Therapeutic study of correction of low vitamin d on fatigue
Journal name: World Journal of Pharmaceutical Research
Original article title: Therapeutic study of correction of low vitamin d on fatigue
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Sohaib Mehroze Iqbal, Dr. Muhammad Soban Bin Salman Meer and Dr. Usama Sarfraz
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Therapeutic study of correction of low vitamin d on fatigue
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202315-29850
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Fatigue is a prevalent issue affecting approximately 33% of patients in ambulatory primary care settings in Pakistan. It is often cited as a contributing factor for reduced quality of life, affecting social interactions, family dynamics, and work performance. Previous studies have linked low vitamin D levels to fatigue, particularly in cancer patients. This study aims to explore the relationship between low vitamin D levels and fatigue in patients with stable chronic medical conditions, assessing whether vitamin D supplementation can alleviate fatigue symptoms.
Prevalence of Low Vitamin D in Fatigue
The study revealed a striking prevalence of low vitamin D (77.2%) among 171 patients presenting with fatigue. Interestingly, over half of these individuals were taking over-the-counter vitamin D supplements, highlighting a potential gap in vitamin D absorption or utilization. Further demographic analysis indicated that the Pathan and other minority ethnic groups exhibited even higher rates of deficiency. This emphasizes the need for targeted approaches to vitamin D supplementation within primary care settings, especially for those experiencing chronic fatigue.
Impact of Ergocalciferol Therapy
The therapeutic intervention employed in this study involved ergocalciferol (vitamin D2) therapy, administered three times a week for five weeks. Following treatment, the median serum vitamin D levels in patients exhibited a significant increase from an average of 19.71 ng/mL to 52.29 ng/mL, indicating successful normalization of vitamin D status. Importantly, patients reported substantial improvements in fatigue symptom scores across various scales, including general, physical, emotional, and mental fatigue dimensions. This suggests that ergocalciferol is an effective treatment modality for addressing low vitamin D-related fatigue.
Role of Depression in Vitamin D Levels
Another noteworthy finding was the significant association between a history of depression and normal vitamin D levels post-intervention. Patients with prior depressive symptoms were 12 times more likely to achieve normalized vitamin D levels after treatment compared to those without such history. This relationship underlines the complex interplay between mental health and vitamin D status, suggesting that addressing vitamin D deficiency could also have favorable implications for depressive symptoms, thereby enhancing overall patient well-being.
Conclusion
In conclusion, this study underscores the critical need for evaluating serum vitamin D levels in patients presenting with fatigue in primary care settings. The normalization of low vitamin D levels through ergocalciferol therapy leads to significant improvements in fatigue symptoms among patients with stable chronic medical conditions. Consequently, healthcare providers should consider routine vitamin D screening and supplementation as part of a holistic approach to managing fatigue. This intervention may not only reduce fatigue but also enhance the overall quality of life for affected individuals.
FAQ section (important questions/answers):
What was the main purpose of this study on vitamin D and fatigue?
The study aimed to observe the prevalence of low vitamin D in fatigue and assess the effect of correcting low vitamin D levels on alleviating fatigue symptoms in patients with stable chronic medical conditions.
How many patients participated in this study and what were their characteristics?
A total of 174 adult patients with fatigue participated, primarily aged 18 to 75, with a high prevalence of low vitamin D levels (77.2%) among them, despite some using over-the-counter vitamin D supplements.
What method was used to assess fatigue levels in patients?
The researchers used the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) questionnaire, which measures fatigue across five subscale categories, to assess the patients' fatigue levels before and after vitamin D treatment.
What treatment did patients receive for low vitamin D levels?
Patients with low vitamin D levels received ergocalciferol therapy, specifically 50,000 international units three times a week for five weeks, to normalize their vitamin D levels.
What were the key findings regarding fatigue symptoms after treatment?
The study found significant improvement in fatigue symptoms across all assessment categories after normalization of vitamin D levels, indicating that correcting low vitamin D can alleviate fatigue in affected patients.
What do the study's conclusions suggest for primary care providers?
The study suggests that primary care providers should test serum 25-hydroxyvitamin D levels in patients presenting with fatigue and consider ergocalciferol therapy to address low levels and improve fatigue symptoms.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Therapeutic study of correction of low vitamin d on fatigue”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
Refers specifically to the investigation presented in the article. It outlines the methodology, results, and conclusions drawn concerning the impact of vitamin D normalization on fatigue among patients with stable chronic conditions.
2) Disease:
This term covers various health conditions, particularly those that the study associates with fatigue. Recognizing the broader context of diseases helps in understanding the multifactorial nature of fatigue and the role of vitamin D in managing it.
3) Post:
Similar to 'post,' this phrase signifies the period after the intervention, primarily indicating the results and conclusions drawn from the data collected after vitamin D normalization therapy, emphasizing its impact on fatigue symptoms.
4) Table:
Tables are essential for presenting structured data in research articles. They allow for clear comparisons between groups, such as those with normal versus low vitamin D levels, facilitating the reader's understanding of results and findings.
5) Depression:
The word 'depression' refers to a mental health condition that can coexist with physical symptoms like fatigue. The study indicates a higher prevalence of low vitamin D in patients with depression, suggesting a relationship that needs further exploration in clinical practice.
6) Cancer:
In this research, cancer is mentioned as a condition where low vitamin D levels and fatigue have previously been associated. The insights gained from the study may help improve patient quality of life by normalizing vitamin D levels in various patient populations, including those with cancer.
