Acute coronary syndrome as a post-covid-19 complication

a review on its prevalence, potential mechanisms, and treatment

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Acute coronary syndrome as a post-covid-19 complication
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Subtitle: a review on its prevalence, potential mechanisms, and treatment

Original source:

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Author:

Priyanka Sri Betha, Amrutha Valli Dasari, Tabitha Sharon, Kantamaneni Padmalatha


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Acute coronary syndrome as a post-covid-19 complication

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20235-27729

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

The COVID-19 pandemic, primarily caused by the SARS-CoV-2 virus, has emerged as a significant global health concern, leading to severe respiratory issues and, alarmingly, a range of cardiovascular complications. Evidence has surfaced linking COVID-19 to acute coronary syndrome (ACS), which encompasses conditions like unstable angina and myocardial infarction (MI). This review aims to explore the prevalence of ACS in post-COVID-19 patients, the potential mechanisms driving this connection, and the available treatment strategies.

Endothelial Dysfunction and Inflammation

A crucial mechanism underlying the development of ACS in COVID-19 patients is endothelial dysfunction. The virus interacts with angiotensin-converting enzyme 2 (ACE2) receptors on endothelial cells, leading to inflammation and vasoconstriction. The inflammatory response, exacerbated by the viral infection, results in elevated levels of cytokines, contributing to the destabilization of atherosclerotic plaques. This causes increased thrombogenesis, which can precipitate myocardial ischemia and elevate the risk of acute coronary events. The interplay of these factors highlights the critical role of endothelial health in mitigating cardiovascular risks associated with COVID-19.

Myocardial Ischemia and Hypoxia

Myocardial ischemia in COVID-19 patients is often exacerbated by hypoxia stemming from acute respiratory infections. The virus affects oxygen supply and demand dynamics, heightening the likelihood of myocardial infarction. Clinical findings have shown the virus’s impact on the heart, especially in patients with pre-existing conditions. COVID-19 patients exhibit higher risks for myocardial ischemia, largely due to impaired ventilation-perfusion ratios and systemic inflammatory responses that disrupt normal cardiac function. Ultimately, these conditions can lead to acute coronary syndrome and elevated morbidity and mortality rates.

Treatment Strategies for COVID-19 Induced ACS

The management of ACS in patients with COVID-19 presents unique challenges. The pandemic has led to delayed treatments and increased complications, as many patients suffering from ACS were discharged prematurely. Treatment options are evolving to include anticoagulants, which not only prevent thrombosis but also address inflammation associated with COVID-19. Recent studies also suggest that immunosuppressants targeting pro-inflammatory cytokines could be beneficial. Ongoing clinical trials are critical to establishing effective therapeutic protocols for managing COVID-induced ACS and refining the approach to minimize adverse outcomes.

Conclusion

In summary, there is a noticeable link between COVID-19 and the development of acute coronary syndrome, revealing a significant public health challenge. The interplay of endothelial dysfunction, systemic inflammation, and impaired myocardial oxygenation underscores the complexity of treating ACS in infected individuals. Addressing these interconnected mechanisms is paramount for improving patient outcomes. Moreover, further extensive randomized trials are needed to optimize management strategies for ACS in the context of COVID-19, aiming to reduce mortality and enhance the quality of life for affected patients.

FAQ section (important questions/answers):

What is the relationship between COVID-19 and acute coronary syndrome (ACS)?

COVID-19 can lead to acute coronary syndrome due to mechanisms like systemic inflammation, hypoxia, and endothelial dysfunction. Patients may experience increased myocardial ischemia and are at higher risk for thrombotic events.

What are the common symptoms of COVID-19 and ACS?

Common COVID-19 symptoms include cough, shortness of breath, and fatigue. ACS symptoms can present atypically as chest pain, palpitations, and even indigestion, making diagnosis challenging in COVID-19 patients.

How does acute respiratory failure impact the heart in COVID-19?

Acute respiratory failure in COVID-19 can cause an imbalance between myocardial oxygen demand and supply, potentially resulting in type 2 myocardial infarction due to increased stress and demand on the heart.

What are the potential treatments for COVID-19 induced ACS?

Treatment may involve anticoagulants, anti-inflammatory agents, or immunosuppressants. Medications like statins, beta-blockers, and IL-6 inhibitors are being investigated for their therapeutic effects on ACS in COVID-19 patients.

What is the epidemiology of ACS in COVID-19 patients?

ACS occurs in a significant proportion of COVID-19 patients, with studies showing myocardial injury rates up to 12%. This condition has emerged as a crucial complication during the pandemic.

What underlying mechanisms lead to ACS in COVID-19 patients?

Key mechanisms include inflammatory responses, endothelial dysfunction, hypoxic damage, and increased thrombotic events. These factors can destabilize existing cardiovascular conditions, leading to higher ACS incidence.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Acute coronary syndrome as a post-covid-19 complication”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
Diseases are disorders of a structure or function in a human, animal, or plant. The interplay between various diseases, particularly viral infections like COVID-19 and their cardiovascular implications, including acute coronary syndrome, highlights the importance of integrated health approaches.

