Formulation and evaluation of gingerol phytosome face serum.

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Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of face serum contain phytosome of gingerol oil, carica papaya pulp extract and aloe vera gel
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Mohini Patidar, Nitin Deshmukh, Nilesh Mandloi, Bhoopendra Patidar, Lokesh Solanki and Dr. Sujit Pillai


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Formulation and evaluation of face serum contain phytosome of gingerol oil, carica papaya pulp extract and aloe vera gel

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202318-29901

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

The formulation and evaluation of face serum containing phytosomes of gingerol oil, Carica papaya pulp extract, and aloe vera gel is the focus of a study conducted by Mohini Patidar and colleagues. This research aims to create a natural skin care product that leverages the beneficial properties of herbal extracts, given the growing consumer awareness regarding the potential adverse effects of synthetic ingredients. The study highlights the extraction techniques used for ginger rhizome and papaya pulp, phytochemical screening, and the various tests performed to assess the efficacy and stability of the resulting serum formulation.

Phytosomes: A Modern Approach to Herbal Extracts

Phytosomes represent a novel method of enhancing the bioavailability of phytochemicals through encapsulation in lipid-based carriers. In this study, phytosomes were created by mixing gingerol oil with soy lecithin and Carica papaya extract with phosphatidylcholine in specific molar ratios. Both types of phytosomes have unique average diameters, indicating their size and potential stability. This technique aims to improve the absorption of beneficial compounds, such as antioxidants and nutrients, resulting in more effective skin care products. The successful synthesis of these phytosomes is crucial for the performance of the resulting face serum.

Antioxidant and Microbial Activity Evaluation

The antioxidant activity of the formulated serum was assessed using a hydrogen peroxide scavenging method. The formulation demonstrated a strong total antioxidant capacity, achieving a 42.26% scavenging effect, which was comparable to the standard rutin. This indicates the serum’s potential in combatting oxidative stress, a significant factor in skin aging and damage. Additionally, microbiological testing confirmed that the serum was free from microbial contamination, suggesting it is safe for use. This dual focus on antioxidant properties and microbial safety underlines the formulation's holistic approach to skincare.

Physicochemical Properties and Stability

The physicochemical properties of the face serum were meticulously evaluated, including parameters such as pH, viscosity, and spreadability. The serum exhibited a pH of 5.6, compatible with skin conditions, and a viscosity of 2687 cps, indicating a desirable texture for application. Furthermore, stability tests revealed that the formulation maintained its quality over three months with no significant changes in its physicochemical characteristics, confirming the formulation's robustness and potential longevity in the market.

Conclusion

This study by Patidar et al. showcases the development and evaluation of a novel face serum that combines traditional herbal extracts through modern formulation techniques, specifically phytosomes. The successful extraction of bioactive compounds, along with favorable antioxidant and stability profiles, highlights the potential of the serum as an effective and safe natural skincare product. As consumer interest in herbal and natural ingredients continues to grow, this research provides a valuable foundation for future investigations into effective formulations that prioritize both efficacy and safety.

FAQ section (important questions/answers):

What is the aim of the study on face serum?

The study aims to develop, evaluate, and apply phytosomes of gingerol oil, Carica papaya pulp extract, and aloe vera gel in face serum formulations, focusing on their potential benefits for skin care.

What methods were used for extracting the plant components?

Ginger rhizome was extracted using water distillation, while Carica papaya pulp was macerated with a methanol-water mixture. Both methods were employed to obtain herbal extracts for serum formulation.

How were the phytosomes prepared in the study?

Phytosomes of gingerol oil and Carica papaya were prepared using anti-solvent precipitation and mixing with soy lecithin and phosphatidyl choline, respectively, in ethanol to enhance bioavailability.

What were the physical characteristics of the formulated face serum?

The formulated face serum was non-greasy, homogeneously dispersed, had a milky white finish, and a pH of 5.6, making it compatible with skin pH and suitable for use.

What were the results of the antioxidant activity test?

The formulation exhibited strong total antioxidant and hydrogen peroxide scavenging properties, demonstrating 42.26% activity compared to rutin, indicating effective antioxidant potential of the ingredients used.

