Pharmacognostic analysis of Guduchi-Mustaadi Kashaya for sthaulya.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacognostical and pharmaceutical analysis of guduchi-mustaadi kashaya – a herbal ayurveda formulation for sthaulya
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Deepak Gangwar, A. S. Baghel and Harisha C. R.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Pharmacognostical and pharmaceutical analysis of guduchi-mustaadi kashaya – a herbal ayurveda formulation for sthaulya

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20237-27936

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study investigates the pharmacognostical and pharmaceutical properties of Guduchi-Mustaadi Kashaya (GMK), an Ayurvedic herbal formulation used for treating obesity as described in the ancient medical text, Charaka Samhita. Despite its historical significance and therapeutic applications, there are limited quality control (QC) parameters established for this formulation. This research aims to collect and evaluate essential data, including pharmacognostical characteristics and high-performance thin-layer chromatography (HPTLC) fingerprinting, in order to develop quality standards for GMK.

Pharmacognostical Analysis of GMK

A significant aspect of this study was the pharmacognostical analysis conducted on GMK, which involved examining its organoleptic properties such as color, taste, and odor, along with microscopic characteristics of its ingredients. The GMK formulation exhibited a light brownish color with a bitter and astringent taste, which can be attributed to its herbal components. Microscopic evaluation revealed the presence of key elements from all ingredients, confirming their identity and indicating that the phytochemicals and structural integrity remained intact during processing. This thorough analysis aims to ensure the genuineness of the formulation and address the need for objective quality standards in herbal medicine.

Pharmaceutical Parameters

Alongside pharmacognostical evaluations, various pharmaceutical parameters were assessed. The GMK was found to have a pH of 6.0, which indicates a slightly acidic nature suitable for its intended use. Additionally, the study measured the loss on drying, ash value, and extractive values in both water and methanol. The results revealed a loss on drying of 5.505% w/w, suggesting adequate drying of herbal materials before formulation, which is crucial for preserving quality. The ash value was 10.22% w/w, indicating low mineral content. Furthermore, extractive values of 2.92% w/w for water-soluble extracts and 30% w/w for methanol-soluble extracts signify the concentration of active constituents essential for therapeutic efficacy.

HPTLC Fingerprinting

The study also utilized HPTLC fingerprinting as a modern qualitative analytical technique to profile GMK. The analysis resulted in 15 spots visible under short UV light (254 nm) and 4 spots under long UV light (366 nm). Each compound's retention factor (Rf) was calculated, providing a unique fingerprint for GMK that could be utilized as a reference for further studies and quality control. This method not only aids in confirming the identity of individual components but also serves as a reproducible standard for future researchers who seek to evaluate or replicate GMK.

Conclusion

In summary, this study provides foundational data on the pharmacognostical and pharmaceutical characteristics of Guduchi-Mustaadi Kashaya, incorporating modern analytical techniques such as HPTLC. The preliminary data generated will support the establishment of quality control parameters for this Ayurvedic formulation, enhancing the reliability and safety of herbal medicines. The findings are expected to be valuable for researchers and practitioners in the field, promoting further exploration and standardization of herbal formulations in Ayurveda. Overall, GMK's pharmacological potential can be better harnessed with a robust quality assurance framework.

FAQ section (important questions/answers):

What is Guduchi-Mustaadi Kashaya (GMK)?

GMK is a polyherbal formulation used in Ayurveda, particularly indicated for the treatment of Sthulya, or obesity, as described in the Charaka Samhita.

What are the key ingredients of GMK?

GMK consists of five main ingredients: Guduchi (Tinospora cordifolia), Musta (Cyperus rotundus), Haritaki (Terminalia chebula), Bibhitaki (Terminalia bellirica), and Amalaki (Emblica officinalis), each contributing to its therapeutic effects.

What methods were used to analyze GMK?

The study utilized pharmacognostical evaluation, physicochemical analysis, and HPTLC fingerprinting to establish quality control parameters for Guduchi-Mustaadi Kashaya.

What were the significant findings from the microscopic analysis?

Microscopic analysis confirmed the presence of characteristic elements from all five ingredients, indicating no significant changes in phytochemicals during manufacturing.

What were the physicochemical parameters of GMK?

The physicochemical parameters included a pH of 6.0, loss on drying of 5.505% w/w, ash value of 10.22% w/w, and water/methanol soluble extractives of 2.92% and 30% w/w, respectively.

Why is HPTLC important for GMK?

