Herbal drugs for neuroprotection in ischemic stroke
Journal name: World Journal of Pharmaceutical Research
Original article title: Herbal drugs for neuroprotection in ischemic stroke
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Nihar Ranjan Kar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Herbal drugs for neuroprotection in ischemic stroke
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202314-29334
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
1. Introduction
Ischemic stroke, characterized by the obstruction of blood flow to the brain, is a leading cause of disability and mortality worldwide. Conventional treatments, primarily thrombolytic therapies and mechanical thrombectomy, aim to restore blood flow but can pose risks and may not be suitable for all patients. Consequently, there is an increasing interest in alternative therapies, particularly herbal medicines, known for their diverse bioactive components and traditional medicinal use. This review highlights the potential of herbal drugs for neuroprotection and their mechanisms of action in the context of ischemic stroke, emphasizing their role as a viable treatment option.
2. The Pathophysiology of Ischemic Stroke
The pathophysiological stages of ischemic stroke involve a series of damaging processes initiated by ischemia. These include cellular energy failure, excitotoxicity, ion imbalance, inflammatory response, and disruption of the blood-brain barrier. Ischemia leads to inadequate blood supply, resulting in energy depletion (ATP) and the accumulation of toxic metabolites. Subsequent excitotoxicity occurs due to neurotransmitter release, especially glutamate, leading to neuronal cell death. The inflammatory response exacerbates tissue damage, while impaired blood-brain barrier function increases vulnerability to harmful substances. Understanding these mechanisms is crucial for developing effective neuroprotective therapies.
3. Herbal Neuroprotective Agents
A variety of herbal medicines exhibit neuroprotective properties, attributed to their rich bioactive compounds. For example, extracts from Bacopa monnieri enhance nerve cell regeneration and neurotransmitter levels, while Ginkgo biloba's flavonoids improve cerebral blood flow and offer antioxidant benefits. Others, like Ashwagandha and Curcuma longa (turmeric), are known for their anti-inflammatory and antioxidant effects, which protect brain cells from oxidative stress and promote cognitive health. These herbal agents often target multiple pathways involved in ischemic injury, providing a multifaceted approach to neuroprotection.
4. Clinical Trials and the Efficacy of Herbal Medicines
Several herbal drugs have advanced into clinical trials as potential adjuncts for ischemic stroke treatment, with a focus on efficacy, safety, and patient acceptability. However, the variability in individual responses and possible interactions with conventional medications can complicate their therapeutic use. Despite promising preclinical findings, many clinical studies face challenges in terms of design and execution, highlighting the need for standardization and quality control of herbal formulations. Continuous exploration of herbal remedies remains essential for unlocking their full neuroprotective potential.
5. Conclusion
Herbal medicines have been integral to traditional healthcare practices and offer a promising avenue for enhancing neuroprotection in ischemic stroke management. The multifaceted mechanisms of these natural compounds present a significant opportunity to address the limitations of current treatments. However, further research, particularly focused on well-structured clinical trials, is necessary to confirm their efficacy, safety, and optimal dosing in ischemic stroke therapy. With ongoing exploration, herbal drugs may evolve into valuable components of comprehensive stroke treatment regimens.
FAQ section (important questions/answers):
What is ischemic stroke and how does it occur?
Ischemic stroke happens when blood flow to the brain is blocked, typically by a blood clot. This results in neuronal death due to lack of oxygen and glucose, leading to various brain injuries.
What are the conventional treatments for ischemic stroke?
Common treatments include thrombolytic therapy to dissolve clots, mechanical thrombectomy to remove them, anticoagulants to prevent new clots, and rehabilitation therapy for recovery.
What role do herbal drugs play in neuroprotection?
Herbal drugs are believed to possess neuroprotective properties through antioxidant, anti-inflammatory, and neuroregenerative effects, which can mitigate brain damage during ischemic stroke.
Which herbs are considered beneficial for ischemic stroke management?
Promising herbal treatments include Bacopa monnieri, Ginkgo biloba, Curcuma longa, and Ashwagandha, among others. These herbs exhibit various beneficial effects on brain function and neuron protection.
What challenges exist in studying herbal medicines for ischemic stroke?
