Brief review on deep eutectic mixture and its application

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Journal name: World Journal of Pharmaceutical Research
Original article title: Brief review on deep eutectic mixture and its application
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Rajesh Ramrao Suryawanshi, Dr. Pravin S. Kawtikwar, Ankita P. Kawtikwar, Shivani M. Suryawanshi, Vaibhav P. Patange


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Brief review on deep eutectic mixture and its application

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20236-27896

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Deep eutectic solvents (DESs) are innovative liquid mixtures comprised of solid components that demonstrate unique properties such as high solvent capacity, biodegradability, low volatility, and low toxicity. This emerging class of solvents has garnered significant attention in the past two decades, particularly owing to their application in the health field. DESs are promising in the formulation of oral drugs, especially for poorly soluble active pharmaceutical ingredients. Their diverse applications extend to synthesis media and the extraction of bioactive compounds, alongside their roles in drug delivery systems and stabilization of medical samples.

Applications of Deep Eutectic Solvents in Drug Solubility

One of the most notable applications of DESs is in improving the solubility of poorly soluble drugs, which poses a significant challenge in the pharmaceutical industry. Solubility directly impacts a drug's therapeutic efficacy; thus, various approaches have been explored to enhance it, including the formulation of eutectic mixtures. DESs have the potential to address this challenge by serving as effective solvents that can dissolve hydrophobic drugs. This ability to enhance solubility follows from the unique properties of DESs, which can significantly alter the pharmaceutical landscape by providing enhanced bioavailability for challenging compounds.

Synthesis and Extraction Applications

Another significant use of DESs lies in their application as green solvents for the synthesis and extraction of metal nanoparticles. Their tunable properties promote the shape-controlled synthesis of nanoparticles, showcasing their versatility in various chemical processes. For instance, researchers have successfully synthesized gold nanoparticles using DESs without surfactants, yielding structures with unique catalytic properties. This innovative application highlights the effectiveness of DESs in facilitating complex chemical reactions while adhering to environmentally friendly practices, making them ideal for nanotechnology and materials science.

The Role of Deep Eutectic Solvents in Drug Delivery

DESs are also being explored as novel drug delivery systems, owing to their capability to form gels and nanoparticles. By combining DESs with biocompatible polymers, researchers can develop drug delivery vehicles that facilitate targeted drug delivery. Studies have shown that DES gels can effectively deliver anti-inflammatory medications, while nanoparticles created using DESs have been tailored for the oral delivery of insulin and targeted delivery of anticancer drugs. However, further research is necessary to optimize the formulations and understand the mechanisms that govern their behavior in biological systems.

Conclusion

In conclusion, deep eutectic solvents represent a promising area of research in developing environmentally friendly alternatives to conventional solvents. Their unique physicochemical properties allow for applications across various fields, particularly in pharmaceuticals and material science. This review has highlighted key aspects of DESs, from their definitions and classifications to their diverse applications in enhancing drug solubility, facilitating nanoparticle synthesis, and developing drug delivery systems. As the exploration of their potential continues, further studies are essential to unlock the full scope of their capabilities and adapt them to practical uses, ensuring a transition toward more sustainable practices in various industries.

FAQ section (important questions/answers):

What are deep eutectic solvents (DES)?

DES are liquid mixtures composed of solid components, characterized by low melting points and unique properties like biodegradability, high solvent capacity, and low toxicity, making them suitable for various applications.

What makes DES environmentally friendly solvents?

DES components are typically renewable, inexpensive, and non-toxic, and they significantly reduce the use of hazardous organic solvents, aligning with principles of green chemistry.

How are DES prepared for use?

DES can be prepared by mixing hydrogen bond donors and acceptors in specific molar ratios, followed by heating or freezing methods to achieve a homogeneous liquid state.

What applications do DES have in pharmaceuticals?

DES are used to enhance the solubility of poorly soluble drugs, act as drug delivery vehicles, and serve as synthesis media for the development of various pharmaceutical formulations.

What are the physicochemical properties of DES?

DES exhibit low vapor pressure, tunable viscosity, thermal stability, and unique phase behavior, making them adaptable for different chemical processes and applications across various fields.

What are some limitations of using DES?

