Pharmaceutical prep and analysis of Amrita Guggulu with/without ghruta.
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmaceutical preparation and physio- chemical analysis of amrita guggulu prepared with or without murchhit ghruta
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Sanjiv Kumar and Prabhat Kumar Dwivedi
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Pharmaceutical preparation and physio- chemical analysis of amrita guggulu prepared with or without murchhit ghruta
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr202319-30068
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
The article discusses the pharmaceutical preparation and physico-chemical analysis of Amrita Guggulu, an Ayurvedic herbal formulation. Authored by Sanjiv Kumar and Prabhat Kumar Dwivedi, the study emphasizes the importance of maintaining high analytical standards in Ayurvedic medicines to enhance their therapeutic effectiveness. The primary focus is on comparing two formulations of Amrita Guggulu: one prepared with Murchhit Ghruta (a clarified butter that has undergone a unique pharmaceutical process) and the other without it. By utilizing modern physico-chemical methods alongside classical organoleptic tests, the research aims to provide insights into the quality assessment and standardization of this Ayurvedic preparation.
Importance of Ghruta Murchhana
One significant concept explored in the study is the role of Ghruta Murchhana in the preparation of Amrita Guggulu. This unique pharmaceutical process entails levigation using clarified butter, a practice traditionally believed to enhance the therapeutic quality of herbal formulations. The study indicates that the sample containing Murchhit Ghruta demonstrated superior results in various analytical tests. This finding suggests that the inclusion of Ghruta Murchhana positively influences the formulation's characteristics, potentially leading to enhanced bioavailability and therapeutic efficacy.
Physico-Chemical Comparison
Another essential aspect discussed is the physico-chemical analysis of the two samples of Amrita Guggulu. The study provides a comprehensive comparison of various parameters, including total ash, acid-insoluble ash, alcohol-soluble extractive, water-soluble extractive, loss on drying, and disintegration time in acidic and neutral solutions. The results reveal notable differences between the two formulations, particularly in their disintegration time and solubility, indicating the effectiveness of Murchhit Ghruta in improving the formulation's overall quality and therapeutic potential.
Organoleptic Properties
The article also details the organoleptic properties of both samples, which include sensory characteristics such as color, odor, and taste. The sample prepared with Murchhit Ghruta exhibited a distinct color, aroma, and texture, showcasing the impact of the levigation process. These organoleptic assessments not only serve as quality indicators but also reflect the traditional understanding in Ayurvedic practices that sensory qualities can predict a formulation's effectiveness. This aspect contributes to the holistic approach of Ayurveda, which intertwines physical and sensory assessments with therapeutic outcomes.
Conclusion
In conclusion, the study underlines the significant role of Murchhit Ghruta in enhancing the quality and therapeutic efficacy of Amrita Guggulu. Through careful preparation and extensive analysis, the research demonstrates that the formulation with Murchhit Ghruta offers better physico-chemical properties compared to the one without. This work not only provides valuable insights into the formulation process of Amrita Guggulu but also highlights the need for rigorous quality assessments in Ayurvedic medicines. The findings suggest that incorporating traditional practices alongside modern analytical techniques can contribute to the standardization and improvement of herbal formulations in Ayurveda.
FAQ section (important questions/answers):
What is the focus of the study on Amrita Guggulu?
The study focuses on the pharmaceutical preparation and physio-chemical analysis of Amrita Guggulu, comparing formulations prepared with and without Murchhit Ghruta for quality assessment and therapeutic efficacy.
What are the main ingredients of Amrita Guggulu?
The main ingredients of Amrita Guggulu include Guduchi, Guggulu, Danti, Vyosha, Vidang, Triphala, Tvak (Dalchini), and Trivrit, which are combined to create the herbal formulation described in the study.
How were the two samples of Amrita Guggulu prepared?
Two samples were prepared: one without Murchhit Ghruta (sample 01) and another with Murchhit Ghruta (sample 02), following the traditional Ayurvedic preparation methods of Chakradutta.
