Curcumin and physiotherapy for oral submucous fibrosis: a study

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Evaluation of efficacy of curcumin and physiotherapy in the management of oral submucous fibrosis - a clinical study
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Dr. Yamuna Rani and Dr. Anuradha Pai


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Evaluation of efficacy of curcumin and physiotherapy in the management of oral submucous fibrosis - a clinical study

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20236-27898

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

Oral submucous fibrosis (OSMF) is a chronic and potentially malignant disorder predominantly affecting the oral cavity and pharynx, primarily linked to areca nut chewing. This debilitating condition can significantly impact quality of life, causing issues related to speech, swallowing, and limited mouth opening, leading to severe complications including malignancy. Despite its increasing prevalence, especially in Southeast Asia and the Indian subcontinent, effective treatment options remain limited. This study explores the efficacy of curcumin gel compared to triamcinolone acetonide gel in managing OSMF, assessing their impact on symptoms such as burning sensation, mouth opening, and other clinical parameters.

Efficacy of Curcumin Gel

The study results indicated that curcumin gel demonstrated significant improvements in managing OSMF symptoms when compared to triamcinolone acetonide gel. Specifically, the curcumin group showed a greater reduction in burning sensations over the 90-day treatment period, improving from an average score of 6.69 to 1.77 on a Visual Analogue Scale. Overall, curcumin's anti-inflammatory properties appear to provide effective relief of the symptoms associated with OSMF, making it a viable alternative treatment option.

Impact on Mouth Opening and Cheek Flexibility

In addition to alleviating burning sensations, curcumin gel was also found to improve inter-incisal mouth opening and cheek flexibility more effectively than triamcinolone acetonide gel. The average increase in mouth opening for the curcumin group reached 42.42 mm by the end of the study, indicating significant clinical relevance in restoring functionality. Similarly, improvements in cheek flexibility were noteworthy, suggesting that curcumin, along with oral physiotherapy, can effectively enhance oral function in OSMF patients.

Potential of Oral Physiotherapy

Oral physiotherapy exercises were incorporated into the treatment regimen for both groups, further enhancing the benefits of curcumin and triamcinolone acetonide. The exercises focused on increasing mouth opening, tongue protrusion, and cheek flexibility, which are critical for patients suffering from OSMF. The data demonstrated that regular physiotherapy, coupled with curcumin treatment, yielded better outcomes than using corticosteroids alone. This approach highlights the importance of multidisciplinary treatment strategies in managing OSMF effectively.

Conclusion

The findings of this study suggest that curcumin gel is as effective as triacrinolone acetonide gel in managing OSMF, with the added benefits of being more readily available, cost-effective, and safer for long-term use. The results advocate for curcumin as a promising alternative treatment option, aligning with its established anti-inflammatory and antioxidant properties. Further comprehensive studies with larger sample sizes and longer follow-up periods are necessary to confirm these results and explore the broader implications of curcumin in the treatment of oral submucous fibrosis.

FAQ section (important questions/answers):

What is the aim of the study on oral submucous fibrosis?

The study aimed to clinically determine and compare the efficacy of curcumin gel and triamcinolone acetonide gel with physiotherapy in managing oral submucous fibrosis (OSMF).

What were the main findings about curcumin's efficacy?

Curcumin gel showed comparable clinical response to triamcinolone acetonide gel, demonstrating significant improvement in burning sensation and interincisal mouth opening in OSMF patients.

How many patients participated in the study and how were they divided?

A total of 60 OSMF patients were randomly divided into two groups, with each group consisting of 30 patients, one receiving curcumin gel and the other receiving triamcinolone acetonide gel.

What parameters were assessed during the study?

The study assessed burning sensation, interincisal distance, tongue protrusion, and cheek flexibility at various intervals throughout the 3-month treatment period.

What recommendation was made based on the study results?

The study concludes that curcumin can be an effective, safe alternative treatment for OSMF. Further long-term studies with larger sample sizes are recommended.

What are the potential benefits of using curcumin in OSMF treatment?

Curcumin has anti-inflammatory, antioxidant, and antifibrotic properties, making it a promising treatment option for OSMF, with fewer side effects compared to conventional treatments.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Curcumin and physiotherapy for oral submucous fibrosis: a study”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
'The study' denotes the specific clinical research project aimed at comparing the effects of curcumin and triamcinolone acetonide in treating oral submucous fibrosis. It encapsulates the research design, methodologies, participant demographics, outcomes measured, and conclusions drawn, serving as a vital reference for future studies in this area.

