Journal name: World Journal of Pharmaceutical Research
Original article title: Techniques for formulation of emulgel drug delivery system
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a review
Original source:
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Guru Prasad Maurya, Mahzbee Bano and Pradeep Kumar Srivastva
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Techniques for formulation of emulgel drug delivery system
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202311-28777
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Emulgels are innovative drug delivery systems that combine the properties of emulsions and gels to enhance the delivery of hydrophobic drugs, which are often challenging to solubilize in regular formulations. The review by Maurya et al. highlights the significance of emulgels in pharmaceutical, cosmetic, and dermatological applications. By merging the controlled release capabilities of emulsions with the stability and user-friendliness of gels, emulgels offer an effective solution for improving patient compliance in topical drug administration.
Importance of Emulsion and Gel Combination
Emulgels are characterized by their dual release mechanism, which facilitates controlled drug release from the emulsion phase while ensuring the stability associated with gel formulations. This amalgamation allows emulgels to retain the advantages of both systems, particularly for therapeutic agents that are hydrophobic and difficult to deliver via traditional methods. Additionally, the review elaborates on the techniques involved in formulating emulgels, underscoring the growing interest in using novel polymers that enhance the stability and performance of these formulations.
Types and Applications of Emulgels
Emulgels can be classified based on the type of active pharmaceutical ingredient (API) and the type of emulsion used. Specifically, they include natural or polyherbal combinations, as well as allopathic formulations like Diclofenac diethyl ammonium emulgel. The review details the different classifications, which include macroemulgels (with dispersed phase droplet size greater than 400 nm), microemulgels (20 nm to 200 nm), and nanoemulgels (less than 1 nm). This classification not only helps in understanding the suitable applications of emulgels but also highlights their role in preventing first-pass metabolism and improving site specificity.
Evaluation Techniques for Emulgels
The assessment of emulgel formulations involves several critical evaluation techniques to ensure their safety and effectiveness. Testing includes physical examination for homogeneity, determination of pH, rheological studies to assess viscosity, stability studies under various conditions, and release studies using diffusion cells. These evaluations help ascertain the formulation's compatibility, quality, and overall performance as a drug delivery system, ensuring consistency in achieving therapeutic outcomes.
Conclusion
In summary, emulgel formulations exemplify an advanced approach to drug delivery that prioritizes patient compliance, stability, and therapeutic effectiveness. The review emphasizes the importance of optimizing formulation techniques, enhancing drug penetration, and utilizing innovative polymers to ensure the successful application of emulgels in various fields. As research progresses, emulgels are poised to become increasingly prominent in the pharmaceutical landscape, offering a viable alternative for delivering hydrophobic drugs effectively and efficiently.
FAQ section (important questions/answers):
What are emulgels and their main components?
Emulgels are drug delivery systems combining emulsions and gels. They deliver hydrophobic drugs effectively by stabilizing them with polymers, providing controlled release and ease of application.
What advantages do emulgels offer for drug delivery?
Emulgels prevent first-pass metabolism, enhance patient compliance, and allow topical application of hydrophobic drugs. They are easy to spread, greaseless, and have a longer shelf life.
What are the different types of emulgels?
Emulgels can be classified based on API type as natural or allopathic, and based on emulsion type as macroemulgel, microemulgel, or nanoemulgel, depending on dispersed phase droplet sizes.
What materials are commonly used in emulgel preparation?
Common materials include aqueous solvents like water and alcohol, oils, emulsifiers like Tween and Span, preservatives, antioxidants, humectants like glycerin, and gelling agents such as carbopol.
How are emulgel formulations evaluated for effectiveness?
Emulgel formulations are evaluated through physical inspection, pH determination, viscosity measurement, stability studies, skin irritation tests, and drug content analysis to ensure quality and effectiveness.
What is the future potential of emulgels in drug delivery?
Emulgels are expected to become popular for drug delivery due to their advantages, including enhanced patient compliance, improved drug penetration, and versatility in pharmaceutical and cosmetic applications.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Techniques for formulation of emulgel drug delivery system”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
Drugs are the active pharmaceutical ingredients intended to produce a therapeutic effect. In conjunction with emulgels, various drugs can be delivered efficiently through the skin, particularly hydrophobic drugs, which often face challenges in solubility and absorption in traditional forms.