HPTLC fingerprinting provides a reliable method to identify and ensure the quality of GMK, helping future researchers reproduce the formulation consistently under similar conditions.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmacognostic analysis of Guduchi-Mustaadi Kashaya for sthaulya.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Kashaya (Kasaya):
Kashaya refers to a traditional herbal formulation, typically a decoction, used in Ayurveda. It is specifically mentioned in classical texts for its applications in treating various ailments, including Sthulya (obesity). The GMK formulation is a Kashaya, designed to leverage the properties of its ingredients for therapeutic effects, particularly in weight management.

2) Study (Studying):
The study encompasses the systematic investigation into the pharmacognostical and pharmaceutical aspects of GMK. This research is vital for generating preliminary quality control data, which aids in establishing benchmarks for future work and enhancing the formulation's scientific credibility.

3) Drug:
Drugs refer to individual herbal components in formulations such as GMK. The formulation includes five different drugs, each with distinct pharmacological effects. Analyzing the characteristics of these drugs is essential for validating their combined efficacy and ensuring the formulation meets quality standards as per Ayurvedic practices.

4) Table:
Tables are often used in research articles to present data concisely and clearly. In this study, tables summarize organoleptic characteristics, pharmacognostical features, and pharmaceutical analysis results of Guduchi-Mustaadi Kashaya. This structured format facilitates quick comparisons and better understanding of the formulation's attributes.

5) Pharmacognostical:
Pharmacognostical refers to the study of the physical, chemical, biochemical, and biological properties of drugs derived from natural sources. In the context of GMK, pharmacognostical analysis helps determine the quality and authenticity of its herbal ingredients, ensuring that they conform to traditional Ayurvedic standards and practices.

6) Musta (Mushta):
Musta (Cyperus rotundus) is one of the key ingredients in the GMK formulation. Known for its medicinal properties in Ayurveda, it has applications for digestion and metabolism. Understanding the role of Musta in this formulation contributes to elucidating the therapeutic efficacy for treating obesity and related metabolic disorders.

7) Haritaki:
Haritaki (Terminalia chebula) is a revered herbal component in Ayurvedic medicine, valued for its ability to promote healthy digestion and detoxification. In GMK, Haritaki's involvement enhances the formulation's capacity to support weight loss and overall well-being, emphasizing its importance within the context of Sthulya management.

8) Amalaki:
Amalaki (Emblica officinalis) is another vital ingredient in GMK, renowned for its high vitamin C content and antioxidant properties. Its inclusion in the formulation complements the health benefits of other herbs, offering synergistic effects that aid in combating obesity and improving overall metabolic health.

9) Quality:
The quality of GMK is assessed through various pharmacognostical and pharmaceutical parameters. Establishing the quality is crucial for ensuring the effectiveness and safety of the formulation, impacting its acceptance and use in therapeutic settings within Ayurvedic practices.

10) Water:
Water plays an essential role in the extraction and preparation of herbal formulations like GMK. The water-soluble extractive value indicates the quantity of soluble active constituents derived from the raw drugs during preparation. This parameter is crucial for assessing the formulation's pharmacological efficacy in treating conditions like Sthulya.

11) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine from India, focusing on holistic health and wellness through natural means. The study of GMK employs Ayurvedic principles, emphasizing the importance of herbal formulations, their properties, and methodologies for preparing remedies aimed at restoring balance in the body.

12) Powder:
In the context of GMK, 'powder' refers to the form in which the raw ingredients are processed before preparation into a formulary. Fine powders of herbal ingredients facilitate efficient extraction of active constituents, ensuring greater bioavailability of therapeutic compounds in the final Kashaya preparation.

13) Rasa (Rasha):
Rasa translates to 'taste' in Ayurvedic terminology, indicating the sensory quality of herbal formulations. The presence of Tikta (bitter) and Kashaya (astringent) Rasa in GMK is significant for its therapeutic effects. Understanding the Rasa helps in assessing the formulation’s impact on the body and its relevance in treatment.

14) Substance:
The substance denotes the specific materials or compounds analyzed in the study, particularly herbal ingredients that constitute GMK. Understanding the uniqueness of each substance is essential for establishing the pharmacological efficacy and quality control standards necessary for effective Ayurvedic formulations.

15) Teaching:
Teaching in this context refers to the educational methodologies applied in the Ayurveda Institute for disseminating knowledge about herbal formulations like GMK. Emphasis is placed on standardizing preparation processes, pharmacognostical evaluations, and results interpretation to ensure educational integrity and practical application in Ayurvedic practices.

