Formulation development and evaluation of herbal effervescent tablet

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Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation development and evaluation of herbal effervescent tablet
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Aniket Kandu Lamkhade, Abhijeet Mhataraba Khade, Akash Raju Mapari, Shweta Kishor Gund, Umesh Santosh Kandekar and Jagdish Vilas Sable


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Formulation development and evaluation of herbal effervescent tablet

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20239-28095

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

1) Introduction

The study focuses on the formulation development and evaluation of effervescent tablets derived from the bael plant (Aegle marmelos), which is known for its medicinal properties and benefits for gastric diseases. Peptic ulcers, which affect the stomach lining and are caused by factors such as gastric acid and Helicobacter pylori, are one of the key medical conditions that the formulation aims to address. The herbal formulation emphasizes the preparation and analysis of these effervescent tablets, aiding in their efficacy for gastrointestinal issues.

2) Healing Properties of Bael

The bael fruit is recognized for its wide range of medicinal effects, specifically in managing diabetes mellitus, digestive disorders, and as an antioxidant. The fruit extracts demonstrate significant antidiabetic activity, outpacing some conventional medications. Additionally, the fruit’s compositions—rich in flavonoids, tannins, and other phenolics—exhibit notable antioxidant properties, making it effective against oxidative stress. The various bioactive compounds found in bael confer antimicrobial, anti-inflammatory, and even anti-ulcer effects, suggesting its comprehensive utility in traditional and modern medicinal practices.

3) Physicochemical Assessments of Effervescent Tablets

Effervescent tablets serve as innovative drug delivery systems that facilitate rapid dissolution and absorption of active ingredients. The research entails various physicochemical evaluations which encompass parameters such as hardness, weight variation, friability, and effervescent time. These assessments are crucial to ensure that the tablets deliver the intended therapeutic effects effectively while maintaining uniformity and stability through compression techniques. The study meticulously outlines both pre-compression and post-compression analyses necessary for the development of high-quality pharmaceutical products.

4) Nutritional and Therapeutic Profile of Bael

Bael fruit not only serves as a medicinal agent but is also nutritionally rich, bolstering its profile as a health-promoting substance. With vitamins A, B, and C, alongside critical minerals like calcium, potassium, and iron, bael provides substantial health benefits. The study indicates that unripe fruit may offer more potent therapeutic benefits than the ripe variant. The nutritional composition aids in various health conditions, including digestive disturbances and gynecological disorders, reinforcing the fruit's integral role in both dietary and herbal medicine.

5) Conclusion

The formulation of herbal effervescent tablets from Aegle marmelos holds promising potential in enhancing gastrointestinal health and managing related illnesses. Through comprehensive studies on the bael fruit's medicinal and nutritional benefits, the research underscores the significance of traditional herbal remedies in contemporary healthcare. The successful development of these effervescent tablets could facilitate improved patient compliance and faster therapeutic outcomes, highlighting the ongoing relevance of herbal medicine in modern pharmacotherapy. Further exploration could pave the way for broader applications and innovations within herbal drug formulation techniques.

FAQ section (important questions/answers):

What is the main aim of the research on Bael plant?

The main aim is to develop a gastro-retentive drug delivery system (GRDDS) herbal effervescent tablet from Bael, which is beneficial for managing stomach and gastric diseases.

What are the key objectives in preparing the Bael effervescent tablet?

Objectives include reviewing Bael plant literature, collecting and drying fruit pulp, conducting phytochemical analysis, selecting excipients, preparing tablets, and assessing their physicochemical properties.

What advantages do effervescent tablets offer for drug delivery?

They enable quick solution production, faster absorption, and better bioavailability while providing prolonged residence time in the stomach for enhancing therapeutic effects.

What therapeutic properties does Aegle marmelos have?

Aegle marmelos exhibits antioxidant, antibacterial, anti-ulcer, and anti-diabetic properties, making it valuable in traditional medicine for treating various ailments.

What are some disadvantages of Gastro-Retentive Drug Delivery Systems?

Challenges include needing high water levels for effective drug release and unsuitability for drugs with solubility and stability issues in the gastrointestinal tract.

What minerals and vitamins are found in Bael fruit?

Bael fruit is rich in vitamins A, B complex, C, and minerals like calcium, potassium, and iron, providing numerous health benefits.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Formulation development and evaluation of herbal effervescent tablet”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'drug' refers to a substance that is used to diagnose, cure, treat, or prevent diseases. In the context of this research, it specifically concerns medications that can be derived from herbal sources, like Aegle marmelos, and their formulation efficacy in treating gastrointestinal issues like ulcers.

2) Ulcer:
The term 'ulcers' refers to multiple sores that can develop in the gastrointestinal tract, particularly in the stomach. This research aims to formulate a remedy to alleviate symptoms associated with ulcers, leveraging the therapeutic properties of Bael fruit.