2) Water:
The term 'the water' emphasizes the importance of the aqueous phase in emulgel formulations. It indicates the solvent's role in solubilizing active ingredients and gelling agents, which is crucial for maintaining the stability and effectiveness of the final emulgel product.
3) Maurya:
Maurya is the name of the corresponding author of the review article on emulgel drug delivery systems. Guru Prasad Maurya's contributions are significant in the field of pharmaceutical research, specifically focusing on formulation techniques showcasing the effectiveness of emulgels in drug delivery.
4) Oil:
Oils are organic compounds crucial for forming the oily phase in emulsion formulations, including emulgels. They serve as solvents for hydrophobic drugs and contribute to the overall texture and spreadability of the final emulgel product, facilitating drug delivery through topical application.
5) Substance:
This is a singular form of 'substances' and similarly denotes any material that possesses specific chemical properties. In emulgel formulations, the careful selection of each substance is imperative for ensuring that the final product is effective, stable, and patient-friendly.
6) Swelling:
Swelling in an emulgel context denotes the expansion of the gel upon contact with water or other solvents. This property is vital for the controlled release of drugs, affecting the delivery rate and enhancing patient compliance during topical applications.
7) Surface:
Surface refers to the external layer of a substance, including the stratum corneum in the skin, which is the primary barrier to drug absorption. In emulgels, modifying surface interactions can enhance the penetration of drugs through this barrier and improve therapeutic outcomes.
8) Glass:
In the context of emulgel preparation and evaluation, glass refers to the apparatus used, such as glass slides for spreadability tests. The non-reactive nature of glass ensures that no chemical reactions interfere with the evaluation of emulgel’s performance and properties.
9) Life:
Life signifies the biological aspect of pharmaceutical formulations, particularly regarding patient health and treatment outcomes. Emulgels, through enhanced drug delivery mechanisms, can significantly improve the quality of life for patients by providing effective and targeted therapy.
10) Pharmacology:
Pharmacology is the branch of medicine that studies the interactions between drugs and biological systems. This discipline is crucial for understanding the mechanisms of action of emulgels and their role in delivering therapeutics effectively and safely to the target site.
11) Inflammation:
Inflammation is a biological response that may necessitate treatment with topical medications. Emulgels containing anti-inflammatory drugs can effectively deliver these therapeutics to reduce swelling, pain, and irritation, thereby aiding in the management of inflammatory conditions.
12) Varanasi (Varanashi):
Varanasi is a city in India associated with the Institute of Pharmacy where the authors are affiliated. This geographical context highlights the academic and research environment contributing to advancements in pharmaceutical sciences, including the development of emulgel formulation techniques.
13) Chandra:
Chandra refers to Harish Chandra, as part of the name of the affiliated institution, indicating a link to higher education and pharmaceutical research. It represents the collaborative efforts of researchers at this institute in advancing the field of drug delivery systems.
14) Cutting:
Cutting refers to innovative advancements in technology and methodologies in pharmaceutical formulation. In the context of emulgels, cutting-edge techniques may enhance drug penetration and efficacy, ensuring that formulations meet modern therapeutic demands.
15) Mineral:
Minerals are inorganic substances often utilized in pharmaceutical formulations. Specific mineral oils play a substantial role in emulgel compositions, enhancing drug solubility and improving the stability of topical preparations, making them integral to effective drug delivery systems.
16) Asara (Ashara):
Ashara is an author referenced in the document, indicating contributions to research on emulgels. The works of researchers like Ashara underscore the collaborative efforts in exploring and optimizing drug delivery systems for enhanced pharmacological effectiveness.
17) Table:
Table likely refers to structured data representation, such as the examples of marketed preparations. In scientific articles, tables summarize and present critical information concisely, aiding in the comparison of research results presented by the authors.
18) Field:
Fields indicate distinct areas of study within pharmaceutical sciences and research. It encompasses the diverse applications of emulgels across dermatology, cosmetics, and therapeutic practices, emphasizing the breadth of interest in drug delivery systems.
19) Study (Studying):
The study highlights the research and evaluation of emulgels as effective drug delivery systems. It focuses on the methodologies for formulation, testing, and optimizing these systems, recognizing the importance of structured scientific inquiry in advancing medical treatment.
