Hydrogen bond interaction study of dmso-water binary mixtures

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Hydrogen bond interaction study of dmso-water binary mixtures
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Original source:

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Author:

A. D. Bokhare, M. P. Lokhande and A. C. Kumbharkhane


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Hydrogen bond interaction study of dmso-water binary mixtures

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20238-28152

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

The research presented by A. D. Bokhare et al. in the World Journal of Pharmaceutical Research focuses on the hydrogen bond interactions in binary mixtures of Dimethylsulphoxide (DMSO) and water. Using time domain reflectometry (TDR) to measure complex permittivity in the frequency range of 10 MHz to 30 GHz, the study seeks to understand the dielectric properties of these mixtures. By employing the Cole-Davidson relaxation model to analyze the obtained spectra, the researchers aim to quantify the changes in dielectric constants and relaxation times as a function of DMSO concentration, revealing significant insights into hydrogen bonding dynamics in these mixtures.

Hydrogen Bond Interactions

One of the central themes of the study is the examination of hydrogen bond interactions between DMSO and water. The strong polar sulfoxide (S=O) group in DMSO is capable of forming hydrogen bonds with water molecules, significantly influencing the system's dielectric properties. The authors utilize the Luzar theoretical model to compute the average number of hydrogen bonds in both water-water and water-DMSO interactions. This modeling allows for a deeper understanding of how the molecular interactions shift with varying DMSO concentrations, leading to insights into the nature of hydrogen bonding in this binary mixture.

Dielectric Parameters and Their Implications

The research extensively discusses the dielectric parameters measured in the DMSO-water mixtures, particularly focusing on the static dielectric constant (ε₀) and relaxation time (τ). The findings indicate that as the concentration of DMSO increases, the static dielectric constant decreases, suggesting a breaking of hydrogen bonds between DMSO and water molecules. The relaxation time exhibits a complex behavior, with variations noted at different concentrations. This reduction in dielectric relaxation time at higher DMSO concentrations implies changes in the arrangement and dynamics of the water structure, providing critical insights into the interactions occurring at the microscopic level.

Experimental Methodology and Results

The methodology employed in the study, specifically the TDR technique, involves precise measurements of complex permittivity in the DMSO-water mixtures across diverse concentrations. Various experimental setups, including the use of a Tektronix Digital Serial Analyzer, facilitated the collection of reflected pulse data necessary for further analysis via Fourier transformation. The results, summarized in various tables and figures, elucidate how the dielectric properties shift with temperature and concentration, enabling a robust discussion on the influence of DMSO on water's molecular configuration.

Conclusion

This study contributes to the existing body of knowledge concerning DMSO-water interactions by elucidating the hydrogen bond dynamics and their impact on dielectric parameters. The research reaffirms the notion that DMSO disrupts the hydrogen bonding networks in water, altering its physical properties. By providing a comprehensive analysis of the complex permittivity spectra and employing theoretical models to interpret the data, the authors enhance understanding of solvation dynamics, which is valuable in fields such as pharmacology and organic chemistry. Overall, the work highlights the importance of studying molecular interactions to unravel the complexities of mixtures commonly used in scientific and industrial applications.

FAQ section (important questions/answers):

What is the purpose of studying DMSO-water binary mixtures?

The study aims to understand hydrogen bond interactions in DMSO-water mixtures by analyzing dielectric parameters like dielectric constant and relaxation time.

What methods were used to measure complex permittivity in this study?

Complex permittivity spectra were measured using time domain reflectometry (TDR) within the frequency range of 10 MHz to 30 GHz.

What significant results were found regarding static dielectric constant?

The static dielectric constant generally decreased with increasing DMSO concentration, indicating that hydrogen bonds between DMSO and water gradually break.

How does temperature affect the dielectric relaxation time in DMSO-water mixtures?

Dielectric relaxation time decreases with increasing temperature and is highest at around 70% DMSO concentration.

What model was utilized to investigate hydrogen bonding in the study?

The Luzar model was employed to compute the average number of hydrogen bonds between water-water and water-DMSO molecules.

What acknowledgments are mentioned in the study?

The author acknowledges support from various institutions and financial assistance from the Department of Science and Technology, New Delhi, India.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Hydrogen bond interaction study of dmso-water binary mixtures”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Water:
Water is a critical solvent in chemical and biological processes, playing a vital role in various applications, including pharmaceutical and biochemical research. In the context of DMSO-water mixtures, water's unique hydrogen bonding characteristics influence the physical properties of the mixture, affecting the interaction dynamics in such systems.

2) Pulse:
Pulses in this context refer to multiple wave signals recorded during time domain reflectometry experiments. Each pulse reflects the dielectric response of the sample, helping researchers determine the characteristics of DMSO-water mixtures through collected data, which is crucial in analyzing the complexity of their interaction.

3) Science (Scientific):
Scientific pertains to the systematic observation and experimentation that underline the study of natural phenomena. The research discusses empirically derived findings that elucidate aspects of physical chemistry, employing scientific rigor to establish reliable conclusions regarding the behavior of DMSO-water mixtures under varying conditions.

4) India:
India is the geographical and cultural context of the study, hosting the institutions and authors involved in this research on DMSO-water mixtures. Its scientific community is growing, focusing on research in chemistry and pharmacology and leveraging resources for advanced experimental studies pertinent to molecular interactions.

