Comparison of PCOS pharmacotherapy: traditional vs. modern medicine.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Comparative assessment on pharmacotherapy of pcos over traditional and modern medicine
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Asiyabi M., Dr. K. B. Ilango, Madhan Kumar S., Santhanam V., Sowkath A. and Veena P. Bhaskaran


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Comparative assessment on pharmacotherapy of pcos over traditional and modern medicine

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr202319-30095

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

Polycystic Ovary Syndrome (PCOS) is a multifaceted endocrine disorder affecting a significant number of women worldwide, with approximately 3.4% globally and up to 9% in India. Characterized by irregular menstrual cycles, hormonal imbalances, and the presence of multiple ovarian cysts, PCOS carries various health risks, including infertility, metabolic disorders, anxiety, and cardiovascular issues. This review assesses the pharmacotherapy approaches for managing PCOS across different medical systems, including Allopathy, Ayurveda, Homeopathy, and Siddha medicine, emphasizing their efficacy, side effects, and duration of treatment.

Allopathic Approach to PCOS Management

Allopathic medicine primarily addresses the symptomatic aspects of PCOS, utilizing pharmacological treatments to regulate ovulation and manage associated symptoms. Key medications include Metformin, Clomiphene Citrate, Letrozole, and oral contraceptives. Metformin enhances insulin sensitivity, while Clomiphene Citrate is used for inducing ovulation. However, allopathic treatments come with potential side effects such as nausea, ovarian hyperstimulation, and weight gain, and often yield results that are temporary rather than curative. The overall improvement rate in patients using allopathic treatments can be moderate, indicating a need for holistic approaches.

Ayurvedic Treatment of PCOS

Ayurvedic medicine offers a comprehensive strategy for managing PCOS, focusing on lifestyle modifications, dietary adjustments, and detoxification therapies such as Panchakarma. This approach aims to restore hormonal balance and improve metabolic health. Specific treatments, such as Agnitundi Vati and Arogyavardhini Vati, along with therapeutic practices like yoga, help address obesity and insulin resistance, while detoxifying the body to facilitate reproductive health. Evidence from Ayurvedic treatments suggests notable improvements in symptoms, typically achieving up to 80% response rates in patients over short periods.

Homeopathy and Siddha Medicine Perspectives

Homeopathy offers a non-toxic and individualized treatment for PCOS, targeting hormonal imbalances and reproductive health through remedies such as Natrum Muriaticum and Pulsatilla. This approach aims to correct underlying physiological disturbances rather than merely alleviating symptoms. Siddha medicine, on the other hand, focuses on addressing the underlying Vatham and Kabam disorders contributing to PCOS, utilizing herbal treatments to restore balance and fertility. Both homeopathy and Siddha show favorable outcomes, with improvement rates ranging from 72% to 76%, emphasizing their potential effectiveness and lower side effect profiles compared to allopathic treatments.

Conclusion

In summary, various medical systems provide effective management strategies for PCOS, each with its unique approaches and benefits. While allopathy delivers quicker symptomatic relief, Ayurveda and Siddha emphasize holistic healing with minimal side effects. The comparative effectiveness of these systems suggests that a personalized treatment plan, tailored to individual patient needs, can optimize outcomes. Further research and clinical studies could solidify these findings, paving the way for integrated practices that leverage the strengths of multiple medicinal frameworks for improved PCOS management and women's health.

FAQ section (important questions/answers):

What is Polycystic Ovary Syndrome (PCOS) and its prevalence?

PCOS is a common endocrine disorder affecting women's reproductive health. Globally, about 3.4% of women and up to 9% of adolescent girls in India are affected, with symptoms like irregular menstrual cycles, hormonal imbalance, and multiple ovarian cysts.

What are the common causes of PCOS?

Common causes include hormonal imbalance, insulin resistance, genetic factors, intrauterine exposure to testosterone, lifestyle choices, and obesity, which exacerbates symptoms but isn't considered a direct cause.

How is PCOS typically diagnosed?