What physio-chemical parameters were analyzed in the study?
Parameters analyzed included total ash, acid-insoluble ash, extractive values, loss on drying, bacterial and fungal counts, and disintegration time in different solutions to assess quality and therapeutic potential.
What were the findings regarding therapeutic efficacy between the samples?
The sample with Murchhit Ghruta demonstrated enhanced therapeutic properties and quicker disintegration time, potentially leading to increased bioavailability and faster action compared to the one without Ghruta.
How does Bhavana (levigation) impact the Amrita Guggulu formulation?
Bhavana, or levigation, affects the physical and chemical properties of the formulation, reducing disintegration time and increasing absorption, thereby enhancing the overall therapeutic efficacy of the Amrita Guggulu preparation.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmaceutical prep and analysis of Amrita Guggulu with/without ghruta.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Guggulu:
Guggulu refers to the resin of the Commiphora mukul tree, which is an important component in Ayurvedic medicine. It is known for its therapeutic properties, particularly in treating conditions related to metabolism and weight management, making it a key ingredient in formulations like Amrita Guggulu.
2) Amrita (Amrta):
Amrita translates to 'immortality' in Sanskrit, representing the life-giving properties attributed to certain herbal formulations in Ayurveda. In this context, it refers specifically to Amrita Guggulu, a traditional Ayurvedic remedy believed to possess powerful healing effects for various ailments.
3) Bhavana (Bha-vana):
Bhavana refers to a process of levigation or mixing of medicinal herbs with a liquid (often with a ghee or oil component) to enhance their therapeutic efficacy. It modifies the physical properties of the drugs, facilitating better absorption and bioavailability, crucial for effective medicinal formulations.
4) Triphala (Tri-phala):
Triphala is a traditional Ayurvedic formulation consisting of three fruits: Amalaki, Haritaki, and Vibhitaki. It is renowned for its detoxifying effects, digestive health benefits, and ability to balance the three doshas in Ayurveda, making it a widely used component in many Ayurvedic preparations.
5) Drug:
Drugs encompass any substances used in the prevention, diagnosis, or treatment of diseases. In Ayurveda, the term refers specifically to herbal, mineral, or animal-derived materials used therapeutically, emphasizing a holistic approach to health.
6) Vatarakta (Vata-rakta):
Vatarakta is a term in Ayurveda that refers to a condition akin to gout, characterized by pain and inflammation due to vitiation of vata and rakta (blood). Herbal formulations, including Amrita Guggulu, are historically prescribed for managing this condition by balancing the doshas.
7) Kalpana:
Kalpana indicates the preparation or formulation of Ayurvedic medicines. This term is commonly used to describe the various methods and processes involved in preparing effective and safe herbal remedies, each tailored to maximize therapeutic benefits and maintain quality standards in traditional Ayurvedic practices.
8) Water:
Water is a fundamental ingredient in the preparation of Ayurvedic medicines, as it is often used as a solvent or medium for extraction and formulation. In the context of Amrita Guggulu, water serves to efficiently dissolve active compounds, enhancing the efficacy of the herbal formulation.
9) Shastra (Sastra):
Shastra, meaning 'scripture' or 'treatise,' denotes the foundational texts in Ayurveda that guide the principles, practices, and methodologies in traditional medicine. Rasa Shastra, a branch of Ayurveda, focuses specifically on alchemical practices and herbal preparations, vital for effective medicinal formulations.
10) Patna:
Patna is the capital city of Bihar, India, and the location of the Government Ayurvedic College where this research was conducted. This city plays a significant role in the promotion of traditional Ayurvedic education and practice, serving as a hub for scholars and practitioners.
11) Bhaishajya (Bhaisajya):
Bhaishajya refers to medicines or pharmaceuticals in Ayurveda. It emphasizes the medicinal properties of herbal formulations and their roles in treating diseases within Ayurvedic frameworks, including the therapeutic use of various herbs in formulations like Amrita Guggulu.
