Analysis of passion fruit extract as an antioxidant for nucleic acids.
Journal name: World Journal of Pharmaceutical Research
Original article title: Analysis of passion fruit (extract protocatechuic acid) as an antioxidant of nucleic acids in the human body
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Danna María Arzeta-Sanabria, Alison Stefany Corona-Hernández, Guadalupe Herrera-Oceguera, Alejandra Tirado-Calderón and Manuel González-Pérez
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Analysis of passion fruit (extract protocatechuic acid) as an antioxidant of nucleic acids in the human body
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202310-28511
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Passion fruit (Passiflora edulis f. flavicarpa) has emerged as a promising source of phytochemical compounds, particularly known for their anti-proliferative properties. The study focuses on Protocatechuic Acid (PCA), a significant component of passion fruit, analyzing its potential as an antioxidant for nucleic acids in the human body. With an increase in the incidence of colorectal cancer, dietary choices, including the consumption of fruits and vegetables rich in compounds like PCA, could play a crucial role in reducing the risk of gastrointestinal cancers. This research utilizes quantum chemistry methods and emphasizes the health benefits associated with PCA, highlighting its role in combating oxidative stress and various health conditions.
Protocatechuic Acid: Chemical Properties and Mechanism
PCA has shown considerable promise in various pharmacological applications, ranging from antioxidant capabilities to anticancer properties. It modulates oxidative stress and inflammatory responses through multiple signaling pathways. Recent studies have also highlighted its neuroprotective effects and potential benefits against neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The chemical structure and properties of PCA enable it to act effectively against harmful oxidative agents, suggesting that it could serve as a powerful therapeutic agent in complementary health care strategies.
Antioxidant Interactions of PCA
The findings reveal that PCA interacts favorably with the nitrogenous bases that compose DNA and RNA. Quantitative assessments of PCA's electron transfer coefficient demonstrate its efficiency in reducing oxidative stress through its interactions with nucleic acid components. The study’s results underline PCA's high antioxidant capability compared to other substances, indicating its potential as a protective agent for cellular nucleic acids, thereby supporting overall genetic integrity and health.
Pharmacological Benefits and Applications
The pharmacological landscape for PCA is expanding, showcasing its multi-faceted benefits, including anti-inflammatory, antibacterial, anticancer, and neuroprotective effects. The study emphasizes the significance of PCA in dietary health, as its chemopreventive potential can inhibit carcinogenesis and exhibit pro-apoptotic effects in various tissues. As such, PCA stands as an essential candidate for further research and clinical studies intended to explore and establish effective treatments for related health conditions.
Conclusion
In conclusion, this research underscores the considerable potential of PCA extracted from passion fruit as a short-acting yet potent antioxidant for nucleic acids in the human body. The evidence presented supports the hypothesis that PCA can effectively mitigate oxidative damage, highlighting its role in promoting health and preventing diseases. Future studies are recommended to investigate the therapeutic applications of PCA further, possibly in combination with other antioxidants to enhance its efficacy in clinical settings.
FAQ section (important questions/answers):
What is the focus of the study on passion fruit extract?
The study investigates the antioxidant properties of Protocatechuic Acid (PCA) from passion fruit and its effects on nucleic acids in the human body.
How was Quantum Chemistry applied in this research?
Quantum chemistry was utilized using Hyperchem software to calculate key molecular properties like HOMO, LUMO, and Electron Transfer Coefficient (ETC) for assessing PCA’s antioxidant capability.
What health benefits are associated with Protocatechuic Acid?
PCA has anti-inflammatory, antioxidant, and anticancer properties, showing potential in neuroprotection and reducing oxidative stress and inflammatory responses in the body.
What were the findings regarding PCA's longevity in the body?
The research concluded that PCA is a non-prolonged-acting substance, indicating it remains in the human body for a limited duration.
What recommendations were made for future research on PCA?
Future studies should explore the effects of PCA on various diseases and investigate its potential interactions with other antioxidants to enhance its efficacy.
Why is the incidence of colorectal cancer mentioned in the study?
The study highlights the increasing incidence of colorectal cancer and emphasizes the role of diet, particularly fruits and vegetables, in potentially reducing this risk.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Analysis of passion fruit extract as an antioxidant for nucleic acids.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Substance:
The word 'substances' encompasses various chemical compounds evaluated in the research, including protocatechuic acid and amino acids. This term highlights the significance of examining multiple interactions among these substances, their biochemical roles, and their potential health benefits, particularly concerning antioxidant properties and their implications for dietary supplementation.
2) Table:
In the context of the research, 'table' represents organized data presentation. Tables summarize interactions, electron transfer coefficients, and the relevant properties of various substances. They facilitate the comparison of data, enabling readers to quickly grasp vital experimental outcomes and the study's implications regarding prooxidant and antioxidant interactions.
3) Disease:
The plural term 'diseases' encompasses multiple pathological conditions that may be influenced by dietary choices and the presence of bioactive compounds. This research emphasizes the connection between antioxidant intake and the mitigation of disease risk, particularly chronic diseases, placing a strong focus on health-promoting dietary strategies.
4) Species:
In biological contexts, 'species' refers to a group of organisms capable of interbreeding. The study focuses on the Passion fruit species, Passiflora edulis f. flavicarpa, known for its bioactive compounds. Understanding the species ensures successful application of its phytochemical properties in biotechnological and health-related research.
5) Cancer:
The term 'cancer' denotes a group of diseases characterized by uncontrolled cell growth. The research addresses the increasing incidence of colorectal cancer and explores the potential anticancer properties of protocatechuic acid derived from passion fruit. Insights into cancer prevention support the relevance of dietary antioxidants in health maintenance.
6) Pharmacological:
Pharmacological refers to the study of drug actions and effects. The research examines the pharmacological activities of protocatechuic acid, including its effects on oxidative stress and inflammation. Understanding the pharmacological properties is essential for developing effective therapeutic agents that leverage natural compounds for health improvement.
7) Phytochemical:
Phytochemical refers to the bioactive chemical compounds found in plants. The study focuses on the phytochemical protocatechuic acid from passion fruit, known for its antioxidant potential. Recognizing the role of phytochemicals is important in dietary studies, as these compounds can influence health outcomes and disease prevention.
8) Calculation:
The term 'calculation' involves mathematical processes applied to analyze experimental data. In this study, calculations of electron transfer coefficients and electrostatic potentials enhance the understanding of interactions between protocatechuic acid and nucleic acids. Accurate calculations are crucial for interpreting results and drawing meaningful conclusions from research findings.
9) Rat:
In this study, 'rats' refers to the animal model used to evaluate the effects of passion fruit extracts on glycemic levels. Rats are commonly employed in research due to their physiological similarities to humans. Findings from such studies can guide human dietary recommendations and supplement formulations.
10) Human body:
The phrase 'human body' represents the complex biological system subject to various internal and external factors influencing health. This study investigates how protocatechuic acid from passion fruit interacts within the human body, particularly concerning antioxidant effects and nucleic acid protection, ultimately contributing to dietary health knowledge.
11) Antibiotic (Antibacterial):
The term 'antibacterial' refers to properties that inhibit bacterial growth. Although the study primarily highlights antioxidant properties, antibacterial attributes of protocatechuic acid contribute to its overall therapeutic profile. Understanding these properties supports the broader application of phytochemicals in health, including their use in preventing infections.
12) Pharmacology:
Pharmacology is the branch of medicine that focuses on drug interactions and effects. This study delves into the pharmacology of protocatechuic acid, examining its potential as an effective health-promoting agent. Insights into pharmacological mechanisms help in assessing the holistic benefits of natural dietary compounds.
13) Accumulation (Accumulating, Accumulate):
The term 'accumulation' refers to the gradual gathering of substances, particularly within biological systems. In the context of neurodegenerative diseases, understanding the accumulation of harmful substances provides insight into disease progression. Maintaining balance through dietary antioxidants can potentially mitigate harmful accumulation effects.
14) Discussion:
In research, 'discussion' refers to the section where findings are interpreted and contextualized. The discussion in this study analyzes the implications of protocatechuic acid's antioxidant properties, how they support health, and their significance in dietary practices, encouraging further exploration of natural compounds in disease prevention.
15) Suffering:
The term 'suffering' relates to the experiences resulting from diseases and health conditions. This study emphasizes that dietary choices can influence the suffering associated with diseases like cancer. The exploration of antioxidants provides pathways toward mitigating suffering through improved health outcomes and quality of life.
16) Toxicity:
Toxicity refers to the degree to which a substance can harm organisms. Understanding toxicity is crucial in assessing the safety of dietary supplements and natural compounds. This research highlights the need to evaluate the toxicological profiles of phytochemicals like protocatechuic acid to ensure their safe consumption and efficacy.
17) Activity:
In a scientific context, 'activity' denotes the functional effects a compound has within biological systems. The research explores the antioxidant activity of protocatechuic acid, providing evidence for its beneficial effects. Understanding such activities helps establish the therapeutic relevance of natural compounds in health promotion.
18) Reason:
The term 'reason' denotes the underlying justification for conducting research. This study investigates the reason behind assessing the antioxidant potential of protocatechuic acid from passion fruit, highlighting its significance in disease prevention and health optimization, ultimately aiming to bolster public health through informed dietary choices.
19) Campu:
In this context, 'campu' likely refers to the technical terms involved in academic settings, especially relating to institutions that conduct research. Recognizing the role of educational and research campuses allows for an understanding of the collaborative efforts necessary in advancing scientific knowledge regarding dietary and health research.
20) Study (Studying):
The term 'study' refers to the systematic investigation of phenomena. This particular study focuses on protocatechuic acid's properties and implications for human health. Understanding the outcomes of this and similar studies is vital for advancing nutritional science and enhancing health outcomes across populations.
21) Food:
Food represents the substances consumed to provide nutritional support. The study emphasizes the role of food, particularly fruits and their phytochemical content, in impacting health. Understanding food's relationship with disease prevention underscores the importance of dietary choices in maintaining overall well-being.
22) Diet:
The term 'diet' refers to the food and beverages consumed regularly by individuals. The research correlates dietary habits with health outcomes, particularly the role of fruits like passion fruit rich in beneficial compounds. This connection highlights diet's impact on preventing diseases though consumption choices.
23) Rich (Rch):
The word 'rich' highlights the abundance of beneficial components within certain foods, particularly those containing phytochemicals like protocatechuic acid. Describing a diet rich in antioxidants can influence public health guidelines, emphasizing the importance of consuming diverse foods to optimize health and minimize disease risk.
24) Hand:
In this context, 'hand' may refer to the concept of having control or influence over one's health through dietary choices. Understanding the relationship between food intake and health outcomes signifies the power that individual choices have in shaping well-being, reinforcing the importance of informed dietary decisions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Analysis of passion fruit extract as an antioxidant for nucleic acids.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Pharmacology, Human body, Pharmacological activities, Dietary Intake, Oxidative stress, Neurodegenerative disorder, Anticancer activity, Ethanolic extract, Amino acid, Colorectal Cancer, Nuclear magnetic resonance, Neurodegenerative processes, Chemical carcinogenesis, Nucleic acid, Health benefit, Chemopreventive potential, Phytochemical compound, Glycemia level.