3) Activity:
In this context, 'activity' pertains to the biological effects seen in certain compounds. For instance, the antioxidant and antibacterial activity of Bael fruit extracts is examined in the study, showcasing their potential therapeutic benefits in treating various diseases, including ulcers and infections.

4) Powder:
The 'powder' refers to the processed form of the Bael fruit pulp used to create the effervescent tablets. The preparation includes drying the fruit and grinding it to a fine consistency, which allows for the extraction of beneficial phytochemicals that contribute to the tablet's efficacy.

5) Disease:
'Diseases' encompass a variety of health conditions targeted by the study. The focus on gastrointestinal issues illustrates the potential of Bael fruit to address common ailments while promoting alternative approaches in natural medicine.

6) Tree:
'The tree' signifies the Aegle marmelos itself, which is central to the study. Understanding its biological characteristics helps in assessing its medicinal value and the effectiveness of its fruit in health applications.

7) Soil:
'The soil' indicates the vital component for cultivating the Aegle marmelos tree. Quality soil promotes good fruit yield, influencing the effective extraction of bioactive compounds necessary for herbal formulations.

8) Aegle marmelos:
Aegle marmelos is the scientific name for the Bael tree, known for its health benefits, including antidiabetic, antibacterial, and anti-ulcer properties. This study focuses on utilizing its fruit for the formulation of effervescent tablets aimed at treating gastric diseases.

9) Measurement:
'Measurement' refers to the quantification of various parameters during the evaluation of the effervescent tablets. The study involves measuring tablet hardness, weight, effervescent time, pH, and other characteristics to ensure the quality and effectiveness of the final product.

10) Mineral:
'Minerals' emphasizes the various essential nutrients found in the Bael fruit that contribute to health. The study examines how these minerals enhance the therapeutic potential of the fruit when developed into pharmaceutical formulations.

11) India:
'India' is significant as it is the indigenous region for Aegle marmelos and its traditional uses in Ayurvedic medicine. The study emphasizes the historical and cultural relevance of Bael in Indian healthcare systems and its applications in modern herbal formulations.

12) Blood:
'Blood' pertains to the circulatory fluid within the body that carries nutrients and oxygen. The study discusses the effects of Aegle marmelos on blood glucose levels, particularly for diabetic patients, indicating its potential role in managing blood-related diseases.

13) Study (Studying):
'Study' encompasses the entire research and evaluation process undertaken to formulate and assess the effervescent tablets from Bael fruit. It includes literature review, pharmacological testing, and analysis of the results to validate the effectiveness of the herbal formulation.

14) Antibiotic (Antibacterial):
'Antibacterial' highlights the property of certain substances to inhibit bacterial growth. The research investigates the antibacterial activity of Bael fruit extracts against specific pathogens, suggesting its potential as a natural therapeutic agent in treating infections.

15) Medicine:
'Medicine' refers to the science and practice of diagnosing, treating, and preventing illness. This study delves into the use of herbal medicines derived from Aegle marmelos, contributing to the body of knowledge on traditional remedies and their modern applications.

16) Surface:
'Surfaces' refers to the exterior properties of the tablet formulation which influence disintegration and dissolution. Understanding the tablet surfaces is essential for its performance in delivering the active ingredients effectively.

17) Water:
'Water' plays a crucial role in the formulation and effectiveness of the effervescent tablets. Adequate hydration is necessary for the tablets to dissolve and release their active ingredients effectively within the gastrointestinal tract.

18) Species:
'Species' denotes the biological classification of Aegle marmelos. Understanding its taxonomy and botanical features is crucial for recognizing its medicinal properties and establishing its validity in herbal medicine.

19) Ripe:
'Ripe' specifies the stage of the Bael fruit that is primarily used for traditional medicinal purposes. Ripe fruit is known for its laxative properties and nutritional benefits, while preparations often focus on the unripe fruit for other health advantages.

20) Phytochemical:
'Phytochemicals' encapsulates the diverse range of bioactive compounds derived from Bael. Their study is essential in understanding how these chemicals contribute to the medicinal effects of the effervescent tablets being formulated.

21) Rat:
'Rats' are commonly used animal models in pharmacological research. The study likely includes experiments conducted on rats to evaluate the effectiveness and safety of the Bael fruit formulations in treating ulcers and other gastrointestinal conditions.

22) Shri-lanka (Srilanka, Sri-lanka, Shrilanka):
'Sri-lanka' represents a geographical location where Bael trees are cultivated. Its mention highlights the ecological significance and potential for utilizing Aegle marmelos beyond India in traditional medicine practices.

