Journal name: World Journal of Pharmaceutical Research
Original article title: The pharmacology, toxicity, and phytochemistry of ipomoea carnea
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: an overview
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Anjali Kumari Maurya and Prashant Kumar Singh
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: The pharmacology, toxicity, and phytochemistry of ipomoea carnea
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202310-28668
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
1) Introduction
Ipomoea carnea, commonly known as Besharam or Behaya tree, is a fast-growing plant from the Convolvulaceae family, native to America but widely spread in India. While traditionally used for various medicinal purposes, it has raised concerns due to its possible toxic effects, especially in pregnant animals. This review article aims to present an overview of the pharmacology, toxicity, and phytochemistry of I. carnea, highlighting its potential as a resource for biogas production and its therapeutic properties.
2) Phytochemical Properties
The pharmacological activities of I. carnea are largely attributed to its diverse phytochemical composition, which includes bioactive compounds such as alkaloids, flavonoids, and phenolic acids. Some notable phytochemicals identified in the plant are swainsonine, a natural alkaloid with demonstrated anticancer effects, and calystegines, which function as competitive inhibitors of specific enzymes. A comprehensive analysis revealed that the leaves, stem, and flowers of I. carnea contain high levels of antioxidants, including polyphenols, which contribute to its health benefits. This rich phytochemical profile reinforces I. carnea’s potential utility in therapeutic applications.
3) Pharmacological Activities
I. carnea exhibits numerous pharmacological properties, including antibacterial, antifungal, antioxidant, anticancer, anticonvulsant, and anti-inflammatory activities. Studies have shown that its extracts can inhibit various pathogenic bacteria and fungi, demonstrating its antimicrobial potential. Additionally, the plant’s high antioxidant content plays a crucial role in mitigating oxidative stress, which is linked to degenerative diseases. Notably, the research indicates that swainsonine stimulates apoptosis in cancer cells, marking I. carnea as a potential candidate for cancer therapy.
4) Toxicity and Health Concerns
Despite its medicinal benefits, I. carnea poses toxicity risks, particularly in livestock. Chronic consumption has resulted in symptoms such as weakness, weight loss, and severe neurological effects. Animal studies suggest that the compounds responsible for these toxic effects include dihydroxynortropane alkaloids found in the plant. Moreover, I. carnea has been associated with lysosomal storage diseases in goats and can induce teratological effects in offspring when ingested by pregnant animals. These findings necessitate careful evaluation of the plant's safety before recommending its use in medicinal contexts.
5) Conclusion
The resurgence of interest in phytomedicine underscores the potential of I. carnea as a source of therapeutic compounds. While the plant has been utilized for its medicinal properties for centuries, scientific validation and further research are essential to fully understand its health benefits and safety concerns. Future studies should focus on pre-clinical and clinical trials to better assess the efficacy and safety of I. carnea's active components. As research progresses, I. carnea may emerge as an integral element in modern phytotherapy, promising novel treatment avenues for various health conditions.
FAQ section (important questions/answers):
What are the medicinal properties of Ipomoea carnea?
Ipomoea carnea exhibits various medicinal properties such as antibacterial, antifungal, antioxidant, anticancer, anticonvulsant, immunomodulatory, antidiabetic, hepatoprotective, anti-inflammatory, anxiolytic, sedative, and wound healing effects, making it a potential resource for drug development.
What are the main phytochemicals found in Ipomoea carnea?
Ipomoea carnea contains bioactive phytochemicals including alkaloids, flavonoids, phenolic acids, terpenoids, saponins, and glycosides, which are responsible for its pharmacological activities and medicinal properties.
How does Ipomoea carnea affect pregnant animals?
Consumption of Ipomoea carnea by pregnant animals can lead to a lack of bonding with their offspring, resulting in detrimental developmental effects.
What toxic effects are associated with Ipomoea carnea?
Ipomoea carnea can cause toxicity in animals, leading to symptoms such as weakness, weight loss, locomotor disturbances, and potentially death due to the presence of toxic compounds like dihydroxynortropane alkaloids.
What are some pharmacological activities of Ipomoea carnea?
Ipomoea carnea has shown pharmacological activities including antimicrobial, antioxidant, anti-cancer, anti-inflammatory, and immunomodulatory effects, providing insights into its potential therapeutic benefits.
What future studies are needed for Ipomoea carnea?
Future studies should focus on preclinical and clinical trials to evaluate the safety and efficacy of Ipomoea carnea for potential therapeutic use in humans.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “The pharmacology, toxicity, and phytochemistry of ipomoea carnea”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the actions or functions of specific substances, particularly in a pharmacological or biological context. In the context of Ipomoea carnea, it pertains to the various medicinal and therapeutic effects that its phytochemical constituents exhibit, such as anti-inflammatory, anti-cancer, and antibacterial properties, thereby playing a crucial role in drug development and therapeutic applications.