Diagnosis involves assessing medical history, physical examination, pelvic exams, blood tests for hormones, and vaginal ultrasounds to check for cysts and evaluate overall reproductive health.

What are the treatment options for PCOS?

Treatment includes lifestyle modifications, pharmacotherapy from various medical systems like Allopathy, Ayurveda, and Homeopathy, as well as surgical options like laparoscopic ovarian drilling, depending on individual symptoms and responses.

What are the side effects of Allopathic treatments for PCOS?

Allopathic treatments often lead to side effects like nausea, ovarian hyperstimulation, weight gain, and mood changes due to medications such as Clomiphene Citrate, Metformin, and oral contraceptives.

How do Ayurvedic treatments differ in treating PCOS?

Ayurvedic treatments focus on holistic approaches, emphasizing detoxification, managing diet, balancing hormones, and restoring reproductive health through methods like Panchakarma therapy, offering fewer side effects compared to conventional drugs.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Comparison of PCOS pharmacotherapy: traditional vs. modern medicine.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Medicine:
Medicines refer to substances used for medical treatment, particularly those preventing and alleviating disease symptoms. The discussion highlights various systems of medicine, including allopathy, Ayurveda, and Siddha, presenting an overview of how different medicines are utilized to address the complex symptoms of PCOS.

2) Siddha:
Siddha is an ancient system of medicine originating from South India, emphasizing holistic health through the balance of body and mind. It addresses conditions like PCOS through natural remedies, detoxification, and herbal treatments, focusing on individual constitution and imbalances, particularly vatham and kabam disorders associated with the syndrome.

3) Disease:
Diseases represent pathological conditions affecting normal bodily functions, leading to dysfunction or distress in various systems. PCOS is one such disease characterized by hormonal imbalances and reproductive issues, showcasing the diverse nature of diseases and the need for nuanced treatment approaches tailored to individual needs.

4) Vati:
Vati refers to a traditional Ayurvedic formulation often in the form of small tablets or pills made from herbs and minerals. It is used in therapeutic regimes to promote health, especially in managing chronic conditions like PCOS, assisting in restoring the body's balance and alleviating symptoms associated with hormonal disturbances.

5) Drug:
Drugs are chemical substances used to treat, cure, prevent, or diagnose diseases. In the context of PCOS, various drugs are analyzed for their effectiveness and side effects, including hormonal agents, insulin sensitizers, and various herbal formulations that target specific symptoms and hormonal imbalances associated with the condition.

6) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian holistic healing system focusing on balance in the body, mind, and spirit. It employs diet, lifestyle changes, and herbal remedies to treat various ailments, including PCOS. Ayurveda differs from conventional medicine by its approach to preventing and managing health issues rather than just treating symptoms.

7) Pain:
Pain is an unpleasant sensory and emotional experience often signaling an underlying health issue. In patients with PCOS, pain may arise from various sources, including hormonal fluctuations, ovarian cysts, and psychological stress, requiring a comprehensive treatment approach that addresses both physical and emotional aspects of health.

8) Science (Scientific):
Scientific refers to principles derived from systematic observations and testing. In exploring treatments for PCOS, the scientific approach is vital for validating methodologies, understanding drug actions and interactions, and ensuring that therapeutic interventions are evidence-based, providing assurance of safety and efficacy in managing health.

9) Study (Studying):
Study refers to the systematic investigation of a subject to establish facts or develop new theories. The presented research on PCOS assesses different medical approaches, examines the efficacy and safety of treatments from various medicinal systems, and analyzes patient responses and outcomes over specified durations.

10) Tamilnadu (Tamil-nadu):
Tamilnadu is a state in southern India known for its rich cultural heritage and traditional medicinal practices such as Siddha and Ayurveda. The study's authors hail from a college in Tamilnadu, emphasizing local practices and knowledge in managing health conditions like PCOS prevalent among women in the region.