23) Maharashtra (Maharastra, Maha-rashtra):
'Maharashtra' is the region in India where the research is conducted. It emphasizes the local significance of the Bael tree and its traditional uses within the cultural context of Maharashtra's healing practices.

24) Flavonoid:
'Flavonoids' highlight the specific group of phytochemicals present in Bael that are linked to health benefits. Their presence in the fruit underlines its potential as a nutritional supplement with antioxidant properties.

25) Indian:
'Indian' pertains to the cultural and traditional context from which Aegle marmelos originates. It highlights the historical use of the plant in Indian herbal systems, emphasizing its relevance in local healthcare practices.

26) Lanka (Lamka, Lànkà):
'Lanka' is mentioned to signify the geographical and cultural connection of Aegle marmelos with neighboring countries like Sri Lanka, hence underscoring the wider influence and application of Bael in traditional medicine practices in the region.

27) Sugar:
'Sugar' may refer to the natural sweeteners present in Bael fruit. The nutritional profile of the fruit includes sugars which provides energy, playing a role in its acceptability as an herbal remedy or dietary supplement.

28) Vila:
'Vila' potentially refers to an individual connected with the research. It indicates the collaborative aspect of scientific inquiry, emphasizing teamwork and diverse expertise contributing to the findings.

29) Crop:
'Crops' relates to agricultural practices involving the cultivation of Aegle marmelos. It conveys the economic aspect of herbal medicine by identifying the potential for Bael to be farmed and harvested for medical use.

30) Post:
'Post' may refer to post-compression tests conducted on the formulated tablets. This phase assesses the characteristics of the tablets after they have been compressed, ensuring their quality and efficacy against set standards.

31) Viru:
'Viru' could denote an aspect related to pathogens or viral infections. In this context, it highlights the importance of effective herbal treatments derived from Aegle marmelos that may support the immune response.

32) Inflammation:
'Inflammation' refers to the body's response to injury or irritation, which can be a factor in gastrointestinal diseases. The study looks at how compounds from Bael may help reduce inflammation associated with conditions like ulcers.

33) Accumulation (Accumulating, Accumulate):
'Accumulated' suggests the build-up of substances, possibly referring to toxins or waste in the digestive system. The study seeks to address these build-up issues through the formulation of Bael fruit-based tablets.

34) Discussion:
'Discussion' refers to the analytic phase of the research where results are interpreted. This section delves into comparisons with existing studies and hypotheses to establish the significance of findings in the context of herbal medicine.

35) Swallowing:
'Swallowing' involves the ingestion process essential for the effectiveness of tablet formulations. The easy swallowability of effervescent tablets is a design factor essential for patient compliance in treatment regimens.

36) Science (Scientific):
'Scientific' encompasses the methodological approach used throughout the research. It reflects precision, systematic investigation, and reliance on evidence-based practices in the formulation and evaluation of Bael fruit-derived products.

37) Substance:
'Substance' refers to the active components found in Bael fruit contributing to its medicinal properties. It emphasizes the necessity of identifying and quantifying these components during the study to support therapeutic claims.

38) Vomiting:
'Vomiting' is a symptom commonly associated with gastric disturbances. The study addresses the potential of Bael fruit formulations in alleviating such symptoms, contributing to its application in gastrointestinal therapies.

39) Swelling:
'Swelling' indicates a potential symptom of gastrointestinal disorders. The research may explore the capacity of Bael fruit constituents to mitigate swelling and discomfort associated with gastric conditions.

40) Killing (Killed):
'Killing' suggests the efficacy of certain compounds in eliminating pathogens. In the context of the study, it relates to the antibacterial activity of Bael extracts that could overcome infections, showcasing its therapeutic potential.

41) Harvesting (Harvest):
'Harvest' indicates the collection of Bael fruits for preparation into medicinal products. The timing and method of harvesting can impact the quality of the fruit and the subsequent efficacy of the derived formulations.

42) Samtosha (Samtosa, Santosa, Santosha, Santosh):
'Santosh' potentially represents a contributor or author involved in the research. This illustrates the collaborative nature of scientific inquiry, noting the importance of teamwork in advancing knowledge and applications in medicine.

43) Forest:
'Forest' underscores the ecological environment where Aegle marmelos thrives. It highlights biodiversity's importance in sourcing medicinal plants and the significance of conservation for future research and application.

44) Siddha:
'Siddha' is a traditional medicine system that utilizes various herbal constituents, including Aegle marmelos. This connection emphasizes the historical roots and cultural significance of Bael in various medicinal practices across India.

45) Shukla (Sukla):
'Shukla' could signify a researcher or reference relevant to the scientific inquiry. It reaffirms collaborative efforts within the research environment for thorough exploration of the medicinal aspects of Bael.