Challenges include variability in individual responses, potential interactions with conventional medications, and the need for standardized quality control in herbal formulations.
Why is more research needed on herbal neuroprotective agents?
Further research is essential to evaluate the safety, efficacy, and optimal dosages of herbal neuroprotective agents, ensuring their effectiveness as complementary therapies for ischemic stroke.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Herbal drugs for neuroprotection in ischemic stroke”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Disease:
Diseases encompass various pathological conditions impacting health. The article emphasizes the prevalence of ischemic stroke as a significant disease, exploring potential herbal treatments that may address its mechanisms and provide neuroprotection, underlining the urgency for effective management solutions.
2) Blood:
Blood is a vital fluid that circulates in the body, delivering oxygen and nutrients to tissues while removing waste products. The article discusses how ischemic strokes occur due to the obstruction of blood flow to the brain, emphasizing the critical role of blood circulation in maintaining brain health.
3) Drug:
Drugs are substances that can alter physiological or biochemical processes in the body. The article discusses a range of drugs, both synthetic and herbal, that are being researched for their efficacy in treating ischemic stroke, highlighting the potential for innovative therapeutic approaches.
4) Medicine:
Medicines refer to substances that promote healing, alleviate symptoms, or prevent disease. The article discusses various herbal and pharmaceutical medicines. Specifically, it emphasizes the potential of herbal medications for neuroprotection, highlighting their role in enhancing stroke therapy outcomes.
5) Inflammation:
Inflammation is the body’s response to injury or infection, often resulting in pain and swelling. In the context of ischemic stroke, understanding the inflammatory response is crucial, as it exacerbates neuronal damage, making anti-inflammatory herbal compounds an attractive therapeutic avenue.
6) Anxiety:
Anxiety is a mental health condition characterized by excessive worry and fear. The article connects anxiety to stroke recovery, suggesting that certain herbal remedies may offer therapeutic benefits through mechanisms that support mental well-being, thereby playing a role in overall health management.
7) Lion:
Referring to Lion’s Mane Mushroom (Hericium erinaceus), this term underscores its neuroprotective properties. The article discusses this mushroom’s potential benefits in enhancing cognitive function and promoting neuronal regeneration, aligning with the search for natural treatments in the context of ischemic stroke.
8) Ashvagandha (Asvagandha, Ashwagandha, Ashvagamdha, Ashva-gandha):
Ashwagandha (Withania somnifera) is a medicinal herb known for its adaptogenic and neuroprotective properties. The article highlights its role in reducing oxidative stress and neuroinflammation, supporting brain health, and potentially assisting recovery from conditions like stroke.
9) Ashoka (Asoka):
The Ashoka tree (Sarcanea ashoka) is highlighted for its antioxidant properties. The article discusses its potential neuroprotective effects, suggesting its use in traditional medicine to support brain health, particularly in contexts involving stress and neurological recovery after stroke.
10) Kola:
Referring to Gotu Kola (Centella asiatica), this plant is known for its neuroprotective and cognitive-enhancing properties. Its inclusion in the article points to the potential of traditional herbal treatments to support memory and reduce oxidative stress in ischemic stroke management.
11) Depression:
Depression is a mental health disorder characterized by persistent sadness and loss of interest. The article mentions herbal remedies that may alleviate depressive symptoms, indicating their holistic potential benefits for mental health, particularly in stroke recovery scenarios.
12) Flavonoid:
Flavonoid, a specific class of flavonoids, plays a significant role in plant-based therapies. The article discusses its neuroprotective effects, particularly in relation to oxidative stress and neuronal health, underscoring their applicability in ischemic stroke treatment strategies.
13) Turmeric:
Turmeric, particularly its active compound curcumin, is recognized for its potent anti-inflammatory and antioxidant properties. The article highlights its neuroprotective effects, making it a valuable herbal remedy for potentially mitigating damage during ischemic strokes.
14) India:
India is often recognized for its rich history of traditional medicine, particularly Ayurvedic practices. The article emphasizes the availability and cultural significance of herbal remedies like Ashwagandha and Brahmi, which are used for neuroprotection and cognitive enhancement.
