Journal name: World Journal of Pharmaceutical Research
Original article title: Nutraceuticals & human health
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a comprehensive review
Original source:
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Krishma Kumari, Diksha Gupta, Jasmine Kaur Bhatia, Monika Sharma, Sonia Gupta and Isha Arora
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Nutraceuticals & human health
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202314-29336
Copyright (license): WJPR: All rights reserved
Summary of article contents:
1) Introduction
Nutraceuticals are specially designed preparations that combine the concepts of nutrition and pharmaceuticals to provide dietary supplements that aid in the prevention and treatment of diseases. The term "nutraceutical," coined by Dr. Stephen De Felice in 1989, refers to food or portions of food that offer health benefits, including the prevention and treatment of diseases. As the understanding of dietary supplements evolves, there is an increased focus on the efficacy, safety, and toxicity of nutraceuticals. Their growing importance in healthcare is evident, as they are employed not only for nutritional supplementation but also for therapeutic purposes across various health conditions.
2) Nutraceuticals in Cardiovascular Diseases
Cardiovascular diseases (CVDs) are one of the leading causes of mortality worldwide, often resulting from risk factors that can be mitigated through nutritional supplementation. Research indicates that several nutraceuticals effectively manage and prevent CVDs by improving heart function and blood vessel health. Key nutraceuticals include allicin from garlic, which reduces cholesterol levels, omega-3 fatty acids from fish oil that lower mortality rates in heart patients, and soy isoflavones that help reduce cholesterol. The use of these nutraceuticals in conjunction with traditional medications can enhance treatment outcomes and promote heart health.
3) Nutraceuticals in Cancer Treatment
Nutraceuticals play a significant role in supporting cancer treatment, particularly in alleviating the side effects of chemotherapy and radiotherapy. These treatments often come with challenging side effects such as nausea and fatigue, which can diminish the quality of life for patients. Certain natural supplements, such as curcumin from turmeric, have demonstrated cancer-fighting capabilities by inhibiting various stages of cancer progression. Additionally, other compounds like ginger, genistein, and various plants have shown potential in reducing the negative effects of traditional cancer therapies while enhancing their efficacy.
4) Nutraceuticals for Skin Treatment
The skin, being the body's largest organ, plays a crucial role in overall health and protection against environmental damage. Nutraceuticals can address various skin-related ailments and reduce signs of aging. Ingredients like bioactive peptides, carotenoids, and plant extracts have been researched for their ability to improve skin health and mitigate damage caused by factors such as UV exposure. Studies have shown that specific nutraceuticals can enhance collagen production, improve skin hydration, and protect against photoaging, demonstrating their potential in dermatological health and cosmetic applications.
5) Conclusion
Nutraceuticals represent an emerging and significant sector that bridges nutrition and medical treatment. Their potential to supplement dietary needs, prevent diseases like cardiovascular conditions, and support cancer treatment underscores their increasing importance in public health. With a comprehensive understanding of the benefits they offer, healthcare professionals increasingly recognize the role of nutraceuticals in promoting wellness. Continued scientific research and advancements in technology, including the use of nanotechnology in nutraceutical development, are expected to enhance their effectiveness, ensuring better health outcomes and expanding the nutraceutical market further.
FAQ section (important questions/answers):
What are nutraceuticals and their primary benefits?
Nutraceuticals are biologically active food components that support health and prevent disease. They combine nutrition and medicine, offering therapeutic effects and safety for maintaining human health.
How do nutraceuticals differ from regular dietary supplements?
Nutraceuticals are specifically designed to provide health benefits and treat diseases. While both nutraceuticals and dietary supplements offer nutritional support, nutraceuticals involve a more complex formulation and targeted health outcomes.
What role do nutraceuticals play in cardiovascular disease management?
Nutraceuticals can help manage cardiovascular diseases by lowering blood cholesterol levels and maintaining heart health. Ingredients like omega-3 fatty acids, garlic, and soy isoflavones have shown effectiveness in cardiovascular risk reduction.
Can nutraceuticals reduce side effects of cancer treatments?
Yes, certain nutraceuticals can alleviate side effects of chemotherapy and radiotherapy. Natural supplements like ginger and curcumin help mitigate pain, nausea, and fatigue during cancer treatment, enhancing patient comfort.