46) Aureus:
Aureus likely refers to Staphylococcus aureus, a common pathogen examined in studies involving antibacterial activity. The ability of Bael extracts to combat this bacteria enhances its credibility as an effective natural remedy.

47) Family:
'Family' indicates the classification of Aegle marmelos within plant taxonomy. Understanding its botanical family, Rutaceae, aids in recognizing related plants that may share similar therapeutic properties.

48) Nausea:
'Nausea' signifies a common gastrointestinal symptom that can be alleviated through herbal remedies like Bael fruit. This highlights the importance of developing effective treatments for such ailments through traditional and modern practices.

49) Nature:
'Nature' points to the overarching influence of natural compounds in medicine. This emphasizes the reliance on plant-based remedies, like Bael, which have been historically employed for their health-promoting properties.

50) Reason:
'Reason' addresses the rationality behind using Aegle marmelos. It encapsulates the scientific foundation guiding the exploration of its therapeutic benefits in treating various health conditions, justifying its significance in modern pharmacology.

51) Medium:
'Medium' refers to the environment or conditions suitable for the growth of Aegle marmelos. It underscores the importance of understanding growth conditions for effective cultivation, which subsequently affects medicinal efficacy.

52) Animal:
'Animal' denotes the use of animal models in testing the effectiveness of Bael fruit extracts. Utilizing animal studies helps verify the safety and efficacy of the formulated products aimed at improving human health.

53) Cotton:
'Cotton' may reference physical traits of the Bael seeds, which have a cotton-like texture. This aspect can be relevant in understanding the morphological features of the fruit and its components during extraction.

54) Kandu (Kamdu):
'Kandu' could specifically represent one of the researchers involved in the study. This highlights collaboration and the diverse expertise contributing to the project and its findings within herbal medicine.

55) Gupta:
'Gupta' likely refers to an author or researcher whose work is relevant to the findings or methodology of the study. It emphasizes the importance of citations and acknowledging influential contributions in research.

56) Kumar:
'Kumar' may denote a researcher who has contributed foundational knowledge or findings related to Aegle marmelos in the realm of herbal medicine, illustrating the collaboration and interdependence of scientific progress.

57) Mango:
'Mango' is compared in nutrient profiles to highlight the richness of Bael fruit. This contextualizes the medicinal benefits of Bael by showing its superiority in certain nutritional aspects, making a case for its therapeutic use.

58) Genu:
'Genu' may suggest authenticity or genuineness in the context of herbal products. It underlines the importance of using authentic sources and materials in the preparation of medicinal formulations.

59) Hair:
'Hair' metaphorically represents the texture or fine morphology of the Bael seeds or plant structures. This can have relevance in understanding the physical properties of the plant impacting its use in extracts.

60) Egypt:
'Egypt' signifies a geographical region where Bael may have historical significance. This expands the context and influence of Aegle marmelos beyond India, highlighting its potential in traditional herbal practices across different cultures.

61) Java:
'Java' indicates a location potentially associated with the cultivation of Aegle marmelos. This adds an aspect of geographical diversity to the study, illustrating Bael's adaptability and significance in different climatic regions.

62) Rich (Rch):
'Rich' denotes the abundance of nutrients and bioactive compounds found in Aegle marmelos. It establishes the plant's value as a natural resource for developing effective herbal medicines with various health benefits.

63) Milk:
'Milk' may refer to the addition of milk in traditional recipes with Bael fruit for palatability. This highlights the versatility of Bael in culinary uses and its integration within cultural medicinal practices.

64) Salt (Salty):
'Salt' could reflect dietary interactions with Bael fruit, indicating potential effects on health and nutritional balance. It underscores the significance of understanding dietary contexts in utilizing herbal remedies efficiently.

65) Tai:
'Thai' indicates a regional comparison regarding nutrient composition or use of Aegle marmelos. It helps situate Bael fruit within a broader context of herbal practices, showcasing its relevance in various traditional systems.

66) Oil:
'Oils' may pertain to the essential oils extracted from Aegle marmelos, known for their medicinal properties. This focuses on the extraction processes that enhance the therapeutic applications of various plant components.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Formulation development and evaluation of herbal effervescent tablet’. Further sources in the context of Science might help you critically compare this page with similair documents:

Literature review, Herbal medicine, Gastrointestinal Tract, Peptic ulcer, Antibacterial activity, Antioxidant activity, Bioavailability, Phytochemical analysis, Drug delivery system, Active ingredient, Physicochemical properties, Gynecological disorder, Physicochemical evaluation, Anti-ulcer activity, Tablet compression, Granules preparation, Antidiabetic effect, Nutritional constituents, Tablet compression machine, Formulation Development, Plant extract preparation, Toxicity evaluation, Effervescent tablet, Digestive disorder.

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