2) Burning sensation:
'Burning sensation' indicates a common symptom experienced by patients with oral submucous fibrosis, characterized by discomfort in the oral mucosa. This sensation can significantly impact a patient's quality of life, affecting their ability to eat, speak, and maintain oral hygiene, thereby necessitating effective treatment strategies.

3) Burning (Burn, Burned, Burnt):
'Burning' in the medical context primarily describes the discomfort or pain patients feel in their oral cavity due to inflammation or irritation. It adds to the psychosocial burden of the affected individuals, prompting the exploration of various therapeutic modalities to relieve this distressing symptom and improve overall health.

4) Rani:
'Rani' refers to one of the lead researchers in the study, Dr. Yamuna Rani. Her role emphasizes the importance of academic research in understanding oral submucous fibrosis and exploring alternative treatment options. The inclusion of her name signifies authorship and accountability in the research findings presented.

5) Disease:
'Diseases' encompasses various health conditions, including oral submucous fibrosis and its potential to progress to malignancy. It underlines the seriousness of OSMF in the context of public health and the importance of early intervention to prevent complications associated with chronic oral disorders.

6) Male:
'Male' refers to the demographic group that predominated in the study's participant population, representing a significant portion of patients with oral submucous fibrosis. This gender-specific data offers insights into the epidemiology of the disease, aiding in understanding risk factors associated with its prevalence among genders.

7) Turmeric:
'Turmeric' is a plant from which curcumin is derived, known for its anti-inflammatory and antioxidant properties. Its relevance lies in its traditional usage in medicine, and its potential application in managing oral submucous fibrosis, providing a natural alternative to conventional therapies like corticosteroids.

8) Medicine:
'Medicine' here represents the broader field concerned with the diagnosis, treatment, and prevention of diseases. It encapsulates various treatment modalities explored in the study, reflecting the evolving nature of healthcare in addressing conditions like oral submucous fibrosis through innovative research and clinical practices.

9) Reason:
'The reason' emphasizes the justification behind choosing specific treatments for oral submucous fibrosis in the study. Understanding the rationale for selecting curcumin and physiotherapy as alternatives reflects the ongoing quest for effective management strategies, taking patient safety and efficacy into consideration.

10) Table:
'Table' refers to the organized data presentation within the study, summarizing results, participant demographics, and clinical findings. Tables aid in the clear communication of complex statistical information, making it easier for readers to comprehend and compare key aspects of the research outcomes.

11) Measurement:
'Measurement' highlights the methods used to quantify symptoms and clinical parameters in the study. Accurate measurement is critical for assessing treatment efficacy and tracking progress over time, ensuring that the results obtained reflect genuine improvements in patient condition related to oral submucous fibrosis.

12) Curcuma longa:
'Curcuma longa' is the botanical name for the turmeric plant, the source of curcumin. Its inclusion in the study underscores the scientific basis for using turmeric as a therapeutic agent in managing oral submucous fibrosis, lending credibility to the research findings.

13) Swallowing:
'Swallowing' is a critical function affected by oral submucous fibrosis, as the condition can lead to painful swallowing difficulties (dysphagia). Exploring this symptom within the study highlights the disease's impact on daily life and the urgency for interventions that restore normal swallowing capabilities.

14) Activity:
'Activity' refers to physiological or functional processes, including the activities of daily living that may be impeded by oral submucous fibrosis. Addressing how these activities are affected helps illustrate the broader implications of the disease on patients' quality of life and functional capabilities.

15) Post:
'Post' denotes the period or actions taken after a specific event, such as treatment or follow-up assessments in the study. It emphasizes the importance of monitoring long-term outcomes following interventions to ensure sustained benefits and to refine future treatment approaches.

16) Quality:
'Quality' refers to the standard of health and well-being that patients experience, particularly those suffering from oral submucous fibrosis. Improvements in treatment aim to enhance patients' quality of life by relieving symptoms and restoring functionality, which is a focal point in the study.