What are the potential health benefits of probiotics?
Probiotics, a type of nutraceutical, support immune health and digestive function. They can help prevent various health issues by balancing gut microbiota and enhancing nutrient absorption.
How are nutraceutical products regulated globally?
Nutraceuticals are classified as specialized medical products and regulated by health authorities like the FDA or EFSA. Different countries have specific protocols governing their safety, efficacy, and labeling.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Nutraceuticals andamp; human health”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Cancer:
Cancer is a significant focus in the context of nutraceuticals as it represents a major health challenge worldwide. The review discusses how nutraceuticals can alleviate the side effects of conventional cancer treatments like chemotherapy and radiotherapy, highlighting natural compounds that may improve patient outcomes and support overall health.
2) Food:
The food context refers to its dual role in nourishment and as a potential medicinal agent. The review delves into how specific foods can transition into nutraceuticals based on their health-promoting properties, highlighting the evolving understanding of nutrition.
3) Disease:
The term diseases refers to the various conditions that can afflict human health, particularly chronic diseases that nutraceuticals aim to address. By studying the efficacy of bioactive compounds in disease prevention and management, the review emphasizes the growing importance of nutraceuticals in healthcare.
4) Diksa (Diksha):
Diksha Gupta is one of the authors of the review article, contributing her expertise in pharmaceutical sciences. Her role reflects the collaboration among researchers in exploring nutraceuticals' potential benefits, enhancing the understanding of their applications in health and disease management.
5) Radiotherapy:
Radiotherapy is a common treatment for cancer that can have significant side effects. The review investigates how nutraceuticals can act as supportive therapies to alleviate radiotherapy's adverse effects, potentially improving patient comfort and treatment outcomes through natural compounds and dietary supplements.
6) Chemotherapy:
Chemotherapy is another standard cancer treatment that often leads to debilitating side effects. The review discusses how nutraceuticals may mitigate these effects, focusing on specific compounds that enhance patient resilience and support the effectiveness of chemotherapy, underlining the importance of integrative treatment approaches.
7) Blood:
Blood is essential for transporting nutrients and oxygen throughout the body. Nutraceuticals that improve blood health or manage conditions like hypertension and high cholesterol are discussed in the article, demonstrating their role in cardiovascular disease prevention and overall human health maintenance.
8) Fish:
Fish, specifically varieties rich in omega-3 fatty acids, are highlighted as critical dietary sources known for their cardiovascular benefits. The review examines how fish oil supplementation can reduce mortality rates and improve heart health, emphasizing the significance of incorporating fish into a healthy diet.
9) Drug:
Drugs are conventional medicinal substances used to treat diseases. The review explores the synergistic potential of nutraceuticals alongside drugs, advocating for a holistic approach to treatment that combines pharmaceuticals with bioactive compounds for improved health outcomes.
10) Substance:
A substance is a specific form of matter with unique properties. The review emphasizes the importance of identifying effective substances in nutraceuticals that can aid in disease prevention and health promotion, contributing to evidence-based dietary recommendations.
11) Animal:
Animals play a vital role in the research of nutraceuticals. The review mentions animal studies that provide foundational insights into the health effects of various nutraceuticals, underscoring the necessity of such research in understanding complex biological systems.
12) Garlic:
Garlic (Allium sativum) is noted for its health-promoting properties, particularly in managing cardiovascular diseases. The review presents evidence supporting garlic's ability to lower cholesterol and improve heart health, showcasing it as a significant nutraceutical with multiple benefits.
13) Gupta:
Gupta refers to Diksha Gupta, one of the authors contributing to the article. Her insights into nutraceuticals reflect a commitment to advancing the understanding of health supplements and their roles in disease prevention and treatment within the pharmaceutical domain.
14) Death:
Death, particularly from preventable diseases, underscores the importance of nutraceuticals in health promotion. The review discusses how effective nutraceuticals can potentially reduce mortality rates associated with chronic conditions, highlighting the urgency of exploring their preventive capabilities.
15) Study (Studying):
Study refers to the research efforts surrounding nutraceuticals, aiming to validate their health benefits and therapeutic applications. The review is a culmination of various studies assessing the impact of nutraceuticals on human health, providing a comprehensive overview of their effectiveness.
