A review on – pharmacological effect of carissa carandas l.
Journal name: World Journal of Pharmaceutical Research
Original article title: A review on – pharmacological effect of carissa carandas l.
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Ram Veer Maurya and Dr. Atul Kumar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A review on – pharmacological effect of carissa carandas l.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202314-29303
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Carissa carandas, commonly known as Karonda, is an indigenous shrub in India recognized for its ability to thrive in harsh growing conditions. This perennial evergreen plant yields fruits rich in iron, vitamin C, and various beneficial phytochemicals. Traditionally, C. carandas has been employed in traditional medicine systems to treat a variety of ailments, including cardiac diseases, headaches, and infections. Recent pharmacological studies have highlighted the diverse health benefits of C. carandas, validating its extensive use in both local and international markets. The fruit is also processed into a variety of products like jams and syrups, further increasing its demand.
Antidiabetic Potential of Carissa carandas
One of the most notable pharmacological activities of Carissa carandas is its antidiabetic effect. Investigations into its methanol extract and various fractions have demonstrated significant reductions in blood glucose levels in diabetic animal models. The ethyl acetate fraction in particular showed an impressive decrease in blood glucose levels and improved insulin secretion. The antioxidants present, such as polyphenolic compounds and flavonoids, contribute to this activity, suggesting a mechanism whereby these constituents enhance insulin secretion from pancreatic β-cells. This supports its traditional uses for managing diabetes and suggests potential for therapeutic applications in treating the condition.
Anticonvulsant Efficacy of Carissa species
Recent studies have also explored the anticonvulsant properties of different species within the Carissa genus, particularly C. carandas and C. edulis. Extracts from these plants have demonstrated protective effects against seizures induced by various stimuli in laboratory animals. For instance, the ethanolic extract of C. carandas showed promise in reducing both the duration and incidence of seizures. These findings highlight the potential of Carissa extracts as alternative adjuncts in the management of epilepsy, bolstering their traditional utilization as remedies for neurological conditions.
Anti-inflammatory and Wound Healing Activities
Another area of pharmacological interest in Carissa carandas is its anti-inflammatory and wound healing properties. Various studies have established that extracts from C. carandas fruits exhibit significant anti-inflammatory activities, especially when assessed through models of paw edema. Moreover, the methanolic extract displays notable wound healing potential by accelerating wound contraction and epithelization in animal models. The presence of active constituents such as flavonoids and phenolics is believed to mediate these effects, suggesting that C. carandas could serve as a potent agent in addressing inflammatory issues and promoting tissue repair.
Conclusion
In summary, Carissa carandas is a highly valuable medicinal plant with a wide spectrum of pharmacological activities, including notable antidiabetic, anticonvulsant, and anti-inflammatory effects. The scientific validation of its traditional uses emphasizes its potential as a therapeutic resource in various fields of medicine. Continued research is essential to elucidate the underlying mechanisms of action of its phytochemicals, explore its use in modern medicine, and establish standardized applications for therapeutic use. Overall, Carissa carandas represents a promising candidate for further pharmaceutical exploration and development.
FAQ section (important questions/answers):
What are the traditional uses of Carissa carandas?
Carissa carandas has been traditionally used to treat various conditions including chest pain, headaches, gonorrhea, rheumatism, syphilis, edema, rabies, stomach pain, hepatitis, cardiac diseases, and asthma.
What pharmacological activities are associated with Carissa carandas?
The pharmacological activities of Carissa carandas include antioxidant, antimicrobial, anticancer, cardioprotective, antipyretic, analgesic, wound healing, anticonvulsant, anti-inflammatory, and antidiabetic effects, validating its use in traditional medicine.
What nutrients are found in Carissa carandas fruits?
Carissa carandas fruits are rich in iron, vitamin C, thiamine, riboflavin, pantothenic acid, pyridoxine, biotin, and folic acid, contributing to their nutritional value.
How is Carissa carandas used in food products?
Fruits of Carissa carandas are processed into jam, jelly, squash, syrup, and chutney, making them a popular choice for both domestic consumption and international markets.
What is the significance of antidiabetic activity in Carissa carandas?
Studies demonstrate that extracts of Carissa carandas can significantly lower blood glucose levels and increase insulin secretion, indicating its potential for managing diabetes.
What toxicological effects have been observed with Carissa carandas?
Research indicates that even at high doses, Carissa carandas extracts generally do not exhibit significant toxicity in animal models, suggesting safety for future medicinal applications.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A review on – pharmacological effect of carissa carandas l.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
The term 'activity' refers to the range of biological effects produced by extracts from plants like Carissa carandas. These activities include antimicrobial, anti-inflammatory, and antidiabetic properties, which are essential for validating traditional uses in medicine and for exploring potential therapeutic applications across various diseases.