17) Betel nut:
'Betel nut' is a key factor associated with the development of oral submucous fibrosis. Highlighting this connection is crucial for understanding the disease's epidemiology and risk factors, guiding prevention strategies that can mitigate its prevalence, especially in populations with high betel nut consumption.

18) Pharmacological:
'Pharmacological' pertains to the properties and effects of drugs used in treatment. In the study, pharmacological interventions are evaluated, emphasizing the importance of understanding drug mechanisms and their clinical efficacy in conditions like oral submucous fibrosis to improve patient outcomes.

19) Developing:
'Developing' signifies the ongoing process of disease progression and the treatment strategies being formulated to address oral submucous fibrosis. This concept highlights the dynamic nature of research in medicine, focusing on improving techniques and therapies to enhance patient care and outcomes.

20) Yamuna:
'Yamuna' is a reference to Dr. Yamuna Rani, the principal investigator in the study. Her involvement exemplifies the role of healthcare professionals in advancing research efforts and addressing critical health issues related to oral submucous fibrosis, underscoring the significance of collaborative medical research.

21) Cotton:
'Cotton' may relate to the materials used during clinical procedures or application of treatments in the study. It represents the practical elements of conducting clinical research, emphasizing the importance of hygienic practices in patient care and safety during therapeutic interventions.

22) India:
'India' denotes the geographic and cultural context of the study, as oral submucous fibrosis is prevalent in this region. This background is vital for understanding the disease's epidemiology, risk factors associated with lifestyle practices, and the importance of culturally relevant treatment strategies.

23) Visit:
'Visit' refers to the scheduled appointments for study participants to monitor their progress and assess treatment efficacy. Structured follow-up visits are critical in clinical studies for collecting data, evaluating outcomes, and ensuring patient adherence to treatment protocols.

24) Life:
'Life' in this context pertains to the overall impact of oral submucous fibrosis on individuals, especially regarding their daily functioning, social interactions, and emotional well-being. The study aims to improve patients' quality of life by effectively managing and treating their symptoms.

25) Antibiotic (Antibacterial):
'Antibacterial' describes the property of substances that prevent the growth of bacteria. This characteristic is relevant in the context of curcumin and its therapeutic potential in treating infections and inflammatory conditions associated with oral submucous fibrosis, highlighting its broader medical applications.

26) Inflammation:
'Inflammation' refers to the body's response to injury or infection, often characterized by redness, swelling, and pain. In the context of oral submucous fibrosis, understanding inflammation is crucial for developing effective treatments that target the underlying causes of symptoms experienced by patients.

27) Vishvambhara (Visvambhara, Vishwambhar):
'Vishwambhar' in the text is likely a reference to another researcher involved in the study or a supporting source. It highlights the collaborative nature of scientific research, illustrating how multiple contributors are essential in advancing knowledge and improving health interventions.

28) Discussion:
'Discussion' refers to a section of the study where findings are analyzed and interpreted in the context of existing literature. It provides insights into the implications of the results, offering explanations, comparisons, and suggestions for further research in the field of oral submucous fibrosis.

29) Flavonoid:
'Flavonoid' refers to a specific category of phytochemicals known for their beneficial health effects. The study suggests that flavonoids, particularly from turmeric, may play a role in managing oral submucous fibrosis, emphasizing the therapeutic potential of natural compounds in medical treatments.

30) Knowledge:
'Knowledge' pertains to the understanding gained through study findings about oral submucous fibrosis. Enhancing knowledge is essential for healthcare professionals and patients, enabling better education, improved treatment strategies, and increased awareness of preventive measures against this debilitating condition.

31) Education:
'Education' refers to the dissemination of information related to oral submucous fibrosis, its symptoms, causes, and treatment options. Increasing educational efforts is vital in empowering patients and communities to make informed health choices and reduce the prevalence of the condition.

32) Swallowed:
'Swallowed' underscores the importance of how habits like betel nut chewing can lead to the ingestion of harmful substances that exacerbate oral submucous fibrosis. Highlighting the act of swallowing emphasizes behavioral changes needed to mitigate the risk associated with the disease.

33) Stiffness:
'Stiffness' describes the rigidity experienced by patients with oral submucous fibrosis, affecting oral functions such as mouth opening and swallowing. Recognizing stiffness as a key symptom enhances the understanding of the disease's impact on quality of life and guides treatment approaches.