2) Maurya:
Maurya is associated with the contributing author, Anjali Kumari Maurya, who is a research scholar affiliated with the Saraswati Higher Education and Technical College of Pharmacy in Varanasi, U.P. Her work emphasizes the significance of studying Ipomoea carnea in relation to its pharmacological properties and traditional usage.
3) Study (Studying):
The study signifies the systematic and scientific investigation into a subject matter. In this context of Ipomoea carnea, the study involves understanding its phytochemistry, pharmacological activities, and safety assessments, ultimately contributing to its potential classification as a medicinal resource.
4) Phytochemical:
Phytochemicals are chemical compounds produced by plants, contributing to their color, flavor, and disease resistance. In Ipomoea carnea, the phytochemical profile is vital for understanding its pharmacological effects, as these compounds are responsible for various biological activities relevant to health and medicine.
5) Flavonoid:
Flavonoids, as a subgroup of phytochemicals, are crucial for their diverse health benefits, including anti-inflammatory, antioxidant, and immune-boosting effects. The presence of flavonoids in Ipomoea carnea emphasizes its role in traditional and potential modern medicine, providing a foundation for further research into its therapeutic applications.
6) Disease:
Diseases are conditions marked by abnormal physiological functions, often requiring treatment. Studies of Ipomoea carnea focus on its potential therapeutic roles in treating multiple diseases, including metabolic, infectious, and auto-immune conditions, underscoring its significance in modern phytotherapy and drug discovery.
7) Medicine:
Medicines are substances used to prevent, diagnose, or treat diseases. Research into Ipomoea carnea aims to uncover its potential as a source of new medicines, highlighting the importance of traditional knowledge and modern scientific validation in developing effective therapeutic agents.
8) Animal:
Animals, as subjects in research studies, provide insights into physiological responses to drugs or treatments. Research on Ipomoea carnea includes studies on its effects in various animal models to elucidate its potential benefits and risks in the treatment of human diseases.
9) Rat:
Rats are commonly used laboratory animals in scientific research, particularly in pharmacology and toxicology studies. Research involving Ipomoea carnea often utilizes rats to assess its medicinal properties and toxic effects, helping establish safety and efficacy for potential future human therapeutic use.
10) Pharmacological:
Pharmacological pertains to the study of drug action and interactions within biological systems. The pharmacological properties of Ipomoea carnea encompass its active compounds' effects on different health conditions, forming a basis for its traditional use and potential incorporation into modern medicine.
11) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth. Research surrounding Ipomoea carnea includes its extracts' potential anticancer activities, investigating how certain phytochemicals may inhibit cancer cell proliferation and induce apoptosis, establishing its relevance in cancer therapy.
12) Science (Scientific):
Scientific denotes a methodical and empirical approach to gaining knowledge through experimentation and observation. The scientific exploration of Ipomoea carnea emphasizes its medicinal possibilities, validating traditional usage through rigorous studies, advancing understanding of its therapeutic applications, and evaluating safety for potential use in medicine.
13) India:
India is significant as the native region of Ipomoea carnea, which thrives in its diverse ecosystems. The plant's study in Indian context considers its traditional uses, cultural relevance, and modern pharmacological research, contributing to a broader understanding of biodiversity and natural resource exploitation for medicine.
14) Fight:
Fight refers to the action of combating or resisting disease or illness. In the context of Ipsomoea carnea, the plant's bioactive constituents may offer natural solutions to fight infections and diseases, illustrating the potential of herbal medicine to serve as an adjunct or alternative in health care.
15) Drug:
Drug signifies a substance used in diagnosing, treating, or preventing disease. Ipomoea carnea is studied for its potential to lead to drug development based on its medicinal properties, advancing the search for natural remedies bound to be effective with fewer side effects in treating health conditions.
16) Inflammation:
Inflammation is a biological response to injury or infection, often associated with pain and swelling. Ipomoea carnea displays anti-inflammatory properties in various studies, suggesting its utility as a natural treatment to mitigate inflammatory diseases and conditions, contributing to the therapeutic landscape.
17) Substance:
The substance refers to specific chemical compounds or materials, crucial in discussions of Ipomoea carnea. Understanding the individual substances that contribute to its phytochemical makeup is essential for exploring therapeutic applications and potential health benefits associated with the plant.
18) Education:
Education represents the process of imparting knowledge and skills. Awareness and knowledge regarding Ipomoea carnea's medicinal uses are crucial for future practitioners in pharmacology and traditional medicine, enhancing understanding and responsible application of plant-based therapies in healthcare.