2) Maurya:
Ram Veer Maurya is likely a primary author of the review on Carissa carandas, significant for bringing scholarly attention to the pharmacological benefits of the plant. His affiliation with S.R. Institute of Pharmacy demonstrates the connection between academic research and traditional medicinal applications, enhancing the credibility of the study.
3) Flavonoid:
Flavonoids, being a subclass of polyphenolic compounds, play a pivotal role in the health benefits attributed to Carissa carandas. They possess anti-inflammatory, antioxidant, and antimicrobial characteristics, contributing to the plant's traditional uses in treating various ailments, particularly in Ayurvedic medicine and natural health practices.
4) Species:
The term 'species' refers to distinct biological classifications, crucial for understanding the diversity within the genus Carissa. Recognizing different species allows researchers and practitioners to identify therapeutic properties unique to each, which may enhance the understanding and application of these plants in traditional and modern medicine.
5) Rat:
Rats are commonly used in pharmacological and toxicological studies to investigate the effects of plant extracts. Due to their physiological similarities to humans, studies involving rats help in translating experimental data into potential therapies for human diseases, thereby providing insights into efficacy and safety profiles.
6) Drug:
Drugs are chemical substances utilized for therapeutic purposes. Carissa carandas extracts may serve as natural alternative drugs in promoting health, showcasing the importance of investigating indigenous plants for drug discovery in modern medicine.
7) Pharmacological:
Pharmacological refers to the study of how drugs affect biological systems. The pharmacological activities of Carissa carandas, including its antioxidant and anti-inflammatory properties, validate its traditional uses and may lead to the development of new natural treatments for various health conditions.
8) Toxicity:
Toxicity evaluates the harmful effects of substances on living organisms. Understanding the toxicity of plant extracts, like those from Carissa carandas, is essential for ensuring safety in medicinal applications, particularly when used in treatments for diseases or as dietary supplements.
9) Ripe:
The term 'ripe' signifies the stage of fruit maturity that can influence its nutritional and medicinal properties. In Carissa carandas, ripe fruits are often considered most effective due to their higher concentrations of vital phytochemicals, contributing to their health benefits in food and traditional medicine.
10) Phytochemical:
Phytochemicals are chemical compounds produced by plants, often credited with health benefits. The review emphasizes the diverse phytochemicals present in Carissa carandas, which inform its diverse pharmacological activities and traditional therapeutic uses.
11) India:
India is significant in the context of Carissa carandas, as the plant is widely found and utilized in traditional medicine there. Understanding its uses, benefits, and cultivation in India is essential for preserving indigenous knowledge and promoting the plant as a valuable resource in pharmacology.
12) Study (Studying):
The phrase 'the study' highlights research focused on Carissa carandas, contributing to knowledge about its health benefits. Critical studies investigate the pharmacological properties of plant extracts, validating long-held beliefs rooted in traditional practices.
13) Medicine:
Medicines indicate various substances used in healing or treating conditions. The exploration of Carissa carandas’ phytochemicals positions them as potential contributors to novel formulations, highlighting the significance of plant-based alternatives in holistic health practices.
14) Sugar:
Sugar is often mentioned in the context of health and nutrition, and in research on Carissa carandas, it may refer to the natural sugars contained within the fruit. Understanding the sugar content helps evaluate its nutritional value and potential effects on blood sugar levels.
15) Animal:
The plural 'animals' indicates the broader category of non-human species used in research. Studies on Carissa carandas involving a range of animals help generalize findings and support its potential as a universal therapeutic option across species.
16) Death:
The phrase 'the death' indicates the outcome of toxicity tests conducted with extracts of Carissa carandas. Understanding lethal dosages ensures safety in consumption and supports the development of effective therapeutic applications, contributing to the validity of its use in traditional medicine.
17) Genu:
Genu could be a typographical error or mean 'genus' in this context, referring to biological taxonomy. Understanding the genu classification of plants helps categorize their relationships and highlights potential shared characteristics across species within the same genus.
18) Inflammation:
Inflammation is a biological response that may indicate disease or injury. The anti-inflammatory activity of Carissa carandas extracts is significant for relieving chronic inflammation, often associated with various health issues, thus enhancing its application in therapeutic contexts.
19) Disease:
A disease is a pathological condition that disrupts normal bodily functions. Carrisa carandas is reviewed for its potential therapeutic effects against various diseases, validating its traditional uses and contributing to the search for natural remedies.
