2-methyl imidazoliumbromo chromate
a new and efficient reagent for oxidation of aliphatic alcoholic compounds
Journal name: World Journal of Pharmaceutical Research
Original article title: 2-methyl imidazoliumbromo chromate
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a new and efficient reagent for oxidation of aliphatic alcoholic compounds
Original source:
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Kyadare G. N.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: 2-methyl imidazoliumbromo chromate
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20238-28164
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The study by Kyadare et al. presents a novel chromium (VI) oxidizing reagent known as 2-methyl imidazolium bromochromate (IBC). This newly synthesized reagent demonstrates stability, high efficiency, and simplicity in preparation, making it a valuable addition to the existing arsenal of oxidizing agents in synthetic organic chemistry. The research emphasizes the importance of chromium (VI) complexes due to their catalytic and oxidizing properties, which have attracted attention in recent decades. The overarching goal of the study is to investigate the oxidation capabilities of the 2-methyl IBC reagent on various organic substrates, particularly focusing on the oxidation of alcohols to carbonyl compounds.
Development of 2-Methyl Imidazolium Bromochromate
The synthesis process for 2-methyl imidazolium bromochromate involves the reaction of chromium trioxide with hydrobromic acid and 2-methyl imidazole. Initially, chromium trioxide is dissolved in water and cooled to a low temperature before the acid is added gradually while stirring. The subsequent addition of 2-methyl imidazole yields a brown solid that is further treated to produce dark brown crystals. The final product's purity is confirmed through thin-layer chromatography (TLC), melting point analysis, and mass spectrometry. This methodology showcases the effective synthesis of a new oxidizing reagent that can be utilized in various organic transformations.
Oxidative Reactions with Alcohols
The study highlights the utility of 2-methyl IBC in oxidizing alcohols within acetic acid as a solvent. The experimental procedure entailed adding a set amount of the oxidizing agent to a solution of the alcohol substrate, followed by magnetic stirring and monitoring through thin-layer chromatography (TLC). The results indicate that the oxidation efficiency of 2-methyl IBC is commendable, as it provides satisfactory yields while maintaining a moderate reaction time. This aspect of the study is crucial for synthetic chemists seeking safer and more efficient methods for alcohol oxidation.
Comparative Efficiency of 2-Methyl IBC
The research includes a comparison between the performance of 2-methyl IBC and other established chromium (VI) oxidizing agents. The findings reveal that 2-methyl IBC provides competitive results concerning the amount of oxidant needed, acidity levels, yield percentages, and overall reaction times. This emphasizes the reagent's potential as a promising alternative to traditional oxidizing agents, which may require harsher conditions or generate less desirable yields. Such comparative studies are vital for advancing organic synthesis techniques, allowing chemists to select reagents based on efficiency and safety.
Conclusion
In summary, the introduction of 2-methyl imidazolium bromochromate represents a significant advancement in the field of oxidation reagents. The reagent's successful synthesis, stability, and efficiency in oxidizing alcohols affirm its applicability in synthetic organic chemistry. With its favorable characteristics and high yield, 2-methyl IBC stands out as an effective option for organic chemists, opening avenues for further exploration and utilization in multiple organic transformations. The contribution of this research underscores the ongoing search for innovative reagents that can enhance reaction efficiency and sustainability in chemical processes.
FAQ section (important questions/answers):
What is 2-methyl imidazoliumbromochromate used for?
2-methyl imidazoliumbromochromate is a new and efficient reagent for oxidizing alcohols to carbonyl compounds and serves as a brominating agent for hydroxylated aromatic compounds.
How was 2-methyl imidazoliumbromochromate prepared?
It was synthesized by mixing chromium trioxide in water with HBr and 2-methyl imidazole, cooled, and then producing a brown solid, which was crystallized for purity.
Why are chromium (VI) complexes important in chemistry?
Chromium (VI) complexes have appealing catalytic and oxidizing properties, making them important for various organic chemistry reactions and the development of new synthetic methodologies.
What are the oxidation states of chromium mentioned?
The stable oxidation states of chromium mentioned are Cr+2, Cr+3, and Cr+6. Cr+4 and Cr+5 are unstable and convert to Cr+3 and Cr+6 in water.
What was the main objective of this study?
The main objective was to synthesize a new chromium (VI) reagent for the oxidation of different organic substrates and contribute to synthetic organic chemistry advancements.
How does the oxidation of alcohols work in this study?
Alcohol substrates are reacted with 2-methyl imidazoliumbromochromate in acetic acid, stirred, and monitored by TLC, followed by extraction and purification to yield carbonyl compounds.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “2-methyl imidazoliumbromo chromate”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Water:
Water is a crucial solvent in the preparation of 2-methyl imidazoliumbromochromate. Its use in the reaction process facilitates the dissolution of chromium trioxide, allowing the addition of other reagents like HBr to proceed smoothly. Water's role as a solvent is vital for ensuring the proper reaction conditions and yield of the desired product.
2) Table:
The term table refers to the organized presentation of the oxidation results obtained from the experiments with 2-methyl imidazoliumbromochromate. It serves to summarize and compare the effects of the reagent on various alcohols, offering a clear view of yields, reaction times, and efficacy, which aids in evaluating the reagent's performance.
3) Field:
Field pertains to the area of study within the research, specifically synthetic organic chemistry. This field involves the synthesis and manipulation of organic compounds, emphasizing the importance of developing efficient reagents for oxidation reactions. The research contributes to advancements in this field, illustrating the significance of chromium (VI) complexes in organic synthesis.
4) Study (Studying):
Study refers to the investigation conducted to synthesize and characterize the new chromium (VI) reagent and its application in the oxidation of alcohols. The study evaluates the efficacy and efficiency of 2-methyl imidazoliumbromochromate as an oxidizing agent compared to existing reagents. This research is pivotal for enhancing synthetic methodologies in organic chemistry.
5) Species:
Species refers to the different forms of chromium (VI) complexes and reagents explored in the research. The study highlights the formation of new chromium species upon adding various anions, which demonstrates their high reactivity and utility in organic transformations, emphasizing the chemical versatility that can be harnessed in synthetic applications.
6) Purity:
Purity is a critical parameter in the characterization of synthesized reagents like 2-methyl imidazoliumbromochromate. It indicates the quality of the product, determined through techniques like TLC and melting point analysis. High purity is essential for ensuring reliable and reproducible results in reactions, impacting the accuracy of subsequent chemical transformations.
Other Science Concepts:
Discover the significance of concepts within the article: ‘2-methyl imidazoliumbromo chromate’. Further sources in the context of Science might help you critically compare this page with similair documents:
Reaction time, Acetic acid, Oxidizing agent, Experimental procedure.