16) Diet:
Diet is a fundamental aspect of human health, influencing both well-being and disease outcomes. The review highlights the role of nutraceuticals within dietary frameworks, emphasizing how specific dietary choices can prevent diseases and promote health, aligning with growing trends in nutrition science.
17) Milk:
Milk is a key dietary component that is discussed in the context of nutraceuticals, particularly in relation to bioactive peptides like casein in the management of hypertension. The review recognizes milk as an essential source of nutrients contributing to overall health.
18) Fish oil:
Fish oil is rich in omega-3 fatty acids, known for their numerous health benefits. The review emphasizes the role of fish oil as a nutraceutical, particularly in cardiovascular health, and presents clinical trial evidence supporting its efficacy in reducing heart disease risk.
19) Science (Scientific):
Science represents the foundation of understanding nutraceuticals and their effects on health. The review emphasizes the need for scientific research to substantiate the efficacy and safety of nutraceuticals, crucial for their acceptance in mainstream healthcare.
20) Toxicity:
Toxicity is a critical consideration when assessing the safety of nutraceuticals. The review discusses the importance of evaluating toxic effects and establishing safety profiles for nutraceutical compounds to ensure their safe integration into health and wellness strategies.
21) Medicine:
Medicine represents the broader field aimed at diagnosing and treating illness. The review advocates for integrating nutraceuticals into mainstream medicine as complementary therapies, enhancing patient care and promoting preventive health strategies.
22) Account:
Account in this context pertains to the representation of the global nutraceutical market, highlighting its growth and potential. The review outlines market statistics, indicating an increasing reliance on nutraceuticals for health management and wellness.
23) India:
India is emerging as a significant player in the global nutraceutical market, with substantial growth potential. The review reflects on India’s rising contribution to the market and the increasing consumer demand for health supplements, indicating a shift in health awareness.
24) Sugar:
Sugar is a critical dietary component that, when consumed excessively, can lead to various health issues. The review underscores the importance of addressing dietary sugars and promoting nutraceuticals that may help manage glucose levels and support metabolic health.
25) Table:
Table refers to the organized presentation of information in the review, summarizing the uses of various nutraceuticals for health promotion. It serves as a quick reference for understanding the specific benefits associated with each nutraceutical.
26) Cina:
China plays a pivotal role in the global nutraceutical supply chain, as many raw materials are sourced from Chinese manufacturers. The review discusses the impact of trade dynamics and the COVID-19 pandemic on the availability and production of nutraceuticals.
27) Beta:
Beta refers to beta-carotene, a type of carotenoid discussed in the review for its antioxidant properties and role in skin health. It highlights the importance of beta-carotene in preventing photodamage and supporting overall skin wellness.
28) Pune:
Pune is mentioned as a location associated with the research contributions of one of the authors, Diksha Gupta. The city's involvement in pharmaceutical education underscores the regional importance in advancing research on nutraceuticals and their health applications.
29) Hair:
Hair health is an aspect mentioned in relation to nutraceuticals that can support skin and hair condition. The review discusses how specific bioactive compounds can help combat effects like dryness and brittleness, promoting overall aesthetic wellness.
30) Pain:
Pain management is a critical area of healthcare where nutraceuticals can play a role. The review explores how various bioactive compounds may assist in alleviating pain associated with conditions like arthritis and cancer treatments.
31) Hand:
The hand symbolizes human capability and function, particularly in areas like dexterity and engagement in health-related activities. Although less directly discussed, the review indirectly reflects on the importance of maintaining health for physical functionality, including hand health.
32) Life:
Life encapsulates the essence of health and well-being that nutraceuticals aim to enhance. The review emphasizes the role of nutraceuticals in improving quality of life by preventing diseases, supporting health, and addressing specific health conditions.
33) Allium sativum:
Allium sativum, or garlic, is emphasized in the review for its health benefits, particularly in cardiovascular health. Its bioactive compounds are noted for their ability to regulate cholesterol levels and provide protective effects against heart disease.