7) Observation:
This term encompasses the key findings recorded during the study. Observations regarding low vitamin D prevalence and improvement in fatigue after treatment contribute valuable information to the understanding of vitamin D's role in general health.
8) Male:
In the context of this research, 'male' identifies one of the demographics considered within the study sample. Gender can influence health outcomes and vitamin D levels, thus examining differences between genders is essential for thorough analysis and understanding of fatigue symptoms.
9) Pulse:
The pulse measurement serves as a vital sign indicating the heart rate of participants. It helps establish baseline health status and monitor any physiological changes during the study, contributed by factors like fatigue or the intervention itself.
10) Blood:
'Blood' refers to the body fluid tested in the study for serum 25-hydroxyvitamin D levels. Assessing blood levels is crucial for determining vitamin D status in patients and understanding its correlation with fatigue outcomes.
11) Performance:
'Performance' in this context relates to the functional capabilities of patients. The study illustrates how fatigue affects overall performance in daily activities, emphasizing the importance of addressing vitamin D deficiency as a potential solution.
12) Activity:
In this research, 'activity' may refer to the physical and mental tasks carried out by patients. Acknowledgment of patient activity levels helps contextualize the findings regarding fatigue and vitamin D's impact on overall well-being.
13) Science (Scientific):
This broader term encapsulates the systematic approach of the study in examining the impact of vitamin D on fatigue. It emphasizes that research operates under scientific principles, leading to reliable conclusions pertaining to health outcomes.
14) Life:
'Life' signifies the overall well-being and quality of existence of the patients involved. By addressing fatigue through the normalization of vitamin D levels, the study aims to enhance patients' quality of life and functional capacity.
15) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory disorder mentioned in the context of conditions that could contribute to fatigue. Validating the role of vitamin D in managing symptoms of this autoimmune disease can lead to better therapeutic approaches.
16) Mental health:
This concept addresses psychological and emotional well-being, closely linked to the experience of fatigue. The study explores the potential impact of low vitamin D levels on mental health outcomes, suggesting a broader context for patient care.
17) Reason:
The repetition of 'reason' emphasizes the need to identify underlying factors contributing to fatigue symptoms. Understanding these reasons plays a crucial role in tailoring effective treatments and improving patient care plans.
18) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India mentioned in the author affiliations. The inclusion of researchers from this region indicates the geographical diversity of contributions to the study and may enrich its applicability to different populations.
19) Calculation:
'Calculation' pertains to the statistical methods and evaluations applied to the data collected during the study. Accurate calculations are crucial for interpreting results and drawing valid conclusions about the effectiveness of interventions.
20) Ahmednagar:
Ahmednagar is another geographical location in India related to the article's authors. This reference highlights the involvement of researchers from specific regions in conducting the study, which may influence the demographic context of the results.
21) Discussion:
'Discussion' refers to the section of the article where researchers interpret the findings, contextualize results within existing literature, and make recommendations for clinical practice based on the observed effects of vitamin D on fatigue.
22) Striroga (Stri-roga):
Stri-roga, meaning women's diseases in Sanskrit, is relevant in a medical context. It underscores the importance of gender-specific health considerations in understanding the impact of vitamin D on fatigue experienced predominantly by women.
23) Toxicity:
The word 'toxicity' denotes the potential adverse effects of medications. In this study, toxicity is discussed concerning ergocalciferol therapy, reaffirming the importance of ensuring patient safety while correcting vitamin D deficiencies.
24) Medicine:
This term encompasses the field of health and healing practices, particularly emphasizing the approach taken in the study to address fatigue through medical intervention and the application of evidence-based therapeutic regimens.
25) Relative:
'Relative' describes how one condition may relate to another, such as the link between vitamin D levels and fatigue. Understanding these relationships can illuminate potential treatment pathways that benefit patients with fatigue.
26) Prasuti:
Prasuti refers to obstetrics and women's health issues. Mentioning this term signifies the importance of addressing gender-specific health concerns regarding fatigue and vitamin D status, particularly among female patients.
27) Tantra (Tantrism, Tamtra):
Tantra, meaning a system or discipline, foundationally supports methodologies and practices in medicine. This term stresses the underlying structured approach taken in conducting the medical study, enhancing the credibility of its findings.
28) Arnika:
Arnika likely refers to one of the authors of the study. The mention of individual researchers highlights the collaborative effort in conducting the research, contributing to the credibility and scholarly impact of the findings.
29) Family:
The term 'family' suggests the social aspect of health and how fatigue can affect relationships and dynamics at home. Recognizing this influence enriches the overall understanding of patient challenges beyond clinical symptoms.
30) Roga:
Roga translates to diseases in Sanskrit, and its inclusion indicates the focus on various health conditions within the study. It reinforces the need to explore how low vitamin D levels may contribute to different ailments.
31) Pur:
'Poor' signifies inadequate health status, which could relate to low vitamin D levels and resultant fatigue. Recognizing poor health outcomes leads to targeted interventions that seek to improve the quality of life for affected individuals.
Other Science Concepts:
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Treatment regimen, Informed consent, Chronic medical condition, Significant improvement, Muscle weakness, Chronic Obstructive Pulmonary Disease, Therapeutic study, Psychometric properties, Symptom score, Correlation, Hypovitaminosis D, Adverse event, Multivariate Logistic Regression, Serum 25-hydroxyvitamin D, Diagnostic workup, Statistical Package for the Social Science.