Herbal gummy formulation of Carralluma fimbriata for weight loss.
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of herbal edible gummy of carraluma fimbriata for weight loss
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Muhasib A. Tamboli and Sofiya Tamboli
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and evaluation of herbal edible gummy of carraluma fimbriata for weight loss
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202312-29066
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Obesity has reached epidemic proportions globally, significantly increasing the incidence of various co-morbidities, including diabetes, cardiovascular diseases, and certain cancers. Although traditional diet and exercise are fundamental strategies for weight management, there is a growing interest in alternative therapies, particularly herbal remedies, for weight loss. One such herbal extract is Caralluma fimbriata, which has been investigated for its potential appetite-suppressant properties and anti-obesity effects. This study evaluates the formulation and effectiveness of herbal edible gummies derived from C. fimbriata for weight loss.
The Role of Caralluma fimbriata
Caralluma fimbriata is an edible succulent plant belonging to the Asclepiadaceae family, traditionally used in Indian medicine as an appetite suppressant and famine food. The research highlights the herb's efficacy in weight management, noting its ability to suppress appetite as a potential solution to obesity. The systematic review conducted according to PRISMA guidelines confirmed the plant's effectiveness by analyzing multiple clinical studies from different countries, which included various demographics, primarily focusing on individuals with a body mass index (BMI) over 25 kg/m². These studies provide a solid foundation for understanding how C. fimbriata can be integrated into weight management strategies.
Methodology and Gummy Formulation
In this study, C. fimbriata was harvested in Nagpur, India, and was extracted using Soxhlet extraction with various solvents. Following extraction, the plant material was transformed into edible gummies using agar and gelatin as gelling agents. The formulation process involved testing different concentrations to achieve the ideal texture and stability, and the final products were assessed for physical appearance, stickiness, pH, viscosity, and in vitro dissolution characteristics. The successful creation of these gummies signifies an innovative approach to delivering herbal remedies for weight management in a user-friendly format.
Anti-Obesity Effects of Formulated Gummies
The anti-obesity potential of the formulated gummies was evaluated through a controlled experimental study using Swiss albino mice. Mice were divided into groups, including a normal control group, an obese control group, and groups receiving standard drugs (Orlistat) and test treatments (C. fimbriata gummies). Throughout the 12-week trial, significant weight reductions were observed in the test group compared to the obese control group, suggesting that the C. fimbriata gummies were effective in promoting weight loss and appetite suppression. The study's results demonstrate the practical application of herbal remedies and point towards their potential benefit as an alternative or complementary approach to existing weight loss medications.
Conclusion
The research successfully formulates herbal edible gummies from Caralluma fimbriata and assesses their effectiveness in weight loss among obese individuals. The findings not only emphasize the potential of C. fimbriata as a natural appetite suppressant but also innovate the delivery of herbal supplements through gummy formulations. Such advancements can lead to increased acceptance and accessibility of herbal remedies in weight management, presenting an alternative to conventional anti-obesity drugs. The study paves the way for further research and development of herbal products targeting obesity and related health issues.
FAQ section (important questions/answers):
What is Caralluma fimbriata and its use in weight loss?
Caralluma fimbriata is an Indian herb used traditionally for obesity. It acts as an appetite suppressant and has been researched for its potential effects on weight management and fat reduction.
What methods were used in the study of Caralluma fimbriata?
The study adhered to PRISMA guidelines, conducting a systematic review of clinical research to evaluate the efficacy of Caralluma fimbriata as an appetite suppressant and anti-obesity agent.
How were the herbal gummy formulations developed in the research?
The gummies were created using agar and gelatin, with various formulations tested for optimal appearance, texture, and the release of active ingredients. Sweeteners and preservatives were also included.
What parameters were measured to evaluate the gummies?
The gummies were assessed for physical appearance, pH, viscosity, drug content, drug release, and stability over time. Various tests ensured they met the required quality standards.
What were the findings related to body weight during the study?
The study found that mice treated with Caralluma fimbriata gummies experienced significant weight loss compared to the obese control group, demonstrating its potential efficacy in weight management.
What were the stability study results for the formulated gummies?