34) Transformation (Transform, Transforming):
Transformation refers to the process of altering existing food products or substances into nutraceuticals through scientific advancements. The review discusses how the development of nutraceuticals can lead to better health solutions, particularly in areas like drug formulation and dietary supplements.
35) Antibiotic (Antibacterial):
Anti-bacterial properties are crucial in nutraceuticals, particularly those derived from natural sources. The review examines how certain nutraceutical ingredients can combat bacterial infections and provide therapeutic benefits, highlighting their relevance in maintaining overall health.
36) Inflammation:
Inflammation is a physiological response that, when chronic, can lead to various diseases. The review discusses how nutraceuticals can reduce inflammation and its related health risks, making them important in managing chronic conditions like arthritis and cardiovascular diseases.
37) Observation:
Observation refers to the careful monitoring and analysis of nutraceutical effects on human health. The review emphasizes the importance of systematic observations in clinical research to establish a solid foundation for the effectiveness of nutraceuticals.
38) Agriculture:
Agriculture plays a vital role in providing the raw materials for nutraceuticals. The review mentions how advancements in agricultural practices can affect the quality and availability of nutraceutical ingredients, influencing the overall industry and its growth potential.
39) Perception:
Perception relates to the growing awareness and understanding of nutraceuticals in society. The review highlights how public perception of nutraceuticals is shifting towards acceptance as valuable tools for health promotion and disease prevention.
40) Discussion:
Discussion in the context of the review encompasses the exploration and dialogue surrounding the uses and benefits of nutraceuticals. It provides insights into current research, consumer behavior, and the potential implications of nutraceuticals in health care.
41) Developing:
Developing refers to the ongoing progress in the nutraceuticals industry, which is adapting to new research findings and consumer demands. The review highlights how developing nutraceutical products is crucial in addressing health challenges and enhancing therapeutic options.
42) Depression:
Depression is a mental health condition that nutraceuticals may potentially help manage. The review mentions various compounds that could support mental health, emphasizing the importance of holistic approaches to health and wellness, including dietary interventions.
43) Knowledge:
Knowledge encompasses the understanding of how nutraceuticals function and their potential health benefits. The review aims to enhance knowledge among researchers, healthcare providers, and consumers regarding the role of nutraceuticals in disease prevention and health promotion.
44) Vomiting:
Vomiting is a common side effect associated with various medical treatments, particularly chemotherapy. The review discusses how certain nutraceuticals may alleviate nausea and vomiting, highlighting their importance in improving patient quality of life during cancer treatment.
45) Turmeric:
Turmeric, particularly its active compound curcumin, is highlighted for its anti-inflammatory and anticancer properties. The review discusses its efficacy in mitigating chemotherapy side effects and its potential role in cancer treatment as a complementary therapy.
46) Epidemic:
Epidemic refers to widespread health issues that influence large populations. The review contextualizes the rising interest in nutraceuticals as a response to various health epidemics, emphasizing their preventive capabilities in addressing chronic diseases prevalent in society.
47) Activity:
Activity in this context pertains to the biological effects of nutraceuticals on human health. The review highlights how the active compounds in nutraceuticals can influence health outcomes, fostering a deeper understanding of their therapeutic mechanisms.
48) Pregnant:
Pregnant individuals require special attention regarding nutrition and supplement intake. The review discusses how certain nutraceuticals can safely support health during pregnancy, addressing concerns related to maternal and fetal health.
49) Mineral:
Mineral refers generally to the inorganic compounds vital for health. The review discusses the incorporation of minerals into nutraceuticals, noting their significance in biological processes and potential health benefits in dietary supplements.
50) Jasmine:
Jasmine Kaur Bhatia is mentioned as one of the contributors to the review. Her involvement showcases the collaborative effort in researching nutraceuticals and supports the collective aim of advancing knowledge in the pharmaceutical sciences.
51) Kumari:
Kumari refers to Krishma Kumari, another contributor to the research article. Her participation reflects the collaborative nature of the research effort and denotes the significance of interdisciplinary approaches in studying nutraceutical applications.
52) Nausea:
Nausea is an unpleasant sensation frequently associated with various medical treatments, especially chemotherapy. The review discusses how specific nutraceuticals may help relieve nausea, enhancing patient comfort and quality of life during challenging treatments.