20) Sweating (Sweat):
Sweat refers to the biological secretions that can impact drug permeation through the skin. Understanding how sweat interacts with emulgel formulations can inform the optimization of drug delivery systems for enhanced absorption and therapeutic efficacy.
21) Guru:
Guru refers to Guru Prasad Maurya, the lead author of the review article. His expertise and leadership in the study of emulgels emphasize the importance of mentorship in advancing pharmaceutical research and the impact of individual contributions to scientific knowledge.
22) Road:
Road symbolizes the path towards advancements in pharmaceutical science. The development and implementation of new drug delivery systems, such as emulgels, represent the ongoing journey to enhance treatment options and patient outcomes in modern medicine.
23) Transformation (Transform, Transforming):
Transform signifies the act of changing the characteristics of traditional formulations into more effective emulgels. The transformation process is pivotal for enhancing drug delivery systems, aiming for improved therapeutic outcomes and patient satisfaction.
24) Biodegradable:
Biodegradable refers to materials that can be broken down naturally by biological processes. In pharmaceutical formulations, using biodegradable components enhances the safety and environmental friendliness of emulgels, ensuring minimal adverse effects post-application.
25) Measurement:
Measurement, being a singular term, reflects the importance of precision in assessing the properties of emulgels. Consistent measurements facilitate the optimization of formulation conditions, ensuring that each batch adheres to established quality criteria.
26) Irritation:
Irritation refers to adverse skin reactions that may occur from emulgel application. Evaluating irritation potential is critical to ensure safety and tolerability in patients, emphasizing the need for careful formulation design to minimize side effects.
27) Stiffness:
Stiffness in the context of gels refers to their resistance to deformation. Understanding stiffness is vital as it influences spreadability, adherence, and overall patient comfort during the topical application of emulgels.
28) Quality:
Quality pertains to the overall standards of emulgel formulations, including criteria such as stability, efficacy, and safety. High-quality formulations are essential for successful patient outcomes, aligning with regulatory expectations in pharmaceutical research and development.
29) Account:
Account can refer to the acknowledgment of factors influencing emulgel properties. Attention to detail in formulation design and assessment will ensure that the final product fulfills both therapeutic and regulatory requirements.
30) Castor:
Castor oil is a type of vegetable oil frequently used in topical formulations, including emulgels. Its unique properties assist in solubilizing hydrophobic drugs and contribute to the overall texture and feel of the emulgel, promoting better patient compliance.
31) Chavda:
Chavda is another referenced author contributing to the research on emulgels. Collaborations among authors like Chavda help advance collective knowledge in pharmaceutical sciences, specifically in understanding drug delivery mechanisms and formulation optimization.
32) Joshi (Josi):
Joshi is mentioned as part of the collective research effort on emulgels. Each contributor like Joshi plays an essential role in elucidating the complexities of formulation science and enhancing the understanding of effective drug delivery methods.
33) Kumar:
Kumar refers to another contributing author in the study of emulgels. The collaboration of researchers like Kumar highlights the interdisciplinary nature of pharmaceutical science and reinforces the significance of shared expertise in developing innovative drug delivery solutions.
34) Blood:
Blood refers to the biological fluid that may relate to the efficacy of topical formulations by influencing systemic absorption. Understanding how drugs permeate through the skin and into the bloodstream is critical for evaluating the effectiveness of emulgels.
35) Cage:
A singular 'cage' might refer to the same controlled environments used in laboratory studies for emulgels. These setups are essential for observing and measuring drug permeation and stability, contributing significantly to validation processes.
36) Hair:
Hair affects the topical delivery of drugs, including those delivered via emulgels. Understanding hair follicle density can influence formulation strategies, potentially enhancing drug absorption rates through these natural pathways.
37) Fish:
Fish oil is sometimes included in pharmaceutical formulations due to its omega-3 fatty acids, which can offer health benefits. Incorporating such oils into emulgels can provide both therapeutic effects and improve the solubility of hydrophobic drugs.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Techniques for formulation of emulgel drug delivery system’. Further sources in the context of Science might help you critically compare this page with similair documents:
Pharmaceutical preparation, Self treatment, Drug delivery system, Research article, Dose administration, Controlled release, Biocompatible, Patient compliance, Stability Studies, Emulsifying agent, Pharmaceutical formulation, Swelling Index, Penetration enhancer, Gelling agent, Rheological Studies.