19) Varanasi (Varanashi):
Varanasi is the location of the Saraswati Higher Education and Technical College of Pharmacy, where important studies on Ipomoea carnea are conducted. The city's rich cultural and spiritual history provides context for traditional medicinal practices that may incorporate findings from contemporary scientific research.
20) Toxicity:
Toxicity refers to the degree to which a substance can harm or poison living organisms. Investigating the toxicity of Ipomoea carnea is essential to ensure its safe use as a potential medicinal resource, assessing the risks associated with its phytochemical constituents and long-term effects on health.
21) Pregnant:
Pregnant denotes a state of carrying offspring within a female organism. In relation to Ipomoea carnea, studies indicate that ingestion of this plant may adversely affect pregnant animals, highlighting the need for further research into its safety for reproduction and development.
22) Species:
Species refers to a group of similar individuals capable of interbreeding and producing fertile offspring. Ipomoea carnea is part of a diverse set of species within the Convolvulaceae family, each exhibiting unique characteristics and potential uses in traditional medicine and research.
23) Family:
The family refers to a hierarchical classification of organisms. Ipomoea carnea belongs to the Convolvulaceae family, noting its relatives and allowing for comparative studies with other species in the family that might share similar phytochemical or medicinal properties.
24) Gupta:
Gupta refers to a contributing author or researcher involved in the study of Ipomoea carnea. Collaborative efforts among researchers like Gupta enhance the body of knowledge regarding the medicinal, pharmacological, and toxicological aspects of this plant, solidifying its research foundation.
25) Anxiety:
Anxiety refers to a mental health condition characterized by excessive worry and fear. Investigations into the effects of Ipomoea carnea on anxiety reveal its potential as a natural anxiolytic, showing promise for alleviating anxiety symptoms through the pharmacological activities of its bioactive compounds.
26) Anjali (Amjali):
Anjali refers to Anjali Kumari Maurya, the lead author of the research paper on Ipomoea carnea. As a researcher, her work is pivotal in documenting and exploring the medicinal properties of the plant, thereby contributing to ongoing studies in pharmacognosy and phytotherapy.
27) Kumari:
Kumari is a part of the name of Anjali Kumari Maurya, emphasizing her status as a research scholar. The inclusion of her name reflects her contributions to the scientific understanding of Ipomoea carnea, underlining the importance of individual researchers in advancing knowledge in phytomedicine.
28) Sharman (Sarma, Sharma, Sarman):
Sharma refers to a contributor to the research on Ipomoea carnea, pointing to the collaborative nature of scientific inquiry. Contributions from various authors, including Sharma, play essential roles in accumulating data and validating findings regarding the medicinal properties and potential applications of the plant.
29) Powder:
Powder signifies a finely ground substance, often used in the context of herbal preparation. In the exploration of Ipomoea carnea, powdered extracts of various parts of the plant, such as leaves and flowers, are routinely analyzed for their bioactive constituents and medicinal effectiveness.
30) Field:
Field can refer to a particular area of study and research specialization. The field of pharmacognosy focuses on exploring and validating the medicinal uses of plants like Ipomoea carnea, contributing to the understanding of their potential benefits and applications in healthcare.
31) Western India:
Western India denotes a region where Ipomoea carnea is widely found. The ecological aspects of this area inform traditional practices involving the plant, enriching studies that analyze regional uses and the challenges of controlling its growth and potential toxicity.
32) Cow dung:
Cow dung refers to the excrement of cows, often used as a fertilizer or biomass for energy production. In discussions involving Ipomoea carnea, cow dung is mentioned in contexts concerning biogas production and natural waste management practices, showcasing sustainable uses of both materials.
33) Antibiotic (Antibacterial):
Antibiotic refers to a specific category of drugs that inhibit bacterial growth. Research involving Ipomoea carnea examines how its constituents may serve as effective antibiotics or synergistic agents, enhancing the effectiveness of conventional treatments against various bacterial infections.
34) Pharmacology:
Pharmacology is the scientific discipline that studies how drugs interact with biological systems. The field covers the investigation of Ipomoea carnea's active compounds, assessing their therapeutic potential and the mechanisms through which they exert their effects on health and disease conditions.
35) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India where Ipomoea carnea is prevalent. Studies conducted in this region contribute insights into traditional practices involving the plant, exploring its ecological significance and the potential risks of toxicity, thus enriching the understanding of its uses and applications.
36) Rajasthan:
Rajasthan is another Indian state where Ipomoea carnea can be found. The geographical distribution of the plant raises important considerations for its ecological impact and the traditional uses that inform local medicinal practices, emphasizing the need for mindful management of this species.
37) Knowledge:
Knowledge encompasses the information gained from research and experience. Understanding the pharmacological properties and traditional uses of Ipomoea carnea contributes to the broader field of phytotherapy, identifying the potential benefits and uses of this plant in modern medicinal contexts.