20) Channel:
Channels, particularly ion channels, indicate pathways through which ions move across membranes, crucial for cellular signaling. Research regarding how Carissa carandas interacts with these channels helps in understanding its pharmacological effects vis-à-vis modern therapeutic approaches.
21) Family:
In biological classification, family groups related genera. Carissa belongs to the Apocynaceae family, which includes various medicinal plants. Recognizing the familial ties helps understand shared properties and potential health benefits across different species in the family.
22) Bhuta:
Bhuta refers to a location, likely where the research was conducted (S.R. Institute of Pharmacy, Bhuta, Bareilly). Identifying the geographical context enhances understanding of local flora and its traditional medicinal importance, indicating regional practices and knowledge.
23) Pain:
Pain is a significant symptom associated with various health conditions. The ability of Carissa carandas extracts to alleviate pain validates its traditional use in treating ailments like headaches and inflammation, making it noteworthy in pharmacological research.
24) Inci (Imci):
Here, 'inch' may refer to a measurement of physical dimensions, possibly in describing macroscopic properties of the plant. Understanding the size and dimensions of plant parts, such as leaves and fruits, is important for taxonomy and usage in medicinal preparations.
25) Antibiotic (Antibacterial):
Antibacterial refers to the properties of substances that inhibit bacterial growth. The antibacterial activity of Carissa carandas highlights its potential in treating infections, supporting its use in traditional medicine and emphasizing the need for further scientific exploration.
26) Pharmacology:
Pharmacology is the field studying drug action and interaction in biological systems. Understanding the pharmacology of Carissa carandas aids in revealing how its active compounds modulate health, fostering the development of new medications derived from natural sources.
27) Science (Scientific):
Science refers to the pursuit of knowledge through empirical methods. Research on Carissa carandas represents an essential intersection of traditional knowledge and modern scientific inquiry, promoting the exploration of plant-based therapies for improved healthcare.
28) Indian:
Indian denotes the geographical and cultural context in which Carissa carandas has been utilized in traditional medicine. Exploring its significance in India underlines the interplay between cultural practices, biodiversity, and medicinal applications.
29) Patil:
Patil might refer to an author or researcher contributing to the study of Carissa carandas. Acknowledging various researchers highlights collaborative efforts in documenting and exploring the scientific merit of traditional medicinal plants.
30) Blood:
Blood refers to bodily fluid crucial for various physiological functions. Studies of Carissa carandas include its potential effects on blood glucose levels, underscoring its significance in managing conditions like diabetes and offering insights for treating related health issues.
31) Crop:
Crops represent cultivated plants, and the white portrayal of Carissa carandas as a valuable crop suggests its economic importance in local agriculture. Acknowledging its role as a crop helps understand its traditional and commercial viability.
32) Rich (Rch):
Rich refers to the abundance of specific nutrients or compounds. Carissa carandas is noted for being rich in vitamins and antioxidants, contributing to its health benefits and traditional uses as a nutritional source.
33) Worm:
In this context, 'worm' pertains to the organisms studied for assessing anthelmintic properties. The effectiveness of Carissa carandas extracts against worms showcases its potential in addressing parasitic infections, adding another dimension to its medicinal applications.
34) Burning (Burn, Burned, Burnt):
Burn refers to types of wounds or injuries. The review includes studies on wound healing properties of Carissa carandas, emphasizing its relevance in treating burn wounds and other severe skin injuries, reflecting the plant's therapeutic capabilities.
35) Life:
Life signifies the biological existence of organisms. Understanding the role of Carissa carandas in promoting health contributes to discussions on enhancing life quality and longevity, especially within traditional medicinal frameworks.
36) Northern India:
Northern India is a significant geographic region where Carissa carandas is traditionally utilized. Exploring its applications in this context helps contextualize cultural practices surrounding herbal medicines and the role of local flora in health.
37) Benincasa hispida:
Benincasa hispida, commonly known as ash gourd, is mentioned in connection with formulations containing Carissa carandas. This relation highlights the plant's culinary and nutritional significance, indicating potential synergies in promoting health through diverse food applications.
38) Purification:
Purification processes in pharmacology involve isolating active compounds from plant materials. Understanding purification techniques for Carissa carandas helps enhance its efficacy by concentrating beneficial components, thereby improving potential therapeutic applications.
39) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is one of the Indian states where Carissa carandas may grow naturally. Recognizing the geographical distribution supports regional herbal medicine practices and highlights local biodiversity as a resource for traditional treatments.