While promising, the toxicological properties of DES require further research, and their lower chemical inertness compared to traditional ionic liquids may limit certain applications.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Brief review on deep eutectic mixture and its application”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Salt (Salty):
Salt refers to ionic compounds often used in the formation of deep eutectic solvents (DESs). These salts consist of a cation and an anion, contributing to the unique properties of DESs, such as their low melting points and high solvating capabilities. They play a key role in various chemical and pharmaceutical applications.

2) Water:
The water is significant in the context of deep eutectic solvents due to its role in influencing their properties. It can modify the viscosity, conductivity, and solubility behavior of DESs. Moreover, its presence is often essential in specific applications, highlighting the multifaceted nature of DES interactions.

3) Drug:
Drugs, the plural form of drug, emphasizes the variety of pharmaceutical compounds that can benefit from deep eutectic solvents. DESs can facilitate the delivery of diverse drugs, including hydrophobic and poorly soluble active compounds, thus enhancing their therapeutic efficacy and aiding in new drug developments.

4) Surface:
Surface properties are significant in evaluating deep eutectic solvents, especially their surface tension. High surface tension can be attributed to the extensive hydrogen bond networks present in DESs. Understanding these properties helps in optimizing DES formulations for various applications, including drug delivery and materials science.

5) Field:
Fields relate to the various scientific and industrial areas where deep eutectic solvents are employed. These include pharmaceuticals, environmental science, and food technology. Understanding the distinct fields where DESs are applicable showcases their versatility and relevance in advancing green chemistry initiatives.

6) Depression:
Depression in this context relates to the depression of melting and freezing points in deep eutectic solvents. This phenomenon is critical for understanding the formation and behavior of DESs. The ability to lower melting points allows for the use of these solvents in a range of temperature-sensitive applications.

7) Species:
Species refers to the different chemical entities involved in forming deep eutectic solvents. These can include various hydrogen bond donors and acceptors derived from renewable resources, affecting the properties and applications of DESs. The choice of species in DES formation is crucial for tailoring solvent characteristics.

8) Toxicity:
Toxicity is an important consideration in evaluating deep eutectic solvents and their components. DESs are generally regarded as having low toxicity due to their renewable and biodegradable nature. Further research is essential to fully assess the toxicological properties of these promising alternative solvents.

9) Nature:
The nature of deep eutectic solvents pertains to their specific properties, such as biodegradability, low toxicity, and tunable physicochemical characteristics. Understanding the nature of DESs is fundamental to exploring their application in environmentally friendly chemistry and various sustainable industrial processes.

10) Sugar:
Sugar is a type of hydrogen bond donor that can be utilized in forming deep eutectic solvents. Natural deep eutectic solvents (NADES) can contain sugars, which enhance the solubility and bioavailability of drugs, making them increasingly valuable in pharmaceutical applications and various green chemistry initiatives.

11) Table:
Table is utilized to present data or information systematically; in the context of this review, it may refer to the tabulated data of freezing points of different deep eutectic solvents. Tables enhance clarity by allowing readers to compare and analyze properties effectively, facilitating better comprehension of DES applications.

12) Study (Studying):
Study denotes the investigation conducted on deep eutectic solvents, exploring their characteristics, applications, and preparation methods. Scientific studies provide invaluable insights into the properties and behaviors of DESs, ultimately shaping their integration into various fields, including medicine, environmental science, and industrial processing.

13) Gold (Golden):
The gold refers specifically to the nanoparticles that can be synthesized using deep eutectic solvents as a medium. The ability to produce gold nanostructures showcases the innovative applications of DESs in materials science, particularly in optoelectronics and drug delivery systems, emphasizing the value of such research.

14) Pur:
Poor refers to the characteristic of certain drugs that exhibit low solubility in water. This poses challenges in pharmacology, as poorly soluble drugs can hinder therapeutic efficacy. Deep eutectic solvents provide a promising solution for improving solubility and bioavailability of these problematic drugs.

15) Biodegradable:
Biodegradable indicates that a substance can be broken down by natural processes. Deep eutectic solvents are often derived from natural materials and are biodegradable, making them environmentally friendly alternatives to traditional solvents. Their biodegradable nature aligns with green chemistry principles and reduces ecological harm.

16) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India that houses the Sudhakarrao Naik Institute of Pharmacy, the institution involved in the research of deep eutectic solvents as mentioned in the review. The location is pivotal in emphasizing regional contributions to pharmaceutical research and development in the field of DESs.

17) Yavatmal:
Yavatmal is a district in Maharashtra, India, and serves as the geographical context from which the authors of the study hail. The district's academic initiatives, like those at the Sudhakarrao Naik Institute of Pharmacy, signify the region’s involvement in cutting-edge pharmaceutical research, particularly on deep eutectic solvents.

18) Heating:
Heating is a vital step in the preparation of deep eutectic solvents, often necessary to achieve homogeneity and optimal physical properties. The process allows different components to interact effectively, facilitating the formation of a clear, stable DES. This illustrates the influence of temperature in solvating applications.

19) Science (Scientific):
The Science reflects the collective knowledge and systematic investigation into the properties and applications of deep eutectic solvents. This encapsulates the empirical and theoretical work done to understand DES systems and their potential to innovate various industrial processes and improve environmental sustainability.

20) Road:
Road may signify the pathway of research and development in the field of deep eutectic solvents as a progressive area of study. It reflects the ongoing journey researchers undertake to explore new applications and optimize existing DES systems for improved efficacy in various scientific fields.

21) Discussion:
Discussion refers to the analytical examination and interpretation of findings regarding deep eutectic solvents. This section often provides insights into the significance of results, potential applications, and future directions in research. Effective discussion enhances the comprehensibility and relevance of the study's conclusions.

22) Reflecting:
Reflecting pertains to the consideration of how the properties and applications of deep eutectic solvents relate to broader themes in green chemistry. This process may include analyzing the environmental impacts of DESs, their sustainability, and their roles in advancing eco-friendly practices across different scientific fields.

23) Substance:
Substance highlights the focus on specific chemical compounds that form deep eutectic solvents. Each substance, particularly in relation to its role as a hydrogen bond donor or acceptor, greatly influences the physicochemical characteristics of DESs, underscoring the necessity of detailed analysis in solvent formulation.

24) Observing:
Observing involves the systematic examination of properties and behaviors of deep eutectic solvents in research. Through careful observation, scientists gather valuable data and insights that lead to understanding the efficacy, safety, and potential applications of DESs, contributing to advancements in the field.

25) Activity:
Activity in this context refers to the effectiveness of deep eutectic solvents in various applications, including their use in drug delivery systems, environmental remediation, and material synthesis. Understanding the activity of DESs enhances our knowledge of their potential impact across multiple scientific disciplines.

26) Biofuel:
Biofuel refers to fuels derived from renewable biological resources. The exploration of deep eutectic solvents in the production and processing of biofuels underscores their potential as green solvents, facilitating efficient reactions and extractions in sustainable energy practices, reflecting the goals of environmental chemistry.

27) Shivani (Sivani):
Shivani is one of the co-authors of the study on deep eutectic solvents. Her contributions, along with her colleagues, emphasize collaborative efforts in research, enhancing the multidisciplinary nature of the field. Authors like Shivani play a crucial role in advancing knowledge and application of DESs.

28) Medium:
Medium refers to the environment in which reactions occur or substances are dissolved. In the context of deep eutectic solvents, they serve as a medium for chemical reactions, enhancing solubility and facilitating synthesis processes. The choice of medium is crucial in optimizing reaction conditions.

29) Glass:
Glass can symbolize the transparent nature of certain deep eutectic solvents that can be achieved through proper formulation and mixing techniques. The term highlights the clarity and stability of DESs, which is significant in many applications, including pharmaceuticals and materials science.

30) Food:
Food signifies an area where deep eutectic solvents show potential applications, particularly in food extraction and preservation. Utilizing DESs can enhance the extraction of bioactive compounds in food sciences, promoting healthier food products and sustainable practices within the food industry.

31) Hand:
Hand may metaphorically refer to the human element in the ongoing research and application of deep eutectic solvents. This highlights the interdisciplinary teamwork and human ingenuity involved in advancing the study of DESs, ultimately benefiting human health and environmental sustainability.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Brief review on deep eutectic mixture and its application’. Further sources in the context of Science might help you critically compare this page with similair documents:

Drug delivery system, Surface tension, Hydrogen bonding interaction, Pharmaceutical application.

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