5) Study (Studying):
The study represents a focused investigation into the interactions of DMSO and water through the lens of dielectric spectroscopy. Conducting experiments and analyses within this framework deepens comprehension of hydrogen bonding phenomena, contributing valuable insights into the physics of binary mixtures and their relevance in applications.

6) Table:
Table refers to a structured presentation of data, often used to summarize and illustrate experimental results. In the study, tables provide a concise overview of dielectric parameters and their relationships with varying concentrations, enabling easier comparisons and analysis, thus enhancing understanding of the results obtained.

7) Vidarbha:
Vidarbha is a region in Maharashtra, India, which houses the Government Vidarbha Institute of Science and Humanities, where researchers conducted this study. The region’s educational institutions play a significant role in advancing scientific research and training in the nation, contributing to various fields, including chemistry and pharmacology.

8) Amravati:
Amravati is a city in Maharashtra, India, and it is home to the Govt. Vidarbha Institute of Science and Humanities. This location is significant as it serves as the research base for the study, reflecting the importance of regional institutes in supporting scientific inquiry and development in the country.

9) Measurement:
Measurement is a fundamental methodological principle in experimental science, involving the act of quantifying aspects of a physical system. In the context of this study, accurate measurements are vital for characterizing dielectric properties of mixtures, ensuring reliability and reproducibility of the experimental data and results obtained.

10) New Delhi:
New Delhi, the capital of India, signifies a central point for policy-making and scientific research advocacy in the country. The Department of Science and Technology, located in New Delhi, provided financial assistance for the project, highlighting the role of governmental support in advancing scientific research and innovation.

11) Transformation (Transform, Transforming):
Transformation in this research context likely refers to the Fourier transformation applied to pulse data collected during the time domain reflectometry process. This mathematical operation is crucial for converting time-domain signals into frequency-domain representations, allowing for the analysis of how dielectric properties change with varying concentration and frequency.

12) Pharmacology:
Pharmacology is the branch of medicine and biology concerned with drug action. The study of DMSO-water mixtures has significant implications in pharmacology, as understanding the solubility, permeability, and interaction of substances within these mixtures can enhance drug formulation and delivery systems in therapeutic applications.

13) Purification:
Purification involves processes of isolating a substance from a mixture, essential in ensuring the quality and efficacy of chemical compounds used in research. DMSO, being of high purity, is utilized in the study to minimize impurities that could affect experimental outcomes and the integrity of the obtained results.

14) Discussion:
Discussion refers to the analytical phase where researchers interpret the results obtained through experiments. In this study, the discussion delves into the implications of dielectric measurements concerning hydrogen bonding in DMSO-water mixtures, relating findings to existing literature and developing insights into molecular behavior.

15) Maharaja (Maha-rajan, Maharajan, Maha-raja):
Maharaja in this context refers to Chhatrapati Shahu Maharaja, an institute providing research and training support. Such institutes are pivotal in fostering educational environments conducive for scientific research development, showcasing the importance of historical and cultural influences in contemporary educational frameworks in India.

16) Training:
Training signifies the process of developing skills and knowledge necessary for conducting research. The author expresses gratitude towards training programs and institutions like SARTHI, recognizing their contribution in enhancing capacities in scientific research and ensuring researchers are well-equipped to tackle complex scientific challenges.

17) Channel:
Channel here may refer to a 'channel' in the context of the time domain reflectometry setup used in the experimental procedure. Each channel collects and processes different signals, thereby facilitating a comprehensive analysis of the dielectric responses of the DMSO-water mixtures under study.

18) Company:
Company refers to the commercial entity from which high-quality DMSO was sourced for research. The reliability of chemical sources is critical for scientific studies, as the use of commercially available reagents ensures consistency and reproducibility of results, a cornerstone of effective research methodology.

19) Purity:
Purity indicates the absence of impurities in a chemical substance. The purity of DMSO used in this study is paramount, as it directly influences the reliability of dielectric measurements, ensuring that observed phenomena are a direct result of DMSO-water interactions without interference from contaminants.

20) Delhi:
Delhi, as a major metropolitan area and the national capital, is significant for discourse in science and policy. It is a hub of educational and research institutions, influencing scientific grants and collaborative efforts, serving as a catalyst for advancements in various fields, including chemical research and development.

21) Svamin (Svami, Swami, Swamin):
Swami refers to the Swami Ramanand Teerth Marathwada University, indicating another pivotal institution involved in the study. Such universities provide essential support for scientific endeavors by nurturing research environments and facilitating collaborations that further knowledge in various scientific domains.

22) Pune:
Pune, a vibrant city in Maharashtra, India, is noted for its educational and research institutions. The acknowledgment of Pune indicates its role in fostering scientific education and research culture, reflecting the collaborative efforts throughout regions in India to advance scientific inquiry and discovery in fields like pharmacology and chemistry.

23) Life:
Life encapsulates the biological aspects and practical applications of the study’s findings. The exploration of DMSO-water mixtures holds significance in life sciences, particularly concerning drug solubility and activity, underscoring the interconnectedness of chemistry with biological systems and health sciences.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Hydrogen bond interaction study of dmso-water binary mixtures’. Further sources in the context of Science might help you critically compare this page with similair documents:

Hydrogen bond interaction, Relaxation time, Frequency range.

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