15) Edema (Oedema):
Edema refers to swelling caused by excess fluid accumulation in tissues. The article emphasizes understanding cerebral edema in the context of stroke, informing the rationale behind using certain herbal drugs that may mitigate swelling and support recovery.
16) Death:
Death, particularly in the context of ischemic stroke, is a significant concern as stroke is a leading cause of mortality. The article highlights the necessity of timely interventions and the potential of herbal remedies to reduce mortality and improve patient outcomes.
17) Substance:
A substance is any material with a definite composition, including bioactive compounds from herbal sources. The article highlights various substances derived from plants that possess neuroprotective properties relevant for treating stroke and supporting cognitive health.
18) Species:
Species refers to distinct classifications of organisms. The article mentions various plant species with potential neuroprotective effects, showcasing the importance of biodiversity in discovering novel treatment options for chronic conditions like ischemic stroke.
19) Study (Studying):
The study refers to research investigations focusing on herbal medicines' effects on ischemic strokes. The article underscores the importance of such studies in identifying effective treatments, contributing to the broader scientific understanding of neuroprotective therapies.
20) Mud:
Mood describes a temporary emotional state that could be positively or negatively influenced. The article discusses herbal remedies that may improve mood and cognitive function, particularly in the context of recovery for patients experiencing stroke-related emotional disturbances.
21) Trigonella foenum-graecum:
Trigonella foenum-graecum, commonly known as fenugreek, is highlighted for its antioxidant, anti-inflammatory, and neuroprotective effects. The article discusses these properties, emphasizing the role of fenugreek as a potential therapeutic agent in managing conditions like ischemic stroke.
22) Crocus sativus:
Crocus sativus, commonly known as saffron, showcases antioxidant properties. The article includes saffron as a potential herbal remedy for neuroprotection, indicating its value in traditional medicine for addressing neurodegenerative conditions and cognitive decline.
23) Curcuma longa:
Curcuma longa, or turmeric, is predominantly noted for curcumin, which exhibits potent neuroprotective properties. The article discusses its use in traditional medicine, underscoring its antioxidant and anti-inflammatory actions beneficial for conditions like ischemic stroke.
24) Mental health:
Mental health encompasses emotional and psychological well-being. The article connects potential herbal remedies to improved mental health outcomes, particularly in stroke recovery scenes, suggesting a holistic approach that includes psychological considerations alongside physical rehabilitation.
25) Vitis vinifera:
Vitis vinifera, known as grapevine, is highlighted for resveratrol’s beneficial properties. The article discusses this compound's potential neuroprotective effects against neurodegenerative diseases, reinforcing the therapeutic promise of herbal substances in contemporary health approaches.
26) Knowledge:
Knowledge is the understanding gained through experience or education. The article emphasizes the importance of acquiring knowledge about herbal medications and their mechanisms to develop effective treatments for ischemic stroke while recognizing the gaps that still need to be addressed through research.
27) Gopalpur:
Gopalpur is a location in India associated with Centurion University of Technology and Management, where research on herbal medicines is conducted. Mentioning Gopalpur in the article connects regional knowledge, traditional medicine practices, and academic exploration of herbal remedies for health.
28) Learning:
Learning involves acquiring knowledge and skills through experience or education. The article implies the necessity of continuous learning and understanding the therapeutic potentials of herbal remedies in improving treatment outcomes for ischemic stroke and other diseases.
29) Quality:
Quality refers to the standard or grade of something. The article highlights the importance of quality control in herbal medicine research, suggesting that maintaining high-quality standards in formulations and studies is essential for ensuring safety and efficacy in therapeutic applications.
30) Cutting:
Cutting generally refers to the act of dividing or reducing. In the context of the article, it could symbolize cutting-edge research in herbal medicine, signifying innovative approaches and advancements aimed at improving treatment efficacy in neuroprotection.
31) Ranjan (Ramjan):
Ranjan refers to Nihar Ranjan Kar, the corresponding author of the article. The mention of his name personalizes the ongoing research into herbal therapies for ischemic stroke, hinting at individual contributions to the broader discourse around neuroprotective treatments.
32) Family:
Family can refer to the biological classification of organisms or familial ties. In this context, it could relate to traditional knowledge passed down through families regarding herbal medicine use and the importance of cultural practices in health management.