11) Shri (Sri, Sr):
Shree is a respectful title often used in India, denoting honor and reverence. In this context, it refers to 'Shree Venkateshwara College of Paramedical Sciences,' where the authors studied and conducted their research on PCOS, showcasing an academic environment committed to medical advancements and knowledge dissemination.

12) Pur:
In medical terms, 'poor' can describe inadequate health status, responses, or results in clinical contexts. Within the study, some patients with PCOS might have 'poor' responses to certain treatments, underscoring the need for personalized approaches and that variability in treatment efficacy exists across different individuals.

13) Pharmacotherapy:
Pharmacotherapy refers to the treatment of disease through the administration of medications. In the context of PCOS, pharmacotherapy encompasses various chemical agents aimed at managing symptoms, improving hormonal balance, and promoting ovulation, demonstrating its significance in the overall treatment strategy for the syndrome.

14) Depression:
Depression is a mental health disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest. Women with PCOS often experience elevated risks of depression due to hormonal imbalances, psychological stress, and the physical consequences of the syndrome, underscoring the need for comprehensive mental health support.

15) Agnitundi (Agni-tundi):
Agnitundi is an Ayurvedic formulation used to stimulate digestion and alleviate abdominal discomfort. Its incorporation in treating PCOS indicates a holistic approach, addressing both metabolic and digestive health, which can play significant roles in managing symptoms related to hormonal imbalances and overall wellness.

16) Vomiting:
Vomiting is the involuntary expulsion of stomach contents, often resulting from irritation or illness. In the management of PCOS, certain medications, such as metformin, may cause gastrointestinal side effects like vomiting, necessitating careful consideration of treatment choices and patient comfort during pharmacotherapy.

17) Anxiety:
Anxiety is a mental health condition characterized by excessive worry, fear, or apprehension. Women with PCOS frequently experience anxiety due to hormonal changes, physical symptoms, and related lifestyle impacts, highlighting the importance of integrating psychological support and stress management in their comprehensive treatment plans.

18) Nausea:
Nausea is a non-specific symptom characterized by an uneasy feeling in the stomach and an urge to vomit. Some pharmacological treatments for PCOS can lead to nausea as a side effect, emphasizing the need to monitor patients closely during medication and explore alternative options with fewer adverse effects.

19) Vattam:
Vatham refers to one of the three doshas in Ayurveda, associated with air and movement. In treating PCOS within the Siddha system, imbalances in vatham are believed to contribute to the disorder's etiology, guiding the selection of herbal remedies aimed at restoring balance and promoting overall health.

20) Blood:
Blood is the vital fluid circulating within the body, responsible for transporting nutrients, oxygen, and waste. In the context of PCOS, blood tests are crucial for diagnosing hormonal imbalances and metabolic issues, providing insights into the underlying factors affecting women's reproductive health and guiding treatment efficacy.

21) Line:
Line refers to a sequence or a path in the context of treatment protocols. In PCOS management, the 'line of treatment' indicates the various approaches and therapies employed, including pharmacotherapy, lifestyle interventions, and Ayurvedic or Siddha practices, to achieve optimal health outcomes for affected patients.

22) Human body:
The human body is a complex biological system comprising various subsystems that interact dynamically. When addressing PCOS, understanding the human body's physiological and biochemical responses is essential for developing effective treatment options tailored to restoring hormonal equilibrium and improving overall reproductive health.

23) Pharmacological:
Pharmacological pertains to the science of drugs and their effects on the biological systems. In the study of PCOS, pharmacological interventions are analyzed in terms of their mechanisms of action, efficacy, side effects, and overall impact on managing the syndrome and improving patients' quality of life.

24) Pharmacology:
Pharmacology is the branch of medicine concerned with the study of drug action and how drugs interact with biological systems. Understanding pharmacology is critical in developing effective treatment strategies for PCOS, as it allows for insights into medication mechanisms, therapeutic benefits, and potential adverse reactions.

25) Purification:
Purification in the context of healthcare often refers to the process of detoxifying the body or clearing harmful substances. Ayurvedic principles promote purification methods to restore balance, particularly in PCOS, where cleansing the body is believed to support hormonal harmony and enhance overall well-being.