2) India:
India is one of the largest nations in South Asia, with a highly diverse population and significant healthcare challenges. The COVID-19 pandemic severely impacted India, leading to high infection rates and exacerbating existing health issues like acute coronary syndrome, highlighting the need for effective public health strategies.

3) Inflammation:
Inflammation is the body’s response to injury or infection, characterized by redness, heat, swelling, and pain. It plays a crucial role in diseases, including those caused by viral infections like SARS-CoV-2, where an exaggerated inflammatory response can lead to serious complications such as acute coronary syndrome.

4) Science (Scientific):
Science is the pursuit of knowledge and understanding of the natural world through observation and experimentation. In the context of healthcare, science informs treatment protocols and preventive strategies for diseases, including how COVID-19 can lead to complications like acute coronary syndrome through systematic study.

5) Vijaya:
Vijaya refers to the Vijaya Institute of Pharmaceutical Sciences for Women in India, which played a key role in the research discussed in this review. Institutions like Vijaya contribute to advancing pharmaceutical knowledge, particularly in understanding complex health issues like COVID-19 and its cardiovascular ramifications.

6) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth and division, leading to tumors that can spread throughout the body. While not directly related to the main focus of COVID-19 and acute coronary syndrome, cancer research often intersects with cardiovascular studies regarding treatment impacts.

7) Vijayawada (Vijaya-vada, Vijayavada):
Vijayawada is a city in Andhra Pradesh, India, and the location of the Vijaya Institute of Pharmaceutical Sciences for Women. This city, like many others, faced the challenges posed by the COVID-19 pandemic, necessitating local research into its health impacts, including acute coronary syndrome.

8) Andhra (Amdhra):
Andhra Pradesh is a state in India with a substantial population impacted by the COVID-19 pandemic. The healthcare outcomes observed in the region, including increases in acute coronary syndrome cases, reflect the importance of regional studies in understanding the broader implications of the pandemic.

9) Cina:
China is where the COVID-19 outbreak began in December 2019. Its experience with the disease offers critical insights into the progression and complications of COVID-19, including acute coronary syndrome, influencing global health responses and pandemic preparedness in other countries, including India.

10) Viru:
The term 'viru' is likely referencing viruses, especially in the context of SARS-CoV-2, the virus responsible for COVID-19. Understanding viral mechanisms is pivotal in researching diseases like COVID-19 and its cardiovascular effects, such as acute coronary syndrome, to develop effective treatment strategies.

11) Developing:
Developing refers to the process of growth, evolution, or improvement. In health contexts, it often signifies developing nations that face unique healthcare challenges, especially during the COVID-19 pandemic, where resources may be limited to address rising issues like acute coronary syndrome.

12) Death:
Death signifies the end of biological functions that sustain a living organism. The COVID-19 pandemic has raised significant mortality rates globally, with acute coronary syndrome among the noted complications in patients, highlighting the urgent need for effective prevention and treatment strategies.

13) Pharmacological:
Pharmacological refers to the study of how drugs interact with biological systems. Investigating pharmacological treatments for conditions associated with COVID-19, such as acute coronary syndrome, is essential in developing effective management protocols and therapeutic interventions to improve patient outcomes.

14) Toxicity:
Toxicity refers to the degree to which a substance can damage an organism. In the context of pharmaceuticals, assessing toxicity is crucial to ensure the safety and efficacy of treatments for COVID-19 and its complications, including acute coronary syndrome, as beneficial drugs must outweigh risks.

15) Pearl:
A pearl, like 'pearls', can signify individual pieces of important information in a medical context. Understanding 'pearls' in clinical practice assists healthcare professionals in improving their response to health crises, such as those related to COVID-19 and complications like acute coronary syndrome.

16) Storm:
In medical parlance, 'storm' often refers to severe, rapid-onset reactions, such as a cytokine storm associated with severe COVID-19 infections. This hyper-inflammatory response can worsen conditions like acute coronary syndrome, making understanding its mechanisms vital for effective treatment.

17) Study (Studying):
A study is an investigation conducted to analyze a hypothesis or question. In healthcare, studies are essential for understanding disease mechanisms and treatment efficacy. This includes research into how COVID-19 can lead to complications like acute coronary syndrome through systemic effects.

18) Drug:
A drug is a therapeutic substance used to treat, cure, or prevent disease. In the context of COVID-19 and its complications, understanding drug interactions and their effects on conditions like acute coronary syndrome is essential for optimizing treatment protocols.

19) Sign:
A sign is an indication or symptom of a disease or condition. Recognizing signs associated with COVID-19 and its cardiovascular implications, including acute coronary syndrome, is crucial for timely diagnosis and treatment, ultimately improving patient outcomes.

20) Life:
Life represents the condition that distinguishes animals and plants from inorganic matter. The COVID-19 pandemic has significantly impacted life expectations, prompting investigations into its effects on health, particularly concerning acute coronary syndrome which can threaten life quality and longevity.

21) Pharmacology:
Pharmacology is the branch of medicine that focuses on drugs and their effects on the body. This field is essential for understanding how drugs can be effectively utilized in treating COVID-19 complications, such as acute coronary syndrome, through various therapeutic mechanisms.