16) Gujarat:
Gujarat is a state in India where the study was conducted at the Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar. The region's rich Ayurvedic heritage plays a crucial role in fostering traditional knowledge and practices, highlighted through research on formulations like Guduchi-Mustaadi Kashaya.

17) Tikta:
Tikta is one of the primary tastes in Ayurvedic medicine, translated as 'bitter.' The presence of Tikta Rasa in GMK is indicative of its potential health benefits, particularly in digestion, metabolism, and detoxification processes, thus aligning it with the formulation's purpose to manage obesity.

18) Tinospora cordifolia:
Tinospora cordifolia, commonly known as Guduchi, is a significant herbal ingredient in GMK. Renowned for its immunomodulatory and anti-inflammatory properties, it contributes to the overall therapeutic profile of the formulation. Understanding its role is essential in establishing the efficacy of GMK in Ayurvedic medicine.

19) Emblica officinalis:
Emblica officinalis, known as Amalaki, is integral to GMK, famed for its rejuvenating and antioxidant qualities. Its inclusion enhances the formulation's ability to support metabolic health and weight management, underscoring the importance of individual ingredients in achieving desired therapeutic outcomes.

20) Terminalia chebula:
Terminalia chebula, or Haritaki, is a crucial component of GMK. It is traditionally used for digestive health, detoxification, and enhancing metabolism. Its properties are vital in formulating a holistic approach to address obesity, showcasing the significance of each ingredient within the comprehensive treatment.

21) Cyperus rotundus:
Cyperus rotundus, commonly referred to as Musta, is a pivotal ingredient in the GMK formulation. Known for its efficacy in digestive health and metabolism, Musta contributes significantly to the therapeutic intent of tackling obesity, thereby enhancing the overall health benefits of the Kashaya.

22) Terminalia bellirica:
Terminalia bellirica, widely known as Bibhitaki, is included in GMK for its health benefits, particularly in digestion and respiratory health. Its role in the formulation underscores the importance of combining various herbs to maximize therapeutic effects for conditions like obesity.

23) Phytochemical:
A phytochemical refers to a specific chemical compound found in plants that can exert health benefits. In the context of GMK, understanding the various phytochemicals present aids in analyzing their roles and contributions to the formulation's overall therapeutic efficacy and safety.

24) Sthaulya:
Sthaulya is the Ayurvedic term for obesity, directly related to the therapeutic intent of GMK. The formulation is designed to combat Sthaulya by leveraging the properties of its ingredients, showcasing the role of traditional medicine in managing prevalent health conditions.

25) Medicine:
Medicines pertain to remedies or treatments utilized to improve health or treat diseases. The GMK formulation is categorized as a traditional herbal medicine within Ayurveda, showcasing the relevance of plant-based treatments in modern health practices for issues like obesity.

26) Samhita:
Samhita denotes ancient Sanskrit texts encapsulating Ayurvedic knowledge, including formulations, practices, and theoretical foundations. The reference to Samhita in this study emphasizes the historical and authoritative context within which GMK and similar herbal formulations are developed and understood.

27) Science (Scientific):
Science pertains to systematic knowledge creation through observations and experimentation. The study embodies scientific principles by employing pharmacognostical methods to assess GMK, contributing to the broader understanding of Ayurveda and herbal medicine through evidence-based research.

28) Bitter:
Bitter reflects the taste profile associated with certain herbal ingredients, specifically in GMK. The presence of bitter constituents is significant in Ayurveda for promoting digestion and metabolic health. Understanding the implications of bitter flavors plays a role in appreciating the complex effects of the formulation.

29) Rasashastra (Rasa-shastra, Rasasastra):
Rasa-shastra is a branch of Ayurveda that focuses on the chemistry and therapeutic properties of minerals and herbs. Its principles guide the formulation and standardization of plant-based medicines like GMK, thereby emphasizing the necessity of traditional wisdom combined with scientific scrutiny.

30) Observation:
Observation, as a key component of scientific research, involves the systematic assessment of various aspects of GMK during its study. The observations gathered help validate the formulation's properties and ensure adherence to established quality standards in Ayurvedic medicine.

31) Performance:
Performance refers to the effectiveness of GMK in achieving its intended therapeutic goals. By analyzing pharmacognostical and pharmaceutical data, the study assesses GMK's performance in treating Sthaulya and other related conditions, ensuring that the formulation meets its health claims.