33) Animal:
Animal refers to living organisms that belong to the animal kingdom. The article mentions preclinical studies done on animal models to evaluate the efficacy of herbal neuroprotectants, highlighting the relevance of such studies in understanding potential human applications.
34) Water:
Water is an essential component of life and is vital for numerous physiological processes. In the article, references to aquatic plants might symbolize the importance of ecological diversity in sourcing herbal remedies for neuroprotection.
35) Viti:
Viti typically refers to Vitis vinifera, the grapevine species. Its inclusion in the article highlights the significance of grape-derived compounds like resveratrol that are being studied for their neuroprotective effects, connecting traditional uses to modern pharmacological research.
36) Beta:
Beta can refer to beta-amyloid, associated with neurodegenerative diseases like Alzheimer’s. The article's focus on neuroprotective compounds hints at the search for remedies that mitigate such pathological mechanisms in strokes and cognitive decline.
37) Tree:
Tree can refer to plants that are used for their medicinal properties. The article mentions various trees that provide herbal compounds used in traditional medicine, illustrating the role of plant biodiversity in therapeutic applications.
38) Line:
Line may refer to a lineage or category. The mention in the article could relate to the exploration of different lines of research investigating herbal therapies, tracing historical uses to current scientific inquiries into neuroprotection.
39) Post:
Post can refer to after or subsequent occurrences. In the context of the article, it emphasizes the importance of post-stroke rehabilitation and management strategies, suggesting that attention to recovery phases is crucial for improving health outcomes.
40) Life:
Life refers to the state of being alive and encompasses physical, mental, and social well-being. The article emphasizes the impact of ischemic stroke on life, underscoring the need for effective treatments that restore and enhance the quality of life for affected individuals.
41) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is noted for its anti-inflammatory and antioxidant properties. The article discusses its potential application in reducing oxidative stress, making it relevant in herbal therapies targeting neuroprotection and stroke management.
42) Withania somnifera:
Withania somnifera, or ashwagandha, is significant for its adaptogenic and neuroprotective properties. The article emphasizes its role in combating stress and fostering brain health, aligning with the search for effective herbal treatments in ischemic stroke recovery.
43) Fish oil:
Fish oil is rich in omega-3 fatty acids, known for their neuroprotective benefits. The article mentions fish oil as a dietary supplement with potential positive effects on brain health, particularly as part of an integrative approach to stroke prevention and recovery.
44) Allium sativum:
Allium sativum, or garlic, is noted for its anticoagulant properties. The article discusses its potential benefits in preventing ischemic strokes, showcasing its place in traditional medicine and the continued relevance of studying natural remedies.
45) Phytochemical:
Phytochemical is a term for a specific group of phytochemicals. The article emphasizes their complexities and interactions that might play a significant role in neuroprotection, suggesting that targeted phytochemical research is vital for enhancing therapeutic outcomes.
46) Transmission:
Transmission refers to the transfer of signals or information. The article discusses neurotransmission processes crucial for cognitive function, highlighting herbal remedies that may enhance neurotransmission, thereby supporting mental health and cognitive performance post-stroke.
47) Performance:
Performance refers to the effectiveness of an individual, often in cognitive or physical tasks. The article suggests that certain herbal remedies can enhance cognitive performance, particularly in recovering stroke patients, linking herbal therapy to improved functional outcomes.
48) Developing:
Developing refers to the process of growth or advancement. The article discusses developing herbal therapies in ischemic stroke management, indicating an ongoing effort to explore and validate natural approaches for neurological health.
49) Accumulation (Accumulating, Accumulate):
Accumulate refers to the process of gathering over time. In the context of the article, it illustrates how oxidative stress or other harmful factors can accumulate in stroke pathology, necessitating effective treatments to counteract these effects.
50) Fenugreek:
Fenugreek (Trigonella foenum-graecum) is noted for its neuroprotective benefits. The article highlights its properties that may support cognitive health, emphasizing its relevance as an herbal remedy in the broader context of stroke management.
51) Suffering:
Suffering pertains to the experience of pain or distress. The article highlights the emotional and physical suffering experienced during and after strokes, underscoring the importance of comprehensive care that addresses both medical and psychological needs.
52) Swelling:
Swelling refers to inflammation resulting from fluid accumulation in tissues. In the context of strokes, it highlights the effects of edema on brain health, emphasizing the need for treatments that address swelling as part of recovery.
53) Activity:
Activity pertains to the dynamic processes occurring within biological systems. The article mentions the activity of bioactive compounds from herbal sources, emphasizing their role in enhancing neuronal function and supporting recovery from ischemic injury.
54) Bleeding:
Bleeding refers to the loss of blood due to vessel rupture. The article discusses the risk of bleeding in stroke management, particularly concerning thrombolytic therapies, which raises the importance of careful intervention strategies.
55) Brahmi:
Brahmi (Bacopa monnieri) is highlighted for its cognitive-enhancing properties. The article emphasizes its longstanding use in traditional medicine to support mental clarity, illustrating the growing interest in its neuroprotective benefits in contemporary research.
56) Repair:
Repair refers to the restoration of damaged tissues. The article emphasizes the potential of herbal compounds to foster neuronal repair post-stroke, highlighting their relevance in promoting recovery and overall brain health.
57) Garlic:
Garlic (Allium sativum) is noted for its health benefits, particularly its potential as an anticoagulant. The article discusses its applications in traditional medicine and its possible role in preventing ischemic strokes, linking dietary choices with health outcomes.
58) Reason:
Reason refers to the underlying motives or justification for actions. The article outlines the reasons for exploring herbal treatments in stroke management, highlighting the need for safe, effective, and holistic approaches to patient care.
59) Chaga:
Chaga (Inonotus obliquus) is a mushroom with antioxidant and anti-inflammatory properties. The article mentions its potential neuroprotective effects, illustrating the growing interest in including lesser-known herbal remedies in the conversation around stroke recovery.
60) Field:
Field refers to a particular domain of study or practice. The article situates herbal medicine within the broader field of pharmacology and neuroscience, highlighting the intersection of traditional knowledge with modern scientific research in health care.
61) Cina:
China is significant for its extensive use of herbal medicine throughout history. The article mentions traditional Chinese herbs in stroke management, underscoring the continued relevance of ancient practices in contemporary therapeutic settings.
62) Wall:
Wall can refer to the integrity of biological barriers, such as the blood-brain barrier. The article stresses the importance of understanding how various treatments can influence the stability of these critical protective walls during ischemic events.
63) Sage:
Sage (Salvia officinalis) is noted for its antioxidant and anti-inflammatory properties. The article discusses its applications in herbal medicine, suggesting its potential benefits in managing conditions related to cognitive decline and neuroprotection.
64) Pose:
Pose refers to presenting or presenting a challenge. In the context of the article, it emphasizes the various challenges presented by ischemic strokes, underscoring the need for efficient and effective management strategies that address these issues.
65) Fish:
Fish refers to aquatic animals often rich in omega-3 fatty acids. The article mentions fish oil's beneficial properties for brain health, highlighting the nutritional aspects of stroke prevention and recovery strategies.
66) Milk:
Milk, noted for its nutritional value, signifies the importance of dietary choices in promoting health. Although not directly addressed, its inclusion may highlight the significance of nutrition as part of a holistic approach to health management.
67) Pur:
Poor refers to inadequate health or insufficient resources. The article builds upon the idea that poor health outcomes in stroke incidence necessitate effective therapeutic measures, particularly highlighting the need for accessible and safe herbal treatment options to mitigate such conditions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Herbal drugs for neuroprotection in ischemic stroke’. Further sources in the context of Science might help you critically compare this page with similair documents:
Ginkgo biloba, Traditional medicine, Herbal medicine, Clinical trial, Oxidative stress, Ischemic Stroke, Neuroprotective agent, Acupuncture therapy, Curcumin, Bacopa monnieri, Antioxidant, Cerebral blood flow, Herbal extract, Nutraceutical, Recovery process, Rehabilitation therapy, Thrombolytic therapy, Anti-inflammatory compound, Antiplatelet therapy, Bioactive component, Prevention strategies, Conventional therapies, Neuroprotective mechanisms, Neuroprotective drug.