40) Performance:
Performance in this context might refer to the effectiveness of Carissa carandas extracts in biological assays. Evaluating performance in studies reveals its potential as a therapeutic agent, demonstrating evidence for traditional medicinal applications.
41) Srivastava (Shri-vastava, Shrivastava, Sri-vastava):
Shrivastava likely refers to a researcher associated with the studies on Carissa carandas. Highlighting contributions of specific authors fosters recognition of collaborative efforts in the scientific community toward understanding traditional plants and their pharmacological potentials.
42) Anti-aging:
Anti-aging signifies properties that may reduce the effects of aging. The application of Carissa carandas extracts in cosmetic formulations is investigated for their potential to provide beneficial effects in skincare, particularly revered in traditional practices.
43) Developing:
Developing refers to the process of enhancing knowledge and practices. In the context of Carissa carandas, developing research on its properties underscores the importance of scientific inquiry in recognizing and harnessing traditional medicines.
44) Karnataka:
Karnataka, another state in India, is part of the geographical region where Carissa carandas is utilized. Its presence in multiple locations emphasizes the plant's widespread tradition and the need for further exploration of its uses across different cultures.
45) Rajasthan:
Rajasthan, being one of the states in India, highlights the cultural diversity and traditional practices associated with the use of Carissa carandas. Recognizing its location underscores the importance of regional knowledge in the usage of medicinal plants.
46) Bhatnagar:
Bhatnagar possibly refers to another contributor or researcher involved in studies on Carissa carandas. Acknowledging multiple authors highlights collaborative research efforts aimed at uncovering the therapeutic potential of traditional plants.
47) Gujarati:
Gujarati relates to the language spoken in the state of Gujarat, which may also refer to local traditions and uses of Carissa carandas in medicinal practices unique to the region, reinforcing the importance of cultural context in herbal therapies.
48) Language:
Language encompasses the means of communication within a culture. Understanding the terminology used in traditional medicinal practices, including those associated with Carissa carandas, is essential for appreciating local knowledge and fostering cross-cultural exchanges in herbal medicine.
49) Epilepsy:
Epilepsy is a neurological disorder associated with recurrent seizures. The review mentions studies examining the anticonvulsant properties of Carissa carandas, validating its traditional use as a remedy for seizure disorders in folk medicine.
50) Sanskrit:
Sanskrit is an ancient Indian language often associated with traditional texts in medicine. Identifying the terms related to Carissa carandas in Sanskrit signifies its historical relevance and contribution to the knowledge framework surrounding Ayurveda and herbal medicine.
51) Gujarat:
Gujarat, an Indian state, is relevant as a geographical area where Carissa carandas can be found. Studying its applications in Gujarat provides insight into local medicinal practices and underscores the broader cultural significance of this plant across various regions.
52) Karaṇda (Karanda, Karamda):
Karanda refers to the common name of Carissa carandas in some local languages. Recognizing its local nomenclature addresses cultural significance and the importance of home-grown plants in regional traditional medicine practices.
53) Kannada:
Kannada is the language spoken predominantly in Karnataka, highlighting regional connections. Recognizing local languages enriches the understanding of cultural practices surrounding Carissa carandas and underscores the integration of traditional medicine in the lives of communities.
54) Bengali:
Bengali refers to the language spoken primarily in the state of West Bengal and influences local herbal practices. Identifying regional names and uses of Carissa carandas elevates the importance of preserving ethnobotanical knowledge across diverse linguistic communities.
55) Siddha:
Siddha is a traditional system of medicine originating in South India. Mention of Siddha in relation to Carissa carandas emphasizes the plant's significance in alternative healing practices, particularly in regions where such traditions are predominant.
56) Mishra (Misra):
Mishra may indicate a contributor to the scholarly research on Carissa carandas. Recognizing individual researchers facilitates a broader understanding of collaborative efforts and shared knowledge in the documentation of herbal medicine studies.
57) Kumari:
Kumari could represent an author of the research articles focused on Carissa carandas, highlighting the collaborative nature of scientific research and the different perspectives brought together in exploring the medicinal potentials of traditional plants.
58) Bengal (Bemgal):
Bengal represents a geographical and cultural area significant for the study of traditional plant uses like Carissa carandas. Understanding its cultural heritage enriches the context of herbal medicine practices and the biodiversity of flora in the region.
59) Aureus:
Aureus often refers to Staphylococcus aureus, a common bacterium in infections. The review’s mention of antibacterial properties of Carissa carandas highlights its potential utility in combating pathogens like Staphylococcus aureus in traditional and modern therapeutics.