22) Transmission:
Transmission refers to the spread of pathogens, such as viruses, from one host to another. Understanding the transmission of COVID-19 is crucial in managing and preventing the disease's spread, especially in relation to its potential cardiovascular complications, including acute coronary syndrome.

23) Transformation (Transform, Transforming):
Transform indicates a significant change in form, appearance, or nature. In a health context, the COVID-19 pandemic has transformed how healthcare is delivered, with evolving treatment guidelines required to address complications like acute coronary syndrome effectively.

24) Medicine:
Medicine is the science or practice of diagnosing, treating, and preventing disease. Advances in medicine are vital in responding to health crises like COVID-19, particularly in understanding its implications for cardiovascular conditions such as acute coronary syndrome.

25) Activity:
Activity refers to the state of doing something, which can encompass various behaviors related to health. In the context of COVID-19 and acute coronary syndrome, physical activity levels and their impacts on cardiovascular health may influence treatment outcomes.

26) Quality:
Quality relates to the standard of something as measured against other things. In healthcare, quality is paramount in patient care delivery, influencing outcomes during the COVID-19 pandemic and the management of complications like acute coronary syndrome.

27) Species:
Species is a group of living organisms consisting of similar individuals capable of exchanging genes. Understanding species-specific responses to viruses like SARS-CoV-2 aids in developing targeted therapies for diseases, including those linking COVID-19 to acute coronary syndrome.

28) Dasari:
Dasari refers to Amrutha Valli Dasari, one of the authors involved in the review. Contributions from individuals like Dasari at research institutions are essential for advancing understanding of COVID-19 effects, particularly concerning complications such as acute coronary syndrome.

29) Family:
Family signifies a group of related organisms. In health contexts, certain diseases, including cardiovascular issues linked to COVID-19, may exhibit familial patterns, necessitating research to identify genetic risk factors and improve preventive strategies for diseases like acute coronary syndrome.

30) Indian:
Indian refers to aspects related to India, one of the countries significantly affected by COVID-19. The study of Indian patient populations provides insights into the unique health challenges faced during the pandemic, including the rise in acute coronary syndrome cases.

31) Visit:
Visit in the healthcare context refers to a patient’s appointment or interaction with a healthcare provider. Regular visits are necessary for monitoring patients with conditions like acute coronary syndrome, particularly during the COVID-19 pandemic when risks may be elevated.

32) Mason:
Mason refers to Dr. Mason J.W., who has suggested the use of immunosuppression in treating myocardial damage associated with COVID-19. Insights from experts like Mason are critical when developing effective treatment protocols for complications like acute coronary syndrome.

33) Kumar:
Kumar refers to Dr. Kumar A., another author recognized in the clinical guidelines discussing acute coronary syndrome management. Contributions like those from Kumar are essential for developing treatment strategies to address the unique challenges posed by COVID-19.

34) Valli:
Valli, as in Amrutha Valli Dasari, contributes to the ongoing discussion of COVID-19's impact on health. Insights from collaborators studying acute coronary syndrome highlight the multifaceted implications of the pandemic on cardiovascular health and require collaborative research efforts.

35) Dina:
Dina likely refers to author Dina V. Shorikova, who contributed insights regarding COVID-19 and cardiovascular implications. Research contributions from authors like Dina enhance understanding of how viral infections like SARS-CoV-2 can complicate cardiovascular health, including acute coronary syndrome.

36) Beta:
Beta can refer to beta-blockers, a class of medications that reduce blood pressure and heart workload. Their role in the management of cardiovascular complications like acute coronary syndrome during COVID-19 underscores the importance of pharmacological research in such contexts.

37) Pain:
Pain is an unpleasant sensory experience often associated with injury or disease. In the context of acute coronary syndrome, chest pain is a critical symptom that requires urgent medical attention, particularly in patients with COVID-19 due to possible cardiac complications.

38) Post:
Post refers to a position or action occurring after a particular event. In medical contexts, post-infection evaluations are important to assess complications such as acute coronary syndrome that may arise after recovering from COVID-19.

39) Pur:
Poor often describes a state of inadequate condition or quality. In healthcare, poor health outcomes related to COVID-19, particularly in patients with comorbidities, can lead to greater risks of complications like acute coronary syndrome, emphasizing the need for holistic care.

40) Male:
Male refers to the sex of an organism that produces small reproductive cells (sperm). In many studies, including those discussing COVID-19 impacts, male patients may exhibit different health outcomes and risks for conditions such as acute coronary syndrome, necessitating tailored approaches.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Acute coronary syndrome as a post-covid-19 complication’. Further sources in the context of Science might help you critically compare this page with similair documents:

Clinical presentation, Endothelial dysfunction, COVID 19, Myocardial ischemia, Cardiac complications, Inflammatory response, Risk factor, Pharmacological agent, CVD, Epidemiology of COVID-19, Cytokine storm, Acute myocardial infarction, Acute coronary syndrome, Beta blocker, Systemic inflammatory response, SARS-CoV-2 Infection, ACE2 receptor, Angiotensin-converting enzyme 2, Statin, Chronic Cardiovascular Disease.

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