What stability tests were conducted on the face serum?

Stability tests showed that the formulation remained free of microorganisms and maintained its physical and chemical properties over a three-month period, indicating good stability and safety for use.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Formulation and evaluation of gingerol phytosome face serum.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The term 'study' refers to the systematic investigation into the formulation and evaluation of the face serum containing phytosomes of gingerol oil, papaya extract, and aloe vera gel. It encapsulates the research efforts aimed at understanding the properties, effectiveness, and potential applications of these natural ingredients in skin care products.

2) Water:
Water is a crucial solvent used during the extraction process of gingerol and Carica papaya pulp. It facilitates the dissolution of various phytochemicals and compounds from herbal materials. Additionally, water serves as an essential ingredient in formulating the face serum, contributing to the product’s overall hydration and texture.

3) Activity:
In this context, 'activity' pertains to the biological effects exhibited by the formulations, particularly their antioxidant and antimicrobial properties. The study assesses the effectiveness of the face serum in neutralizing free radicals and its ability to inhibit microbial growth, thereby determining its potential skin care benefits.

4) Phytochemical:
Phytochemicals are naturally occurring compounds found in plants that contribute to their therapeutic effects. The study emphasizes the importance of identifying and utilizing phytochemicals from extracts of ginger and papaya to enhance the serum's functional properties, particularly in antioxidant and antimicrobial activity.

5) Table:
The term 'table' represents organized data presented within the research article. It is used to summarize key information regarding the parameters evaluated and their results, allowing for easy understanding and analysis. Such tables facilitate comparison between different formulations and their respective outcomes in the study.

6) Flavonoid:
A flavonoid refers to an individual compound belonging to the flavonoid class, known for its varied biological activities, including anti-inflammatory and antimicrobial effects. In the context of the study, understanding flavonoids helps elucidate their role in enhancing the protective and therapeutic benefits of the face serum.

7) Surface:
In this study, 'surface' relates to aspects such as the surface charge of phytosomes and the texture of the serum when applied to the skin. Surface properties influence the stability, absorption, and effectiveness of the serum's formulation, impacting how well it interacts with the skin's outer layers.

8) Measurement:
Measurement refers to the quantitative assessment of various parameters in the study, including pH, viscosity, and particle size of the serum. Accurate measurements are essential for ensuring the formulation's consistency, stability, and overall performance in delivering the desired skincare benefits.

9) Powder:
Powder denotes the physical form of the dried extracts used in the study, like the powdered ginger and Carica papaya pulp. These powders are essential in the formulation process as they undergo extraction to yield active components, later utilized in preparing the face serum.

10) Antibiotic (Antibacterial):
The term 'antibacterial' refers to the property of substances that inhibit the growth of bacteria. In the context of this research, the antibacterial activity of the formulated serum is evaluated to ensure safety and effectiveness against skin infections, highlighting its potential use in skincare applications.

11) Substance:
A substance is a specific type of chemical or material examined in the study, such as gingerol oil or aloe vera gel. Each substance's effectiveness in skincare formulation influences the resultant product's performance, stability, and therapeutic properties, impacting its efficacy in treating skin conditions.

12) India:
India is significant as the country of origin for the research and the botanical sources studied, including ginger and Carica papaya. The rich biodiversity and long-standing traditions of utilizing herbal remedies in Indian culture provide a foundation for the exploration of natural ingredients in modern skincare formulations.

13) Honey:
Honey is included as an emollient and humectant in the face serum formulation. It is recognized for its moisturizing and antibacterial properties, enhancing the serum's overall efficacy while providing additional skin benefits, making it a valuable ingredient in natural cosmetic products.

14) Drug:
Drugs denote biologically active compounds intended for therapeutic use. In the context of the study, understanding the pharmacological properties of the formulated serum supports its positioning within the broader category of pharmaceutical and topical treatment products.

15) Oil:
Oils in this study refer to lipid-based ingredients included in the serum, such as gingerol oil, which contributes to the formulation's moisturizing and nourishing effects. The presence of oils enhances the serum's texture and absorption, while delivering active compounds beneficial for skin health.

16) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is one of the primary herbal extracts investigated in this study. Its bioactive compounds, particularly gingerol, are associated with numerous health benefits including anti-inflammatory, antioxidant, and antimicrobial effects, enhancing the face serum's potential in skincare applications.

17) Discussion:
The discussion section in the research reflects on synthesizing results, interpretations, and the implications of findings regarding the serum formulation. It provides context to overall study outcomes and evaluates the practical applications of the serum in skincare, underscoring its benefits and future prospects.

18) Medicine:
Medicine pertains to the field concerned with health care and treatment, underscoring the potential therapeutic applications of the formulated face serum. The study's focus on natural and herbal ingredients positions the serum as an alternative to synthetic formulations, aligning with contemporary trends in medicine and wellness.

19) Relative:
The term 'relative' is used in the context of comparative analysis, especially concerning the properties or effectiveness of components compared to established standards. Understanding relative performance assists in evaluating the formulated serum's efficacy and determining its position within the broader landscape of skincare products.

20) Quality:
Quality highlights the standard of the formulated face serum in terms of safety, efficacy, and performance. Ensuring high quality through rigorous evaluation methods is vital for establishing consumer trust and meeting regulatory requirements in the competitive skincare industry.

21) Species:
Species refers to the particular types of plants or organisms from which the extracts are derived. In the study, the focus is on species such as ginger and Carica papaya, whose specific properties are explored for their potential contributions to the effectiveness and safety of the skincare formulation.

22) Mohini:
Mohini refers to Mohini Patidar, the lead author of the study, who directed the research into the formulation and evaluation of the face serum. The contributions made by individuals like her are crucial in advancing knowledge within the field of pharmaceutical sciences and cosmetic formulations.

23) Pillai:
Pillai refers to Dr. Sujit Pillai, a key figure involved in the research, likely providing mentorship and guidance throughout the study. The contributions of experienced professionals enhance the quality and credibility of research outcomes, fostering development in the formulation of effective skincare products.

24) Rich (Rch):
Rich describes the abundance of beneficial compounds found within the extracts of the studied plants. Such richness in vitamins, antioxidants, and other phytochemicals underscores the potential efficacy of the formulated serum, enhancing its appeal in the natural skincare market.

25) Hand:
In this context, 'hand' may refer figuratively to the method of application or testing of the serum. It signifies the practical aspect of how the formulation affects users directly, addressing sensory experiences like texture, absorption, and overall user satisfaction during application.

26) Pur:
Poor typically relates to inadequate qualities of certain substances or formulations that may have undesirable properties. It highlights the importance of careful formulation to avoid negative outcomes, ensuring that skincare products do not compromise the health and safety of users.

27) Dish (Dis):
Dish probably refers to the vessel used for preparing or testing the formulation. In laboratory settings, proper containment is essential for the handling of ingredients, ensuring that formulations are developed under controlled conditions to maintain integrity and safety.

28) Azadirachta indica:
Azadirachta indica, commonly known as neem, is significant in the study as it belongs to the same domain of herbal ingredients explored for their skincare benefits. Its properties could complement the efficacy of the formulated serum, underscoring the broader potential of using natural ingredients in cosmetic applications.

29) Pharmacological:
Pharmacological pertains to the effects and mechanisms of action of compounds in biological systems. This term is relevant in the context of understanding how the active ingredients of the formulated face serum exert their effects, thereby maximizing therapeutic benefits for skin health.

30) Anti-aging:
Anti-aging denotes properties or benefits associated with reducing signs of aging, such as wrinkles and fine lines. The formulated face serum aims to incorporate such properties through natural extracts, making it attractive to consumers seeking effective solutions in their skincare regimens.

31) Irritation:
Irritation refers to adverse reactions that may result from using skincare products, particularly in sensitive populations. The study emphasizes the importance of evaluating the serum’s formulation to ensure compatibility with skin, aiming to minimize the potential for irritation among users.

32) Science (Scientific):
Scientific relates to the systematic and empirical approach taken in the study to investigate and assess the formulated face serum. Emphasizing a scientific basis ensures that claims made about the product's efficacy are supported by rigorous testing and analysis.

33) Patanjali:
Patanjali is a brand known for its natural and Ayurvedic products, indicating the study's relevance to the wider context of herbal and natural-based formulations. The connection to brands like Patanjali underscores the increasing consumer interest in products formulated from traditional wisdom and natural ingredients.

34) Container:
Container signifies the vessel used to hold or prepare the formulated serum. Whether during testing or packaging, appropriate containers ensure the preservation and stability of the skincare product, impacting its shelf life and usability.

35) Fragrance:
Fragrance refers to the components blended into the face serum to impart aroma and enhance the user’s sensory experience. While often used to improve appeal, careful selection of fragrance ingredients is crucial to ensure they do not cause irritation or adverse reactions on the skin.

36) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India that emphasizes the use of natural ingredients and holistic health practices. The study's focus on herbal components aligns with Ayurvedic principles, promoting the use of botanical extracts for skincare and overall wellness in modern formulations.

37) Solanki:
Solanki refers to one of the authors involved in the study, contributing to the research efforts into the formulation and evaluation of the face serum. The involvement of diverse contributors enriches the research approach and broadens perspectives in the pharmaceutical and cosmetic fields.

38) Heating:
Heating denotes processes used in the extraction and formulation steps, such as performing reflux during phytosome preparation. Proper heating conditions are crucial for ensuring the efficient extraction of bioactive compounds without damaging their beneficial properties, influencing the effectiveness of the final product.

39) Animal:
Animal often refers to studies involving animal models or testing methods that help elucidate the safety and efficacy of formulations. This underscores the role of animal testing in the development of therapeutic products, ensuring they are safe for human use.

40) Aureus:
Aureus typically refers to Staphylococcus aureus, a bacterium studied in the context of testing the antibacterial properties of the formulated serum. Understanding its susceptibility to the serum’s bioactive components helps determine the formulation’s potential effectiveness in preventing or treating infections.

41) Family:
Family in this context could pertain to the broader classification of plants or herbs under common categories, aiding in understanding their relationships and shared characteristics. Exploring family classifications assists in identifying potential benefits of natural ingredients relevant to skincare.

42) Purity:
Purity signifies the degree to which the extracts or ingredients used in the study are uncontaminated and free from adulteration. Ensuring purity is critical for validating the safety, efficacy, and quality of the formulated serum, aligning with consumer expectations in natural product markets.

43) Cotton:
Cotton can refer to the material used during certain testing procedures, such as microbial studies, typically used to apply formulations or in laboratory settings for managing samples. Its usage ensures proper handling and application of substances under investigation.

44) Filling (Filled):
Filled signifies the process of encasing the formulated serum within its designated container or packaging. Proper filling techniques are necessary to maintain the integrity and stability of the product, ensuring it remains effective and safe for consumer use throughout its shelf life.

45) Aroma (A-roma):
Aroma refers to the smell of the face serum, which can enhance user experience. The careful selection of aromatic compounds within the formulation contributes to its sensory appeal, making the product more attractive to consumers as part of their skincare routine.

46) Glass:
Glass refers to the material often used to store or present formulated products, as it protects them from external factors while ensuring product integrity. The use of glass for packaging or storing the serum helps maintain quality and prevents contamination.

47) Line:
Line may represent the boundary or continuity in terms of testing protocols and results, defining processes and evaluations employed to establish product efficacy. It highlights the importance of clear methodologies in deriving results from the study.

48) Milk:
Milk in this context could relate to a component used in the formulation for its moisturizing properties. Its inclusion can offer additional benefits to the serum, contributing to nourishing and hydrating effects on the skin.

49) Burning (Burn, Burned, Burnt):
Burn refers contextually to skin irritation or reactions that may occur from product application, underscoring the importance of evaluating formulations for safety and tolerability. It emphasizes the need for formulations to be gentle and suitable for all skin types.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Formulation and evaluation of gingerol phytosome face serum.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Aloe vera, Antioxidant activity, Ash value, Phytochemical screening, Antimicrobial activity, Stability study, Preliminary phytochemical testing, Moisturizing properties, Dynamic light scattering, Moisturizing, Viscosity measurement, UV Spectrophotometer, Spreadability test.

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