34) Transformation (Transform, Transforming):
'Transform' signifies the potential changes in health status as a result of effective treatments for oral submucous fibrosis. This term underscores the aim of the study to facilitate significant improvements in patient symptoms and overall well-being through therapeutic interventions.

35) Mutation:
'Mutation' refers to changes in the genetic material that can result from the carcinogenic effects of substances such as areca nut. Acknowledging mutations in the context of oral submucous fibrosis highlights the importance of understanding risk factors related to cancer development.

36) Science (Scientific):
'Science' refers to the systematic pursuit of knowledge, including studies on diseases like oral submucous fibrosis. The scientific method is essential for validating treatment approaches, ensuring they are based on rigorous research and ethical standards in clinical practice.

37) Hygiene (Hygienic):
'Hygiene' encompasses practices that maintain health and prevent disease, particularly important in the management of oral conditions. Good oral hygiene is vital for patients with oral submucous fibrosis to minimize complications and promote recovery, highlighting the interplay between cleanliness and health.

38) Allergy:
'Allergy' refers to adverse reactions that some patients may experience due to certain medications or treatments. Understanding allergic responses is crucial in selecting safe therapy options for individuals with oral submucous fibrosis, as allergies can complicate management strategies.

39) Greece:
'Greece' indicates reference to geographical diversity in the occurrence of oral submucous fibrosis, suggesting the need to consider global perspectives on health issues. Understanding the disease's prevalence in various regions aids in identifying effective preventive and therapeutic strategies.

40) Cancer:
'Cancer' refers to the malignant potential associated with oral submucous fibrosis. The recognition of this risk underscores the importance of timely diagnosis and intervention, aiming to prevent progression to more severe health issues, including cancerous transformation of affected tissues.

41) Indian:
'Indian' refers to individuals from the Indian subcontinent, where oral submucous fibrosis is prevalent. This ethnic focus on the population emphasizes the need for community-targeted health interventions and culturally sensitive educational measures to reduce the incidence of the disease.

42) Seat (Seated):
'Seated' describes the position of patients during clinical evaluations in the study. Proper positioning is crucial for conducting thorough examinations, including the measurement of parameters related to oral health, thereby ensuring accurate data collection and assessment of treatment outcomes.

43) Tulsi:
'Tulsi' is another herbal remedy known for its health benefits, suggesting it may also have potential in treating oral conditions like submucous fibrosis. Its inclusion indicates the growing interest in natural therapies and the need for research on holistic approaches to patient care.

44) Cina:
'China' is likely representative of other regions with similar health challenges, possibly indicating the global interest in the treatment and prevalence of oral submucous fibrosis, highlighting the necessity for broad-ranging studies across different demographics and cultural contexts.

45) Drug:
'Drug' refers to any substance used for medical treatment, similar to drugs mentioned earlier like curcumin and triamcinolone acetonide. The study evaluates the efficacy of these drugs, underscoring the significance of pharmacological interventions in managing conditions like oral submucous fibrosis.

46) Fear:
'Fear' pertains to the apprehension felt by individuals concerning the harmful effects of areca nut and the potential implications for their health, particularly regarding oral submucous fibrosis. Addressing fear through education can empower patients to make informed decisions about their habits.

47) Sign:
'Sign' indicates objective findings in clinical assessments, such as changes in symptoms or health status during the study. Recognizing signs is vital in the evaluation process as they provide measurable evidence that aids in determining treatment efficacy.

48) Pain:
'Pain' relates to the subjective suffering experienced by patients, often exacerbated by oral submucous fibrosis. Addressing pain is a key aspect of treatment strategies aimed at improving patients' quality of life and ensuring a comprehensive approach to managing the disease.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Curcumin and physiotherapy for oral submucous fibrosis: a study’. Further sources in the context of Science might help you critically compare this page with similair documents:

Areca nut, Burning sensation, Comparative study, Statistical analysis, Clinical study, Sample size, Statistically Significant, Visual analogue scale, Systematic Review, Nutritional supplement, Oral submucous fibrosis, Inter incisal distance, Long-term follow-up studies, Group I and Group II, Ethical Committee Clearance, Clinical Staging, Non-invasive treatment, Long-term studies, Tongue protrusion, Curcumin gel, Efficacy of curcumin, Adolescents and adults, Cultural barrier, Malignant lesion.

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