Stability studies indicated that the gummies maintained their physical properties, pH, and viscosity over three months, confirming their stability and suitability as a long-term weight loss supplement.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Herbal gummy formulation of Carralluma fimbriata for weight loss.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'drugs' encompasses various substances used for medical purposes, particularly in treating specific conditions. In this study, the focus is on herbal drugs derived from Caralluma fimbriata, examining their effectiveness and safety as alternatives to traditional pharmacological interventions for obesity.
2) Gelatin:
Gelatin is a gelling agent derived from collagen, often used in food and pharmaceuticals. In this study, gelatin plays a critical role in formulating the edible gummy, providing structure and texture, enhancing palatability, and ensuring effective delivery of Caralluma fimbriata extracts for weight loss.
3) Table:
The term 'table' in this study refers to the organized presentation of data, including results from experimental trials. Tables are essential tools for summarizing findings, like the effects of the formulated gummies on body weight and drug concentration, making complex information accessible and understandable.
4) Animal:
The use of 'animals' in this research underscores the animal testing component necessary for preclinical trials. The Swiss albino mice serve as models for understanding metabolic responses to the gummies, allowing researchers to assess therapeutic outcomes and side effects relevant to human health.
5) Study (Studying):
The word 'study' indicates a structured investigation aimed at uncovering specific information or insights. This particular study assesses the formulation and evaluation of herbal gummies containing Caralluma fimbriata, measuring their effectiveness as an appetite suppressant in combating obesity, highlighting its scientific importance.
6) India:
India is highlighted as the origin of Caralluma fimbriata, illustrating the plant's traditional use in local medicine. The country is also significant as a source of research into herbal remedies for obesity, emphasizing the cultural and scientific context of this study within Indian ethnobotany.
7) Diet:
The term 'diet' refers to the kinds of food consumed. In the context of the study, it relates to the impact of different dietary conditions on the obesity of experimental mice, highlighting the relationship between nutritional intake and the effectiveness of anti-obesity treatments.
8) Medicine:
The phrase 'the medicine' can denote the specific formulation or the active ingredient derived from Caralluma fimbriata investigated for its therapeutic effects. Understanding its efficacy in treating obesity is crucial for validating its use in clinical practice.
9) Science (Scientific):
Science denotes the systematic pursuit of knowledge through observation and experimentation. This study exemplifies scientific inquiry in pharmacology by investigating the compounds in Caralluma fimbriata, introducing new findings about herbal treatments aimed at addressing obesity through well-defined methodologies.
10) Water:
Water is a fundamental solvent used in the extraction process of plant compounds. In the herbal gummy formulation, water plays a critical role as a medium for dissolving ingredients, ensuring effective extraction of bioactive substances from Caralluma fimbriata that contribute to its weight loss properties.
11) Sugar:
Sugar is used in the formulation of the gummies to enhance sweetness and improve taste, making them more palatable. The inclusion of sugar also relates to discussions about dietary sugar intake in obesity management, highlighting the need for balanced formulations in functional foods.
12) Food:
Food refers to any substance consumed for nutritional support. This study investigates gummies as a functional food product designed for weight management, merging concepts of diet, nutrition, and medicinal properties inherent in Caralluma fimbriata, thus bridging culinary and pharmacological knowledge.
13) Phytochemical:
Phytochemicals are bioactive compounds derived from plants that may have health benefits. This study analyzes the phytochemical profile of Caralluma fimbriata, focusing on how these compounds contribute to its anti-obesity effects, vital for developing effective herbal supplements and understanding their mechanisms.
14) Pharmacology:
Pharmacology is the branch of medicine concerned with the study of drugs and their effects on biological systems. This research emphasizes pharmacological principles by exploring how Caralluma fimbriata acts as an appetite suppressant, contributing to the scientific discourse on herbal medicines.
15) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is the Indian state where the research is conducted, emphasizing local flora and traditional uses. The geographic context is significant in this study to assess the efficacy of Caralluma fimbriata, illustrating the importance of regional plants in the search for obesity treatments.
16) Measurement:
Measurement in this research pertains to quantifying the efficacy of the herbal gummies. Techniques like weight assessment and drug concentration analysis are employed to provide objective data, ensuring that findings are statistically valid and reliable, contributing to the overall integrity of the study.
17) Substance:
Substances refer to the various active components derived from Caralluma fimbriata that contribute to its medicinal properties. Analyzing these substances helps clarify their roles in weight management and provides a framework for future research on similar herbal compounds.