12) Shodhana (Sodhana):
Shodhana means purification in Ayurveda, highlighting the process used to clean and prepare herbal ingredients, particularly Guggulu. This step is crucial in removing impurities to enhance the safety and efficacy of the final medicinal product.
13) Bihar:
Bihar is a state in eastern India and home to a rich cultural and historical tradition in Ayurveda. The presence of educational institutions like the Government Ayurvedic College in Patna underscores its significance in the training of Ayurvedic practitioners.
14) Table:
Table refers to organized data presented in a systematic manner, often for clarity and comparison. In this study, tables summarize the ingredients, preparations, and pharmacological analyses, facilitating easier interpretation of the findings from the research.
15) Trikatu (Tri-katu):
Trikatu is a traditional Ayurvedic formula composed of three spices: black pepper (Piper nigrum), long pepper (Piper longum), and ginger (Zingiber officinale). Known for its digestive and metabolic enhancing properties, it is often included in formulations to improve efficacy.
16) Trivrit (Tri-vrit, Trivrt):
Trivrit (Operculina turpethum) is a medicinal herb used in Ayurveda, primarily known for its purgative properties. It plays an important role in herbal formulations aimed at balancing bodily doshas and addressing digestive ailments.
17) Vyosha (Vyosa):
Vyosha, referring to Embelia ribes, is a medicinal plant used in Ayurveda known for its role as a digestive aid and its effectiveness in managing various ailments. It is often included in formulations to enhance therapeutic effects.
18) Danti (Damti, Dantin):
Danti refers to the herb Baliospermum montanum, used in Ayurvedic formulations for its laxative properties. This herb is known to support digestive health and detoxification, making it relevant in various therapeutic contexts.
19) India:
India is the birthplace of Ayurveda, a traditional system of medicine that emphasizes holistic healing through natural remedies. The country's rich biodiversity provides a wide variety of medicinal plants used in formulations like Amrita Guggulu.
20) Rasa (Rasha):
Rasa refers to 'essence' or 'taste' in Ayurveda, which also denotes the pharmacological properties of substances. In Rasa Shastra, it is crucial for understanding how different substances affect bodily health and their therapeutic applications.
21) Tvak:
Tvak, also known as cinnamon (Cinnamomum verum), is a commonly used spice in Ayurvedic medicine. It is valued for its warming properties and benefits in digestive health, circulation, and overall wellness, often featured in herbal formulations.
22) Commiphora mukul:
Commiphora mukul is the botanical name for Guggulu, the resin extracted from this tree is central to many Ayurvedic treatments. Its therapeutic benefits, particularly for metabolic and inflammatory conditions, are widely recognized in traditional medicine.
23) Rasashastra (Rasa-shastra, Rasasastra):
Rasa-shastra is a specialized branch of Ayurveda focusing on the use of metals, minerals, and herbal preparations in medicine. It encompasses the principles of alchemy and the pharmaceutical processes needed to create potent medicinal formulations.
24) Kumar:
Kumar is a common surname in India, often used as part of the names of researchers or practitioners. In this context, Sanjiv Kumar is one of the authors contributing to the study and findings regarding the preparation of Amrita Guggulu.
25) Purification:
Purification in Ayurveda, known as Shodhana, is the process of cleansing raw materials to remove impurities and improve the quality of herbal products. This step is essential for ensuring the safety and efficacy of preparation for medicinal use.
26) Shotharoga (Sotharoga, Shotha-roga):
Shotharoga refers to a category of diseases characterized by inflammation or swelling, including conditions similar to arthritis. Herbal formulations like Amrita Guggulu are indicated for such conditions, aiming to reduce symptoms and promote health.
27) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, focusing on holistic well-being and natural remedies. It integrates herbal medicine, dietary practices, and lifestyle modifications to treat various health conditions and maintain balance in the body.
28) Prameha:
Prameha is a term in Ayurveda signifying a group of disorders related to metabolic disturbances, including diabetes. Herbal formulations like Amrita Guggulu may be used to help manage blood sugar levels and improve metabolic health.