26) Activity:
Activity can refer to physiological processes or dynamic actions in the body. In PCOS management, the level of physical activity is crucial not only for weight management but also for improving insulin sensitivity and reducing symptoms associated with hormonal imbalances, thus promoting overall health.

27) Quality:
Quality refers to the standard or level of something. In healthcare, the quality of treatment refers to its effectiveness, safety, and overall patient satisfaction. The study assesses the quality of different treatment modalities for PCOS, focusing on the impact of various medicines and therapeutic approaches on patients' health.

28) Kumar:
Kumar is a common Indian surname, often used as a last name or title. In the context of the study, it refers to Madhan Kumar S., one of the authors researching PCOS, thereby representing academic contributions from individuals interested in addressing women's health issues through various medicinal systems.

29) Diet:
Diet refers to the types and amounts of food consumed, and it plays a crucial role in health management, particularly for hormonal disorders like PCOS. Nutritional interventions can support weight management, hormonal balance, and overall metabolic functions, being an integral part of comprehensive treatment strategies.

30) Sign:
Sign refers to an objective evidence of a medical condition. In PCOS, signs might include irregular menstrual cycles, obesity, or hirsutism, which reflect underlying hormonal imbalances and necessitate accurate diagnosis and appropriate therapeutic approaches to effectively address the complexity of the syndrome.

31) Hair:
Hair can indicate hormonal health, with conditions like hirsutism commonly seen in PCOS due to elevated androgen levels. Managing excessive hair growth is often a significant concern for affected women, prompting the use of various treatments aimed at normalizing hormonal levels and improving self-esteem.

32) Mud:
Mood refers to a temporary state of mind or feeling, which can be influenced by hormonal changes. Women with PCOS often experience mood swings, anxiety, and depression; thus, managing these psychological elements is crucial in providing holistic care and improving their overall quality of life.

33) Raktadhatu (Rakta-dhatu):
Rakta-dhatu refers to the blood tissue in Ayurvedic medicine, associated with nourishing the body and maintaining vitality. Imbalances in rakta-dhatu may contribute to conditions like PCOS, and treatments often aim to restore healthy blood flow and balance to support reproductive health and wellness.

34) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha is one of the three energies in Ayurvedic medicine, reflecting stability, structure, and moisture. In the context of PCOS, managing kapha imbalances can play a crucial role in restoring health and mitigating symptoms, utilizing dietary and lifestyle adjustments as part of the treatment regimen.

35) Transformation (Transform, Transforming):
Transform signifies the process of undergoing a significant change. In the treatment of PCOS, applying holistic approaches can transform not just physical symptoms but also improve emotional well-being, thereby fostering empowerment and enhancing the quality of life for women diagnosed with this condition.

36) Discussion:
Discussion refers to the exchange of ideas or debate about a topic. In the context of this study on PCOS, it encompasses the analysis of different treatment modalities, implications of findings, and suggestions for future research, helping to comprehensively understand the disorder and potential solutions.

37) Shatapushpa (Satapuspa, Shata-pushpa):
Satapuspa is an Ayurvedic herb used traditionally for its medicinal properties, often included in formulations for treating various conditions, including PCOS. It's believed to support hormonal balance, enhance reproductive function, and improve overall health, exemplifying the role of herbs in traditional medicine approaches.

38) Substance:
Substance refers to a particular kind of matter with uniform properties. In medicine, a substance can be any drug, herb, or compound used for therapeutic effects. The study discusses various substances employed in different systems of medicine to manage PCOS, evaluating their effectiveness and side effects.

39) Mandagni (Mamdagni, Manda-agni):
Mandagni refers to a condition of low digestive fire in Ayurveda, leading to poor metabolism and the accumulation of toxin-like substances. In treating PCOS, addressing mandagni is essential for enhancing digestive health, facilitating proper nutrient assimilation, and improving hormonal balance through dietary and herbal interventions.

40) Toxicity:
Toxicity refers to the degree to which a substance can damage an organism. In the context of pharmacological treatments for PCOS, understanding and managing potential toxicity is crucial as certain medications may present risks of harmful side effects, emphasizing the importance of careful clinical evaluations.

41) Bleeding:
Bleeding refers to the loss of blood from the circulatory system, which can occur unnoticed or may signal health issues. In women with PCOS, irregular menstrual bleeding can be a symptom of hormonal imbalance, thus necessitating a thorough investigation and effective management strategies to restore menstrual regularity.

42) Sukshma (Shukshma, Suksma):
Sukshma denotes subtle or micro levels in Ayurvedic medicine, particularly concerning the body's subtle energies and their balance. In managing PCOS, sukshma therapies may focus on fine-tuning the body's functions and enhancing metabolic processes, aligning physical health with emotional balance and wellness.

43) Shivani (Sivani):
Shivani is another common Indian name, representing one of the authors of the study on PCOS. This highlights the collaborative nature of research within the medical field, as professionals from various backgrounds contribute to advancing understanding and treatment of women's health issues.

44) Vamana:
Vamana is a therapeutic procedure in Ayurveda involving therapeutic vomiting as a purification process. It aims to expel toxins and alleviate conditions associated with excess kapha and water elements, which is particularly useful in managing PCOS by restoring balance and improving metabolic functions.

45) Sakshi (Saksi):
Sakshi is a name often used in India and appears as one of the authors of the PCOS study. The contributions of diverse professionals in the medical field underscore the collaborative effort in addressing health challenges, such as PCOS, and enhancing multidisciplinary understanding.

46) Bitter:
Bitter flavor is significant in Ayurveda, often associated with detoxification and digestion. Bitter herbs are commonly used in treating PCOS to enhance metabolic activity, control weight, and restore hormonal balance, reflecting the importance of balanced flavors in achieving overall health.

47) Sharman (Sarma, Sarman, Sharma):
Sharma is another common Indian surname, used here to reference one of the researchers in the publication regarding PCOS. Such collaborations strengthen the collective knowledge base, enhancing research efforts aimed at uncovering effective treatments for women’s reproductive health issues.

48) Dosha (Dosa):
Dosha is a fundamental concept in Ayurveda, indicating bodily energies that govern physiological processes. The balance of doshas—vata, pitta, and kapha—is crucial for health. Understanding how doshas relate to conditions like PCOS aids in personalized treatment plans that address specific imbalances.

49) Kapha:
Kapha is one of the three doshas in Ayurvedic medicine, associated with structure, stability, and lubrication. Understanding kapha imbalances is essential for managing PCOS effectively, as lifestyle and dietary adjustments may help restore equilibrium and alleviate symptoms related to excess weight and hormonal disturbances.

50) Nasya (Nashya):
Nasya refers to an Ayurvedic treatment involving the administration of medicated oils through the nasal passages. This therapy helps in clearing nasal sinuses and enhancing overall wellbeing, with potential benefits in the context of PCOS by supporting hormonal balance and improving neurological functions.

51) Rakta:
Rakta refers to the blood element in Ayurvedic medicine, which is crucial for nourishing all body tissues. Addressing rakta imbalances is important in managing conditions like PCOS, as enhancing healthy blood flow supports overall reproductive health and helps in alleviating related symptoms.

52) Basti:
Basti is an Ayurvedic therapeutic enema used to restore balance and treat various conditions by cleansing the colon. In the context of PCOS, basti therapies may help harmonize vata and promote overall digestive health, which is essential for regulating hormonal functions and metabolism.

53) Dhatu:
Dhatu refers to the seven bodily tissues in Ayurveda, which transform and nourish the body. In treating PCOS, understanding dhatu imbalances helps tailor treatments to restore harmonious physiological functions, ensuring that each tissue contributes effectively to overall health and well-being.

