Development and Characterization of Herbal-Based Liposomal Gel
development and characterization of herbal based liposomal gel for treatment of inflammation
Journal name: World Journal of Pharmaceutical Research
Original article title: An overview
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: the novel carrier for vesicular drug delivery system
Original source:
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Dinesh Chandra, Kamlesh Km Yadav, Vijay Kumar Singh, Anand Patel,Shashi Chaurasia
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: An overview
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
The development of herbal-based liposomal gels has garnered significant attention in recent years due to their potential to enhance the bioavailability and therapeutic efficacy of various pharmaceutical and cosmetic formulations. These innovative systems combine lipid-based vesicles with herbal extracts, resulting in a unique drug delivery mechanism that protects active ingredients, regulates their release, and improves penetration into the skin. The review conducted by Ajmal et al. emphasizes the advantages of liposomal gels over traditional gel formulations, such as improved controlled release and targeted drug delivery, thereby offering better therapeutic outcomes with fewer systemic side effects.
Enhanced Delivery Efficiency
One of the most critical features of herbal-based liposomal gels is their superior drug delivery efficiency. Liposomes, which are spherical vesicles composed of lipid bilayers, can encapsulate both hydrophilic and hydrophobic herbal extracts. This encapsulation not only prevents the degradation of active ingredients but also stabilizes them during storage and application. Unlike traditional gels, which often provide burst releases of active compounds, liposomal gels enable controlled release, resulting in prolonged therapeutic effects. This unique delivery mechanism enhances the bioavailability of the herbal components and ensures that the desired effects are achieved effectively.
Targeted Delivery Mechanism
Another significant advantage of herbal-based liposomal gels lies in their ability to facilitate targeted delivery of active ingredients. By functionalizing the surface of liposomes with specific ligands or antibodies, these gels can selectively direct herbal constituents to specific tissues or cells. This targeted approach minimizes systemic exposure and reduces the risk of adverse effects, making these formulations safer and more effective than conventional herbal gels. Traditional herbal gels often lack the precision offered by liposomal systems, which enhances the overall therapeutic efficacy and offers new opportunities for local treatments.
Importance of Characterization
The characterization of herbal-based liposomal gels is essential for assessing their physicochemical properties and therapeutic potential. Various techniques, such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM), are employed to analyze the morphology and size distribution of liposomes. Furthermore, parameters like zeta potential, drug content, and stability studies provide critical insights into the formulation's stability, release profiles, and overall functionality. These characterization efforts ensure that the gels maintain desirable qualities for topical application and effective delivery of herbal extracts.
Conclusion
In conclusion, the development and characterization of herbal-based liposomal gels represent a significant advancement in drug delivery and skincare technologies. This innovative formulation showcases enhanced drug delivery efficiency, targeted distribution, and better user experience compared to traditional herbal gels. The findings highlight liposomal gels' potential to improve the medicinal properties of herbal extracts, suggesting that future research and clinical studies will be crucial for validating their efficacy and safety for various therapeutic and cosmetic applications. Ultimately, this evolution in formulation technology promises to provide more effective natural remedies in the field of healthcare.
FAQ section (important questions/answers):
What is the focus of Ajmal et al.'s research on herbal gels?
Ajmal et al. focus on developing and characterizing herbal-based liposomal gels, exploring their potential in improving bioavailability and therapeutic effectiveness compared to traditional gel formulations.
What are the main advantages of liposomal gels over traditional gels?
Liposomal gels offer controlled release, targeted delivery, enhanced skin penetration, and improved stability of active ingredients, leading to more effective treatment outcomes with fewer systemic side effects.
How do liposomes enhance drug delivery for herbal extracts?
Liposomes encapsulate herbal extracts, protecting them from degradation and allowing sustained release. This enhances drug delivery efficiency and bioavailability compared to conventional herbal gel formulations.
What methodologies are used to prepare herbal-based liposomal gels?
Common methods include thin-film hydration, reverse phase evaporation, and sonication, which help create liposomes with desired size and encapsulation efficiency for herbal extracts.