18) Stiffness:
Stiffness relates to the physical characteristics of the formulated gummies, affecting their texture and mouthfeel. Understanding the stiffness is important for consumer acceptance and delivery dynamics of the gummy, as it relates to how the product behaves during consumption.
19) Pravara:
Pravara refers to the educational institution involved in this research study, contributing to the academic foundation from which the research is conducted. The association highlights the role of academic institutions in advancing knowledge in pharmacology and herbal medicine.
20) Disease:
Disease denotes an impairment of health or a condition of abnormal functioning. This study addresses obesity, classified as a disease due to its associated health risks. Understanding herbal remedies aligns with the broader goal of managing and treating chronic health conditions effectively.
21) Powder:
Powder may refer to the powdered form of herbal extracts used in the gummy formulation. The processing into powder is essential for consistency and accurate dosing, ensuring that the therapeutic benefits of Caralluma fimbriata are effectively delivered in the final product.
22) House:
Houses could refer to the facilities where experimental animals are maintained and cared for. Proper housing conditions are essential for ensuring the health of subjects, directly influencing the reliability of experimental outcomes.
23) Calculation:
Calculation relates to the methodical process of quantifying data to derive meaningful results. This study involves calculations for evaluating drug dosage, treatment efficacy, and statistical significance, ensuring that the findings are supported by a robust analysis.
24) Discussion:
Discussion refers to the analysis and interpretation of research findings. In this study, the discussion evaluates implications regarding the effectiveness of Caralluma fimbriata, contextualizing results within existing literature and considering future research directions and practical applications.
25) Depression:
Depression may be referenced concerning the comorbidities associated with obesity. The study's investigation into weight management through herbal remedies like Caralluma fimbriata highlights the importance of addressing underlying psychological conditions as part of holistic treatment strategies.
26) Vaishnavi (Vaisnavi):
Vaishnavi is likely a reference to an individual involved in the study, indicating collaboration in research efforts. Her inclusion signifies the importance of teamwork in academic research, where different expertise and perspectives converge to enhance the study's quality.
27) Relative:
Relative may denote a comparison in terms of control versus test groups within the study. Evaluating relative efficacy is critical in determining how the new formulation compares against existing treatments for obesity.
28) Painting:
Similar to 'paintings', 'painting' may represent visual context or the broader narrative regarding research themes. An analogy could be drawn between the complexity of addressing obesity and the layers depicted in an intricate painting.
29) Nandini (Namdini):
Nandini is likely a collaborator or researcher associated with the study, underscoring the collaborative nature of scientific research. Each contributor brings unique expertise that is essential in navigating complex topics such as obesity and herbal medicine efficacy.
30) Shivani (Sivani):
Shivani appears to be another collaborator or researcher involved in this study. Her contributions are important in illustrating the collective effort of a research team to explore effective formulations aimed at combating obesity and enhancing public health.
31) Kandula (Kamdula):
Kandula may refer to the researcher or an associated team member whose expertise is critical to this study's success. The diversity of skills among collaborators leads to comprehensive interpretations of data and research findings.
32) Quality:
Quality pertains to the attributes of the herbal gummy formulations, including safety, efficacy, and consumer acceptability. Ensuring high quality in development is vital for fostering trust among consumers and validation within the broader healthcare frameworks.
33) Cutting:
Cutting may refer to the process of preparing plant material for extraction or creating gummies. This procedural aspect emphasizes the importance of precision and methodical approaches in the formulation of effective herbal treatments.
34) Mishra (Misra):
Mishra likely refers to a researcher or author connected to the study. Acknowledging individuals such as Mishra emphasizes the importance of recognizing contributions to scientific literature and the diverse roles needed in interdisciplinary research contexts.
35) Wardha:
Wardha is the district in Maharashtra, India, where Caralluma fimbriata was collected for this study. This geographical context helps ground the research in local practices and emphasizes the significance of regional biodiversity in developing herbal solutions.
36) Cancer:
Cancer is mentioned in connection with obesity's comorbidity risks. Understanding the relationship between obesity and cancer underscores the necessity of addressing obesity and its associated health risks through effective interventions and public health strategies.