38) Incision:
Incision refers to a surgical cut made in living tissue. In research involving wound healing, the incision model assesses the efficacy of Ipomoea carnea extracts in promoting tissue repair and regeneration, indicating its medicinal potential in treating injuries.
39) Marathi:
Marathi is a language spoken predominantly in Maharashtra, India. The cultural context of the plant's uses may include its traditional names in local languages, such as Marathi. Such language connections can provide insights into the historical and cultural significance of Ipomoea carnea within different communities.
40) Bengali:
Bengali is a language spoken in the Indian state of West Bengal and Bangladesh. Local dialects, including Bengali, may refer to Ipomoea carnea by various names, showcasing the plant's prevalence and cultural relevance across regions, highlighting its use in traditional medicine.
41) Madhya:
Madhya refers to Madhya Pradesh, an Indian state where Ipomoea carnea is also found. This geographical factor underlines the spread of the plant across India and examines its ecological adaptabilities and local usages, which inform its research and potential pharmacological applications.
42) Kumar:
Kumar is a common Indian surname, often seen among authors. It references Prashant Kumar Singh, a co-author, indicating collaboration in research on Ipomoea carnea. The input of multiple contributors is essential in enhancing the study’s depth and understanding of plant applications.
43) Patel:
Patel is a common surname in India, indicating potential affiliation or contribution to the research. In the context of studies on Ipomoea carnea, authorship by individuals such as Patel suggests collaboration and the gathering of diverse expertise to advance the understanding of the plant's properties.
44) Grove:
Grove refers to a researcher who has contributed to understanding plant biology, particularly in the context of hormone-like compounds. Studies by researchers like Grove contextualize the similarity between plant and human metabolic processes, informing research related to the pharmacological aspects of Ipomoea carnea.
45) Sugar:
Sugar, in terms of chemistry, pertains to simple carbohydrates that are essential for energy. Research into Ipomoea carnea mentions compounds such as D-glucose which contribute to understanding its nutritional and metabolic implications, as well as the role phytochemicals play in influencing health.
46) Hindi (Himdi):
Hindi is one of the official languages of India, indicating the cultural and linguistic context of Ipomoea carnea's usage. Knowledge of local names in Hindi enriches the understanding of how traditional medicine practices incorporate this plant and its significance within communities.
47) Death:
Death signifies the cessation of biological function and is a critical concern in toxicology. Studies regarding Ipomoea carnea highlight its potential toxicity and the severe health implications of ingestion, particularly in livestock, emphasizing the need for further research on safe consumption.
48) Oriya:
Oriya is a language spoken in the Indian state of Odisha. The mention of Oriya in relation to Ipomoea carnea shows its cultural relevance and provides insights into local vernacular uses, enhancing knowledge of the plant's traditional medicinal applications and significance.
49) Ruci:
Ruchi refers to a contributor to research related to Ipomoea carnea, likely indicating collaboration. The collective effort of researchers like Ruchi enriches the study of this plant’s properties and its applications in traditional medicine and pharmacology.
50) Genu:
Genu is a term that typically refers to a knee or a bending part. In the context of botanical studies, it might imply the study of specific plant structures or adaptations, although its relevance to Ipomoea carnea appears less direct in this context.
51) Kota:
Kota refers to a city in Rajasthan, India, where Ipomoea carnea might be found. The geographical aspect reflects the plant's distribution and informs studies related to its local ecological significance and traditional uses in various regions of India.
52) Food:
Food signifies substances consumed to provide nutritional support. The contextual reference to Ipomoea carnea may hint at the plant's traditional culinary uses or nutritional aspects that may be explored, potentially framing its role in diet alongside its medicinal properties.
53) Tree:
Tree refers to a perennial plant with a trunk and leaves. Ipomoea carnea is often referred to as a tree owing to its considerable size and growth habits. Its classification illustrates its ecological role and informs studies regarding its invasive tendencies and biotechnological applications.
54) Hair:
Hair can denote the outer growth on organisms. In the context of toxicity studies, the relationship between I. carnea intake and hair loss in animals may indicate the broader implications of its toxic components, highlighting the need for safety assessments in animal health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘The pharmacology, toxicity, and phytochemistry of ipomoea carnea’. Further sources in the context of Science might help you critically compare this page with similair documents:
Ipomoea carnea, Flavonoid, Phytochemical, Traditional medicine, Medicinal importance, Antioxidant activity, Phytotherapy, Wound healing activity, Immunomodulatory effect, Anti-inflammatory effect, Anti-cancer activity, Hepatoprotective effect, Antibacterial properties, Anxiolytic activity, Convolvulaceae family, Anti-diabetic activity, Toxic effect, Sedative activity, Antifungal properties, Alkaloid, Anticancer effect, Bioactive component, Lysosomal storage disease.