53) Sharman (Sarma, Sarman, Sharma):
Sharma refers to Monika Sharma, one of the authors of the review. Her contributions to the paper underline the collaborative effort in exploring nutraceuticals' potential, emphasizing the importance of diverse expertise in advancing the field.
54) Indian:
Indian refers to the context of the burgeoning nutraceutical market in India. The review highlights the potential for growth in the Indian nutraceutical sector, reflecting the increasing consumer interest in health supplements and wellness products.
55) Pulse:
In this context, pulse refers to legumes that are vital for nutritional intake. The review highlights their significant health benefits and their emerging role as nutraceuticals in disease prevention, emphasizing their versatile applications in dietary practices.
56) Water:
Water is fundamental to life and overall health. The review underscores the importance of adequate hydration in conjunction with nutraceutical intake for optimal health outcomes, advocating for a holistic approach to nutrition and wellness.
57) Trade:
Trade refers to the exchange of goods, including nutraceuticals, which is affected by various economic and global factors. The review discusses how trade dynamics influence the availability and cost of nutraceutical ingredients in the market.
58) Svamin (Swami, Svami, Swamin):
Swami refers to Swami Devi Dyal College of Pharmacy, where some authors are affiliated. It represents the academic backdrop for the research, demonstrating the institution's commitment to advancing pharmaceutical sciences and nutraceutical research.
59) Devi:
Devi is part of the name of Swami Devi Dyal College of Pharmacy, indicating the affiliation of some authors to this academic institution. It highlights the importance of academic collaboration in conducting research on nutraceuticals.
60) Isha (Isa):
Isha Arora is mentioned as an author of the review, contributing her insights into the research on nutraceuticals. Her participation signifies the collaborative effort within academic and research environments focused on health applications.
61) Hemp:
Hemp is mentioned in the context of nutraceuticals due to its rich nutrient profile, including omega fatty acids. The review highlights the potential of hemp-based products in providing health benefits and supporting wellness initiatives.
62) Meat:
Meat sources are discussed regarding their role in providing essential nutrients. The review acknowledges the importance of incorporating balanced amounts of meat within a nutraceutical-focused diet to ensure comprehensive nutritional coverage.
63) Line:
Line refers to a pathway or focus within the context of the review. It may symbolize the line of research or inquiry into the benefits and applications of nutraceuticals in human health.
64) Post:
Post refers to the time or state following significant events, such as the COVID-19 pandemic, which has influenced consumer behavior and market dynamics in the nutraceutical industry. The review addresses how trends have evolved in response to these changes.
65) Viru:
Viru is less directly related in the review and might refer to a name associated with studies or research themes. Its relevance would depend on specific contexts within ongoing research or community health discussions.
66) Oil:
Oils, particularly those rich in healthy fats like olive oil and fish oil, are crucial in the context of nutraceuticals. The review emphasizes their role in enhancing health and preventing diseases, highlighting the importance of including beneficial oils in the diet.
Other Science Concepts:
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Therapeutic effect, Adverse effect, Complementary and alternative medicine, Wound healing, Illness prevention, Dietary needs, Clinical trial, Safety profile, Nanotechnology, Bioavailability, Health Promotion, Anti-inflammatory, Cardiovascular disease, COVID-19 Pandemic, Nutritional supplement, Regulatory organization, Dietary supplement, Cancer prevention, Bioactive peptides, Bioactive compound, Cancer treatment, Skin treatment, Chronic illnesses, Vitamins and minerals, Calcium supplement, Nutraceutical formulation, Covid 19 impact, Nutritional advantages, Biologically active, Omega-3 fatty acid, Department of Pharmacy, Carotenoid, Nutraceutical industry, Nutraceutical growth, European Food Safety Authority, Antioxidant vitamin, Emerging Market, Radiotherapy and chemotherapy, Probiotic supplements, Curcumin from turmeric, Human health care, Manufacturing challenges, Nutraceuticals and human health, Nutraceuticals in cardiovascular diseases, Nutraceuticals for skin treatment, Clinical proof, Skin-related illnesses, General public knowledge, Food-derived bioactive peptides, Nutrition science, Public knowledge, Health advantages, Specialized medical products, Epidemiological target, Nutraceutical medicine, Immune system control.