What tests are performed to characterize herbal-based liposomal gels?
Characterization tests include morphological studies using SEM and TEM, as well as assessing particle size, zeta potential, encapsulation efficiency, and stability of the liposomal gel.
What are potential applications for herbal-based liposomal gels?
They can be used in pharmaceuticals for targeted drug delivery, in skincare for improved product efficacy, and in nutraceuticals to enhance absorption of beneficial herbal compounds.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Development and Characterization of Herbal-Based Liposomal Gel”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
Drugs are chemical substances used in the diagnosis, treatment, or prevention of diseases. In liposomal gels, encapsulating drugs within liposomes enhances their stability and absorption, maximizing therapeutic effects and minimizing side effects when applied topically or systemically.
2) Medicine:
Medicines are substances with therapeutic properties used for treating diseases and health conditions. The exploration of herbal-based formulations emphasizes the role of traditional medicines, incorporating innovative delivery systems like liposomal gels to improve efficacy and safety.
3) Substance:
A 'substance' is a specific form of matter with a particular composition and properties. In drug formulation, substances are often a focus of study to determine their efficacy and safety. Correct characterization of substances is crucial to ensuring optimal therapeutic outcomes within liposomal gel formulations.
4) Surface:
In this context, 'surface' refers to the outer layer of liposomes or gels, which interacts with skin or other biological tissues. Optimizing the surface characteristics of liposomal gels, such as charge and functionality, can significantly affect drug delivery efficiency and skin absorption of herbal extracts.
5) Study (Studying):
The phrase 'the study' may refer to specific research efforts investigating a phenomenon or area. In the context of liposomal gels, the study includes examining physicochemical properties, formulation techniques, and the overall efficacy of herbal plant extracts in targeted drug delivery.
6) Measurement:
Measurements denote the quantitative assessment of specific properties in a study. Accurate measurements of particle size, surface charge, and encapsulation efficiency are crucial in evaluating the formulation of liposomal gels for their efficacy in drug delivery applications.
7) Cutting:
The term 'cutting' in this context may refer to cutting-edge technology or methods in the development of liposomal gel formulations. Cutting-edge implies the use of the latest advancements in science and technology to innovate and enhance the effectiveness of herbal preparations.
8) Science (Scientific):
Scientific relates to the systematic pursuit of knowledge through observation and experimentation. In herbal drug formulations, scientific methods are used to characterize liposomal gels, validating their properties and effectiveness in delivering herbal extracts.
9) Field:
Fields refer to specific domains of study or expertise. In the context of liposomal gels, various fields such as pharmacology, herbal medicine, and nanotechnology intersect to drive research forward, enhancing drug delivery methods and therapeutic efficacy.
10) Transmission:
Transmission refers to the process by which something is conveyed. In the context of liposomal gels, it may indicate the technology for delivering herbal medications to intended sites through controlled release mechanisms, enhancing the effectiveness of therapeutic interventions.
11) Inflammation:
Inflammation is a biological process characterized by redness, heat, swelling, and pain, often in response to injury or infection. Many herbal therapies aim to address inflammation, and using liposomal gels can enhance the delivery of anti-inflammatory herbal compounds directly to affected areas.
12) Performance:
The term 'performance' relates to the efficiency or effectiveness of a product or system. In liposomal gels, performance is evaluated based on their ability to deliver herbal active ingredients effectively, ensuring optimal therapeutic outcomes and patient satisfaction.
13) Nature:
Nature refers to the inherent qualities or characteristics of a substance. In the context of herbal medicine, the nature of active ingredients within liposomal gels plays a critical role in determining their bioactivity and therapeutic potential when administered to patients.
14) Life:
Life refers to the condition characteristic of organisms that exhibit biological processes. The development of herbal-based liposomal gels aims to improve health and wellness, ultimately enhancing the quality of life for individuals through effective treatments and therapeutic strategies.
15) Pharmacological:
Pharmacological relates to the study of drug action and its effects on living systems. In the context of herbal-based liposomal gels, pharmacological studies assess the efficacy, safety, and mechanisms of herbal extracts when enhanced by advanced delivery systems.
16) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit bacterial growth or kill bacteria. Herbal extracts incorporated into liposomal gels can exhibit antibacterial properties, providing a dual benefit of effective delivery and combating infections through enhanced skin penetration.
17) Developing:
Developing pertains to the process of creating and improving products. In pharmaceutical research, developing herbal-based liposomal gels focuses on improving formulation techniques, enhancing therapeutic delivery, and ensuring the stability and efficacy of herbal extracts.
18) Flavonoid:
Flavonoid refers specifically to members of the flavonoid class, which are known for their beneficial health effects. The incorporation of flavonoids in herbal gels enhances their antioxidant properties, crucial for therapeutic applications geared towards oxidative stress and inflammation.
19) Knowledge:
Knowledge refers to the information and understanding about a subject. In the context of herbal-based liposomal gels, knowledge drives research initiatives aimed at improving formulations and therapeutic efficacy, leading to innovative healthcare solutions.
20) Container:
A 'container' refers to a vessel or medium used to hold substances. In liposomal gel formulations, the liposome acts as a container for herbal extracts, providing protection and controlled release upon application for better therapeutic effects.
21) Resolving:
Resolving pertains to finding solutions or addressing issues. In the context of herbal-based formulations, resolving challenges related to stability and delivery mechanisms is crucial for developing effective liposomal gels that maximize therapeutic benefits.
22) Activity:
Activity refers to the functionality or efficacy of a substance. In the context of herbal-based liposomal gels, the activity of encapsulated extracts is crucial for determining their therapeutic efficacy and overall contribution to health treatments.
23) Relative:
Relative indicates the consideration of one thing in relation to another. In studies concerning herbal-based liposomal gels, evaluating relative effectiveness compared to traditional formulations is essential for establishing improvements in drug delivery and therapeutic outcomes.
24) Disease:
Disease refers to a specific pathological condition affecting health. Herbal formulations within liposomal gels are designed to target particular diseases, enhancing the precision and efficacy of treatments through improved delivery and absorption mechanisms.
25) Account:
Account refers to a detailed report or description of something. In the realm of herbal-based liposomal gels, maintaining accurate accounts of formulation processes and research findings is critical to ensure reproducibility and credibility in scientific studies.
26) Repair:
Repair refers to the process of restoring health or function. In dermatological applications, herbal-based liposomal gels aim to enhance tissue repair by delivering active ingredients directly to damaged areas, promoting healing and improving skin health.
27) Water:
Water is a vital solvent in which many biological and chemical processes occur. In liposomal gel formulations, water is an essential component for hydrating lipid layers and facilitating the encapsulation of herbal extracts for effective delivery.
28) Wall:
Wall refers to the singular boundary that encapsulates. In liposomal formulations, the wall consists of lipid bilayers that protect and enclose herbal extracts, allowing for effective targeted drug delivery in therapeutic applications.
29) Hand:
Hand signifies the action of using or manipulating. In developing herbal-based liposomal gels, careful hand-involvement in formulating, characterizing, and testing is vital to achieving optimal textures and delivery capabilities for effective therapeutic solutions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Development and Characterization of Herbal-Based Liposomal Gel’. Further sources in the context of Science might help you critically compare this page with similair documents:
Holistic approach, Herbal medicine, Bioavailability, Biocompatibility, Particle size, Active ingredient, Comprehensive approach, Particle size analysis, Physicochemical assessment, Herbal extract, Natural alternative, First Pass Metabolism, Zeta potential, Traditional herbal formulation, Stability Studies, Nutraceutical formulation, Skincare formulations, Encapsulation efficiency, Zeta potential measurement, Targeted delivery, Enhanced Bioavailability, Liposomal drug delivery system, Skin penetration, Rheological characteristics, Skin compatibility, Herbal-based liposomal gel, Controlled release qualities, Encapsulating herbal extracts, Targeted medication administration, Non-invasive mode of medication delivery, Effective encapsulation, Functionalization of liposomes, Drug delivery efficiency, Long-term viability.