37) Sharman (Sarma, Sarman, Sharma):
Sharma likely denotes a researcher involved in the study, reinforcing the collaborative efforts required for complex investigations like this. Individual contributions are critical for achieving reliable outcomes and broadening the understanding of herbal efficacy in weight management.
38) Famine:
Famine highlights the historical usage of Caralluma fimbriata as a food source during scarcity, showcasing its cultural significance. This historical perspective emphasizes the plant's nutritional aspects and potential benefits beyond modern therapeutic applications.
39) Nagapura (Naga-pura):
Nagpur is the city in Maharashtra from which Caralluma fimbriata was gathered. The importance of local flora in the formulation of effective medicinal products is reflected in the research context, emphasizing a connection to Indian traditional medicine.
40) Indian:
Indian not only refers to the geographical context but also emphasizes the cultural heritage associated with the use of plants like Caralluma fimbriata in traditional medicine. This cultural lens is crucial in understanding the relevance of herbal treatments in the broader medical landscape.
41) Filling (Filled):
Filled pertains to the formulation aspect where the gummy contains active extracts. This characteristic underscores the significance of ingredient composition in developing health products intended for specific therapeutic benefits, such as weight management.
42) Botany:
Botany is the scientific study of plants and their uses, which is foundational in herbal research. This study involves botanical knowledge to understand the properties and potential health benefits of Caralluma fimbriata in treating obesity.
43) Kaila:
Kaila could indicate a collaborator or researcher involved in the study. Recognizing each individual’s role in research underscores the collective effort needed to advance knowledge and develop effective health interventions.
44) Gupta:
Gupta likely refers to a contributor in the study, emphasizing the collaborative nature of research. Acknowledging multiple authors reflects the merging of expertise and perspectives necessary for addressing multifaceted health issues like obesity.
45) Priya:
Priya may denote a researcher associated with the study, showcasing the diverse team required for scientific investigations. Each member's unique contributions enrich the research outcomes, enhancing the understanding of the tested formulations.
46) Patil:
Patil is potentially a researcher contributing to the study, highlighting collaboration in scientific endeavors. Each team member plays a vital role in ensuring rigorous investigation and effective outcomes in the context of herbal treatments.
47) Kadam:
Kadam may refer to an individual involved in the research team. Acknowledging scientists' contributions emphasizes the teamwork foundational to scientific progress and the importance of diverse skill sets in complex research areas.
48) Ulcer:
Ulcer may relate to conditions being investigated alongside obesity. References to ulcers in pharmacological contexts may indicate the importance of understanding multi-faceted health conditions that require careful treatment approaches.
49) Trade:
Trade may refer to the commercialization aspect of herbal remedies like Caralluma fimbriata. Understanding the trade dynamics surrounding these products highlights the intersection of traditional knowledge and modern herbal markets.
50) Death:
Death may relate to the severe consequences of obesity, highlighting its potential mortality risks. Understanding these aspects emphasizes the urgency of effective interventions and the need for research that focuses on enhancing health outcomes.
51) Para (Para°, Párá):
Para may refer to specific paragraphing within the study or contexts within which Caralluma fimbriata is discussed. Clear sectioning helps organize information for better understanding and facilitates effective communication of research findings.
52) Naga (Nag):
Naga could indicate a collaborator or be associated with geographical or cultural contexts relevant to the study. Recognizing diverse contributions and influences enhances the research narrative, providing a more holistic view of the subject matter.
53) Pune:
Pune is another city in Maharashtra, India, highlighting the geographical context of the research. It may refer to the institutions involved or contribute to the traditional knowledge related to the use of Caralluma fimbriata in local medicine.
54) Life:
Life may refer broadly to the context of health and personal well-being concerning obesity. Understanding the implications of weight management emphasizes the importance of research into effective treatments that can enhance quality of life.
55) Rat:
Rats are often used in biomedical studies as model organisms. While this study focuses on mice, referring to rats underscores the broader spectrum of animal models utilized in obesity research, illustrating techniques applicable across various species.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Herbal gummy formulation of Carralluma fimbriata for weight loss.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Phytochemical screening, Clinical research, Systematic Review, Obesity prevalence, Weight loss, Soxhlet extraction, High-fat diet, Stability Studies, Nutraceutical formulation, UV-visible spectrophotometer, Experimental animal, Appetite suppressant, Dose form, Phytochemical component.
Concepts being referred in other categories, contexts and sources.