60) Farman:
Farman could refer to an author who has contributed to the studies on Carissa carandas. Recognition of individuals involved in this research supports collaboration and builds scholarly dialogue in the field of ethnopharmacology and natural product research.
61) Edema (Oedema):
Edema, similar to oedema, depicts swelling in tissues resulting from fluid accumulation. The potential of Carissa carandas extracts to mitigate edema symptoms aligns with traditional uses in managing inflammation, thus reinforcing the plant’s role in addressing various health issues.
62) Nature:
Nature signifies the inherent qualities and characteristics of the environment and organisms. The study of Carissa carandas emphasizes the importance of understanding the natural properties of plants to harness their therapeutic potential in phytomedicine.
63) Medium:
Medium refers to substances used for extraction of bioactive compounds or processing of food. The study of various extraction mediums for Carissa carandas reveals effective methods for isolating beneficial components, ensuring potent applications in medicine.
64) Cotton:
Cotton in this context may refer to its use in traditional medicine or agricultural aspects related to Carissa carandas. Recognizing potential partnerships with other crops highlights the significance of sustainable practices in holistic agriculture.
65) Kappa:
Kappa may refer to specific receptors or channels in biological systems associated with pharmacological effects. The significance of kappa systems in understanding the mechanisms of action of active compounds from Carissa carandas is essential in determining their therapeutic reliability and safety.
66) Joshi (Josi):
Joshi likely indicates a researcher or author involved in studies concerning Carissa carandas. Recognizing contributors helps acknowledge the collaborative nature of scientific research, enriching the narrative surrounding traditional plant uses and their medicinal applications.
67) Shalem (Salem):
Salem could reference a researcher associated with the study of Carissa carandas, emphasizing the diverse contributions of various authors in exploring the medicinal and pharmacological significance of traditional plants.
68) Kumar:
Kumar may signify a researcher involved in the exploration of Carissa carandas' medicinal properties. Identifying key contributors to the research aids in recognizing collaborative partnerships that drive forward the understanding and applications of plant-based therapies.
69) Bihar:
Bihar is a state in India where Carissa carandas may be traditionally used. The geographical connection emphasizes the plant's significance in local herbal medicine practices and highlights regional biodiversity as a resource for traditional health solutions.
70) Water:
Water is essential for all biological processes and moderates the extraction of phytochemicals from plants like Carissa carandas. Evaluating water's role in extraction processes can help enhance the efficacy of plant-based remedies in medicinal applications.
71) Ulcer:
Ulcer pertains to open sores or injuries on skin or mucous membranes. The antiulcer properties of Carissa carandas extracts are investigated, validating its traditional applications in treating gastrointestinal disorders and promoting digestive health.
72) Hindi (Himdi):
Hindi, the official language of India, is relevant for understanding local practices and concepts surrounding the use of Carissa carandas. Recognizing terminology and cultural nuances is crucial for enhancing appreciation of regional herbal medicine traditions.
73) Field:
Field refers to areas of study or investigation. The examination of Carissa carandas relates to a broader field of ethnobotany, which studies the intersection of culture and plant use in traditional medicinal practices.
74) Fever:
Fever is a common symptom of many illnesses. The utilization of Carissa carandas in treating fever highlights its significance in traditional medicine, where various parts of the plant are valued for their antipyretic properties.
75) Acrid:
Acrid refers to a strong, sharp taste or smell often associated with some plant compounds. The sensory characteristics of Carissa carandas, including its acrid properties, contribute to its cultural and medicinal uses, affecting how it is valued and consumed.
[Note: The above list is limited to 75. Total glossary definitions available: 84]
Other Science Concepts:
Discover the significance of concepts within the article: ‘A review on – pharmacological effect of carissa carandas l.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Carissa carandas, Medicinal plant, Cultural significance, Practical application, Traditional medicine, Ayurvedic medicine, Wound healing, Geographical distribution, Anti-inflammatory activity, Antioxidant activity, Pharmacological activity, Nutritional value, Safety and efficacy, Toxicity studies, Antimicrobial properties, Wound healing activity, Antimicrobial activity, Microbial resistance, Antidepressant activity, Antidiabetic activity, Vitamin C, Clinical application, Total phenolic content, Anticonvulsant activity, Ayurvedic preparation, Anti-ulcer activity, Extraction method, Antiulcer activity, Anthelminthic activity, Macro Nutrients, Chemical constituent, Pharmacological effect, Phenolic compound, Cardiac disease, Dietary applications, Indigenous medicine system, Phytochemical constituent.