32) Transformation (Transform, Transforming):
Transformed indicates the process of converting raw herbal materials into a usable form, like a Kashaya. This transformation involves careful preparation techniques that are crucial for maximizing the active ingredients’ therapeutic potential and ensuring the efficacy of formulations like GMK.

33) Dravyaguna (Dravya-guna):
Dravyaguna is the Ayurvedic branch that focuses on the properties of medicinal plants. The principles of Dravyaguna guide the selection, identification, and use of herbs in formulations like GMK, ensuring that each ingredient contributes effectively to the preparation's therapeutic intentions.

34) Bhaishajya (Bhaisajya):
Bhaishajya, meaning 'medicine' in Sanskrit, encompasses various aspects of Ayurvedic formulations and healing practices. The focus on Bhaishajya highlights the importance of herbal formulations like GMK in therapeutic settings, representing the application of traditional knowledge in modern healthcare.

35) Discussion:
Discussion refers to the analytical segment of the study where researchers interpret the results and findings related to GMK. This discussion is crucial for contextualizing the study's findings, drawing connections to existing knowledge, and proposing avenues for future research.

36) Bibhitaka:
Bibhitaka, or Terminalia bellirica, is one of the key ingredients in GMK that enhances its therapeutic benefits. Known for its digestive health properties, Bibhitaka's role in the formulation illustrates the synergy of various herbs working together to support weight loss and overall health.

37) Triphala (Tri-phala):
Triphala is a traditional Ayurvedic formulation comprising three fruits: Amalaki, Bibhitaki, and Haritaki. While Triphala is not explicitly included in GMK, its mention reflects the significance of synergistic herbal combinations in Ayurvedic practices, emphasizing the holistic approach to health and wellness.

38) Shastra (Sastra):
Shastra indicates a body of knowledge or science, particularly in a specific discipline like Ayurveda. Rasa-shastra and Bhaishajya are examples of Shastra that guide practitioners in the application of Ayurvedic principles, showcasing the systematic nature of traditional medicinal practices.

39) Kalpana:
Kalpana refers to the process of formulation and preparation within Ayurvedic medicine. The study emphasizes the importance of proper Kalpana techniques in formulating Kashayas like GMK to ensure the effective extraction and stabilization of the beneficial properties of the ingredients.

40) Harisha (Harisa):
Harisha refers to one of the authors of the present study, contributing knowledge from their expertise in pharmacognosy. The involvement of researchers like Harisha is essential for ensuring comprehensive evaluations of herbal formulations, aiding in the establishment of quality control and efficacy standards.

41) Nature:
Nature in this context pertains to the intrinsic characteristics of the herbal ingredients in GMK. Understanding the nature of the components allows for a better synthesis of their therapeutic potentials and reinforces the holistic approach inherent in Ayurveda towards health and treatment.

42) Reason:
Reason underscores the justification behind conducting the study on GMK, mainly to establish quality control parameters and verify the formulation's efficacy and safety. This exploration lends credibility to Ayurvedic practices and promotes a deeper understanding of herbal medicine's role in modern health.

43) Indian:
Indian denotes the geographical and cultural context wherein Ayurveda originated. The study of GMK relates to the broader Indian heritage of herbal medicine, reflecting the persistence of age-old traditions in addressing contemporary health issues amidst a growing global interest in natural remedies.

44) India:
India is the birthplace of Ayurveda, and its rich tapestry of traditional medical knowledge deeply informs studies like GMK. This context highlights the cultural significance of herbal formulations within India, underlining their continuing relevance and application in both local and global health settings.

45) Life:
Life in this context is connected to the holistic philosophy of Ayurveda, which emphasizes the balance and well-being of the body and mind. Formulations like GMK aim to enhance the quality of life by addressing health issues and promoting overall wellness through natural remedies.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Pharmacognostic analysis of Guduchi-Mustaadi Kashaya for sthaulya.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Rasashastra, Charakasamhita, Authentication, Bhaishajya kalpana, Organoleptic parameters, Loss on drying, Ash value, Organoleptic characteristics, Holistic science, High performance thin layer chromatography (HPTLC), Water soluble extract, Methanol soluble extract, Densitogram, Raw drug, Pharmaceutical analysis, API standards, Microscopic Analysis, Pharmacognostical analysis, Pharmaceutical parameters, Quality control parameter, Ayurveda Classic.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: