytochemicals are biologically active compounds found in plants that contribute to their medicinal properties. Research into phytochemicals helps to understand their health benefits and informs the use of plants in traditional and modern medicine.
26) Substance:
A substance is a particular kind of matter with uniform properties. In medicinal research, the study of various substances, including natural extracts and synthetic compounds, contributes to advancements in treatment methodologies and therapeutic effectiveness.
27) Epilepsy:
Epilepsy is a neurological disorder characterized by recurrent seizures due to excessive electrical activity in the brain. Understanding epilepsy's mechanisms is critical for developing effective treatments, which may include traditional remedies and modern pharmaceuticals.
28) Mineral:
Minerals are naturally occurring inorganic substances critical for various biological processes. Their role in human health underlines the importance of understanding how different minerals influence bodily functions and contribute to disease prevention.
29) Science (Scientific):
Sciences encompass systematic fields of study aimed at understanding the natural world, including biology, chemistry, and pharmacology. The integration of scientific knowledge is essential for advancing medical research and improving healthcare outcomes.
30) Momordica charantia:
Momordica charantia, or bitter melon, is a fruit known for its therapeutic properties, including anti-diabetic and anti-inflammatory effects. Its broad medicinal applications highlight the value of studying traditional foods and their potential health benefits.
31) Pharmacology:
Pharmacology is the study of drugs and their interactions with biological systems. This discipline is vital for understanding how drugs work, their therapeutic effects, and any potential adverse reactions, thus informing safer and more effective patient treatments.
32) Table:
A table is a systematic arrangement of data, often used to summarize research findings. In scientific literature, tables help present complex information clearly, facilitating better understanding and comparison of study results.
33) Diet:
Diet refers to the sum of foods consumed by an individual. It significantly impacts overall health and disease prevention, making dietary studies essential in understanding the role of nutrition in health management and therapeutic interventions.
34) Wall:
Walls generally refer to the protective barriers of organs or cells. Studying walls, such as the gastric wall, is crucial for understanding factors influencing health and treatment outcomes.
35) Salt (Salty):
Salt is an essential mineral that plays a crucial role in many bodily functions, including fluid balance and nerve transmission. However, excessive salt intake can lead to various health problems, necessitating ongoing research into dietary guidelines.
36) Tori (Dhori):
Dori may refer to a specific subject, context, or name within a scientific study. Its connection to relevant research is crucial for understanding its impact on health or specific therapeutic functions scouted for in related studies.
37) Pur:
Poor health or nutritional status can significantly impact well-being and the incidence of diseases. It underlines the importance of research into socioeconomic factors that contribute to health disparities and the development of effective interventions.
38) Antibiotic (Antibacterial):
Antibiotics are powerful medications used to treat bacterial infections. The study of antibiotics, including their resistance patterns, is essential for ensuring effective treatments and preventing the spread of resistant bacteria, a significant public health challenge.
39) Tuberculosis:
Tuberculosis (TB) is a contagious bacterial infection primarily affecting the lungs. Understanding TB's mechanisms and treatment options is essential in global health initiatives, especially in regions with high prevalence, where effective management strategies are crucial.
40) Toxicology:
Toxicology is the study of the adverse effects of chemicals on living organisms. This field is vital for assessing the safety of drugs and toxic substances, contributing to public health and environmental protection.
41) Bleeding:
Bleeding is the loss of blood, either externally or internally, often a sign of injury or medical conditions. Understanding its causes and potential treatments is essential for effective medical interventions and improving patient outcomes.
42) Leprosy:
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Understanding its pathophysiology and treatment options is critical for controlling its spread and improving the quality of life for affected individuals.
43) Camara (Camará):
Camara often refers to Lantana camara, a plant studied for its medicinal properties, particularly its potential antibacterial activities. Investigating the pharmacological effects of such plants helps in identifying natural remedies for various ailments.
44) Reason:
Reason refers to a justification or explanation for an occurrence or phenomenon. In scientific research, understanding the reasons behind observed effects is crucial for developing theories and applications in pharmacology and medicine.
45) Animal:
Animals are frequently used in medical research to model human diseases and assess new treatments. Understanding animal models enhances the knowledge of human physiology and pathology, supporting advancements in healthcare.
46) Water:
Water is essential for life, serving various physiological functions, including nutrient transport and thermoregulation. Understanding its implications in health, particularly hydration and detoxification, reinforces its importance in dietary considerations.
47) Kola:
Kola typically refers to kola nuts, which are rich in caffeine and have traditional uses in various cultures. Research into kola nuts focuses on their potential stimulant effects and health benefits in traditional medicine.
48) Alam (Alaṁ):
Alam, potentially referring to a researcher or a term in a study, highlights the collaborative nature of scientific discovery. The involvement of various researchers contributes to a comprehensive understanding of medicinal processes and pharmacological applications.
49) Bile:
Bile is a digestive fluid produced by the liver that helps emulsify fats. Its role in digestion and absorption underscores the importance of studying stomach and gastrointestinal health in the context of diet and disease management.
50) Mast:
Mast cells are immune cells that play a key role in allergic responses and inflammation. Their study is crucial for understanding various conditions, including asthma and autoimmune diseases, emphasizing the need for targeted therapies.
51) Rich (Rch):
Rich, in this context, typically refers to the abundance of specific compounds in certain plants or foods. A rich source of nutrients or phytochemicals can enhance therapeutic potential, informing dietary recommendations and supplementations.
52) Life:
Life refers to the characteristic state of living organisms, encompassing biological and metabolic processes. Understanding life at the cellular and organism levels informs medical and ecological research, contributing to advances in health and disease prevention.
53) Emblica officinalis:
Emblica officinalis, commonly known as Indian gooseberry or amla, is a fruit recognized for its health benefits, particularly its antioxidant properties. Research into this plant supports its use in traditional and modern medicine for various health conditions.
54) Relative:
Relative often denotes a relationship or comparison between entities or phenomena. In scientific research, establishing relative effects of treatments informs best practices and therapeutic options, guiding clinical decision-making.
55) Pharmacotherapy:
Pharmacotherapy is the use of medications to treat diseases. Understanding pharmacotherapy allows healthcare providers to make informed decisions about drug prescriptions and their potential interactions, ultimately improving patient care.
56) Civilization:
Civilization refers to the complex societies developed by humans, impacting various cultural practices, including the use of medicinal plants. The historical perspectives on treatment options inform contemporary medicine, emphasizing the importance of traditional knowledge.
57) Dysmenorrhea (Dysmenorrhoea):
Dysmenorrhea refers to painful menstrual cramps. Understanding its mechanisms and treatment options, including pharmacologic and herbal therapies, is essential in reproductive health, guiding effective management strategies.
58) Transformation (Transform, Transforming):
Transforming refers to significant changes or developments, particularly in understanding health or disease mechanisms. In medical research, transforming insights lead to improved therapies and better patient outcomes.
59) Discussion:
Discussion in scientific literature refers to the section where authors interpret results, relate findings to existing knowledge, and suggest implications for future research. This dialogue fosters advancement in understanding complex health issues.
60) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Srivastava likely refers to a researcher or a specific study. Identifying contributions from various researchers helps to build a comprehensive understanding of medical and pharmacological advancements, informing future inquiries.
61) Accumulation (Accumulating, Accumulate):
Accumulate refers to gathering or increasing over time, often used in describing the build-up of substances in the body. In pharmacology, understanding how substances accumulate can inform dosing regimens and safety profiles.
62) Alcoholism:
Alcoholism is a chronic disease characterized by uncontrolled drinking. Understanding its mechanisms and impacts on health is crucial for developing effective behavioral treatments and medications to combat this pervasive health issue.
63) Knowledge:
Knowledge is the understanding and information gained through experience or education. In medical contexts, knowledge is critical for informed decision-making regarding treatment options and patient education, impacting overall health outcomes.
64) Evolution:
Evolution refers to the gradual development of organisms, including adaptations that enhance survival. Understanding the principles of evolution informs biomedical research, emphasizing the importance of the genetic foundations underlying health and disease.
65) Surendra (Sura-indra, Suremdra):
Surendra may refer to a researcher, highlighting the collaborative nature of scientific inquiries. Recognizing contributions from diverse researchers enriches the medical field, facilitating a comprehensive approach to understanding health challenges.
66) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. Understanding toxicity is critical in medicinal research to ensure that drugs and herbal products are safe for human consumption.
67) Vomiting:
Vomiting is the forceful expulsion of stomach contents. It can signal various health problems and understanding its mechanisms is essential for effective management and treatment of underlying conditions.
68) Debility:
Debility refers to physical weakness or incapacity, often resulting from illness or prolonged lack of nourishment. Understanding debility is crucial in managing patient health, particularly in chronic conditions.
69) Carmara:
Carmara may refer to a specific plant or study, underscoring the potential for natural substances in health management. Investigating such plants contributes to a broader understanding of alternative therapeutics.
70) Samtana (Santana):
Santana could denote a researcher or specific study related to medical science. Contributions from various scientific minds enrich the research landscape, advancing the field and generating innovative approaches to health issues.
71) Account:
Account may refer to reporting or detailing findings in research. Accurate accounting of methodologies and results is vital for scientific integrity and reproducibility in medical research.
72) Jasmine:
Jasmine often refers to plants known for their fragrance and potential therapeutic properties. Understanding jasmine's medicinal qualities can yield insights into traditional medicine practices and their application in contemporary health approaches.
73) Vaṇita (Vanita):
Vanita may refer to a researcher contributing to a specific study in the field of medicine. Recognizing the roles of diverse researchers supports collaborative efforts aimed at enhancing medical knowledge and treatment strategies.
74) Challa:
Challa may refer to a researcher or specific study within pharmacological research. Individual contributions help to advance understanding in medicine, fostering developments in treatment options for various health conditions.
75) Mysore:
Mysore is a city in India known for its rich cultural heritage and contributions to traditional medicine. Understanding local practices can enhance knowledge of natural healing methods and their relevance in modern healthcare.
[Note: The above list is limited to 75. Total glossary definitions available: 103]
Other Science Concepts:
Discover the significance of concepts within the article: ‘Tadalafil’s gastroprotective effect on stress ulcers in rats’. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal plant, Flavonoid, Herbal preparation, Herbal medicine, Oxidative stress, Reactive oxygen species, Secondary metabolite, Cyto-protection, Gastric ulcer, Dietary habit, Acid Secretion, Antacid, Peptic ulcer disease, Vitamins and minerals, Natural source, Cytoprotection, Alkaloid, Wistar rat model, Gastric acidity, Ethanol induced gastric ulcer, Gastroprotective effect, H. pylori infection, Prostaglandin E2, Phytoconstituent, Prostaglandins production, Bicarbonate ion, Prostaglandin, Stress-induced ulcer, Bicarbonate secretion, Traditional medicine practice, Phyto therapy, Herbal Remedie.