29) Kashaya (Kasaya):
Kashaya refers to astringent in taste, which is one of the six tastes recognized in Ayurveda. This taste is believed to have a drying and cooling effect, influencing the preparation and application of various herbal formulations.
30) Dravya:
Dravya translates to 'substance' or 'material' in Ayurveda, referring to any therapeutic agent, including herbs, minerals, or composite formulations used to treat ailments. Understanding the properties and effects of Dravya is crucial for effective Ayurvedic practice.
31) Kushtha (Kustha):
Kustha denotes a skin disease or leprosy in Ayurveda. Formulations like Amrita Guggulu are often prescribed for managing such conditions due to their purifying and healing properties, aiming to restore skin health and balance.
32) Arshas (Arsa, Arsas, Arsha):
Arsha refers to hemorrhoids in Ayurveda, a condition that requires effective management through herbal formulations. Amrita Guggulu may be indicated due to its anti-inflammatory and soothing properties, providing relief for symptoms associated with this ailment.
33) Study (Studying):
Study relates to the systematic investigation of a subject or phenomenon. In this context, it reflects the research conducted on the preparation and analysis of Amrita Guggulu, aimed at assessing its quality, safety, and therapeutic efficacy as a traditional medicine.
34) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is used in Ayurveda for its anti-inflammatory and digestive properties. It is a key component in numerous formulations, providing warming effects that aid digestion and improve overall health.
35) Emblica officinalis:
Emblica officinalis, known as Amla, is a crucial Ayurvedic herb celebrated for its antioxidant properties and its role in immune support. It is often included in formulations for its rejuvenating effects and overall health benefits.
36) Terminalia chebula:
Terminalia chebula, known as Haritaki, is an important herb in Ayurveda recognized for its digestive and detoxifying properties. It is often included in formulations like Triphala for its ability to enhance digestion and support metabolic health.
37) Piper longum:
Piper longum, known as long pepper, is used in Ayurveda as a digestive aid and to enhance respiratory health. It is commonly incorporated into formulations for its ability to stimulate digestion and improve bioavailability of other herbs.
38) New Delhi:
New Delhi, the capital of India, is a significant center for education and research in traditional medicine, including Ayurveda. Its universities and institutions promote the study, practice, and development of Ayurvedic therapies and formulations.
39) Terminalia bellirica:
Terminalia bellirica, known as Bibhitaki, is a traditional Ayurvedic herb used for its cleansing properties and role in respiratory health. It is often included in formulations for its balancing effects on bodily doshas.
40) Dravyaguna (Dravya-guna):
Dravyaguna is the branch of Ayurveda that focuses on the properties of medicinal substances. It helps practitioners understand how different Dravyas work within the body and their potential therapeutic effects, guiding formulation development.
41) Rasaushadhi (Rasa-aushadhi, Rasausadhi):
Rasausadhi refers to medicines derived from metallic or mineral sources in Ayurveda. It emphasizes the role of such substances in creating potent formulations used in traditional healing practices for various ailments.
42) Discussion:
Discussion in the context of research refers to the analysis and interpretation of results obtained from the study. It provides insights into the significance of findings related to Amrita Guggulu's preparation and processes influencing its therapeutic efficacy.
43) Vibhitaki:
Vibhitaki, also known as Terminalia bellirica, is one of the three fruits in the Triphala formulation. It is valued for its detoxifying and rejuvenating properties in Ayurveda, playing a key role in digestive health and balanced bodily functions.
44) Murcchita:
Murcchita refers to the process of maturing or conditioning substances in Ayurveda, often involving ghee (butter oil) to enhance the potency of herbal formulations. This practice is crucially employed to prepare effective remedies like Amrita Guggulu.
45) Murchana (Murcchana):
Murcchana is the refinement process in Ayurvedic medicine where herbs are mixed with substances like ghee to improve their medicinal properties. This enhances the absorption and efficacy of the herbal drug in patients.
46) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing illness. In Ayurveda, it pertains to the holistic approach to health that combines herbal remedies, diet, and lifestyle practices to promote overall well-being.
47) Haritaki:
Haritaki is the fruit of Terminalia chebula, revered in Ayurveda for its numerous health benefits, particularly in digestion and detoxification. It is commonly used in formulas like Triphala to enhance overall wellness and metabolic function.
48) Samhita:
Samhita are ancient texts that provide foundational knowledge in Ayurveda, covering theories of medicine, herbal preparations, and treatment methods. These texts serve as crucial references for practitioners to understand and apply Ayurvedic principles.
49) Amalaki:
Amalaki is the fruit of Emblica officinalis, known for its high vitamin C content and strong antioxidant properties. In Ayurveda, it is revered for supporting immunity, digestive health, and overall vitality, commonly used in various herbal formulations.
50) Pippali (Pippalin):
Pippali, or long pepper (Piper longum), is known for its warming properties that enhance digestion and absorption of nutrients. It is utilized in Ayurvedic formulations to assist in respiratory health and provide other therapeutic benefits.
51) Shunthi (Sunthi, Sumthi, Shumthi):
Shunthi, or dry ginger (Zingiber officinale), is valued in Ayurveda for its ability to stimulate digestion and combat nausea. Its warming nature makes it an integral component in many herbal formulations due to its health-promoting properties.
52) Quality:
Quality in herbal preparations refers to the characteristics that ensure efficacy, safety, and consistency of the product. In the context of Amrita Guggulu, quality assessment methods are essential for standardizing formulations and verifying their therapeutic action.
53) Science (Scientific):
Science, in the context of Ayurveda, pertains to the systematic study of natural phenomena through observation and experimentation. It is vital for understanding herbal efficacy and for the continual advancement of traditional medicine.
54) Yantra (Yamtra):
Yantra refers to a device or tool used in Ayurvedic practice, particularly in the preparation of herbal medicines. The Khalwa yantra, used for grinding and mixing, is essential for achieving the ideal consistency of powdered formulations.
55) Shrita (Srta, Srita):
Shrita refers to water-based preparations of herbs in Ayurveda. This method of extraction is crucial for isolating the active components from drugs, allowing for effective formulation and therapeutic benefits in herbal medicines.
56) Phanta (Phamta):
Phanta refers to herbal decoctions made by boiling herbs in water. This preparation method is commonly used in Ayurveda to extract beneficial compounds from plants, enhancing the bioavailability and effectiveness of herbal remedies.
57) Family:
Family refers to the classification of plants into categories based on shared characteristics. In Ayurveda, understanding the family of medicinal herbs is essential for selecting appropriate ingredients and recognizing their therapeutic properties.
58) Powder:
Powder in the context of Ayurveda refers to the ground form of herbal materials used for preparation of medicines. Herbal powders are integral for creating capsules, tablets, or other formulations, making them easy to consume and effective for therapeutic benefits.
59) Indian:
Indian refers to the geographical and cultural context of Ayurveda, with its roots deeply embedded in Indian traditions. It emphasizes the significance of indigenous knowledge systems, plants, and practices in creating a holistic approach to health.
60) Nidhi:
Nidhi signifies 'treasure' or 'resource' in Sanskrit and often refers to collections or repositories of knowledge. In Ayurveda, Nidhi may pertain to compilations of medicinal formulations and practices that serve as valuable sources of healing traditions.
61) Kalka:
Kalka refers to a paste made from fresh herbs or powdered substances in Ayurveda. This preparation method enhances the effectiveness of herbal remedies, providing a concentrated form of active ingredients for improved therapeutic outcomes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Pharmaceutical prep and analysis of Amrita Guggulu with/without ghruta.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Shodhana, Kalka, Phanta, Therapeutic effect, Pharmaceutical preparation, Quality assessment, Bhaishajya kalpana, Swarasa, Total ash, Amrita guggulu, Analytical standards, Disintegration time, Sheeta, Organoleptic test, Physio chemical analysis, Levigation process.