54) Malai (Malai°):
Malai refers to cream, which in Ayurvedic texts can denote the richest part of the substance, often symbolizing health and vitality. It may indicate dietary components integral to maintaining a balanced diet that supports women diagnosed with hormonal disturbances such as PCOS.

55) India:
India is a country known for its diverse cultures and rich history of traditional medical systems like Ayurveda and Siddha. In studying PCOS, incorporating local medical practices from India highlights the significance and effectiveness of integrative medicine tailored to regional health challenges.

56) Pulse:
Pulse is a vital sign reflecting the heart rate, indicative of overall health. Monitoring pulse is significant in assessing stress and metabolic states in women with PCOS, as hormonal imbalances can impact cardiovascular health, necessitating a focus on holistic treatments for women's reproductive health.

57) Birth:
Birth represents the beginning of life and can relate to reproductive health issues in women. In the context of PCOS, complications during birth and pregnancy might arise, emphasizing the importance of managing the syndrome effectively to ensure favorable outcomes for mothers and babies alike.

58) Nocci:
Nochi, a herbal remedy in Siddha medicine, is utilized for regulating bodily processes. In managing PCOS, nochi plays a role in balancing vatham and can assist in promoting hormonal stability and improving overall health, showcasing the diversity in treatments across different medicinal systems.

59) Borax:
Borax is commonly known as a cleaning agent but is mentioned in traditional medicine. In certain contexts, it has been believed to have medicinal properties and may be included in formulations aimed at treating various conditions, though its use should be approached with caution due to potential toxicity.

60) Vayu:
Vaayu signifies the air element in Ayurvedic philosophy, representing movement and communication in the body. Understanding the role of vaayu is crucial in managing PCOS as it governs vital functions and can be influenced through dietary and lifestyle modifications to restore balance.

61) Vina:
Veena is a name often associated with Indian culture and may refer to one of the study's authors contributing to the research on PCOS. Collaboration in medical research from diverse backgrounds helps enhance understanding of women's health and improve therapeutic outcomes.

62) Agni:
Agni refers to the digestive fire in Ayurveda, essential for metabolic processes and overall health. In the management of PCOS, balancing agni through diet and lifestyle is critical for ensuring proper digestion, nutrient absorption, and hormonal regulation within the body.

63) Raja:
Raja denotes a quality of dominance or supremacy in certain contexts, reflecting influence over processes. In Ayurveda, understanding the transformative qualities of substances can guide effective treatment strategies for imbalances leading to PCOS, promoting restoration and balance among bodily functions.

64) Rasa (Rasha):
Rasa means flavor in Ayurveda and often signifies taste or essence that influences health. In the context of dietary recommendations for PCOS, managing rasa helps promote balance within the body, supporting digestion and nutritional health crucial for managing the symptoms associated with the syndrome.

65) Dani:
Dani is a name that could refer to one of the authors contributing to the research on PCOS. Collaborative authorship demonstrates the interdisciplinary nature of addressing women's health issues, pooling knowledge from various fields to enhance the understanding and treatment of complex conditions.

66) Pita:
Pita is one of the three doshas, associated with heat, metabolism, and transformation in Ayurvedic medicine. Balancing pita is essential in managing PCOS, as elevated levels may exacerbate symptoms, necessitating dietary adjustments and treatments that promote harmony within the body.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Comparison of PCOS pharmacotherapy: traditional vs. modern medicine.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Pharmacotherapy, Obesity, Siddha medicine, Lifestyle modification, Ayurvedic treatment, Case studies, Environmental factor, Psychological problem, Panchakarma Therapy, Body mass index, Hormonal imbalance, Insulin resistance, Ovulation induction, Ayurvedic panchakarma therapy, Metformin, Diet modification, Homeopathic treatment, Clomiphene citrate, Laparoscopic ovarian drilling, Polycystic Ovary Syndrome, Non-Pharmacological Management, Statin drugs, Genetic cause, Homeopathy treatment, Oral contraceptive, Clinical symptom, Traditional and modern medicine.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Consider supporting this website: